Molecular architecture of native fibronectin fibrils.

abstract：:Theory, simulations and experimental results have suggested an important role of internal friction in the kinetics of protein folding. Recent experiments on spectrin domains provided the first evidence for a pronounced contribution of internal friction in proteins that fold on the millisecond timescale. However, it ha...

journal_title：Nature communications

authors： Borgia A,Wensley BG,Soranno A,Nettels D,Borgia MB,Hoffmann A,Pfeil SH,Lipman EA,Clarke J,Schuler B

更新日期：2012-01-01 00:00:00

abstract：:Standard optical tweezers rely on optical forces arising when a focused laser beam interacts with a microscopic particle: scattering forces, pushing the particle along the beam direction, and gradient forces, attracting it towards the high-intensity focal spot. Importantly, the incoming laser beam is not affected by t...

journal_title：Nature communications

authors： Kalantarifard F,Elahi P,Makey G,Maragò OM,Ilday FÖ,Volpe G

更新日期：2019-06-18 00:00:00

abstract：:PET hydrolase (PETase), which hydrolyzes polyethylene terephthalate (PET) into soluble building blocks, provides an attractive avenue for the bioconversion of plastics. Here we present the structures of a novel PETase from the PET-consuming microbe Ideonella sakaiensis in complex with substrate and product analogs. Th...

journal_title：Nature communications

authors： Han X,Liu W,Huang JW,Ma J,Zheng Y,Ko TP,Xu L,Cheng YS,Chen CC,Guo RT

更新日期：2017-12-13 00:00:00

abstract：:Generation and recombination of electrons and holes in organic solar cells occurs via charge transfer states located at the donor/acceptor interface. The energy of these charge transfer states is a crucial factor for the attainable open-circuit voltage and its correct determination is thus of utmost importance for a d...

journal_title：Nature communications

authors： List M,Sarkar T,Perkhun P,Ackermann J,Luo C,Würfel U

更新日期：2018-09-07 00:00:00

abstract：:Oceanic anoxic events have been associated with warm climates in Earth history, and there are concerns that current ocean deoxygenation may eventually lead to anoxia. Here we show results of a multi-millennial global-warming simulation that reveal, after a transitory deoxygenation, a marine oxygen inventory 6% higher ...

journal_title：Nature communications

authors： Oschlies A,Koeve W,Landolfi A,Kähler P

更新日期：2019-06-26 00:00:00

abstract：:Magnetic skyrmions are localized, topologically protected spin structures that have been proposed for storing or processing information due to their intriguing dynamical and transport properties. Important in terms of applications is the recent discovery of interface stabilized skyrmions as evidenced in ultra-thin tra...

journal_title：Nature communications

authors： Dupé B,Bihlmayer G,Böttcher M,Blügel S,Heinze S

更新日期：2016-06-03 00:00:00

abstract：:Tumour cells secrete exosomes that are involved in the remodelling of the tumour-stromal environment and promoting malignancy. The mechanisms governing tumour exosome release, however, remain incompletely understood. Here we show that tumour cell exosomes secretion is controlled by pyruvate kinase type M2 (PKM2), whic...

journal_title：Nature communications

authors： Wei Y,Wang D,Jin F,Bian Z,Li L,Liang H,Li M,Shi L,Pan C,Zhu D,Chen X,Hu G,Liu Y,Zhang CY,Zen K

更新日期：2017-01-09 00:00:00

abstract：:Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with t...

journal_title：Nature communications

authors： Cai W,Sakaguchi M,Kleinridders A,Gonzalez-Del Pino G,Dreyfuss JM,O'Neill BT,Ramirez AK,Pan H,Winnay JN,Boucher J,Eck MJ,Kahn CR

更新日期：2017-03-27 00:00:00

abstract：:Recent progress in nanotechnology enables the production of atomically abrupt interfaces in multilayered junctions, allowing for an increase in the number of transistors in a processor. However, uniform electron transport has not yet been achieved across the entire interfacial area in junctions due to the existence of...

journal_title：Nature communications

authors： Hirohata A,Yamamoto Y,Murphy BA,Vick AJ

更新日期：2016-09-02 00:00:00

abstract：:Artificial molecules containing just one or two electrons provide a powerful platform for studies of orbital and spin quantum dynamics in nanoscale devices. A well-known example of these dynamics is tunnelling of electrons between two coupled quantum dots triggered by mi...

journal_title：Nature communications

authors： Schreiber LR,Braakman FR,Meunier T,Calado V,Danon J,Taylor JM,Wegscheider W,Vandersypen LM

更新日期：2011-11-22 00:00:00

abstract：:As in human speech acquisition, songbird vocal learning depends on early auditory experience. During development, juvenile songbirds listen to and form auditory memories of adult tutor songs, which they use to shape their own vocalizations in later sensorimotor learning. The higher-level auditory cortex, called the ca...

