Addendum: A very large-scale microelectrode array for cellular-resolution electrophysiology.

abstract：:Multidrug resistance is a major challenge to cancer chemotherapy. The multidrug resistance phenotype is associated with the overexpression of the adenosine triphosphate (ATP)-driven transmembrane efflux pumps in cancer cells. Here, we report a lipid membrane-coated silica-carbon (LSC) hybrid nanoparticle that targets ...

journal_title：Nature communications

authors： Wang H,Gao Z,Liu X,Agarwal P,Zhao S,Conroy DW,Ji G,Yu J,Jaroniec CP,Liu Z,Lu X,Li X,He X

更新日期：2018-02-08 00:00:00

abstract：:Architectural proteins have an important role in shaping the genome and act as global regulators of gene expression. How these proteins jointly modulate genome plasticity is largely unknown. In archaea, one of the most abundant proteins, Alba, is considered to have a key role in organizing the genome. Here we characte...

journal_title：Nature communications

authors： Laurens N,Driessen RP,Heller I,Vorselen D,Noom MC,Hol FJ,White MF,Dame RT,Wuite GJ

更新日期：2012-01-01 00:00:00

abstract：:Osmoregulation is important for plant growth, development and response to environmental changes. SNF1-related protein kinase 2s (SnRK2s) are quickly activated by osmotic stress and are central components in osmotic stress and abscisic acid (ABA) signaling pathways; however, the upstream components required for SnRK2 a...

journal_title：Nature communications

authors： Lin Z,Li Y,Zhang Z,Liu X,Hsu CC,Du Y,Sang T,Zhu C,Wang Y,Satheesh V,Pratibha P,Zhao Y,Song CP,Tao WA,Zhu JK,Wang P

更新日期：2020-01-30 00:00:00

abstract：:In the inner ear, cochlear and vestibular sensory epithelia utilize grossly similar cell types to transduce different stimuli: sound and acceleration. Each individual sensory epithelium is composed of highly heterogeneous populations of cells based on physiological and anatomical criteria. However, limited numbers of ...

journal_title：Nature communications

authors： Burns JC,Kelly MC,Hoa M,Morell RJ,Kelley MW

更新日期：2015-10-15 00:00:00

abstract：:Knots are natural topologies of chains. Yet, little is known about spontaneous knot formation in a polypeptide chain-an event that can potentially impair its folding-and about the effect of a knot on the stability and folding kinetics of a protein. Here we used optical tweezers to show that the free energy cost to for...

journal_title：Nature communications

authors： Bustamante A,Sotelo-Campos J,Guerra DG,Floor M,Wilson CAM,Bustamante C,Báez M

更新日期：2017-11-17 00:00:00

abstract：:The HIV Tat protein competes with the 7SK:HEXIM interaction to hijack pTEFb from 7SK snRNP and recruit it to the TAR motif on stalled viral transcripts. Here we solve structures of 7SK stemloop-1 and TAR in complex with Tat's RNA binding domain (RBD) to gain insights into this process. We find that 7SK is peppered wit...

journal_title：Nature communications

authors： Pham VV,Salguero C,Khan SN,Meagher JL,Brown WC,Humbert N,de Rocquigny H,Smith JL,D'Souza VM

更新日期：2018-10-15 00:00:00

abstract：:Bacterial vaginosis is a condition associated with adverse reproductive outcomes and characterized by a shift from a Lactobacillus-dominant vaginal microbiota to a polymicrobial microbiota, consistently colonized by strains of Gardnerella vaginalis. Metronidazole is the first-line treatment; however, treatment failure...

journal_title：Nature communications

authors： Lee CY,Cheu RK,Lemke MM,Gustin AT,France MT,Hampel B,Thurman AR,Doncel GF,Ravel J,Klatt NR,Arnold KB

更新日期：2020-12-01 00:00:00

abstract：:Induction of endogenous adult stem cells by administering soluble molecules provides an advantageous approach for tissue damage repair, which could be a clinically applicable and cost-effective alternative to transplantation of embryonic or pluripotent stem cell-derived tissues for the treatment of acute organ failure...

journal_title：Nature communications

authors： Lin Y,Fang ZP,Liu HJ,Wang LJ,Cheng Z,Tang N,Li T,Liu T,Han HX,Cao G,Liang L,Ding YQ,Zhou WJ

更新日期：2017-10-27 00:00:00

abstract：:The photons in circularly polarized light can transfer their quantized spin angular momentum to micro- and nanostructures via absorption and scattering. This normally exerts positive torque on the objects wher the sign (i.e., handedness or angular direction) follows that of the spin angular momentum. Here we show that...

journal_title：Nature communications

authors： Han F,Parker JA,Yifat Y,Peterson C,Gray SK,Scherer NF,Yan Z

更新日期：2018-11-20 00:00:00

abstract：:The coupled translocation of transfer RNA and messenger RNA through the ribosome entails large-scale structural rearrangements, including step-wise movements of the tRNAs. Recent structural work has visualized intermediates of translocation induced by elongation factor G (EF-G) with tRNAs trapped in chimeric states wi...

