Abstract:
:Pentacyclic triterpenoids (PTs) constitute one of the biggest families of natural products, many with higher oxidation state at the D/E rings possess a wide spectrum of biological activties but are poorly accessible. Here we report a site-selective C-H hydroxylation at the D/E rings of PTs paving a way toward these important natural products. We find that Schönecker and Baran's Cu-mediated aerobic oxidation can be applied and become site-selective on PT skeletons, as being effected unexpectedly by the chirality of the transient pyridine-imino directing groups. To prove the applicability, starting from the most abundant triterpenoid feedstock oleanane, three representative saponins bearing hydroxyl groups at C16 or C22 are expeditiously synthesized, and barringtogenol C which bears hydroxyl groups at C16, C21, and C22 is synthesized via a sequential hydroxylation as the key steps.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Mu T,Wei B,Zhu D,Yu Bdoi
10.1038/s41467-020-18138-9subject
Has Abstractpub_date
2020-09-01 00:00:00pages
4371issue
1issn
2041-1723pii
10.1038/s41467-020-18138-9journal_volume
11pub_type
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