Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations.

abstract：:Chromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosome(s). Considered as an early event in tumour development, this form of genome instability plays a prominent role in tumour onset. Chromothri...

journal_title：Nature communications

authors： Voronina N,Wong JKL,Hübschmann D,Hlevnjak M,Uhrig S,Heilig CE,Horak P,Kreutzfeldt S,Mock A,Stenzinger A,Hutter B,Fröhlich M,Brors B,Jahn A,Klink B,Gieldon L,Sieverling L,Feuerbach L,Chudasama P,Beck K,Kroiss M,H

更新日期：2020-05-08 00:00:00

abstract：:The Barbier reaction, a widely utilized reaction for carbon-carbon bond formation, has played important roles in modern organic chemistry for more than a century. Here, we show its successful introduction to polymer chemistry. Through one-pot Barbier polyaddition (both A2+B2 type and AB type) of monomers containing an...

journal_title：Nature communications

authors： Sun XL,Liu DM,Tian D,Zhang XY,Wu W,Wan WM

更新日期：2017-10-31 00:00:00

abstract：:Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in industrialized countries. Type I interferon (IFN) is important for control of herpes simplex virus (HSV-1) in the central nervous system (CNS). Here we show that microglia are the main source of HSV-induced type I IFN expression i...

journal_title：Nature communications

authors： Reinert LS,Lopušná K,Winther H,Sun C,Thomsen MK,Nandakumar R,Mogensen TH,Meyer M,Vægter C,Nyengaard JR,Fitzgerald KA,Paludan SR

更新日期：2016-11-10 00:00:00

abstract：:Schizophrenia and bipolar disorder are major psychiatric disorders with high heritability and overlapping genetic variance. Here we perform a genome-wide association study in an ethnically homogeneous cohort of 904 schizophrenia cases and 1,640 controls drawn from the Ashkenazi Jewish population. We identify a novel g...

journal_title：Nature communications

authors： Lencz T,Guha S,Liu C,Rosenfeld J,Mukherjee S,DeRosse P,John M,Cheng L,Zhang C,Badner JA,Ikeda M,Iwata N,Cichon S,Rietschel M,Nöthen MM,Cheng AT,Hodgkinson C,Yuan Q,Kane JM,Lee AT,Pisanté A,Gregersen PK,Pe'er I

更新日期：2013-01-01 00:00:00

abstract：:The diversity in our genome is crucial to understanding the demographic history of worldwide populations. However, we have yet to know whether subtle genetic differences within a population can be disentangled, or whether they have an impact on complex traits. Here we apply dimensionality reduction methods (PCA, t-SNE...

journal_title：Nature communications

authors： Sakaue S,Hirata J,Kanai M,Suzuki K,Akiyama M,Lai Too C,Arayssi T,Hammoudeh M,Al Emadi S,Masri BK,Halabi H,Badsha H,Uthman IW,Saxena R,Padyukov L,Hirata M,Matsuda K,Murakami Y,Kamatani Y,Okada Y

更新日期：2020-03-26 00:00:00

abstract：:Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham...

journal_title：Nature communications

authors： Chu AY,Tin A,Schlosser P,Ko YA,Qiu C,Yao C,Joehanes R,Grams ME,Liang L,Gluck CA,Liu C,Coresh J,Hwang SJ,Levy D,Boerwinkle E,Pankow JS,Yang Q,Fornage M,Fox CS,Susztak K,Köttgen A

更新日期：2017-11-03 00:00:00

abstract：:Priming of the mucosal immune system during the postnatal period substantially influences host-microbial interaction and susceptibility to immune-mediated diseases in adult life. The underlying mechanisms are ill defined. Here we show that shortly after birth, CD4 T cells populate preformed lymphoid structures in the ...

journal_title：Nature communications

authors： Torow N,Yu K,Hassani K,Freitag J,Schulz O,Basic M,Brennecke A,Sparwasser T,Wagner N,Bleich A,Lochner M,Weiss S,Förster R,Pabst O,Hornef MW

