Abstract：
:Schwann cells (SCs) generate the myelin wrapping of peripheral nerve axons and are promising candidates for cell therapy. However, to date a renewable source of SCs is lacking. In this study, we show the conversion of skin fibroblasts into induced Schwann cells (iSCs) by driving the expression of two transcription factors, Sox10 and Egr2. iSCs resembled primary SCs in global gene expression profiling and PNS identity. In vitro, iSCs wrapped axons generating compact myelin sheaths with regular nodal structures. Conversely, iSCs from Twitcher mice showed a severe loss in their myelinogenic potential, demonstrating that iSCs can be an attractive system for in vitro modelling of PNS diseases. The same two factors were sufficient to convert human fibroblasts into iSCs as defined by distinctive molecular and functional traits. Generating iSCs through direct conversion of somatic cells offers opportunities for in vitro disease modelling and regenerative therapies.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Mazzara PG,Massimino L,Pellegatta M,Ronchi G,Ricca A,Iannielli A,Giannelli SG,Cursi M,Cancellieri C,Sessa A,Del Carro U,Quattrini A,Geuna S,Gritti A,Taveggia C,Broccoli Vdoi
10.1038/ncomms14088subject
Has Abstractpub_date
2017-02-07 00:00:00pages
14088issn
2041-1723pii
ncomms14088journal_volume
8pub_type
杂志文章abstract：:Taxanes are the only chemotherapies used to treat patients with metastatic castration-resistant prostate cancer (CRPC). Despite the initial efficacy of taxanes in treating CRPC, all patients ultimately fail due to the development of drug resistance. In this study, we show that ERG overexpression in in vitro and in viv...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6548
更新日期：2014-11-25 00:00:00
abstract：:Heterogeneous catalysis is an enabling technology that utilises transition metal nanoparticles (NPs) supported on oxides to promote chemical reactions. Structural mismatch at the NP-support interface generates lattice strain that could affect catalytic properties. However, detailed knowledge about strain in supported ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05055-1
更新日期：2018-07-13 00:00:00
abstract：:Triboelectrification is a well-known phenomenon that commonly occurs in nature and in our lives at any time and any place. Although each and every material exhibits triboelectrification, its quantification has not been standardized. A triboelectric series has been qualitatively ranked with regards to triboelectric pol...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09461-x
更新日期：2019-03-29 00:00:00
abstract：:Optogenetics has emerged as an alternative method for electrical control of the heart, where illumination is used to elicit a bioelectric response in tissue modified to express photosensitive proteins (opsins). This technology promises to enable evocation of spatiotemporally precise responses in targeted cells or tiss...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms3370
更新日期：2013-01-01 00:00:00
abstract：:Organic semiconductors are usually polycyclic aromatic hydrocarbons and their analogs containing heteroatom substitution. Bioinspired materials chemistry of organic electronics promises new charge transport mechanism and specific molecular recognition with biomolecules. We discover organic semiconductors from deoxyrib...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12248-9
更新日期：2019-09-16 00:00:00
abstract：:Gemcitabine is the first-line treatment for locally advanced and metastatic gallbladder cancer (GBC), but poor gemcitabine response is universal. Here, we utilize a genome-wide CRISPR screen to identify that loss of ELP5 reduces the gemcitabine-induced apoptosis in GBC cells in a P53-dependent manner through the Elong...
journal_title：Nature communications
pub_type： 临床试验,杂志文章
doi：10.1038/s41467-019-13420-x
更新日期：2019-12-02 00:00:00
abstract：:The main advantage of organic transistors with dual gates/bases is that the threshold voltages can be set as a function of the applied second gate/base bias, which is crucial for the application in logic gates and integrated circuits. However, incorporating a dual gate/base structure into an ultra-short channel vertic...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18576-5
更新日期：2020-09-18 00:00:00
abstract：:Catalytic C-H activation and hydroamination represent two important strategies for eco-friendly chemical synthesis with high atom efficiency and reduced waste production. Combining both C-H activation and hydroamination in a cascade process, preferably with a single catalyst, would allow rapid access to valuable nitro...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms11506
更新日期：2016-06-20 00:00:00
abstract：:Energy circulation in geospace lies at the heart of space weather research. In the inner magnetosphere, the steep plasmapause boundary separates the cold dense plasmasphere, which corotates with the planet, from the hot ring current/plasma sheet outside. Theoretical studies suggested that plasmapause surface waves rel...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15506-3
更新日期：2020-04-03 00:00:00
abstract：:It has been observed that concentrated solutions of short DNA oligomers develop liquid crystal ordering as the result of a hierarchically structured supramolecular self-assembly. In mixtures of oligomers with various degree of complementarity, liquid crystal microdomains are formed via the selective aggregation of tho...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7424
更新日期：2015-03-10 00:00:00
abstract：:Subglacial lakes are widespread beneath the Antarctic Ice Sheet but their control on ice-sheet dynamics and their ability to harbour life remain poorly characterized. Here we present evidence for a palaeo-subglacial lake on the Antarctic continental shelf. A distinct sediment facies recovered from a bedrock basin in P...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15591
更新日期：2017-06-01 00:00:00
