A comprehensive multiscale framework for simulating optogenetics in the heart.

abstract：:Quantifying chemical compositions around nanovoids is a fundamental task for research and development of various materials. Atom probe tomography (APT) and scanning transmission electron microscopy (STEM) are currently the most suitable tools because of their ability to probe materials at the nanoscale. Both technique...

journal_title：Nature communications

authors： Wang X,Hatzoglou C,Sneed B,Fan Z,Guo W,Jin K,Chen D,Bei H,Wang Y,Weber WJ,Zhang Y,Gault B,More KL,Vurpillot F,Poplawsky JD

更新日期：2020-02-24 00:00:00

abstract：:Flexible barrier films preventing permeation of gases and moistures are important for many industries ranging from food to medical and from chemical to electronic. From this perspective, graphene has recently attracted particular interest because its defect-free monolayers are impermeable to all atoms and molecules. H...

journal_title：Nature communications

authors： Su Y,Kravets VG,Wong SL,Waters J,Geim AK,Nair RR

更新日期：2014-09-11 00:00:00

abstract：:Calcareous microplankton shells form the dominant components of ancient and modern pelagic sea-floor carbonates and are widely used in palaeoenvironmental reconstructions. The efficacy of these applications, however, is dependent upon minimal geochemical alteration during diagenesis, but these modifying processes are ...

journal_title：Nature communications

authors： Wendler JE,Bown P

更新日期：2013-01-01 00:00:00

abstract：:Different horticultural types of lettuce exhibit tremendous morphological variation. However, the molecular basis for domestication and divergence among the different horticultural types of lettuce remains unknown. Here, we report the RNA sequencing of 240 lettuce accessions sampled from the major horticultural types ...

journal_title：Nature communications

authors： Zhang L,Su W,Tao R,Zhang W,Chen J,Wu P,Yan C,Jia Y,Larkin RM,Lavelle D,Truco MJ,Chin-Wo SR,Michelmore RW,Kuang H

更新日期：2017-12-22 00:00:00

abstract：:Culture (behaviour based on socially transmitted information) is present in diverse animal species, yet how it interacts with genetic evolution remains largely unexplored. Here, we review the evidence for gene-culture coevolution in animals, especially birds, cetaceans and primates. We describe how culture can relax o...

journal_title：Nature communications

authors： Whitehead H,Laland KN,Rendell L,Thorogood R,Whiten A

更新日期：2019-06-03 00:00:00

abstract：:β-Adrenergic receptor (β-AR) signaling is a pathway controlling adaptive thermogenesis in brown or beige adipocytes. Here we investigate the biological roles of the transcription factor Foxp1 in brown/beige adipocyte differentiation and thermogenesis. Adipose-specific deletion of Foxp1 leads to an increase of brown ad...

journal_title：Nature communications

authors： Liu P,Huang S,Ling S,Xu S,Wang F,Zhang W,Zhou R,He L,Xia X,Yao Z,Fan Y,Wang N,Hu C,Zhao X,Tucker HO,Wang J,Guo X

更新日期：2019-11-07 00:00:00

abstract：:Mycobacterium tuberculosis is a pathogen with a unique cell envelope including very long fatty acids, implicated in bacterial resistance and host immune modulation. FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis....

journal_title：Nature communications

authors： Lara J,Diacovich L,Trajtenberg F,Larrieux N,Malchiodi EL,Fernández MM,Gago G,Gramajo H,Buschiazzo A

更新日期：2020-07-24 00:00:00

abstract：:Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways. Overnight fasted participants rated the palatability of food pictures ...

journal_title：Nature communications

authors： Tiedemann LJ,Schmid SM,Hettel J,Giesen K,Francke P,Büchel C,Brassen S

更新日期：2017-07-18 00:00:00

abstract：:G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between different G4 structures are rare. Here, we describe DC-34, a small molec...

journal_title：Nature communications

authors： Calabrese DR,Chen X,Leon EC,Gaikwad SM,Phyo Z,Hewitt WM,Alden S,Hilimire TA,He F,Michalowski AM,Simmons JK,Saunders LB,Zhang S,Connors D,Walters KJ,Mock BA,Schneekloth JS Jr

更新日期：2018-10-12 00:00:00

abstract：:Rapid growth in size and complexity of biological data sets has led to the 'Big Data to Knowledge' challenge. We develop advanced data integration methods for multi-level analysis of genomic, transcriptomic, ribosomal profiling, proteomic and fluxomic data. First, we show that pairwise integration of primary omics dat...

journal_title：Nature communications

authors： Ebrahim A,Brunk E,Tan J,O'Brien EJ,Kim D,Szubin R,Lerman JA,Lechner A,Sastry A,Bordbar A,Feist AM,Palsson BO