更新日期：2015-07-21 00:00:00

abstract：:Characterizing complex viral transcriptomes by conventional RNA sequencing approaches is complicated by high gene density, overlapping reading frames, and complex splicing patterns. Direct RNA sequencing (direct RNA-seq) using nanopore arrays offers an exciting alternative whereby individual polyadenylated RNAs are se...

journal_title：Nature communications

authors： Depledge DP,Srinivas KP,Sadaoka T,Bready D,Mori Y,Placantonakis DG,Mohr I,Wilson AC

更新日期：2019-02-14 00:00:00

abstract：:Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication. We analyse the cellular pathways in which human proviral genes are...

journal_title：Nature communications

authors： Karlas A,Berre S,Couderc T,Varjak M,Braun P,Meyer M,Gangneux N,Karo-Astover L,Weege F,Raftery M,Schönrich G,Klemm U,Wurzlbauer A,Bracher F,Merits A,Meyer TF,Lecuit M

更新日期：2016-05-12 00:00:00

abstract：:Macrophages serve multiple functions including immune regulation, morphogenesis, tissue homeostasis and healing reactions. The current paradigm holds that mammary gland macrophages first arise postnatally during the prepubertal period from the bone marrow-derived monocytes. Here we delineate the origins of tissue-resi...

journal_title：Nature communications

authors： Jäppinen N,Félix I,Lokka E,Tyystjärvi S,Pynttäri A,Lahtela T,Gerke H,Elima K,Rantakari P,Salmi M

更新日期：2019-01-17 00:00:00

abstract：:As an in-plane charge current flows in a heavy metal film with spin-orbit coupling, it produces a torque on and thereby switches the magnetization in a neighbouring ferromagnetic metal film. Such spin-orbit torque (SOT)-induced switching has been studied extensively in recent years and has shown higher efficiency than...

journal_title：Nature communications

authors： Li P,Liu T,Chang H,Kalitsov A,Zhang W,Csaba G,Li W,Richardson D,DeMann A,Rimal G,Dey H,Jiang JS,Porod W,Field SB,Tang J,Marconi MC,Hoffmann A,Mryasov O,Wu M

更新日期：2016-09-01 00:00:00

abstract：:Many heritable mutualisms, in which beneficial symbionts are transmitted vertically between host generations, originate as antagonisms with parasite dispersal constrained by the host. Only after the parasite gains control over its transmission is the symbiosis expected to transition from antagonism to mutualism. Here,...

journal_title：Nature communications

authors： Mondo SJ,Lastovetsky OA,Gaspar ML,Schwardt NH,Barber CC,Riley R,Sun H,Grigoriev IV,Pawlowska TE

更新日期：2017-11-29 00:00:00

abstract：:Aqueous nanofibres constructed by the self-assembly of small amphiphilic molecules can become entangled to form hydrogels that have a variety of applications including tissue engineering, and controlled drug delivery. The hydrogels are formed through the random physical cross-linkings of flexible nanofibres. Here we r...

journal_title：Nature communications

authors： Huang Z,Lee H,Lee E,Kang SK,Nam JM,Lee M

更新日期：2011-09-06 00:00:00

abstract：:Samarium hexaboride is a classic three-dimensional mixed valence system with a high-temperature metallic phase that evolves into a paramagnetic charge insulator below 40 K. A number of recent experiments have suggested the possibility that the low-temperature insulating bulk hosts electrically neutral gapless fermioni...

journal_title：Nature communications

authors： Chowdhury D,Sodemann I,Senthil T

更新日期：2018-05-02 00:00:00

abstract：:In the original version of this Article, the sixth sentence of the abstract incorrectly read 'Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26Met HCC model undergo the same change.', and should have read 'Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26Met HCC model ...

