Abstract:
:Immune checkpoint blockade therapies have extended patient survival across multiple cancer lineages, but there is a heated debate on whether cancer immunotherapy efficacy is different between male and female patients. We summarize the existing meta-analysis to show inconsistent conclusions for whether gender is associated with the immunotherapy response. We analyze molecular profiling from ICB-treated patients to identify molecular differences for immunotherapy responsiveness. We perform comprehensive analyses for patients from The Cancer Genome Atlas (TCGA) and reveal divergent patterns for sex bias in immune features across multiple cancer types. We further validate our observations in multiple independent data sets. Considering that the majority of clinical trials are in melanoma and lung cancer, meta-analyses that pool multiple cancer types have limitations to discern whether cancer immunotherapy efficacy is different between male and female patients. Future studies should include omics profiling to investigate sex-associated molecular differences in immunotherapy.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Ye Y,Jing Y,Li L,Mills GB,Diao L,Liu H,Han Ldoi
10.1038/s41467-020-15679-xsubject
Has Abstractpub_date
2020-04-14 00:00:00pages
1779issue
1issn
2041-1723pii
10.1038/s41467-020-15679-xjournal_volume
11pub_type
杂志文章abstract::In the original version of this Article, financial support and contributions in manuscript preparation were not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include the following:'M.P. and P.O. would like to thank Prof. Roderick Y.H. Lim for advice during manuscript preparati...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-03304-x
更新日期:2018-03-07 00:00:00
abstract::On-surface chemical reactions hold the potential for manufacturing nanoscale structures directly onto surfaces by linking carbon atoms in a single-step reaction. To fabricate more complex and functionalized structures, the control of the on-surface chemical reactions must be developed significantly. Here, we present a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12711
更新日期:2016-09-13 00:00:00
abstract::Holocene summer temperature reconstructions from northern Europe based on sedimentary pollen records suggest an onset of peak summer warmth around 9,000 years ago. However, pollen-based temperature reconstructions are largely driven by changes in the proportions of tree taxa, and thus the early-Holocene warming signal...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7809
更新日期:2015-04-10 00:00:00
abstract::The effects of high-fat diet (HFD) and postprandial endotoxemia on the development of type 2 diabetes are not fully understood. Here we show that the serine protease prostasin (PRSS8) regulates hepatic insulin sensitivity by modulating Toll-like receptor 4 (TLR4)-mediated signalling. HFD triggers the suppression of PR...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4428
更新日期:2014-03-11 00:00:00
abstract::The original version of this Article contained an error in the spelling of the author Dan Credgington, which was incorrectly given as Dan Credington. This has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-019-09013-3
更新日期:2019-02-22 00:00:00
abstract::Persistent exposure to man-made endocrine disrupting chemicals during fetal endocrine development may lead to disruption of metabolic homeostasis contributing to childhood obesity. Limited cellular platforms exist to test endocrine disrupting chemical-induced developmental abnormalities in human endocrine tissues. Her...
journal_title:Nature communications
pub_type: 杂志文章,收录出版
doi:10.1038/s41467-017-00254-8
更新日期:2017-08-09 00:00:00
abstract::Developing physical models of complex dynamic systems showing emergent behaviour is key to informing on persistence and replication in biology, how living matter emerges from chemistry, and how to design systems with new properties. Herein we report a fully synthetic small molecule system in which a surfactant replica...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04670-2
更新日期:2018-06-08 00:00:00
abstract::Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing ne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04049-3
更新日期:2018-04-24 00:00:00
abstract::In photosystem II, light-induced water oxidation occurs at the Mn4CaO5 cluster. Here we demonstrate proton releases, dioxygen formation, and substrate water incorporation in response to Mn4CaO5 oxidation in the protein environment, using a quantum mechanical/molecular mechanical approach and molecular dynamics simulat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03545-w
更新日期:2018-03-28 00:00:00
abstract::The most explosive basaltic scoria cone eruption yet documented (>20 km high plumes) occurred at Sunset Crater (Arizona) ca. 1085 AD by undetermined eruptive mechanisms. We present melt inclusion analysis, including bubble contents by Raman spectroscopy, yielding high total CO2 (approaching 6000 ppm) and S (~2000 ppm)...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20354-2
更新日期:2021-01-11 00:00:00
abstract::Flexible barrier films preventing permeation of gases and moistures are important for many industries ranging from food to medical and from chemical to electronic. From this perspective, graphene has recently attracted particular interest because its defect-free monolayers are impermeable to all atoms and molecules. H...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5843
更新日期:2014-09-11 00:00:00
abstract::The importance of singlet oxygen (1O2) in the environmental and biomedical fields has motivated research for effective 1O2 production. Electrocatalytic processes hold great potential for highly-automated and scalable 1O2 synthesis, but they are energy- and chemical-intensive. Herein, we present a Janus electrocatalyti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20071-w
更新日期:2020-12-04 00:00:00
abstract::Strain engineering is widely used in material science to tune the (opto-)electronic properties of materials and enhance the performance of devices. Two-dimensional atomic crystals are a versatile playground to study the influence of strain, as they can sustain very large deformations without breaking. Various optical ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02830-y
