Differentiation but not ALS mutations in FUS rewires motor neuron metabolism.

abstract：:X-linked lymphoproliferative syndrome type-2 (XLP-2) is a primary immunodeficiency disease attributed to XIAP mutation and is triggered by infection. Here, we show that mouse Xiap-/- regulatory T (Treg) cells and human XIAP-deficient Treg cells are defective in suppressive function. The Xiap-/- Treg cell defect is lin...

journal_title：Nature communications

authors： Hsieh WC,Hsu TS,Chang YJ,Lai MZ

更新日期：2018-01-31 00:00:00

abstract：:CD8+ T cells provide a critical defence from pathogens at mucosal epithelia including the female reproductive tract (FRT). Mucosal immunisation is considered essential to initiate this response, however this is difficult to reconcile with evidence that antigen delivered to skin can recruit protective CD8+ T cells to m...

journal_title：Nature communications

authors： Zaric M,Becker PD,Hervouet C,Kalcheva P,Doszpoly A,Blattman N,A O' Neill L,Yus BI,Cocita C,Kwon SY,Baker AH,Lord GM,Klavinskis LS

更新日期：2019-05-17 00:00:00

abstract：:Fibronectin fibrils within the extracellular matrix play central roles in physiological and pathological processes, yet many structural details about their hierarchical and molecular assembly remain unknown. Here we combine site-specific protein labelling with single-molecule localization by stepwise photobleaching or...

journal_title：Nature communications

authors： Früh SM,Schoen I,Ries J,Vogel V

更新日期：2015-06-04 00:00:00

abstract：:Changes in cellular metabolism are associated with the activation of diverse immune subsets. These changes are fuelled by nutrients including glucose, amino acids and fatty acids, and are closely linked to immune cell fate and function. An emerging concept is that nutrients are not equally available to all immune cell...

journal_title：Nature communications

authors： Kedia-Mehta N,Finlay DK

更新日期：2019-05-09 00:00:00

abstract：:Ion distribution in aqueous electrolytes near the interface plays a critical role in electrochemical, biological and colloidal systems, and is expected to be particularly significant inside nanoconfined regions. Electroneutrality of the total charge inside nanoconfined regions is commonly assumed a priori in solving i...

journal_title：Nature communications

authors： Luo ZX,Xing YZ,Ling YC,Kleinhammes A,Wu Y

更新日期：2015-02-20 00:00:00

abstract：:In the original version of this Article, Supplementary Table 10 contained incorrect primer sequences for the mobility shift assay for SNP rs4776984. These errors have now been fixed and the corrected version of the Supplementary Information PDF is available to download from the HTML version of the Article. ...

journal_title：Nature communications

authors： Pan DZ,Garske KM,Alvarez M,Bhagat YV,Boocock J,Nikkola E,Miao Z,Raulerson CK,Cantor RM,Civelek M,Glastonbury CA,Small KS,Boehnke M,Lusis AJ,Sinsheimer JS,Mohlke KL,Laakso M,Pajukanta P,Ko A

更新日期：2018-08-22 00:00:00

abstract：:Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on ART combination therapies (ACTs). Decreased sensitivity to ARTs is emerging, making it critically important to understand the mechan...

journal_title：Nature communications

authors： Bridgford JL,Xie SC,Cobbold SA,Pasaje CFA,Herrmann S,Yang T,Gillett DL,Dick LR,Ralph SA,Dogovski C,Spillman NJ,Tilley L

更新日期：2018-09-18 00:00:00

abstract：:Solid substrates often induce non-uniform strain and doping in graphene monolayer, therefore altering the intrinsic properties of graphene, reducing its charge carrier mobilities and, consequently, the overall electrical performance. Here, we exploit confocal Raman spectroscopy to study graphene directly free-floating...

journal_title：Nature communications

authors： Belyaeva LA,Jiang L,Soleimani A,Methorst J,Risselada HJ,Schneider GF

更新日期：2020-02-14 00:00:00

abstract：:Ice-shelf channels are long curvilinear tracts of thin ice found on Antarctic ice shelves. Many of them originate near the grounding line, but their formation mechanisms remain poorly understood. Here we use ice-penetrating radar data from Roi Baudouin Ice Shelf, East Antarctica, to infer that the morphology of severa...

journal_title：Nature communications

authors： Drews R,Pattyn F,Hewitt IJ,Ng FSL,Berger S,Matsuoka K,Helm V,Bergeot N,Favier L,Neckel N

更新日期：2017-05-09 00:00:00

abstract：:The core of a ferromagnetic vortex domain creates a strong, localized magnetic field, which can be manipulated on nanosecond timescales, providing a platform for addressing and controlling individual nitrogen-vacancy centre spins in diamond at room temperature, with nanometre-scale resolution. Here, we show that the f...

journal_title：Nature communications

authors： Wolf MS,Badea R,Berezovsky J

更新日期：2016-06-14 00:00:00

abstract：:Polyborylated organic compounds have been emerging as versatile building blocks in chemical synthesis. Here we report a selective cobalt-catalyzed deoxygenative 1,1,3-triborylation reaction of allylic ethers with pinacolborane to prepare 1,1,3-triborylalkane compounds. With naturally abundant and/or synthetic cinnamic...