更新日期：2016-10-26 00:00:00

abstract：:The most explosive basaltic scoria cone eruption yet documented (>20 km high plumes) occurred at Sunset Crater (Arizona) ca. 1085 AD by undetermined eruptive mechanisms. We present melt inclusion analysis, including bubble contents by Raman spectroscopy, yielding high total CO2 (approaching 6000 ppm) and S (~2000 ppm)...

journal_title：Nature communications

authors： Allison CM,Roggensack K,Clarke AB

更新日期：2021-01-11 00:00:00

abstract：:Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble proteins in lysosomes. CMA contributes to cellular quality control and is activated as part of the cellular response to different stressors. Defective CMA has been identified in ageing and different age-related diseases. Until n...

journal_title：Nature communications

authors： Koga H,Martinez-Vicente M,Macian F,Verkhusha VV,Cuervo AM

更新日期：2011-07-12 00:00:00

abstract：:The bacterial effector MavC catalyzes non-canonical ubiquitination of host E2 enzyme UBE2N without engaging any of the conventional ubiquitination machinery, thereby abolishing UBE2N's function in forming K63-linked ubiquitin (Ub) chains and dampening NF-кB signaling. We now report the structures of MavC in complex wi...

journal_title：Nature communications

authors： Wang Y,Zhan Q,Wang X,Li P,Liu S,Gao G,Gao P

更新日期：2020-06-02 00:00:00

abstract：:Heartbeat is required for normal development of the heart, and perturbation of intracardiac flow leads to morphological defects resembling congenital heart diseases. These observations implicate intracardiac haemodynamics in cardiogenesis, but the signalling cascades connecting physical forces, gene expression and mor...

journal_title：Nature communications

authors： Banjo T,Grajcarek J,Yoshino D,Osada H,Miyasaka KY,Kida YS,Ueki Y,Nagayama K,Kawakami K,Matsumoto T,Sato M,Ogura T

更新日期：2013-01-01 00:00:00

abstract：:Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. ...

journal_title：Nature communications

authors： Liu W,Li Y,Shaw KS,Learn GH,Plenderleith LJ,Malenke JA,Sundararaman SA,Ramirez MA,Crystal PA,Smith AG,Bibollet-Ruche F,Ayouba A,Locatelli S,Esteban A,Mouacha F,Guichet E,Butel C,Ahuka-Mundeke S,Inogwabini BI,Ndjango

更新日期：2014-01-01 00:00:00

abstract：:TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly express DR3. Here, we report that activation of DR3 signaling by an agonistic anti-DR3 antibody incr...

journal_title：Nature communications

authors： Li J,Shi W,Sun H,Ji Y,Chen Y,Guo X,Sheng H,Shu J,Zhou L,Cai T,Qiu J

更新日期：2019-07-29 00:00:00

abstract：:Carbon coating is a simple, effective and common technique for improving the conductivity of active materials in lithium ion batteries. However, carbon coating provides a strong reducing atmosphere and many factors remain unclear concerning the interface nature and underlying interaction mechanism that occurs between ...

journal_title：Nature communications

authors： Wang J,Yang J,Tang Y,Liu J,Zhang Y,Liang G,Gauthier M,Chen-Wiegart YC,Norouzi Banis M,Li X,Li R,Wang J,Sham TK,Sun X

更新日期：2014-03-05 00:00:00

abstract：:Biocatalytic cyclization is highly desirable for efficient synthesis of biologically derived chemical substances, such as the commodity chemicals ε-caprolactam and δ-valerolactam. To identify biocatalysts in lactam biosynthesis, we develop a caprolactam-detecting genetic enzyme screening system (CL-GESS). The Alcalige...

journal_title：Nature communications

authors： Yeom SJ,Kim M,Kwon KK,Fu Y,Rha E,Park SH,Lee H,Kim H,Lee DH,Kim DM,Lee SG

更新日期：2018-11-29 00:00:00

abstract：:Centrioles are vital cellular structures that form centrosomes and cilia. The formation and function of cilia depends on a set of centriole's distal appendages. In this study, we use correlative super resolution and electron microscopy to precisely determine where distal appendage proteins localize in relation to the ...

journal_title：Nature communications

authors： Bowler M,Kong D,Sun S,Nanjundappa R,Evans L,Farmer V,Holland A,Mahjoub MR,Sui H,Loncarek J

更新日期：2019-03-01 00:00:00

abstract：:Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that the human microcephaly protein, RTTN, is recruited to the proximal end of the procentriole at early S phase, and is located at the inner luminal walls of centrioles. Further stud...