journal_title：Nature communications

authors： Adio S,Senyushkina T,Peske F,Fischer N,Wintermeyer W,Rodnina MV

更新日期：2015-06-15 00:00:00

abstract：:A widely appreciated aspect of developmental robustness is pattern formation in proportion to size. But how such scaling features emerge dynamically remains poorly understood. Here we generate a data set of the expression profiles of six gap genes in Drosophila melanogaster embryos that differ significantly in size. E...

journal_title：Nature communications

authors： Wu H,Manu,Jiao R,Ma J

更新日期：2015-12-08 00:00:00

abstract：:Quantum triangular-lattice antiferromagnets are important prototype systems to investigate numerous phenomena of the geometrical frustration in condensed matter. Apart from highly unusual magnetic properties, they possess a rich phase diagram (ranging from an unfrustrated square lattice to a quantum spin liquid), yet ...

journal_title：Nature communications

authors： Zvyagin SA,Graf D,Sakurai T,Kimura S,Nojiri H,Wosnitza J,Ohta H,Ono T,Tanaka H

更新日期：2019-03-06 00:00:00

abstract：:IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory diseases. Here we demonstrate that TNF inhibitor (TNFi) drugs induce the anti-inflammatory cytokine IL-10 in CD4+ T cells including IL-17+ CD4+ T cells. TNFi-mediated induction of IL-10 in IL-17+ CD4+ T cells is Treg-/Foxp3-indepen...

journal_title：Nature communications

authors： Evans HG,Roostalu U,Walter GJ,Gullick NJ,Frederiksen KS,Roberts CA,Sumner J,Baeten DL,Gerwien JG,Cope AP,Geissmann F,Kirkham BW,Taams LS

更新日期：2014-01-01 00:00:00

abstract：:Topology has an increasingly important role in the physics of condensed matter, quantum systems, material science, photonics and biology, with spectacular realizations of topological concepts in liquid crystals. Here we report on long-lived hidden topological states in thermally quenched, chiral nematic droplets, form...

journal_title：Nature communications

authors： Posnjak G,Čopar S,Muševič I

更新日期：2017-02-21 00:00:00

abstract：:Hearing relies on mechanical stimulation of stereocilia bundles on the sensory cells of the inner ear. When sound hits the ear, each stereocilium pivots about a neck-like taper near their base. More than three decades of research have established that sideways deflection of stereocilia is essential for converting mech...

journal_title：Nature communications

authors： Hakizimana P,Brownell WE,Jacob S,Fridberger A

更新日期：2012-01-01 00:00:00

abstract：:The reversible modification of cysteine residues by thioester formation with palmitate (S-palmitoylation) is an abundant lipid post-translational modification (PTM) in mammalian systems. S-palmitoylation has been observed on mitochondrial proteins, providing an intriguing potential connection between metabolic lipids ...

journal_title：Nature communications

authors： Kathayat RS,Cao Y,Elvira PD,Sandoz PA,Zaballa ME,Springer MZ,Drake LE,Macleod KF,van der Goot FG,Dickinson BC

更新日期：2018-01-23 00:00:00

abstract：:Synthetic DNA is becoming an attractive substrate for digital data storage due to its density, durability, and relevance in biological research. A major challenge in making DNA data storage a reality is that reading DNA back into data using sequencing by synthesis remains a laborious, slow and expensive process. Here,...

journal_title：Nature communications

authors： Lopez R,Chen YJ,Dumas Ang S,Yekhanin S,Makarychev K,Racz MZ,Seelig G,Strauss K,Ceze L

更新日期：2019-07-03 00:00:00

abstract：:Human pressures on the ocean are thought to be increasing globally, yet we know little about their patterns of cumulative change, which pressures are most responsible for change, and which places are experiencing the greatest increases. Managers and policymakers require such information to make strategic decisions and...

journal_title：Nature communications

authors： Halpern BS,Frazier M,Potapenko J,Casey KS,Koenig K,Longo C,Lowndes JS,Rockwood RC,Selig ER,Selkoe KA,Walbridge S

更新日期：2015-07-14 00:00:00

abstract：:In June 2015, Cassini high-resolution images of Saturn's limb southwards of the planet's hexagonal wave revealed a system of at least six stacked haze layers above the upper cloud deck. Here, we characterize those haze layers and discuss their nature. Vertical thickness of layers ranged from 7 to 18 km, and they exten...

journal_title：Nature communications

authors： Sánchez-Lavega A,García-Muñoz A,Del Río-Gaztelurrutia T,Pérez-Hoyos S,Sanz-Requena JF,Hueso R,Guerlet S,Peralta J

更新日期：2020-05-08 00:00:00

abstract：:Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The contribution of cell adhesion molecules to the cortical localization of the dynein-dynactin complex is poorly understood. Here we find that junctional adh...