abstract：:Boron has become the principle proxy for the release of seawater-derived fluids into arc volcanics, linked to cross-arc variations in boron content and isotopic ratio. Because all ocean floor serpentinites so far analysed are strongly enriched in boron, it is generally assumed that if the uppermost slab mantle is hydr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07064-6
更新日期：2018-11-02 00:00:00
abstract：:Incited by public fascination and engineering application, water-skipping of rigid stones and spheres has received considerable study. While these objects can be coaxed to ricochet, elastic spheres demonstrate superior water-skipping ability, but little is known about the effect of large material compliance on water i...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10551
更新日期：2016-02-04 00:00:00
abstract：: ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06969-6
更新日期：2018-10-24 00:00:00
abstract：:TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly express DR3. Here, we report that activation of DR3 signaling by an agonistic anti-DR3 antibody incr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11304-8
更新日期：2019-07-29 00:00:00
abstract：:During stress, prompt export of stress-inducible transcripts is critical for cell survival. Here, we characterize a function of the SAGA (Spt-Ada-Gcn5 acetyltransferase) deubiquitylating module (DUBm) in monitoring messenger ribonucleoprotein (mRNP) biogenesis to regulate non-canonical mRNA export of stress-inducible ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10350-6
更新日期：2019-06-05 00:00:00
abstract：:The investigations on optical angular momenta and their interactions have broadened our knowledge of light's behavior at sub-wavelength scales. Recent studies further unveil the extraordinary characteristics of transverse spin angular momentum in confined light fields and orbital angular momentum in optical vortices. ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03237-5
更新日期：2018-03-02 00:00:00
abstract：:Pentacyclic triterpenoids (PTs) constitute one of the biggest families of natural products, many with higher oxidation state at the D/E rings possess a wide spectrum of biological activties but are poorly accessible. Here we report a site-selective C-H hydroxylation at the D/E rings of PTs paving a way toward these im...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18138-9
更新日期：2020-09-01 00:00:00
abstract：:Understanding the resilience of aquatic ectothermic animals to climate warming has been hindered by the absence of experimental systems experiencing warming across relevant timescales (for example, decades). Here, we examine European perch (Perca fluviatilis, L.) from the Biotest enclosure, a unique coastal ecosystem ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms11447
更新日期：2016-05-17 00:00:00
abstract：:Subduction zone magmas are more oxidised on eruption than those at mid-ocean ridges. This is attributed either to oxidising components, derived from subducted lithosphere (slab) and added to the mantle wedge, or to oxidation processes occurring during magma ascent via differentiation. Here we provide direct evidence f...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05804-2
更新日期：2018-08-29 00:00:00
abstract：:Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain undergoes epig...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09676-y
更新日期：2019-05-09 00:00:00
abstract：:Solution self-assembly of block copolymers into inverse bicontinuous cubic mesophases is a promising new approach for creating porous polymer films and monoliths with highly organized bicontinuous mesoporous networks. Here we report the direct self-assembly of block copolymers with branched hydrophilic blocks into lar...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7392
更新日期：2015-03-05 00:00:00
abstract：:Phosphorylation is a major post-translational mechanism of regulation that frequently targets disordered protein domains, but it remains unclear how phosphorylation modulates disordered states of proteins. Here we determine the kinetics and energetics of a disordered protein domain the kinase-inducible domain (KID) of...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6272
更新日期：2014-10-28 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-019-11801-w
更新日期：2019-08-19 00:00:00
abstract：:The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we show...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11013-2
更新日期：2019-07-24 00:00:00
abstract：:Understanding and reshaping cellular behaviors with synthetic gene networks requires the ability to sense and respond to changes in the intracellular environment. Intracellular proteins are involved in almost all cellular processes, and thus can provide important information about changes in cellular conditions such a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03984-5
更新日期：2018-05-14 00:00:00
abstract：:The proton-activated sodium channel ASIC1 belongs to the ENaC/Degenerins family of ion channels. Little is known about gating of the pore in any member of this class. Here we outline the shape of the ion pathway of ASIC1 in the open and closed conformations by measuring apparent rates of cysteine modification by thiol...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1409
更新日期：2011-07-19 00:00:00
abstract：:Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03001-9
更新日期：2018-02-12 00:00:00
abstract：:Due to the generally delocalized nature of molecular valence orbitals, valence-shell spectroscopies do not usually allow to specifically target a selected atom in a molecule. However, in X-ray electron spectroscopy, the photoelectron momentum is large and the recoil angular momentum transferred to the molecule is larg...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4816
更新日期：2014-05-09 00:00:00
abstract：:The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05220-6
更新日期：2018-07-24 00:00:00
