Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma.

abstract：:The investigations on optical angular momenta and their interactions have broadened our knowledge of light's behavior at sub-wavelength scales. Recent studies further unveil the extraordinary characteristics of transverse spin angular momentum in confined light fields and orbital angular momentum in optical vortices. ...

journal_title：Nature communications

authors： Shao Z,Zhu J,Chen Y,Zhang Y,Yu S

更新日期：2018-03-02 00:00:00

abstract：:Materials with a negative Poisson's ratio, also known as auxetic materials, exhibit unusual and counterintuitive mechanical behaviour-becoming fatter in cross-section when stretched. Such behaviour is mostly attributed to some special re-entrant or hinged geometric structures regardless of the chemical composition and...

journal_title：Nature communications

authors： Yu L,Yan Q,Ruzsinszky A

更新日期：2017-05-25 00:00:00

abstract：:Anion-π interactions occur on the surface of π-acidic aromatic planes with positive quadrupole moments. Their ability to contribute to the binding and transport of anions has been demonstrated recently. However, their ability to stabilize anionic reactive intermediates and transition states remains essentially unexplo...

journal_title：Nature communications

authors： Zhao Y,Sakai N,Matile S

更新日期：2014-05-21 00:00:00

abstract：:DNA strands of well-defined sequence are valuable in synthetic biology and nanostructure assembly. Drawing inspiration from solid-phase synthesis, here we describe a DNA assembly method that uses time, or order of addition, as a parameter to define structural complexity. DNA building blocks are sequentially added with...

journal_title：Nature communications

authors： Hamblin GD,Rahbani JF,Sleiman HF

更新日期：2015-05-05 00:00:00

abstract：:Geometric phase, associated with holonomy transformation in quantum state space, is an important quantum-mechanical effect. Besides fundamental interest, this effect has practical applications, among which geometric quantum computation is a paradigm, where quantum logic operations are realized through geometric phase ...

journal_title：Nature communications

authors： Song C,Zheng SB,Zhang P,Xu K,Zhang L,Guo Q,Liu W,Xu D,Deng H,Huang K,Zheng D,Zhu X,Wang H

更新日期：2017-10-20 00:00:00

abstract：:In nature, electrical signalling occurs with ions and protons, rather than electrons. Artificial devices that can control and monitor ionic and protonic currents are thus an ideal means for interfacing with biological systems. Here we report the first demonstration of a biopolymer protonic field-effect transistor with...

journal_title：Nature communications

authors： Zhong C,Deng Y,Roudsari AF,Kapetanovic A,Anantram MP,Rolandi M

更新日期：2011-09-20 00:00:00

abstract：:Aging is characterized by a chronic, low-grade inflammation, which is a major risk factor for cardiovascular diseases. It remains poorly understood whether pro-inflammatory factors released from non-cardiac tissues contribute to the non-autonomous regulation of age-related cardiac dysfunction. Here, we report that age...

journal_title：Nature communications

authors： Huang K,Miao T,Chang K,Kim J,Kang P,Jiang Q,Simmonds AJ,Di Cara F,Bai H

更新日期：2020-06-10 00:00:00

abstract：:The rice blast fungus Magnaporthe oryzae is a model for studying fungal-plant interactions. Although it produces two types of spores (microconidia and macroconidia), previous infection studies have exclusively dealt with macroconidia. Germination of microconidia has not been reported, and their role in plant infection...

journal_title：Nature communications

authors： Zhang H,Wu Z,Wang C,Li Y,Xu JR

更新日期：2014-08-01 00:00:00

abstract：:Recently, stretchable electronics combined with wireless technology have been crucial for realizing efficient human-machine interaction. Here, we demonstrate highly stretchable transparent wireless electronics composed of Ag nanofibers coils and functional electronic components for power transfer and information commu...

journal_title：Nature communications

authors： Zhang Y,Huo Z,Wang X,Han X,Wu W,Wan B,Wang H,Zhai J,Tao J,Pan C,Wang ZL

更新日期：2020-11-06 00:00:00

abstract：:Non-Abelian quasiparticles have been predicted to exist in a variety of condensed matter systems. Their defining property is that an adiabatic braid between two of them results in a non-trivial change of the quantum state of the system. The simplest non-Abelian quasiparticles--the Majorana bound states--can occur in o...

