JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis.

Abstract:

:Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The contribution of cell adhesion molecules to the cortical localization of the dynein-dynactin complex is poorly understood. Here we find that junctional adhesion molecule-A (JAM-A) regulates the planar orientation of the mitotic spindle during epithelial morphogenesis. During mitosis, JAM-A triggers a transient activation of Cdc42 and PI(3)K, generates a gradient of PtdIns(3,4,5)P3 at the cortex and regulates the formation of the cortical actin cytoskeleton. In the absence of functional JAM-A, dynactin localization at the cortex is reduced, the mitotic spindle apparatus is misaligned and epithelial morphogenesis in three-dimensional culture is compromised. Our findings indicate that a PI(3)K- and cortical F-actin-dependent pathway of planar spindle orientation operates in polarized epithelial cells to regulate epithelial morphogenesis, and we identify JAM-A as a junctional regulator of this pathway.

journal_name

Nat Commun

journal_title

Nature communications

authors

Tuncay H,Brinkmann BF,Steinbacher T,Schürmann A,Gerke V,Iden S,Ebnet K

doi

10.1038/ncomms9128

subject

Has Abstract

pub_date

2015-08-26 00:00:00

pages

8128

issn

2041-1723

pii

ncomms9128

journal_volume

6

pub_type

杂志文章
  • Spatial and temporal changes in cumulative human impacts on the world's ocean.

    abstract::Human pressures on the ocean are thought to be increasing globally, yet we know little about their patterns of cumulative change, which pressures are most responsible for change, and which places are experiencing the greatest increases. Managers and policymakers require such information to make strategic decisions and...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms8615

    authors: Halpern BS,Frazier M,Potapenko J,Casey KS,Koenig K,Longo C,Lowndes JS,Rockwood RC,Selig ER,Selkoe KA,Walbridge S

    更新日期:2015-07-14 00:00:00

  • Potential regime shift in decreased sea ice production after the Mertz Glacier calving.

    abstract::Variability in dense shelf water formation can potentially impact Antarctic Bottom Water (AABW) production, a vital component of the global climate system. In East Antarctica, the George V Land polynya system (142-150°E) is structured by the local 'icescape', promoting sea ice formation that is driven by the offshore ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1820

    authors: Tamura T,Williams GD,Fraser AD,Ohshima KI

    更新日期:2012-05-08 00:00:00

  • The genetic architecture of floral traits in the woody plant Prunus mume.

    abstract::Mei (Prunus mume) is an ornamental woody plant that has been domesticated in East Asia for thousands of years. High diversity in floral traits, along with its recent genome sequence, makes mei an ideal model system for studying the evolution of woody plants. Here, we investigate the genetic architecture of floral trai...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04093-z

    authors: Zhang Q,Zhang H,Sun L,Fan G,Ye M,Jiang L,Liu X,Ma K,Shi C,Bao F,Guan R,Han Y,Fu Y,Pan H,Chen Z,Li L,Wang J,Lv M,Zheng T,Yuan C,Zhou Y,Lee SM,Yan X,Xu X,Wu R,Chen W,Cheng T

    更新日期:2018-04-27 00:00:00

  • Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents.

    abstract::How sleep influences brain plasticity is not known. In particular, why certain electroencephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-00735-w

    authors: Seibt J,Richard CJ,Sigl-Glöckner J,Takahashi N,Kaplan DI,Doron G,de Limoges D,Bocklisch C,Larkum ME

    更新日期:2017-09-25 00:00:00

  • Terrestrial land-cover type richness is positively linked to landscape-level functioning.

    abstract::Biodiversity-ecosystem functioning (BEF) experiments have shown that local species richness promotes ecosystem functioning and stability. Whether this also applies under real-world conditions is still debated. Here, we focus on larger scales of space, time and ecological organization. We develop a quasi-experimental d...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-14002-7

    authors: Oehri J,Schmid B,Schaepman-Strub G,Niklaus PA

    更新日期:2020-01-09 00:00:00

  • Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease.

    abstract::COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electro...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18709-w

    authors: Douangamath A,Fearon D,Gehrtz P,Krojer T,Lukacik P,Owen CD,Resnick E,Strain-Damerell C,Aimon A,Ábrányi-Balogh P,Brandão-Neto J,Carbery A,Davison G,Dias A,Downes TD,Dunnett L,Fairhead M,Firth JD,Jones SP,Keeley A,K