journal_title：Nature communications

authors： Arechederra M,Daian F,Yim A,Bazai SK,Richelme S,Dono R,Saurin AJ,Habermann BH,Maina F

更新日期：2018-09-25 00:00:00

abstract：:Graphene is a single-atomic-layer material with excellent mechanical properties and has the potential to enhance the strength of composites. Its two-dimensional geometry, high intrinsic strength and modulus can effectively constrain dislocation motion, resulting in the significant strengthening of metals. Here we demo...

journal_title：Nature communications

authors： Kim Y,Lee J,Yeom MS,Shin JW,Kim H,Cui Y,Kysar JW,Hone J,Jung Y,Jeon S,Han SM

更新日期：2013-01-01 00:00:00

abstract：:Engineering lattice thermal conductivity requires to control the heat carried by atomic vibration waves, the phonons. The key parameter for quantifying it is the phonon lifetime, limiting the travelling distance, whose determination is however at the limits of instrumental capabilities. Here, we show the achievement o...

journal_title：Nature communications

authors： Lory PF,Pailhès S,Giordano VM,Euchner H,Nguyen HD,Ramlau R,Borrmann H,Schmidt M,Baitinger M,Ikeda M,Tomeš P,Mihalkovič M,Allio C,Johnson MR,Schober H,Sidis Y,Bourdarot F,Regnault LP,Ollivier J,Paschen S,Grin Y,d

更新日期：2017-09-08 00:00:00

abstract：:Understanding the role of intermolecular interaction on through-space charge transfer characteristics in π-stacked molecular systems is central to the rational design of electronic materials. However, a quantitative study of charge transfer in such systems is often difficult because of poor control over molecular morp...

journal_title：Nature communications

authors： Batra A,Kladnik G,Vázquez H,Meisner JS,Floreano L,Nuckolls C,Cvetko D,Morgante A,Venkataraman L

更新日期：2012-01-01 00:00:00

abstract：:Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased clustering of gene expression profiles and canonical markers. The...

journal_title：Nature communications

authors： Zhou Y,Yang D,Yang Q,Lv X,Huang W,Zhou Z,Wang Y,Zhang Z,Yuan T,Ding X,Tang L,Zhang J,Yin J,Huang Y,Yu W,Wang Y,Zhou C,Su Y,He A,Sun Y,Shen Z,Qian B,Meng W,Fei J,Yao Y,Pan X,Chen P,Hu H

更新日期：2020-12-10 00:00:00

abstract：:Post-translational protein modifications are systems designed to expand restricted genomic information through functional conversion of target molecules. Ubiquitin-like post-translational modifiers regulate numerous cellular events through their covalent linkages to target protein(s) by an enzymatic cascade analogous ...

journal_title：Nature communications

authors： Tatsumi K,Yamamoto-Mukai H,Shimizu R,Waguri S,Sou YS,Sakamoto A,Taya C,Shitara H,Hara T,Chung CH,Tanaka K,Yamamoto M,Komatsu M

更新日期：2011-02-08 00:00:00

abstract：:Proton conduction is a fundamental process in biology and in devices such as proton exchange membrane fuel cells. To maximize proton conduction, three-dimensional conduction pathways are preferred over one-dimensional pathways, which prevent conduction in two dimensions. Many crystalline porous solids to date show one...

journal_title：Nature communications

authors： Liu M,Chen L,Lewis S,Chong SY,Little MA,Hasell T,Aldous IM,Brown CM,Smith MW,Morrison CA,Hardwick LJ,Cooper AI

更新日期：2016-09-13 00:00:00

abstract：:The intestinal microbiome is a unique ecosystem and an essential mediator of metabolism and obesity in mammals. However, studies investigating the impact of the diet on the establishment of the gut microbiome early in life are generally lacking, and most notably so in primate models. Here we report that a high-fat mat...