journal_title：Nature communications

authors： Li J,Neupert T,Bernevig BA,Yazdani A

更新日期：2016-01-21 00:00:00

abstract：:Accumulation of nucleotide building blocks prior to and during S phase facilitates DNA duplication. Herein, we find that the anaphase-promoting complex/cyclosome (APC/C) synchronizes ribose-5-phosphate levels and DNA synthesis during the cell cycle. In late G1 and S phases, transketolase-like 1 (TKTL1) is overexpresse...

journal_title：Nature communications

authors： Li Y,Yao CF,Xu FJ,Qu YY,Li JT,Lin Y,Cao ZL,Lin PC,Xu W,Zhao SM,Zhao JY

更新日期：2019-06-07 00:00:00

abstract：:Necroptosis is a type of programmed cell death with great significance in many pathological processes. Tumour necrosis factor-α(TNF), a proinflammatory cytokine, is a prototypic trigger of necroptosis. It is known that mitochondrial reactive oxygen species (ROS) promote necroptosis, and that kinase activity of recepto...

journal_title：Nature communications

authors： Zhang Y,Su SS,Zhao S,Yang Z,Zhong CQ,Chen X,Cai Q,Yang ZH,Huang D,Wu R,Han J

更新日期：2017-02-08 00:00:00

abstract：:Acute stroke causes complex, pathological, and systemic responses that have not been treatable by any single medication. In this study, using a murine transient middle cerebral artery occlusion stroke model, a novel therapeutic strategy is proposed, where blood replacement (BR) robustly reduces infarctions and improve...

journal_title：Nature communications

authors： Ren X,Hu H,Farooqi I,Simpkins JW

更新日期：2020-08-25 00:00:00

abstract：:The virulence factor pyocyanin and the intracellular second messenger cyclic diguanylate monophosphate (c-di-GMP) play key roles in regulating biofilm formation and multi-drug efflux pump expression in Pseudomonas aeruginosa. However, the crosstalk between these two signaling pathways remains unclear. Here we show tha...

journal_title：Nature communications

authors： Wang F,He Q,Yin J,Xu S,Hu W,Gu L

更新日期：2018-07-02 00:00:00

abstract：:The practices of synthetic biology are being integrated into 'multiscale' designs enabling two-way communication across organic and inorganic information substrates in biological, digital and cyber-physical system integrations. Novel applications of 'bio-informational' engineering will arise in environmental monitorin...

journal_title：Nature communications

authors： Dixon TA,Williams TC,Pretorius IS

更新日期：2021-01-15 00:00:00

abstract：:Inelastic collisions involving molecular species are key to energy transfer in gaseous environments. They are commonly governed by an energy gap law, which dictates that transitions are dominated by those between initial and final states with roughly the same ro-vibrational energy. Transitions involving rotational ine...

journal_title：Nature communications

authors： Yang D,Huang J,Hu X,Guo H,Xie D

更新日期：2019-10-11 00:00:00

abstract：:Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for robust NK cell responses. However, the mechanisms leading to this metabolic phenotype are unclear. Here we show that the transcription facto...

journal_title：Nature communications

authors： Loftus RM,Assmann N,Kedia-Mehta N,O'Brien KL,Garcia A,Gillespie C,Hukelmann JL,Oefner PJ,Lamond AI,Gardiner CM,Dettmer K,Cantrell DA,Sinclair LV,Finlay DK

更新日期：2018-06-14 00:00:00

abstract：:Traumatic spinal cord injury results in severe and irreversible loss of function. The injury triggers a complex cascade of inflammatory and pathological processes, culminating in formation of a scar. While traditionally referred to as a glial scar, the spinal injury scar in fact comprises multiple cellular and extrace...

journal_title：Nature communications

authors： Bradbury EJ,Burnside ER

更新日期：2019-08-28 00:00:00

abstract：:Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer's and Parkinson's disease; thus, increasing PGRN levels is a promising therapeutic f...

journal_title：Nature communications

authors： Nicholson AM,Finch NA,Almeida M,Perkerson RB,van Blitterswijk M,Wojtas A,Cenik B,Rotondo S,Inskeep V,Almasy L,Dyer T,Peralta J,Jun G,Wood AR,Frayling TM,Fuchsberger C,Fowler S,Teslovich TM,Manning AK,Kumar S,Curra

更新日期：2016-06-30 00:00:00

abstract：:Chromosomal regions of identical or nearly identical DNA sequence can preferentially associate with one another in the apparent absence of DNA breakage. Molecular mechanism(s) underlying such homology-dependent pairing phenomena remain(s) unknown. Using Neurospora crassa repeat-induced point mutation (RIP) as a model ...