    更新日期:2020-10-07 00:00:00

  • Functional evaluation of autism-associated mutations in NHE9.

    abstract::NHE9 (SLC9A9) is an endosomal cation/proton antiporter with orthologues in yeast and bacteria. Rare, missense substitutions in NHE9 are genetically linked with autism but have not been functionally evaluated. Here we use evolutionary conservation analysis to build a model structure of NHE9 based on the crystal structu...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms3510

    authors: Kondapalli KC,Hack A,Schushan M,Landau M,Ben-Tal N,Rao R

    更新日期:2013-01-01 00:00:00

  • Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis.

    abstract::During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting mechanical tension. In this context, it is unclear how mechanica...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07448-8

    authors: Kale GR,Yang X,Philippe JM,Mani M,Lenne PF,Lecuit T

    更新日期:2018-11-27 00:00:00

  • Transcription reinitiation by recycling RNA polymerase that diffuses on DNA after releasing terminated RNA.

    abstract::Despite extensive studies on transcription mechanisms, it is unknown how termination complexes are disassembled, especially in what order the essential components dissociate. Our single-molecule fluorescence study unveils that RNA transcript release precedes RNA polymerase (RNAP) dissociation from the DNA template muc...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-14200-3

    authors: Kang W,Ha KS,Uhm H,Park K,Lee JY,Hohng S,Kang C

    更新日期:2020-01-23 00:00:00

  • Full-field implementation of a perfect eavesdropper on a quantum cryptography system.

    abstract::Quantum key distribution (QKD) allows two remote parties to grow a shared secret key. Its security is founded on the principles of quantum mechanics, but in reality it significantly relies on the physical implementation. Technological imperfections of QKD systems have been previously explored, but no attack on an esta...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1348

    authors: Gerhardt I,Liu Q,Lamas-Linares A,Skaar J,Kurtsiefer C,Makarov V

    更新日期:2011-06-14 00:00:00

  • Very-Low-Frequency transmitters bifurcate energetic electron belt in near-earth space.

    abstract::Very-Low-Frequency (VLF) transmitters operate worldwide mostly at frequencies of 10-30 kilohertz for submarine communications. While it has been of intense scientific interest and practical importance to understand whether VLF transmitters can affect the natural environment of charged energetic particles, for decades ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18545-y

    authors: Hua M,Li W,Ni B,Ma Q,Green A,Shen X,Claudepierre SG,Bortnik J,Gu X,Fu S,Xiang Z,Reeves GD

    更新日期:2020-09-24 00:00:00

  • An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment.

    abstract::How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-13329-5

    authors: Tekpli X,Lien T,Røssevold AH,Nebdal D,Borgen E,Ohnstad HO,Kyte JA,Vallon-Christersson J,Fongaard M,Due EU,Svartdal LG,Sveli MAT,Garred Ø,OSBREAC.,Frigessi A,Sahlberg KK,Sørlie T,Russnes HG,Naume B,Kristensen VN

    更新日期:2019-12-03 00:00:00

  • Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies.

    abstract::Heparin-like oligosaccharides mediate numerous important biological interactions, of which many are implicated in various diseases. Synthetic improvements are central to the development of such oligosaccharides as therapeutics and, in addition, there are no methods to elucidate the pharmacokinetics of structurally def...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms3016

    authors: Hansen SU,Miller GJ,Cole C,Rushton G,Avizienyte E,Jayson GC,Gardiner JM

    更新日期:2013-01-01 00:00:00

  • Precise capture and dynamic relocation of nanoparticulate biomolecules through dielectrophoretic enhancement by vertical nanogap architectures.

    abstract::Toward the development of surface-sensitive analytical techniques for biosensors and diagnostic biochip assays, a local integration of low-concentration target materials into the sensing region of interest is essential to improve the sensitivity and reliability of the devices. As a result, the dynamic process of sorti...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-16630-w

    authors: Yu ES,Lee H,Lee SM,Kim J,Kim T,Lee J,Kim C,Seo M,Kim JH,Byun YT,Park SC,Lee SY,Lee SD,Ryu YS

    更新日期:2020-06-04 00:00:00

  • Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems.

