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SAGA DUBm-mediated surveillance regulates prompt export of stress-inducible transcripts for proteostasis.

Abstract：

:During stress, prompt export of stress-inducible transcripts is critical for cell survival. Here, we characterize a function of the SAGA (Spt-Ada-Gcn5 acetyltransferase) deubiquitylating module (DUBm) in monitoring messenger ribonucleoprotein (mRNP) biogenesis to regulate non-canonical mRNA export of stress-inducible transcripts. Our genetic and biochemical analyses suggest that there is a functional relationship between Sgf73p of DUBm and the essential mRNA export factor, Yra1p. Under physiological conditions, Sgf73p is critical for the proper chromatin localization and RNA binding of Yra1p, while also quality controlling the biogenesis of mRNPs in conjunction with the nuclear exosome exonuclease, Rrp6p. Under environmental stress, when immediate transport of stress-inducible transcripts is imperative, Sgf73p facilitates the bypass of canonical surveillance and promotes the timely export of necessary transcripts. Overall, our results show that the Sgf73p-mediated plasticity of gene expression is important for the ability of cells to tolerate stress and regulate proteostasis to survive under environmental uncertainty.

journal_name

Nat Commun

journal_title

Nature communications

authors

Kim M,Choi Y,Kim H,Lee D

doi

10.1038/s41467-019-10350-6

subject

Has Abstract

pub_date

2019-06-05 00:00:00

pages

2458

issue

1

issn

2041-1723

pii

10.1038/s41467-019-10350-6

journal_volume

10

pub_type

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