journal_title：Nature communications

authors： Teo WJ,Yang X,Poon YY,Ge S

更新日期：2020-10-15 00:00:00

abstract：:Metals and polymers are dissimilar materials in terms of their physicochemical properties, but complementary in terms of functionality. As a result, metal-organic structures can introduce a wealth of novel applications in small-scale robotics. However, current fabrication techniques are unable to process three-dimensi...

journal_title：Nature communications

authors： Alcântara CCJ,Landers FC,Kim S,De Marco C,Ahmed D,Nelson BJ,Pané S

更新日期：2020-11-24 00:00:00

abstract：:Base editors (BEs) are RNA-guided CRISPR-Cas-derived genome editing tools that induce single-nucleotide changes. The limitations of current BEs lie in their low precision (especially when multiple target nucleotides of the deaminase are present within the activity window) and their restriction to targets that are in p...

journal_title：Nature communications

authors： Tan J,Zhang F,Karcher D,Bock R

更新日期：2020-01-31 00:00:00

abstract：:Gamma-ray 'glows' are long duration (seconds to tens of minutes) X-ray and gamma-ray emission coming from thunderclouds. Measurements suggest the presence of relativistic runaway electron avalanches (RREA), the same process underlying terrestrial gamma-ray flashes. Here we demonstrate that glows are relatively a commo...

journal_title：Nature communications

authors： Kelley NA,Smith DM,Dwyer JR,Splitt M,Lazarus S,Martinez-McKinney F,Hazelton B,Grefenstette B,Lowell A,Rassoul HK

更新日期：2015-08-12 00:00:00

abstract：:The magnetostructural coupling between the structural and the magnetic transition has a crucial role in magnetoresponsive effects in a martensitic-transition system. A combination of various magnetoresponsive effects based on this coupling may facilitate the multifunctional applications of a host material. Here we dem...

journal_title：Nature communications

authors： Liu E,Wang W,Feng L,Zhu W,Li G,Chen J,Zhang H,Wu G,Jiang C,Xu H,de Boer F

更新日期：2012-05-29 00:00:00

abstract：:Although it has become increasingly clear that cancers display extensive cellular heterogeneity, the spatial growth dynamics of genetically distinct clones within developing solid tumours remain poorly understood. Here we leverage mosaic analysis with double markers (MADM) to trace subclonal populations retaining or l...

journal_title：Nature communications

authors： Muzumdar MD,Dorans KJ,Chung KM,Robbins R,Tammela T,Gocheva V,Li CM,Jacks T

更新日期：2016-09-02 00:00:00

abstract：:Iridium N-heterocyclic carbene (NHC) complexes catalyse the para-hydrogen-induced hyperpolarization process, Signal Amplification by Reversible Exchange (SABRE). This process transfers the latent magnetism of para-hydrogen into a substrate, without changing its chemical identity, to dramatically improve its nuclear ma...

journal_title：Nature communications

authors： Rayner PJ,Norcott P,Appleby KM,Iali W,John RO,Hart SJ,Whitwood AC,Duckett SB

更新日期：2018-10-12 00:00:00

abstract：:Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of neurexin and is nee...

journal_title：Nature communications

authors： Muhammad K,Reddy-Alla S,Driller JH,Schreiner D,Rey U,Böhme MA,Hollmann C,Ramesh N,Depner H,Lützkendorf J,Matkovic T,Götz T,Bergeron DD,Schmoranzer J,Goettfert F,Holt M,Wahl MC,Hell SW,Scheiffele P,Walter AM,Loll B

更新日期：2015-10-16 00:00:00

abstract：:Amyloid supramolecular assemblies have found widespread exploitation as ordered nanomaterials in a range of applications from materials science to biotechnology. New strategies are, however, required for understanding and promoting mature fibril formation from simple monomer motifs through easy and scalable processes....

journal_title：Nature communications

authors： Bertolani A,Pirrie L,Stefan L,Houbenov N,Haataja JS,Catalano L,Terraneo G,Giancane G,Valli L,Milani R,Ikkala O,Resnati G,Metrangolo P

更新日期：2015-06-30 00:00:00

abstract：:Superlubricity of graphite and graphene has aroused increasing interest in recent years. Yet how to obtain a long-lasting superlubricity between graphene layers, under high applied normal load in ambient atmosphere still remains a challenge but is highly desirable. Here, we report a direct measurement of sliding frict...

journal_title：Nature communications

authors： Liu SW,Wang HP,Xu Q,Ma TB,Yu G,Zhang C,Geng D,Yu Z,Zhang S,Wang W,Hu YZ,Wang H,Luo J

更新日期：2017-02-14 00:00:00

abstract：:Anthropogenic CO2 emissions are causing ocean acidification, which can affect the physiology of marine organisms. Here we assess the possible effects of ocean acidification on the metabolic potential of sponge symbionts, inferred by metagenomic analyses of the microbiomes of two sponge species sampled at a shallow vol...

