Abstract:
:Catalytic C-H activation and hydroamination represent two important strategies for eco-friendly chemical synthesis with high atom efficiency and reduced waste production. Combining both C-H activation and hydroamination in a cascade process, preferably with a single catalyst, would allow rapid access to valuable nitrogen-containing molecules from readily available building blocks. Here we report a single metal catalyst-based approach for N-heterocycle construction by tandem C-H functionalization and alkene hydroamination. A simple catalyst system of cationic rhodium(I) precursor and phosphine ligand promotes redox-neutral [4+2] annulation between N-H aromatic ketimines and internal alkynes to form multi-substituted 3,4-dihydroisoquinolines (DHIQs) in high chemoselectivity over competing annulation processes, exclusive cis-diastereoselectivity, and distinct regioselectivity for alkyne addition. This study demonstrates the potential of tandem C-H activation and alkene hydrofunctionalization as a general strategy for modular and atom-efficient assembly of six-membered heterocycles with multiple chirality centres.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Manan RS,Zhao Pdoi
10.1038/ncomms11506subject
Has Abstractpub_date
2016-06-20 00:00:00pages
11506issn
2041-1723pii
ncomms11506journal_volume
7pub_type
杂志文章abstract::It is known that temperature estimates of macroscopic systems in equilibrium are most precise when their energy fluctuations are large. However, for nanoscale systems deviations from standard thermodynamics arise due to their interactions with the environment. Here we include such interactions and, using quantum estim...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04536-7
更新日期:2018-06-06 00:00:00
abstract::Inorganic perovskites such as CsPbX3 (X=Cl, Br, I) have attracted attention due to their excellent thermal stability and high photoluminescence quantum efficiency. However, the electroluminescence quantum efficiency of their light-emitting diodes was <1%. We posited that this low efficiency was a result of high leakag...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15640
更新日期:2017-06-07 00:00:00
abstract::Generation of periodic patterns is fundamental to the differentiation of multiple tissues during development. How such patterns form robustly is still unclear. The Drosophila eye comprises ∼750 units, whose crystalline order is set during differentiation of the eye imaginal disc: an activation wave sweeping across the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10461
更新日期:2016-02-15 00:00:00
abstract::The electron deficiency and strong bonding capacity of boron have led to a vast variety of molecular structures in chemistry and materials science. Here we report the observation of highly symmetric cobalt-centered boron drum-like structures of CoB16(-), characterized by photoelectron spectroscopy and ab initio calcul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9654
更新日期:2015-10-12 00:00:00
abstract::Supercooled liquids exhibit spatial heterogeneity in the dynamics of their fluctuating atomic arrangements. The length and time scales of the heterogeneous dynamics are central to the glass transition and influence nucleation and growth of crystals from the liquid. Here, we report direct experimental visualization of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03604-2
更新日期:2018-03-19 00:00:00
abstract::Spontaneous molecular oscillations are ubiquitous in biology. But to our knowledge, periodic cell migratory patterns have not been observed. Here we report the highly regular, periodic migration of cells along rectilinear tracks generated inside three-dimensional matrices, with each excursion encompassing several cell...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1711
更新日期:2012-03-06 00:00:00
abstract::Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that the human microcephaly protein, RTTN, is recruited to the proximal end of the procentriole at early S phase, and is located at the inner luminal walls of centrioles. Further stud...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00305-0
更新日期:2017-08-15 00:00:00
abstract::Immune checkpoint blockade therapies have extended patient survival across multiple cancer lineages, but there is a heated debate on whether cancer immunotherapy efficacy is different between male and female patients. We summarize the existing meta-analysis to show inconsistent conclusions for whether gender is associ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15679-x
更新日期:2020-04-14 00:00:00
abstract::It is generally believed that the remarkable sensitivity and frequency selectivity of mammalian hearing depend on outer hair cell-generated force, which amplifies sound-induced vibrations inside the cochlea. This 'reverse transduction' force production has never been demonstrated experimentally, however, in the living...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10282
更新日期:2016-01-06 00:00:00
abstract::Magnetic storage and logic devices based on magnetic domain wall motion rely on the precise and synchronous displacement of multiple domain walls. The conventional approach using magnetic fields does not allow for the synchronous motion of multiple domains. As an alternative method, synchronous current-induced domain ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4429
更新日期:2014-03-24 00:00:00
abstract::Differences in white adipose tissue (WAT) lipid turnover between the visceral (vWAT) and subcutaneous (sWAT) depots may cause metabolic complications in obesity. Here we compare triglyceride age and, thereby, triglyceride turnover in vWAT and sWAT biopsies from 346 individuals and find that subcutaneous triglyceride a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15253
更新日期:2017-05-23 00:00:00
abstract::Arctic warming can influence tundra ecosystem function with consequences for climate feedbacks, wildlife and human communities. Yet ecological change across the Arctic tundra biome remains poorly quantified due to field measurement limitations and reliance on coarse-resolution satellite data. Here, we assess decadal c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18479-5
更新日期:2020-09-22 00:00:00
abstract::Transcribing and replicating a double-stranded genome require protein modules to unwind, transcribe/replicate nucleic acid substrates, and release products. Here we present in situ cryo-electron microscopy structures of rotavirus dsRNA-dependent RNA polymerase (RdRp) in two states pertaining to transcription. In addit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10236-7
