当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.

Abstract：

:Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that the human microcephaly protein, RTTN, is recruited to the proximal end of the procentriole at early S phase, and is located at the inner luminal walls of centrioles. Further studies demonstrate that RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly. CRISPR/Cas9-mediated RTTN gene knockout in p53-deficient cells induce amplification of primitive procentriole bodies that lack the distal-half centriolar proteins, POC5 and POC1B. Additional analyses show that RTTN serves as an upstream effector of CEP295, which mediates the loading of POC1B and POC5 to the distal-half centrioles. Interestingly, the naturally occurring microcephaly-associated mutant, RTTN (A578P), shows a low affinity for STIL binding and blocks centriole assembly. These findings reveal that RTTN contributes to building full-length centrioles and illuminate the molecular mechanism through which the RTTN (A578P) mutation causes primary microcephaly.Mutations in many centriolar protein-encoding genes cause primary microcephaly. Here the authors show that human microcephaly protein RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building full-length centrioles.

journal_name

Nat Commun

journal_title

Nature communications

authors

Chen HY,Wu CT,Tang CC,Lin YN,Wang WJ,Tang TK

doi

10.1038/s41467-017-00305-0

subject

Has Abstract

pub_date

2017-08-15 00:00:00

pages

247

issue

1

issn

2041-1723

pii

10.1038/s41467-017-00305-0

journal_volume

8

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Multiscale real time and high sensitivity ion detection with complementary organic electrochemical transistors amplifier.

    abstract：:Ions are ubiquitous biological regulators playing a key role for vital processes in animals and plants. The combined detection of ion concentration and real-time monitoring of small variations with respect to the resting conditions is a multiscale functionality providing important information on health states. This mu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17547-0

    authors： Romele P,Gkoupidenis P,Koutsouras DA,Lieberth K,Kovács-Vajna ZM,Blom PWM,Torricelli F

    更新日期：2020-07-27 00:00:00

  • Early Cretaceous chalks from the North Sea giving evidence for global change.

    abstract：:Among calcareous nannofossils, important primary producers in Jurassic and Cretaceous oceans, nannoconids were carbonate rock-forming organisms. During the late Barremian and early Aptian (~126 to 122 million years ago), nannoconids went through a crisis culminating during the Oceanic Anoxic Event 1a. Here we present ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2698

    authors： Mutterlose J,Bottini C

    更新日期：2013-01-01 00:00:00

  • Gaussian-preserved, non-volatile shape morphing in three-dimensional microstructures for dual-functional electronic devices.

    abstract：:Motile plant structures such as Mimosa pudica leaves, Impatiens glandulifera seedpods, and Dionaea muscipula leaves exhibit fast nastic movements in a few seconds or less. This motion is stimuli-independent mechanical movement following theorema egregium rules. Artificial analogs of tropistic motion in plants are exem...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20843-4

    authors： Tian Z,Xu B,Wan G,Han X,Di Z,Chen Z,Mei Y

    更新日期：2021-01-21 00:00:00

  • Microbial abundance, activity and population genomic profiling with mOTUs2.

    abstract：:Metagenomic sequencing has greatly improved our ability to profile the composition of environmental and host-associated microbial communities. However, the dependency of most methods on reference genomes, which are currently unavailable for a substantial fraction of microbial species, introduces estimation biases. We ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08844-4

    authors： Milanese A,Mende DR,Paoli L,Salazar G,Ruscheweyh HJ,Cuenca M,Hingamp P,Alves R,Costea PI,Coelho LP,Schmidt TSB,Almeida A,Mitchell AL,Finn RD,Huerta-Cepas J,Bork P,Zeller G,Sunagawa S

    更新日期：2019-03-04 00:00:00

  • MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.

    abstract：:Lung cancer is the leading cause of cancer deaths, and effective treatments are urgently needed. Loss-of-function mutations in the DNA damage response kinase ATM are common in lung adenocarcinoma but directly targeting these with drugs remains challenging. Here we report that ATM loss-of-function is synthetic lethal w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13701

    authors： Smida M,Fece de la Cruz F,Kerzendorfer C,Uras IZ,Mair B,Mazouzi A,Suchankova T,Konopka T,Katz AM,Paz K,Nagy-Bojarszky K,Muellner MK,Bago-Horvath Z,Haura EB,Loizou JI,Nijman SM