journal_title：Nature communications

authors： Ma J,Prince AL,Bader D,Hu M,Ganu R,Baquero K,Blundell P,Alan Harris R,Frias AE,Grove KL,Aagaard KM

更新日期：2014-05-20 00:00:00

abstract：:Topologically protected pseudospin transport, analogous to the quantum spin Hall effect, cannot be strictly implemented for photons and in general bosons because of the lack of symmetry-protected pseudospins. Here we show that the required protection can be provided by the real-space topological excitation of an inter...

journal_title：Nature communications

authors： Bleu O,Malpuech G,Solnyshkov DD

更新日期：2018-09-28 00:00:00

abstract：:The ionic conductance through a nanometer-sized pore in a membrane changes when a biopolymer slides through it, making nanopores sensitive to single molecules in solution. Their possible use for sequencing has motivated numerous studies on how DNA, a semi-flexible polymer, translocates nanopores. Here we study voltage...

journal_title：Nature communications

authors： McMullen A,de Haan HW,Tang JX,Stein D

更新日期：2014-06-16 00:00:00

abstract：:Steels belong to one of the best established materials, however, the mechanisms of various phase transformations down to the nano length scale are still not fully clear. In this work, high-resolution transmission electron microscopy is combined with atomistic simulations to study the nanoscale carbide precipitation in...

journal_title：Nature communications

authors： Wang H,Zhang X,Yan D,Somsen C,Eggeler G

更新日期：2018-10-01 00:00:00

abstract：:Methanol represents an attractive substrate for biotechnological applications. Utilization of reduced one-carbon compounds for growth is currently limited to methylotrophic organisms, and engineering synthetic methylotrophy remains a major challenge. Here we apply an in silico-guided multiple knockout approach to engi...

journal_title：Nature communications

authors： Meyer F,Keller P,Hartl J,Gröninger OG,Kiefer P,Vorholt JA

更新日期：2018-04-17 00:00:00

abstract：:Mitochondria and peroxisomes proliferate by division. During division, a part of their membrane is pinched off by constriction of the ring-shaped mitochondrial division (MD) and peroxisome-dividing (POD) machinery. This constriction is mediated by a dynamin-like GTPase Dnm1 that requires a large amount of GTP as an en...

journal_title：Nature communications

authors： Imoto Y,Abe Y,Honsho M,Okumoto K,Ohnuma M,Kuroiwa H,Kuroiwa T,Fujiki Y

更新日期：2018-11-06 00:00:00

abstract：:How spatial and temporal information are integrated to determine the direction of cell migration remains poorly understood. Here, by precise microfluidics emulation of dynamic chemoattractant waves, we demonstrate that, in Dictyostelium, directional movement as well as activation of small guanosine triphosphatase Ras ...

journal_title：Nature communications

authors： Nakajima A,Ishihara S,Imoto D,Sawai S

更新日期：2014-11-06 00:00:00

abstract：:Modern ab initio calculations predict ionic and superionic states in highly compressed water and ammonia. The prediction apparently contradicts state-of-the-art experimentally established phase diagrams overwhelmingly dominated by molecular phases. Here we present experimental evidence that the threshold pressure of ~...

journal_title：Nature communications

authors： Palasyuk T,Troyan I,Eremets M,Drozd V,Medvedev S,Zaleski-Ejgierd P,Magos-Palasyuk E,Wang H,Bonev SA,Dudenko D,Naumov P

更新日期：2014-03-24 00:00:00

abstract：:Controlling the structure of catalysts at the atomic level provides an opportunity to establish detailed understanding of the catalytic form-to-function and realize new, non-equilibrium catalytic structures. Here, advanced thin-film deposition is used to control the atomic structure of La2/3Sr1/3MnO3, a well-known cat...

journal_title：Nature communications

authors： Eom CJ,Kuo DY,Adamo C,Moon EJ,May SJ,Crumlin EJ,Schlom DG,Suntivich J

更新日期：2018-10-02 00:00:00