更新日期:2019-05-17 00:00:00
abstract::When assembling individual quantum components into a mesoscopic circuit, the interplay between Coulomb interaction and charge granularity breaks down the classical laws of electrical impedance composition. Here we explore experimentally the thermal consequences, and observe an additional quantum mechanism of electroni...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13566-8
更新日期:2019-12-10 00:00:00
abstract::Highly specific Cas9 nucleases derived from SpCas9 are valuable tools for genome editing, but their wide applications are hampered by a lack of knowledge governing guide RNA (gRNA) activity. Here, we perform a genome-scale screen to measure gRNA activity for two highly specific SpCas9 variants (eSpCas9(1.1) and SpCas9...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12281-8
更新日期:2019-09-19 00:00:00
abstract::A reliable method for recording evoked synaptic events in identified neurons in Caenorhabditis elegans would greatly accelerate our understanding of its nervous system at the molecular, cellular and network levels. Here we describe a method for recording synaptic currents and potentials from identified neurons in near...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1304
更新日期:2011-01-01 00:00:00
abstract::Submarine channels are ubiquitous on the seafloor and their inception and evolution is a result of dynamic interaction between turbidity currents and the evolving seafloor. However, the morphodynamic links between channel inception and flow dynamics have not yet been monitored in experiments and only in one instance o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10886
更新日期:2016-03-21 00:00:00
abstract::Providing high performance electrical nano-interconnects for micro-nano electronics that are robust in harsh environments is highly demanded. Today, electrical nano-interconnects based on metallic nanowires, e.g. Ag and Cu, are limited by their positive physicochemical reactivity and ductility under large strain (i.e....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14244-5
更新日期:2020-01-31 00:00:00
abstract::Soil microorganisms dominate terrestrial biogeochemical cycles; however, we know very little about their spatial distribution and how changes in the distributions of specific groups of microbes translate into landscape and global patterns of biogeochemical processes. In this paper, we use a nested sampling scheme at s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1055
更新日期:2010-08-10 00:00:00
abstract::To function, biomolecules require sufficient specificity of interaction as well as stability to live in the cell while still being able to move. Thermodynamic stability of only a limited number of specific structures is important so as to prevent promiscuous interactions. The individual interactions in proteins, there...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19560-9
更新日期:2020-11-23 00:00:00
abstract::Soil bacterial diversity varies across biomes with potential impacts on soil ecological functioning. Here, we incorporate key factors that affect soil bacterial abundance and diversity across spatial scales into a mechanistic modeling framework considering soil type, carbon inputs and climate towards predicting soil b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13966-w
更新日期:2020-01-08 00:00:00
abstract::Endolysosomal organelles play a key role in trafficking, breakdown and receptor-mediated recycling of different macromolecules such as low-density lipoprotein (LDL)-cholesterol, epithelial growth factor (EGF) or transferrin. Here we examine the role of two-pore channel (TPC) 2, an endolysosomal cation channel, in thes...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5699
更新日期:2014-08-21 00:00:00
abstract::Alkenes are fundamental functionalities in nature and highly useful intermediates in organic synthesis, medicinal chemistry and material sciences. Transition-metal-catalyzed Heck couplings with organic halides as electrophiles have been established as a powerful protocol for the synthesis of this valuable building blo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08631-1
更新日期:2019-02-12 00:00:00
abstract::Mei (Prunus mume) is an ornamental woody plant that has been domesticated in East Asia for thousands of years. High diversity in floral traits, along with its recent genome sequence, makes mei an ideal model system for studying the evolution of woody plants. Here, we investigate the genetic architecture of floral trai...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04093-z
更新日期:2018-04-27 00:00:00
abstract::The original version of this Article omitted the Received and Accepted dates; they should have been 22nd January 2018 and 19th April 2018, respectively. This has been corrected in the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-04902-5
更新日期:2018-06-13 00:00:00
abstract::The continuum hypothesis states that both deterministic and stochastic processes contribute to the assembly of ecological communities. However, the contextual dependency of these processes remains an open question that imposes strong limitations on predictions of community responses to environmental change. Here we me...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9444
更新日期:2015-10-05 00:00:00
abstract::Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography is recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present a specific deep-learning-based model trained on 1,177 digital subtraction angiography verified bone-removal co...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19527-w
更新日期:2020-11-30 00:00:00
abstract::High strength and high ductility are often mutually exclusive properties for structural metallic materials. This is particularly important for aluminum (Al)-based alloys which are widely commercially employed. Here, we introduce a hierarchical nanostructured Al alloy with a structure of Al nanograins surrounded by nan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13087-4
更新日期:2019-11-08 00:00:00
abstract::The superconducting state is formed by the condensation of Cooper pairs and protected by the superconducting gap. The pairing interaction between the two electrons of a Cooper pair determines the gap function. Thus, it is pivotal to detect the gap structure for understanding the mechanism of superconductivity. In cupr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09340-5
更新日期:2019-04-08 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-020-14339-4
更新日期:2020-01-24 00:00:00