    更新日期：2016-12-06 00:00:00

  • Critical length scale controls adhesive wear mechanisms.

    abstract：:The adhesive wear process remains one of the least understood areas of mechanics. While it has long been established that adhesive wear is a direct result of contacting surface asperities, an agreed upon understanding of how contacting asperities lead to wear debris particle has remained elusive. This has restricted a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11816

    authors： Aghababaei R,Warner DH,Molinari JF

    更新日期：2016-06-06 00:00:00

  • Heterovalent cation substitutional doping for quantum dot homojunction solar cells.

    abstract：:Colloidal quantum dots have emerged as a material platform for low-cost high-performance optoelectronics. At the heart of optoelectronic devices lies the formation of a junction, which requires the intimate contact of n-type and p-type semiconductors. Doping in bulk semiconductors has been largely deployed for many de...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3981

    authors： Stavrinadis A,Rath AK,de Arquer FP,Diedenhofen SL,Magén C,Martinez L,So D,Konstantatos G

    更新日期：2013-01-01 00:00:00

  • Limits to growth of forest biomass carbon sink under climate change.

    abstract：:Widely recognized as a significant carbon sink, North American forests have experienced a history of recovery and are facing an uncertain future. This growing carbon sink is dictated by recovery from land-use change, with growth trajectory modified by environmental change. To address both processes, we compiled a fore...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05132-5

    authors： Zhu K,Zhang J,Niu S,Chu C,Luo Y

    更新日期：2018-07-13 00:00:00

  • Symbiosis limits establishment of legumes outside their native range at a global scale.

    abstract：:Microbial symbiosis is integral to plant growth and reproduction, but its contribution to global patterns of plant distribution is unknown. Legumes (Fabaceae) are a diverse and widely distributed plant family largely dependent on symbiosis with nitrogen-fixing rhizobia, which are acquired from soil after germination. ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14790

    authors： Simonsen AK,Dinnage R,Barrett LG,Prober SM,Thrall PH

    更新日期：2017-04-07 00:00:00

  • Publisher Correction: Unveiling the Re effect in Ni-based single crystal superalloys.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-020-14820-0

    authors： Wu X,Makineni SK,Liebscher CH,Dehm G,Mianroodi JR,Shanthraj P,Svendsen B,Bürger D,Eggeler G,Raabe D,Gault B

    更新日期：2020-02-21 00:00:00

  • Critical slowing down as a biomarker for seizure susceptibility.

    abstract：:The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit criti...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15908-3

    authors： Maturana MI,Meisel C,Dell K,Karoly PJ,D'Souza W,Grayden DB,Burkitt AN,Jiruska P,Kudlacek J,Hlinka J,Cook MJ,Kuhlmann L,Freestone DR

    更新日期：2020-05-01 00:00:00

  • Efficient direct solar-to-hydrogen conversion by in situ interface transformation of a tandem structure.

    abstract：:Photosynthesis is nature's route to convert intermittent solar irradiation into storable energy, while its use for an industrial energy supply is impaired by low efficiency. Artificial photosynthesis provides a promising alternative for efficient robust carbon-neutral renewable energy generation. The approach of direc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9286

    authors： May MM,Lewerenz HJ,Lackner D,Dimroth F,Hannappel T

    更新日期：2015-09-15 00:00:00

  • Modeling early stage atherosclerosis in a primary human vascular microphysiological system.

    abstract：:Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compression. TEBVs maintain mechanical strength, vasoactivity, and nitric oxide...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19197-8

    authors： Zhang X,Bishawi M,Zhang G,Prasad V,Salmon E,Breithaupt JJ,Zhang Q,Truskey GA

    更新日期：2020-10-27 00:00:00

  • Arabidopsis calcium-dependent protein kinase 3 regulates actin cytoskeleton organization and immunity.

    abstract：:Pattern-triggered immunity and effector-triggered immunity are two primary forms of innate immunity in land plants. The molecular components and connecting nodes of pattern-triggered immunity and effector-triggered immunity are not fully understood. Here, we report that the Arabidopsis calcium-dependent protein kinase...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20007-4

    authors： Lu YJ,Li P,Shimono M,Corrion A,Higaki T,He SY,Day B

    更新日期：2020-12-04 00:00:00

  • Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer.