journal_title：Nature communications

authors： Tuncay H,Brinkmann BF,Steinbacher T,Schürmann A,Gerke V,Iden S,Ebnet K

更新日期：2015-08-26 00:00:00

abstract：:The bacterial effector MavC catalyzes non-canonical ubiquitination of host E2 enzyme UBE2N without engaging any of the conventional ubiquitination machinery, thereby abolishing UBE2N's function in forming K63-linked ubiquitin (Ub) chains and dampening NF-кB signaling. We now report the structures of MavC in complex wi...

journal_title：Nature communications

authors： Wang Y,Zhan Q,Wang X,Li P,Liu S,Gao G,Gao P

更新日期：2020-06-02 00:00:00

abstract：:Interaction between light and matter results in new quantum states whose energetics can modify chemical kinetics. In the regime of ensemble vibrational strong coupling (VSC), a macroscopic number [Formula: see text] of molecular transitions couple to each resonant cavity mode, yielding two hybrid light-matter (polarit...

journal_title：Nature communications

authors： Campos-Gonzalez-Angulo JA,Ribeiro RF,Yuen-Zhou J

更新日期：2019-10-15 00:00:00

abstract：:Increased vascular permeability contributes to many diseases, including acute respiratory distress syndrome, cancer and inflammation. Most past work on vascular barrier function has focused on soluble regulators, such as tumour-necrosis factor-α. Here we show that lung vascular permeability is controlled mechanically ...

journal_title：Nature communications

authors： Mammoto A,Mammoto T,Kanapathipillai M,Wing Yung C,Jiang E,Jiang A,Lofgren K,Gee EP,Ingber DE

更新日期：2013-01-01 00:00:00

abstract：:Colloidal interactions in nematic liquid crystals can be described as interactions between elastic multipoles that depend on particle shape, topology, chirality, boundary conditions and induced topological defects. Here, we describe a nematic colloidal system consisting of mesostructures of gold capable of inducing el...

journal_title：Nature communications

authors： Yuan Y,Tasinkevych M,Smalyukh II

更新日期：2020-01-10 00:00:00

abstract：:Predicting ecological effects of contaminants remains challenging because of the sheer number of chemicals and their ambiguous role in biodiversity-ecosystem function relationships. We evaluate responses of experimental pond ecosystems to standardized concentrations of 12 pesticides, nested in four pesticide classes a...

journal_title：Nature communications

authors： Rumschlag SL,Mahon MB,Hoverman JT,Raffel TR,Carrick HJ,Hudson PJ,Rohr JR

更新日期：2020-12-10 00:00:00

abstract：:We demonstrate a method based on symmetry to predict the structure of self-assembling, multicomponent colloidal mixtures. This method allows us to feasibly enumerate candidate structures from all symmetry groups and is many orders of magnitude more computationally efficient than combinatorial enumeration of these cand...

journal_title：Nature communications

authors： Mahynski NA,Pretti E,Shen VK,Mittal J

更新日期：2019-05-02 00:00:00

abstract：:Recent years have witnessed the growing interest in the remote functionalization of alkenes for it offers a strategy to activate the challenging C-H bonds distant from the initiation point via alkene isomerization/functionalization. However, the catalytic enantioselective isomerization/functionalization with one singl...

journal_title：Nature communications

authors： Chen X,Cheng Z,Guo J,Lu Z

更新日期：2018-09-26 00:00:00

abstract：:Understanding the emerging models of adaptive resistance is key to overcoming cancer chemotherapy failure. Using human breast cancer explants, in vitro cell lines, mouse in vivo studies and mathematical modelling, here we show that exposure to a taxane induces phenotypic cell state transition towards a favoured transi...

journal_title：Nature communications

authors： Goldman A,Majumder B,Dhawan A,Ravi S,Goldman D,Kohandel M,Majumder PK,Sengupta S

更新日期：2015-02-11 00:00:00

abstract：:The Amazon river basin receives ~2000 mm of precipitation annually and contributes ~17% of global river freshwater input to the oceans; its hydroclimatic variations can exert profound impacts on the marine ecosystem in the Amazon plume region (APR) and have potential far-reaching influences on hydroclimate over the tr...

journal_title：Nature communications

authors： Liang YC,Lo MH,Lan CW,Seo H,Ummenhofer CC,Yeager S,Wu RJ,Steffen JD

更新日期：2020-09-01 00:00:00

abstract：:Phagocytosis is responsible for the elimination of particles of widely disparate sizes, from large fungi or effete cells to small bacteria. Though superficially similar, the molecular mechanisms involved differ: engulfment of large targets requires phosphoinositide 3-kinase (PI3K), while that of small ones does not. H...

journal_title：Nature communications

authors： Schlam D,Bagshaw RD,Freeman SA,Collins RF,Pawson T,Fairn GD,Grinstein S

更新日期：2015-10-14 00:00:00