    abstract::Essential components of animal behaviour are modulated by dopaminergic (DA) and noradrenergic circuitry. In this study, we reveal at cellular resolution the complete set of projections ('projectome') of every single type of DA and noradrenergio neurons in the central nervous system of zebrafish larvae. The most extens...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1171

    authors: Tay TL,Ronneberger O,Ryu S,Nitschke R,Driever W

    更新日期:2011-01-25 00:00:00

  • Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells.

    abstract::Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppress...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06609-z

    authors: Straub T,Freudenberg MA,Schleicher U,Bogdan C,Gasteiger G,Pircher H

    更新日期:2018-10-08 00:00:00

  • Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible.

    abstract::A key mechanism of bacterial resistance to macrolide antibiotics is the dimethylation of a nucleotide in the large ribosomal subunit by erythromycin resistance methyltransferases. The majority of erm genes are expressed only when the antibiotic is present and the erythromycin resistance methyltransferase activity is c...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2984

    authors: Gupta P,Sothiselvam S,Vázquez-Laslop N,Mankin AS

    更新日期:2013-01-01 00:00:00

  • Configurable topological textures in strain graded ferroelectric nanoplates.

    abstract::Topological defects in matter behave collectively to form highly non-trivial structures called topological textures that are characterised by conserved quantities such as the winding number. Here we show that an epitaxial ferroelectric square nanoplate of bismuth ferrite subjected to a large strain gradient (as much a...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-02813-5

    authors: Kim KE,Jeong S,Chu K,Lee JH,Kim GY,Xue F,Koo TY,Chen LQ,Choi SY,Ramesh R,Yang CH

    更新日期:2018-01-26 00:00:00

  • FLOWERING LOCUS C in monocots and the tandem origin of angiosperm-specific MADS-box genes.

    abstract::MADS-domain transcription factors have been shown to act as key repressors or activators of the transition to flowering and as master regulators of reproductive organ identities. Despite their important roles in plant development, the origin of several MADS-box subfamilies has remained enigmatic so far. Here we demons...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms3280

    authors: Ruelens P,de Maagd RA,Proost S,Theißen G,Geuten K,Kaufmann K

    更新日期:2013-01-01 00:00:00

  • Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion.

    abstract::The long external filament of bacterial flagella is composed of several thousand copies of a single protein, flagellin. Here, we explore the role played by lysine methylation of flagellin in Salmonella, which requires the methylase FliB. We show that both flagellins of Salmonella enterica serovar Typhimurium, FliC and...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-15738-3

    authors: Horstmann JA,Lunelli M,Cazzola H,Heidemann J,Kühne C,Steffen P,Szefs S,Rossi C,Lokareddy RK,Wang C,Lemaire L,Hughes KT,Uetrecht C,Schlüter H,Grassl GA,Stradal TEB,Rossez Y,Kolbe M,Erhardt M

    更新日期:2020-04-24 00:00:00

  • Phase fluctuations and the absence of topological defects in a photo-excited charge-ordered nickelate.

    abstract::The dynamics of an order parameter's amplitude and phase determines the collective behaviour of novel states emerging in complex materials. Time- and momentum-resolved pump-probe spectroscopy, by virtue of measuring material properties at atomic and electronic time scales out of equilibrium, can decouple entangled deg...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1837

    authors: Lee WS,Chuang YD,Moore RG,Zhu Y,Patthey L,Trigo M,Lu DH,Kirchmann PS,Krupin O,Yi M,Langner M,Huse N,Robinson JS,Chen Y,Zhou SY,Coslovich G,Huber B,Reis DA,Kaindl RA,Schoenlein RW,Doering D,Denes P,Schlotter WF

    更新日期:2012-05-15 00:00:00

  • Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET.

    abstract::Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor. When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity. When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IREs) in messenger RNAs (mRNAs) en...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-13237-8

    authors: Huynh N,Ou Q,Cox P,Lill R,King-Jones K

    更新日期:2019-11-29 00:00:00

  • Antiskyrmions stabilized at interfaces by anisotropic Dzyaloshinskii-Moriya interactions.