    abstract：:Molecularly targeted therapies for advanced prostate cancer include castration modalities that suppress ligand-dependent transcriptional activity of the androgen receptor (AR). However, persistent AR signalling undermines therapeutic efficacy and promotes progression to lethal castration-resistant prostate cancer (CRP...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13668

    authors： Henzler C,Li Y,Yang R,McBride T,Ho Y,Sprenger C,Liu G,Coleman I,Lakely B,Li R,Ma S,Landman SR,Kumar V,Hwang TH,Raj GV,Higano CS,Morrissey C,Nelson PS,Plymate SR,Dehm SM

    更新日期：2016-11-29 00:00:00

  • Nanoparticles suppress fluid instabilities in the thermal drawing of ultralong nanowires.

    abstract：:Ultra-long metal nanowires and their facile fabrication have been long sought after as they promise to offer substantial improvements of performance in numerous applications. However, ultra-long metal ultrafine/nanowires are beyond the capability of current manufacturing techniques, which impose limitations on their s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19796-5

    authors： Hwang I,Guan Z,Cao C,Tang W,Chui CO,Li X

    更新日期：2020-11-23 00:00:00

  • Proteomic maps of breast cancer subtypes.

    abstract：:Systems-wide profiling of breast cancer has almost always entailed RNA and DNA analysis by microarray and sequencing techniques. Marked developments in proteomic technologies now enable very deep profiling of clinical samples, with high identification and quantification accuracy. We analysed 40 oestrogen receptor posi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10259

    authors： Tyanova S,Albrechtsen R,Kronqvist P,Cox J,Mann M,Geiger T

    更新日期：2016-01-04 00:00:00

  • Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor.

    abstract：:Kevin J. Cao and Richard H. Kramer, who developed extended release with beta cyclodextrin, were inadvertently omitted from the author list and author contributions section of this Article. These errors have now been corrected in both the PDF and HTML versions of the Article. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-018-03585-2

    authors： Berry MH,Holt A,Levitz J,Broichhagen J,Gaub BM,Visel M,Stanley C,Aghi K,Kim YJ,Cao K,Kramer RH,Trauner D,Flannery J,Isacoff EY

    更新日期：2018-03-13 00:00:00

  • Excitonic effects from geometric order and disorder explain broadband optical absorption in eumelanin.

    abstract：:Eumelanin is a ubiquitous biological pigment, and the origin of its broadband absorption spectrum has long been a topic of scientific debate. Here, we report a first-principles computational investigation to explain its broadband absorption feature. These computations are complemented by experimental results showing a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4859

    authors： Chen CT,Chuang C,Cao J,Ball V,Ruch D,Buehler MJ

    更新日期：2014-05-22 00:00:00

  • Spatial ultrasound modulation by digitally controlling microbubble arrays.

    abstract：:Acoustic waves, capable of transmitting through optically opaque objects, have been widely used in biomedical imaging, industrial sensing and particle manipulation. High-fidelity wave front shaping is essential to further improve performance in these applications. An acoustic analog to the successful spatial light mod...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18347-2

    authors： Ma Z,Melde K,Athanassiadis AG,Schau M,Richter H,Qiu T,Fischer P

    更新日期：2020-09-10 00:00:00

  • Vocal learning promotes patterned inhibitory connectivity.

    abstract：:Skill learning is instantiated by changes to functional connectivity within premotor circuits, but whether the specificity of learning depends on structured changes to inhibitory circuitry remains unclear. We used slice electrophysiology to measure connectivity changes associated with song learning in the avian analog...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01914-5

    authors： Miller MN,Cheung CYJ,Brainard MS

    更新日期：2017-12-13 00:00:00

  • Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

    abstract：:Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a...

    journal_title：Nature communications

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41467-018-04109-8

    authors： Dadaev T,Saunders EJ,Newcombe PJ,Anokian E,Leongamornlert DA,Brook MN,Cieza-Borrella C,Mijuskovic M,Wakerell S,Olama AAA,Schumacher FR,Berndt SI,Benlloch S,Ahmed M,Goh C,Sheng X,Zhang Z,Muir K,Govindasami K,Lophatan

    更新日期：2018-06-11 00:00:00

  • STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment.