journal_title：Nature communications

authors： Gladyshev E,Kleckner N

更新日期：2014-04-03 00:00:00

abstract：:Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific metabolic changes remains unclear. Here we show, using the comprehensive measurement of metabolic enzymes by large-scale targeted proteomics, that the metabolism both carbon and nitrogen is altered during the malignant progression of ...

journal_title：Nature communications

authors： Kodama M,Oshikawa K,Shimizu H,Yoshioka S,Takahashi M,Izumi Y,Bamba T,Tateishi C,Tomonaga T,Matsumoto M,Nakayama KI

更新日期：2020-03-17 00:00:00

abstract：:Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of ...

journal_title：Nature communications

authors： Adhireksan Z,Palermo G,Riedel T,Ma Z,Muhammad R,Rothlisberger U,Dyson PJ,Davey CA

更新日期：2017-03-30 00:00:00

abstract：:Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the enzyme cGAS may act anti-inflammatory. Here we report the discovery of ...

journal_title：Nature communications

authors： Lama L,Adura C,Xie W,Tomita D,Kamei T,Kuryavyi V,Gogakos T,Steinberg JI,Miller M,Ramos-Espiritu L,Asano Y,Hashizume S,Aida J,Imaeda T,Okamoto R,Jennings AJ,Michino M,Kuroita T,Stamford A,Gao P,Meinke P,Glickman

更新日期：2019-05-21 00:00:00

abstract：:A key challenge in the field of molecular spintronics, and for the design of single-molecule magnet-based devices in particular, is the understanding and control of the molecular coupling at the electrode interfaces. It was demonstrated for the field of molecular electronics that the characterization of the molecule-m...

journal_title：Nature communications

authors： Schwöbel J,Fu Y,Brede J,Dilullo A,Hoffmann G,Klyatskaya S,Ruben M,Wiesendanger R

更新日期：2012-07-17 00:00:00

abstract：:Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time 13C MRI. The type of applications is however limited by the relatively fast decay time of the hyperpolarized spin state together wit...

journal_title：Nature communications

authors： Capozzi A,Cheng T,Boero G,Roussel C,Comment A

更新日期：2017-06-01 00:00:00

abstract：:Accumulating evidence suggests that transcriptional regulation is required for maintenance of long-term memories (LTMs). Here we characterize global transcriptional and epigenetic changes that occur during LTM storage in the Drosophila mushroom bodies (MBs), structures important for memory. Although LTM formation requ...

journal_title：Nature communications

authors： Hirano Y,Ihara K,Masuda T,Yamamoto T,Iwata I,Takahashi A,Awata H,Nakamura N,Takakura M,Suzuki Y,Horiuchi J,Okuno H,Saitoe M

更新日期：2016-11-14 00:00:00

abstract：:Percolation in complex networks is a process that mimics network degradation and a tool that reveals peculiarities of the network structure. During the course of percolation, the emergent properties of networks undergo non-trivial transformations, which include a phase transition in the connectivity, and in some speci...

journal_title：Nature communications

authors： Kryven I

更新日期：2019-01-24 00:00:00

abstract：:The proliferative and functional heterogeneity among seemingly uniform cells is a universal phenomenon. Identifying the underlying factors requires single-cell analysis of function and proliferation. Here we show that the pancreatic beta-cells in zebrafish exhibit different growth-promoting and functional properties, ...

journal_title：Nature communications

authors： Singh SP,Janjuha S,Hartmann T,Kayisoglu Ö,Konantz J,Birke S,Murawala P,Alfar EA,Murata K,Eugster A,Tsuji N,Morrissey ER,Brand M,Ninov N

更新日期：2017-09-22 00:00:00

abstract：:In the original version of this Article, the Acknowledgement section omitted financial support from the Deutsche Forschungsgemeinschaft grant SFB 958/A4. This error has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Paul F,Wehmeyer C,Abualrous ET,Wu H,Crabtree MD,Schöneberg J,Clarke J,Freund C,Weikl TR,Noé F

更新日期：2018-03-09 00:00:00

abstract：:While engineering the phase and structure of electrocatalysts could regulate the performance of many typical electrochemical processes, its importance to the carbon dioxide electroreduction has been largely unexplored. Herein, a series of phase and structure engineered copper-tin dioxide catalysts have been created an...

journal_title：Nature communications

authors： Wang P,Qiao M,Shao Q,Pi Y,Zhu X,Li Y,Huang X

更新日期：2018-11-22 00:00:00