journal_title：Nature communications

authors： Yanagihara S,Yazaki-Sugiyama Y

更新日期：2016-06-21 00:00:00

abstract：:The Warburg effect is a prominent metabolic feature associated with neoplastic diseases; however, the underlying mechanism remains incompletely understood. TAp73, a structural homolog of the tumor suppressor p53, is frequently overexpressed in human tumors, indicating a proliferative advantage that it can confer to tu...

journal_title：Nature communications

authors： Li L,Li L,Li W,Chen T,Bin Zou,Zhao L,Wang H,Wang X,Xu L,Liu X,Wang D,Li B,Mak TW,Du W,Yang X,Jiang P

更新日期：2018-11-08 00:00:00

abstract：:Schwann cells (SCs) generate the myelin wrapping of peripheral nerve axons and are promising candidates for cell therapy. However, to date a renewable source of SCs is lacking. In this study, we show the conversion of skin fibroblasts into induced Schwann cells (iSCs) by driving the expression of two transcription fac...

journal_title：Nature communications

authors： Mazzara PG,Massimino L,Pellegatta M,Ronchi G,Ricca A,Iannielli A,Giannelli SG,Cursi M,Cancellieri C,Sessa A,Del Carro U,Quattrini A,Geuna S,Gritti A,Taveggia C,Broccoli V

更新日期：2017-02-07 00:00:00

abstract：:Epitaxial films may be released from growth substrates and transferred to structurally and chemically incompatible substrates, but epitaxial films of transition metal perovskite oxides have not been transferred to electroactive substrates for voltage control of their myriad functional properties. Here we demonstrate g...

journal_title：Nature communications

authors： Pesquera D,Khestanova E,Ghidini M,Zhang S,Rooney AP,Maccherozzi F,Riego P,Farokhipoor S,Kim J,Moya X,Vickers ME,Stelmashenko NA,Haigh SJ,Dhesi SS,Mathur ND

更新日期：2020-06-24 00:00:00

abstract：:Orai channels are required for store-operated Ca(2+) entry (SOCE) in multiple cell types. Septins are a class of GTP-binding proteins that function as diffusion barriers in cells. Here we show that Septin 7 acts as a 'molecular brake' on activation of Orai channels in Drosophila neurons. Lowering Septin 7 levels resul...

journal_title：Nature communications

authors： Deb BK,Pathak T,Hasan G

更新日期：2016-05-26 00:00:00

abstract：:A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19868-6. ...

journal_title：Nature communications

authors： Heimbucher T,Hog J,Gupta P,Murphy CT

更新日期：2020-11-20 00:00:00

abstract：:Emerging evidence supports roles of enhancer RNAs (eRNAs) in regulating target gene. Here, we study eRNA regulation and function during skeletal myoblast differentiation. We provide a panoramic view of enhancer transcription and categorization of eRNAs. Master transcription factor MyoD is crucial in activating eRNA pr...

journal_title：Nature communications

authors： Zhao Y,Zhou J,He L,Li Y,Yuan J,Sun K,Chen X,Bao X,Esteban MA,Sun H,Wang H

更新日期：2019-12-19 00:00:00

abstract：:The worldwide prevalence of infections caused by antibiotic-resistant Gram-negative bacteria poses a serious threat to public health due to the limited therapeutic alternatives. Cationic peptides represent a large family of antibiotics and have attracted interest due to their diverse chemical structures and potential ...

journal_title：Nature communications

authors： Li YX,Zhong Z,Zhang WP,Qian PY

更新日期：2018-08-16 00:00:00

abstract：:The emergence of larger brains with large numbers of neurons is an evolutionary innovation in mammals and birds. However, the corresponding changes in cortical developmental programmes during amniote evolution are poorly understood. Here we examine the cortical development of Madagascar ground geckos, and report uniqu...

journal_title：Nature communications

authors： Nomura T,Gotoh H,Ono K

更新日期：2013-01-01 00:00:00

abstract：:Lithium metal is an ideal battery anode. However, dendrite growth and limited Coulombic efficiency during cycling have prevented its practical application in rechargeable batteries. Herein, we report that the use of highly concentrated electrolytes composed of ether solvents and the lithium bis(fluorosulfonyl)imide sa...

journal_title：Nature communications

authors： Qian J,Henderson WA,Xu W,Bhattacharya P,Engelhard M,Borodin O,Zhang JG

更新日期：2015-02-20 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and progressive weakness. There is considerable inter-patient variability in disease onset and progression, which can confound the results of clinical trials. Here we show that a common null polymorphism (R577X) in ACTN3 results in significantly...