journal_title：Nature communications

authors： Botté ES,Nielsen S,Abdul Wahab MA,Webster J,Robbins S,Thomas T,Webster NS

更新日期：2019-09-12 00:00:00

abstract：:Human metapneumovirus (hMPV) is a frequent cause of bronchiolitis in young children. Its F glycoprotein mediates virus-cell membrane fusion and is the primary target of neutralizing antibodies. The inability to produce recombinant hMPV F glycoprotein in the metastable pre-fusion conformation has hindered structural an...

journal_title：Nature communications

authors： Battles MB,Más V,Olmedillas E,Cano O,Vázquez M,Rodríguez L,Melero JA,McLellan JS

更新日期：2017-11-16 00:00:00

abstract：:Tauopathies are neurodegenerative diseases characterized by intracellular amyloid deposits of tau protein. Missense mutations in the tau gene (MAPT) correlate with aggregation propensity and cause dominantly inherited tauopathies, but their biophysical mechanism driving amyloid formation is poorly understood. Many dis...

journal_title：Nature communications

authors： Chen D,Drombosky KW,Hou Z,Sari L,Kashmer OM,Ryder BD,Perez VA,Woodard DR,Lin MM,Diamond MI,Joachimiak LA

更新日期：2019-06-07 00:00:00

abstract：:Organic-inorganic hybrid perovskites are promising candidates for the next-generation solar cells. Many efforts have been made to study their structures in the search for a better mechanistic understanding to guide the materials optimization. Here, we investigate the structure instability of the single-crystalline CH3...

journal_title：Nature communications

authors： Chen S,Zhang X,Zhao J,Zhang Y,Kong G,Li Q,Li N,Yu Y,Xu N,Zhang J,Liu K,Zhao Q,Cao J,Feng J,Li X,Qi J,Yu D,Li J,Gao P

更新日期：2018-11-15 00:00:00

abstract：:Visualizing the rearrangement of atoms in a wide range of molecular and condensed-matter systems requires resolving picometre displacements on a 10-fs timescale, which is achievable using pump-probe diffraction, given short enough pulses. Here we demonstrate the compression of single-electron pulses with a de Broglie ...

journal_title：Nature communications

authors： Gliserin A,Walbran M,Krausz F,Baum P

更新日期：2015-10-27 00:00:00

abstract：:Solid-state quantum acoustodynamic (QAD) systems provide a compact platform for quantum information storage and processing by coupling acoustic phonon sources with superconducting or spin qubits. The multi-mode composite high-overtone bulk acoustic wave resonator (HBAR) is a popular phonon source well suited for QAD. ...

journal_title：Nature communications

authors： Gokhale VJ,Downey BP,Katzer DS,Nepal N,Lang AC,Stroud RM,Meyer DJ

更新日期：2020-05-08 00:00:00

abstract：:Neuroimaging modalities such as MRI and EEG are able to record from the whole brain, but this comes at the price of either limited spatiotemporal resolution or limited sensitivity. Here, we show that functional ultrasound imaging (fUS) of the brain is able to assess local changes in cerebral blood volume during cognit...

journal_title：Nature communications

authors： Dizeux A,Gesnik M,Ahnine H,Blaize K,Arcizet F,Picaud S,Sahel JA,Deffieux T,Pouget P,Tanter M

更新日期：2019-03-28 00:00:00

abstract：:Although B cell response is frequently found in cancer, there is little evidence that it alters tumor development or progression. The process through which tumor-associated antigens trigger humoral response is not well delineated. We investigate the repertoire of antigens associated with humoral immune response in pan...

journal_title：Nature communications

authors： Capello M,Vykoukal JV,Katayama H,Bantis LE,Wang H,Kundnani DL,Aguilar-Bonavides C,Aguilar M,Tripathi SC,Dhillon DS,Momin AA,Peters H,Katz MH,Alvarez H,Bernard V,Ferri-Borgogno S,Brand R,Adler DG,Firpo MA,Mulvihill S

更新日期：2019-01-16 00:00:00

abstract：:The fracture toughness of glassy materials remains poorly understood. In large part, this is due to the disordered, intrinsically non-equilibrium nature of the glass structure, which challenges its theoretical description and experimental determination. We show that the notch fracture toughness of metallic glasses exh...

journal_title：Nature communications

authors： Ketkaew J,Chen W,Wang H,Datye A,Fan M,Pereira G,Schwarz UD,Liu Z,Yamada R,Dmowski W,Shattuck MD,O'Hern CS,Egami T,Bouchbinder E,Schroers J

更新日期：2018-08-16 00:00:00

abstract：:A major conundrum in climate science is how to account for dependence between climate models. This complicates interpretation of probabilistic projections derived from such models. Here we show that this problem can be addressed using a novel method to test multiple non-exclusive hypotheses, and to make predictions un...

journal_title：Nature communications

authors： Olson R,An SI,Fan Y,Chang W,Evans JP,Lee JY

更新日期：2019-07-09 00:00:00