更新日期:2018-02-06 00:00:00
abstract::Amplitude modes arising from symmetry breaking in materials are of broad interest in condensed matter physics. These modes reflect an oscillation in the amplitude of a complex order parameter, yet are typically unstable and decay into oscillations of the order parameter's phase. This renders stable amplitude modes rar...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04601-1
更新日期:2018-06-05 00:00:00
abstract::Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate that the Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), which has been implicated in inflammation, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9995
更新日期:2015-12-21 00:00:00
abstract::The removal of dying neurons by microglia has a key role during both development and in several diseases. To date, little is known about the cellular and molecular processes underlying neuronal engulfment in the brain. Here we took a live imaging approach to quantify neuronal cell death progression in embryonic zebraf...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5046
更新日期:2014-06-05 00:00:00
abstract::Drought comprehensively affects different interlinked aspects of the terrestrial water cycle, which have so far been mostly investigated without direct comparison. Resolving the partitioning of water deficit during drought into blue-water runoff and green-water evapotranspiration fluxes is critical, as anomalies in th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06013-7
更新日期:2018-09-06 00:00:00
abstract::Although B cell response is frequently found in cancer, there is little evidence that it alters tumor development or progression. The process through which tumor-associated antigens trigger humoral response is not well delineated. We investigate the repertoire of antigens associated with humoral immune response in pan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08109-6
更新日期:2019-01-16 00:00:00
abstract::The intestinal microbiome is a unique ecosystem and an essential mediator of metabolism and obesity in mammals. However, studies investigating the impact of the diet on the establishment of the gut microbiome early in life are generally lacking, and most notably so in primate models. Here we report that a high-fat mat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4889
更新日期:2014-05-20 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-11151-7
更新日期:2019-07-22 00:00:00
abstract::Blends of electron-donating and -accepting organic semiconductors are widely used as photoactive materials in next-generation solar cells and photodetectors. The yield of free charges in these systems is often determined by the separation of interfacial electron-hole pairs, which is expected to depend on the ability o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11944
更新日期:2016-06-21 00:00:00
abstract::Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs, including the most commonly prescribed antifungal, fluconazole. Here, we use a combinatorial screening approach to identify a bis-benzodioxolylindolinone (azoffluxin) that synergizes with fluconazole against C. auris. Azoffluxin e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20183-3
更新日期:2020-12-22 00:00:00
abstract::One of the fundamental design paradigms in organic photovoltaic device engineering is based on the idea that charge separation is an extrinsically driven process requiring an interface for exciton fission. This idea has driven an enormous materials science engineering effort focused on construction of domain sizes com...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10629
更新日期:2016-02-25 00:00:00
abstract::Epithelial barrier function is maintained by coordination of cell proliferation and cell loss, whereas barrier dysfunction can lead to disease and organismal death. JNK signalling is a conserved stress signalling pathway activated by bacterial infection and tissue damage, often leading to apoptotic cell death and comp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14289
更新日期:2017-03-08 00:00:00
abstract::FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (Saccharomyces cerevisiae--Erg26p, Homo sapiens--NSDHL (NAD(P)...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9613
更新日期:2015-10-12 00:00:00
abstract::Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. However, it remains unclear how MSI and hypermutation arise and contribute to cancer development. Here, we show that MSI and hypermutation are triggered by replication stress in an MMR-deficient background,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11760-2
更新日期:2019-09-02 00:00:00
abstract::Charge acceleration during an intense light field application to solids attracts much attention as elementary processes in high-harmonic generation and photoelectron emission. For manipulating such attosecond dynamics of charge, carrier-envelope-phase (CEP: relative phase between carrier oscillation of light field and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17776-3
更新日期:2020-08-18 00:00:00
abstract::The interpretation of molecular vibrational spectroscopic signals in terms of atomic motion is essential to understand molecular mechanisms and for chemical characterization. The signals are usually assigned after harmonic normal mode analysis, even if molecular vibrations are known to be anharmonic. Here we obtain th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18211-3
更新日期:2020-08-28 00:00:00
abstract::Efficient and low-cost electrocatalysts for the oxygen evolution reaction are essential components of renewable energy technologies, such as solar fuel synthesis and providing a hydrogen source for powering fuel cells. Here we report that the nitrogen-doped carbon materials function as the efficient oxygen evolution e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3390
更新日期:2013-01-01 00:00:00
abstract::Connection of tubules into larger networks is the key process for the development of circulatory systems. In Drosophila development, tip cells of the tracheal system lead the migration of each branch and connect tubules by adhering to each other and simultaneously changing into a torus-shape. We show that as adhesion ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11141
更新日期:2016-04-12 00:00:00