    abstract::Chiral magnets are an emerging class of topological matter harboring localized and topologically protected vortex-like magnetic textures called skyrmions, which are currently under intense scrutiny as an entity for information storage and processing. Here, on the level of micromagnetics we rigorously show that chiral ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-00313-0

    authors: Hoffmann M,Zimmermann B,Müller GP,Schürhoff D,Kiselev NS,Melcher C,Blügel S

    更新日期:2017-08-21 00:00:00

  • A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.

    abstract::Mutations in the gene coding for membrane-bound fatty aldehyde dehydrogenase (FALDH) lead to toxic accumulation of lipid species and development of the Sjögren-Larsson Syndrome (SLS), a rare disorder characterized by skin defects and mental retardation. Here, we present the crystallographic structure of human FALDH, t...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms5439

    authors: Keller MA,Zander U,Fuchs JE,Kreutz C,Watschinger K,Mueller T,Golderer G,Liedl KR,Ralser M,Kräutler B,Werner ER,Marquez JA

    更新日期:2014-07-22 00:00:00

  • Relativistic and resonant effects in the ionization of heavy atoms by ultra-intense hard X-rays.

    abstract::An accurate description of the interaction of intense hard X-ray pulses with heavy atoms, which is crucial for many applications of free-electron lasers, represents a hitherto unresolved challenge for theory because of the enormous number of electronic configurations and relativistic effects, which need to be taken in...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06745-6

    authors: Rudek B,Toyota K,Foucar L,Erk B,Boll R,Bomme C,Correa J,Carron S,Boutet S,Williams GJ,Ferguson KR,Alonso-Mori R,Koglin JE,Gorkhover T,Bucher M,Lehmann CS,Krässig B,Southworth SH,Young L,Bostedt C,Ueda K,Marchenk

    更新日期:2018-10-10 00:00:00

  • Tolerance induction to human stem cell transplants with extension to their differentiated progeny.

    abstract::There is increasing interest in transplantation of human stem cells for therapeutic purposes. It would benefit future application if one could achieve their long-term acceptance and functional differentiation in allogeneic hosts using minimal immunosuppression. Allogeneic stem cell transplants differ from conventional...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6629

    authors: Lui KO,Howie D,Ng SW,Liu S,Chien KR,Waldmann H

    更新日期:2014-12-01 00:00:00

  • Extreme oceanographic forcing and coastal response due to the 2015-2016 El Niño.

    abstract::The El Niño-Southern Oscillation is the dominant mode of interannual climate variability across the Pacific Ocean basin, with influence on the global climate. The two end members of the cycle, El Niño and La Niña, force anomalous oceanographic conditions and coastal response along the Pacific margin, exposing many hea...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14365

    authors: Barnard PL,Hoover D,Hubbard DM,Snyder A,Ludka BC,Allan J,Kaminsky GM,Ruggiero P,Gallien TW,Gabel L,McCandless D,Weiner HM,Cohn N,Anderson DL,Serafin KA

    更新日期:2017-02-14 00:00:00

  • Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior.

    abstract::Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the ability to select appropriate responses from a vast behavioral repertoire. Modulation by the prefrontal cortex (PFC) is thought to be key for both processes, but the precise role of specific circuits remains unclear. We examined th...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-19772-z

    authors: Huda R,Sipe GO,Breton-Provencher V,Cruz KG,Pho GN,Adam E,Gunter LM,Sullins A,Wickersham IR,Sur M

    更新日期:2020-11-26 00:00:00

  • Store-independent modulation of Ca(2+) entry through Orai by Septin 7.

    abstract::Orai channels are required for store-operated Ca(2+) entry (SOCE) in multiple cell types. Septins are a class of GTP-binding proteins that function as diffusion barriers in cells. Here we show that Septin 7 acts as a 'molecular brake' on activation of Orai channels in Drosophila neurons. Lowering Septin 7 levels resul...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms11751

    authors: Deb BK,Pathak T,Hasan G

    更新日期:2016-05-26 00:00:00

  • A general-purpose machine-learning force field for bulk and nanostructured phosphorus.

    abstract::Elemental phosphorus is attracting growing interest across fundamental and applied fields of research. However, atomistic simulations of phosphorus have remained an outstanding challenge. Here, we show that a universally applicable force field for phosphorus can be created by machine learning (ML) from a suitably chos...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-19168-z

    authors: Deringer VL,Caro MA,Csányi G

    更新日期:2020-10-29 00:00:00