    abstract：:A fascinating but uncharacterized action of antimitotic chemotherapy is to collectively prime cancer cells to apoptotic mitochondrial outer membrane permeabilization (MOMP), while impacting only on cycling cell subsets. Here, we show that a proapoptotic secretory phenotype is induced by activation of cGAS/STING in can...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13689-y

    authors： Lohard S,Bourgeois N,Maillet L,Gautier F,Fétiveau A,Lasla H,Nguyen F,Vuillier C,Dumont A,Moreau-Aubry A,Frapin M,David L,Loussouarn D,Kerdraon O,Campone M,Jézéquel P,Juin PP,Barillé-Nion S

    更新日期：2020-01-14 00:00:00

  • Diapause is associated with a change in the polarity of secretion of insulin-like peptides.

    abstract：:The insulin/IGF-1 signalling (IIS) pathway plays an important role in the regulation of larval diapause, the long-lived growth arrest state called dauer arrest, in Caenorhabditis elegans. In this nematode, 40 insulin-like peptides (ILPs) have been identified as putative ligands of the IIS pathway; however, it remains ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10573

    authors： Matsunaga Y,Honda Y,Honda S,Iwasaki T,Qadota H,Benian GM,Kawano T

    更新日期：2016-02-03 00:00:00

  • Percolation transition of cooperative mutational effects in colorectal tumorigenesis.

    abstract：:Cancer is caused by the accumulation of multiple genetic mutations, but their cooperative effects are poorly understood. Using a genome-wide analysis of all the somatic mutations in colorectal cancer patients in a large-scale molecular interaction network, here we find that a giant cluster of mutation-propagating modu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01171-6

    authors： Shin D,Lee J,Gong JR,Cho KH

    更新日期：2017-11-02 00:00:00

  • Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.

    abstract：:Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased risk of MM, the genetic basis of inherited MM susceptibility is incompletely understood. Here we report a genome-wide association study in the Nordic region identi...

    journal_title：Nature communications

    pub_type： 杂志文章,meta分析,多中心研究

    doi：10.1038/ncomms8213

    authors： Swaminathan B,Thorleifsson G,Jöud M,Ali M,Johnsson E,Ajore R,Sulem P,Halvarsson BM,Eyjolfsson G,Haraldsdottir V,Hultman C,Ingelsson E,Kristinsson SY,Kähler AK,Lenhoff S,Masson G,Mellqvist UH,Månsson R,Nelander S,Ola

    更新日期：2015-05-26 00:00:00

  • DG-CA3 circuitry mediates hippocampal representations of latent information.

    abstract：:Survival in complex environments necessitates a flexible navigation system that incorporates memory of recent behavior and associations. Yet, how the hippocampal spatial circuit represents latent information independent of sensory inputs and future goals has not been determined. To address this, we image the activity ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16825-1

    authors： Keinath AT,Nieto-Posadas A,Robinson JC,Brandon MP

    更新日期：2020-06-15 00:00:00

  • Field-programmable silicon temporal cloak.

    abstract：:Temporal cloaks have aroused tremendous research interest in both optical physics and optical communications, unfolding a distinct approach to conceal temporal events from an interrogating optical field. The state-of-the-art temporal cloaks exhibit picosecond-scale and static cloaking window, owing to significantly li...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10521-5

    authors： Zhou F,Yan S,Zhou H,Wang X,Qiu H,Dong J,Zhou L,Ding Y,Qiu CW,Zhang X

    更新日期：2019-06-20 00:00:00

  • Superconducting phase diagram of H3S under high magnetic fields.

    abstract：:The discovery of superconductivity at 260 K in hydrogen-rich compounds like LaH10 re-invigorated the quest for room temperature superconductivity. Here, we report the temperature dependence of the upper critical fields μ0Hc2(T) of superconducting H3S under a record-high combination of applied pressures up to 160 GPa a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10552-y

    authors： Mozaffari S,Sun D,Minkov VS,Drozdov AP,Knyazev D,Betts JB,Einaga M,Shimizu K,Eremets MI,Balicas L,Balakirev FF

    更新日期：2019-06-07 00:00:00

  • PhyloPhlAn is a new method for improved phylogenetic and taxonomic placement of microbes.

    abstract：:New microbial genomes are constantly being sequenced, and it is crucial to accurately determine their taxonomic identities and evolutionary relationships. Here we report PhyloPhlAn, a new method to assign microbial phylogeny and putative taxonomy using >400 proteins optimized from among 3,737 genomes. This method meas...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3304

    authors： Segata N,Börnigen D,Morgan XC,Huttenhower C

    更新日期：2013-01-01 00:00:00