journal_title：Nature communications

authors： Chen HY,Wu CT,Tang CC,Lin YN,Wang WJ,Tang TK

更新日期：2017-08-15 00:00:00

abstract：:Melting of the Greenland Ice Sheet is a leading cause of land-ice mass loss and cryosphere-attributed sea level rise. Blooms of pigmented glacier ice algae lower ice albedo and accelerate surface melting in the ice sheet's southwest sector. Although glacier ice algae cause up to 13% of the surface melting in this regi...

journal_title：Nature communications

authors： McCutcheon J,Lutz S,Williamson C,Cook JM,Tedstone AJ,Vanderstraeten A,Wilson SA,Stockdale A,Bonneville S,Anesio AM,Yallop ML,McQuaid JB,Tranter M,Benning LG

更新日期：2021-01-25 00:00:00

abstract：:Platinum nanoparticles (Pt NPs) are one of the most efficient cocatalysts in photocatalysis, and their size determines the activity and the selectivity of the catalytic reaction. Nevertheless, an in-depth understanding of the platinum's size effect in the carbon dioxide photocatalytic reduction is still lacking. Throu...

journal_title：Nature communications

authors： Dong C,Lian C,Hu S,Deng Z,Gong J,Li M,Liu H,Xing M,Zhang J

更新日期：2018-03-28 00:00:00

abstract：:Practice improves perception and enhances neural representations of trained visual stimuli, a phenomenon known as visual perceptual learning (VPL). While attention to task-relevant stimuli plays an important role in such learning, Pavlovian stimulus-reinforcer associations are sufficient to drive VPL, even subconsciou...

journal_title：Nature communications

authors： Arsenault JT,Vanduffel W

更新日期：2019-08-09 00:00:00

abstract：:Group O D-negative blood cells are universal donors in transfusion medicine and methods for converting other blood groups into this universal donor group have been researched. However, conversion of D-positive cells into D-negative is yet to be achieved, although conversion of group A or B cells into O cells has been ...

journal_title：Nature communications

authors： Kim YH,Kim HO,Baek EJ,Kurita R,Cha HJ,Nakamura Y,Kim H

更新日期：2015-06-16 00:00:00

abstract：:Hybrid organic-inorganic perovskites have attractive optoelectronic properties including exceptional solar cell performance. The improved properties of perovskites have been attributed to polaronic effects involving stabilization of localized charge character by structural deformations and polarizations. Here we exami...

journal_title：Nature communications

authors： Park M,Neukirch AJ,Reyes-Lillo SE,Lai M,Ellis SR,Dietze D,Neaton JB,Yang P,Tretiak S,Mathies RA

更新日期：2018-06-28 00:00:00

abstract：:The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastable phenotypic variants (persisters), some of which represent ste...

journal_title：Nature communications

authors： Pisco AO,Brock A,Zhou J,Moor A,Mojtahedi M,Jackson D,Huang S

更新日期：2013-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Masid M,Ataman M,Hatzimanikatis V

更新日期：2020-07-23 00:00:00

abstract：:The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 nm), but an ongoing challenge is the solvatochromism-caused quenching in aqueous solution for the long-wavelength absorbing fluorophores. Herein...

journal_title：Nature communications

authors： Wang S,Fan Y,Li D,Sun C,Lei Z,Lu L,Wang T,Zhang F

更新日期：2019-03-05 00:00:00

abstract：:Identifying therapeutic targets in rare cancers remains challenging due to the paucity of established models to perform preclinical studies. As a proof-of-concept, we developed a patient-derived cancer cell line, CLF-PED-015-T, from a paediatric patient with a rare undifferentiated sarcoma. Here, we confirm that this ...

journal_title：Nature communications

authors： Hong AL,Tseng YY,Cowley GS,Jonas O,Cheah JH,Kynnap BD,Doshi MB,Oh C,Meyer SC,Church AJ,Gill S,Bielski CM,Keskula P,Imamovic A,Howell S,Kryukov GV,Clemons PA,Tsherniak A,Vazquez F,Crompton BD,Shamji AF,Rodriguez-

更新日期：2016-06-22 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and progressive weakness. There is considerable inter-patient variability in disease onset and progression, which can confound the results of clinical trials. Here we show that a common null polymorphism (R577X) in ACTN3 results in significantly...

journal_title：Nature communications

authors： Hogarth MW,Houweling PJ,Thomas KC,Gordish-Dressman H,Bello L,Cooperative International Neuromuscular Research Group (CINRG).,Pegoraro E,Hoffman EP,Head SI,North KN

更新日期：2017-01-31 00:00:00