journal_title：Nature communications

authors： Hogarth MW,Houweling PJ,Thomas KC,Gordish-Dressman H,Bello L,Cooperative International Neuromuscular Research Group (CINRG).,Pegoraro E,Hoffman EP,Head SI,North KN

更新日期：2017-01-31 00:00:00

abstract：:Understanding the conformational sampling of translation-arrested ribosome nascent chain complexes is key to understand co-translational folding. Up to now, coupling of cysteine oxidation, disulfide bond formation and structure formation in nascent chains has remained elusive. Here, we investigate the eye-lens protein...

journal_title：Nature communications

authors： Schulte L,Mao J,Reitz J,Sreeramulu S,Kudlinzki D,Hodirnau VV,Meier-Credo J,Saxena K,Buhr F,Langer JD,Blackledge M,Frangakis AS,Glaubitz C,Schwalbe H

更新日期：2020-11-04 00:00:00

abstract：:C-Analogues of the canonical N-nucleosides have considerable importance in medicinal chemistry and are promising building blocks of xenobiotic nucleic acids (XNA) in synthetic biology. Although well established for synthesis of N-nucleosides, biocatalytic methods are lacking in C-nucleoside synthetic chemistry. Here, ...

journal_title：Nature communications

authors： Pfeiffer M,Nidetzky B

更新日期：2020-12-08 00:00:00

abstract：:Observing the crucial first few femtoseconds of photochemical reactions requires tools typically not available in the femtochemistry toolkit. Such dynamics are now within reach with the instruments provided by attosecond science. Here, we apply experimental and theoretical methods to assess the ultrafast nonadiabatic ...

journal_title：Nature communications

authors： Galbraith MCE,Scheit S,Golubev NV,Reitsma G,Zhavoronkov N,Despré V,Lépine F,Kuleff AI,Vrakking MJJ,Kornilov O,Köppel H,Mikosch J

更新日期：2017-10-18 00:00:00

abstract：:Complex behaviours may be viewed as sequences of modular actions, each elicited by specific sensory cues in their characteristic timescales. From this perspective, we can construct models in which unitary behavioural modules are hierarchically placed in context of related actions. Here, we analyse antennal positioning...

journal_title：Nature communications

authors： Natesan D,Saxena N,Ekeberg Ö,Sane SP

更新日期：2019-12-06 00:00:00

abstract：:Hedgehog (Hh) signalling regulates embryonic development and adult tissue homoeostasis. Mutations of its pathway components including Suppressor of Fused (Sufu) and Gli/Ci predispose to cancers and congenital anomalies. The Sufu-Gli protein complex occupies a central position in the vertebrate Hh signalling pathway, e...

journal_title：Nature communications

authors： Zhang Y,Fu L,Qi X,Zhang Z,Xia Y,Jia J,Jiang J,Zhao Y,Wu G

更新日期：2013-01-01 00:00:00

abstract：:Flicker or 1/f noise in metal-oxide-semiconductor field-effect transistors (MOSFETs) has been identified as the main source of noise at low frequency. It often originates from an ensemble of a huge number of charges becoming trapped and de-trapped. However, as a deviation from the well-known model of 1/f noise is obse...

journal_title：Nature communications

authors： Clément N,Nishiguchi K,Fujiwara A,Vuillaume D

更新日期：2010-10-19 00:00:00

abstract：:Recent years have seen great advances in the development of synthetic self-assembling molecular systems. Designing out-of-equilibrium architectures, however, requires a more subtle control over the thermodynamics and kinetics of reactions. We propose a mechanism for enhancing the thermodynamic drive of DNA strand-disp...

journal_title：Nature communications

authors： Haley NEC,Ouldridge TE,Mullor Ruiz I,Geraldini A,Louis AA,Bath J,Turberfield AJ

更新日期：2020-05-22 00:00:00

abstract：:Repeated cell divisions and aging impair stem cell function. However, the mechanisms by which this occurs are not fully understood. Here we show that protection of telomeres 1A (Pot1a), a component of the Shelterin complex that protects telomeres, improves haematopoietic stem cell (HSC) activity during aging. Pot1a is...

journal_title：Nature communications

authors： Hosokawa K,MacArthur BD,Ikushima YM,Toyama H,Masuhiro Y,Hanazawa S,Suda T,Arai F

更新日期：2017-10-06 00:00:00

abstract：:Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for the synthesis of glycerolipids, interacts with and is a direct sub...

journal_title：Nature communications

authors： Song L,Liu Z,Hu HH,Yang Y,Li TY,Lin ZZ,Ye J,Chen J,Huang X,Liu DT,Zhou J,Shi Y,Zhao H,Xie C,Chen L,Song E,Lin SY,Lin SC

更新日期：2020-11-17 00:00:00