Abstract:
:Tumors are mixtures of different compartments. While global gene expression analysis profiles the average expression of all compartments in a sample, identifying the specific contribution of each compartment remains a challenge. With the increasing recognition of the importance of non-neoplastic components, the ability to breakdown the gene expression contribution of each is critical. Here, we develop DECODER, an integrated framework which performs de novo deconvolution and single-sample compartment weight estimation. We use DECODER to deconvolve 33 TCGA tumor RNA-seq data sets and show that it may be applied to other data types including ATAC-seq. We demonstrate that it can be utilized to reproducibly estimate cellular compartment weights in pancreatic cancer that are clinically meaningful. Application of DECODER across cancer types advances the capability of identifying cellular compartments in an unknown sample and may have implications for identifying the tumor of origin for cancers of unknown primary.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Peng XL,Moffitt RA,Torphy RJ,Volmar KE,Yeh JJdoi
10.1038/s41467-019-12517-7subject
Has Abstractpub_date
2019-10-18 00:00:00pages
4729issue
1issn
2041-1723pii
10.1038/s41467-019-12517-7journal_volume
10pub_type
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