Development of oculomotor circuitry independent of hox3 genes.

abstract：:Activation-induced cytidine deaminase (AID) initiates both antibody class switch recombination (CSR) and somatic hypermutation (SHM) in antibody diversification. DNA double-strand break response (DSBR) factors promote rearrangement in CSR, while translesion synthesis (TLS) polymerases generate mutations in SHM. REV7, ...

journal_title：Nature communications

authors： Yang D,Sun Y,Chen J,Zhang Y,Fan S,Huang M,Xie X,Cai Y,Shang Y,Gui T,Sun L,Hu J,Dong J,Yeap LS,Wang X,Xiao W,Meng FL

更新日期：2020-06-04 00:00:00

abstract：:Glucose-induced insulin secretion is an essential function of pancreatic β-cells that is partially lost in individuals affected by Type 2 diabetes. This unique property of β-cells is acquired through a poorly understood postnatal maturation process involving major modifications in gene expression programs. Here we sho...

journal_title：Nature communications

authors： Jacovetti C,Matkovich SJ,Rodriguez-Trejo A,Guay C,Regazzi R

更新日期：2015-09-02 00:00:00

abstract：:The Barbier reaction, a widely utilized reaction for carbon-carbon bond formation, has played important roles in modern organic chemistry for more than a century. Here, we show its successful introduction to polymer chemistry. Through one-pot Barbier polyaddition (both A2+B2 type and AB type) of monomers containing an...

journal_title：Nature communications

authors： Sun XL,Liu DM,Tian D,Zhang XY,Wu W,Wan WM

更新日期：2017-10-31 00:00:00

abstract：:Visualizing the rearrangement of atoms in a wide range of molecular and condensed-matter systems requires resolving picometre displacements on a 10-fs timescale, which is achievable using pump-probe diffraction, given short enough pulses. Here we demonstrate the compression of single-electron pulses with a de Broglie ...

journal_title：Nature communications

authors： Gliserin A,Walbran M,Krausz F,Baum P

更新日期：2015-10-27 00:00:00

abstract：:Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides. Erastin, the ferroptosis activator, binds to voltage-dependent anion channels VDAC2 and VDCA3, but treatment with erastin can result in the degradation of the channels. Here, the author...

journal_title：Nature communications

authors： Yang Y,Luo M,Zhang K,Zhang J,Gao T,Connell DO,Yao F,Mu C,Cai B,Shang Y,Chen W

更新日期：2020-01-23 00:00:00

abstract：:Temperature measurement is critical for many technological applications and scientific experiments, and different types of thermometers have been developed to detect temperature at macroscopic length scales. However, quantitative measurement of the temperature of nanostructures remains a challenge. Here, we show a new...

journal_title：Nature communications

authors： Guo H,Khan MI,Cheng C,Fan W,Dames C,Wu J,Minor AM

更新日期：2014-10-13 00:00:00

abstract：:Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic ...

journal_title：Nature communications

authors： Muthana M,Kennerley AJ,Hughes R,Fagnano E,Richardson J,Paul M,Murdoch C,Wright F,Payne C,Lythgoe MF,Farrow N,Dobson J,Conner J,Wild JM,Lewis C

更新日期：2015-08-18 00:00:00

abstract：:Scaffolded DNA origami has proven to be a powerful and efficient technique to fabricate functional nanomachines by programming the folding of a single-stranded DNA template strand into three-dimensional (3D) nanostructures, designed to be precisely motion-controlled. Although two-dimensional (2D) imaging of DNA nanoma...

journal_title：Nature communications

authors： Lei D,Marras AE,Liu J,Huang CM,Zhou L,Castro CE,Su HJ,Ren G

更新日期：2018-02-09 00:00:00

abstract：:The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 nm), but an ongoing challenge is the solvatochromism-caused quenching in aqueous solution for the long-wavelength absorbing fluorophores. Herein...

journal_title：Nature communications

authors： Wang S,Fan Y,Li D,Sun C,Lei Z,Lu L,Wang T,Zhang F

更新日期：2019-03-05 00:00:00

abstract：:The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells....

journal_title：Nature communications

authors： Bunnik EM,Cook KB,Varoquaux N,Batugedara G,Prudhomme J,Cort A,Shi L,Andolina C,Ross LS,Brady D,Fidock DA,Nosten F,Tewari R,Sinnis P,Ay F,Vert JP,Noble WS,Le Roch KG

更新日期：2018-05-15 00:00:00

abstract：:Orexins are associated with drug relapse in rodents. Here, we show that acute restraint stress in mice activates lateral hypothalamic (LH) orexin neurons, increases levels of orexin A and 2-arachidonoylglycerol (2-AG) in the ventral tegmental area (VTA), and reinstates extinguished cocaine-conditioned place preference...

journal_title：Nature communications

authors： Tung LW,Lu GL,Lee YH,Yu L,Lee HJ,Leishman E,Bradshaw H,Hwang LL,Hung MS,Mackie K,Zimmer A,Chiou LC

更新日期：2016-07-22 00:00:00

abstract：:The transcription factor BMAL1 is a core component of the molecular clock, regulating biological pathways that drive 24 h (circadian) rhythms in behaviour and physiology. The molecular clock has a profound influence on innate immune function, and circadian disruption is linked with increased incidence of multiple scle...

journal_title：Nature communications

authors： Sutton CE,Finlay CM,Raverdeau M,Early JO,DeCourcey J,Zaslona Z,O'Neill LAJ,Mills KHG,Curtis AM

更新日期：2017-12-12 00:00:00

abstract：:Proteins and nucleic acids are sequence-regulated macromolecules with various properties originating from their perfectly sequenced primary structures. However, the sequence regulation of synthetic polymers, particularly vinyl polymers, has not been achieved and is one of the ultimate goals in polymer chemistry. In th...

journal_title：Nature communications

authors： Satoh K,Ozawa S,Mizutani M,Nagai K,Kamigaito M

更新日期：2010-04-12 00:00:00

abstract：:Influenza viruses annually kill 290,000-650,000 people worldwide. Antivirals can reduce death tolls. Baloxavir, the recently approved influenza antiviral, inhibits initiation of viral mRNA synthesis, whereas oseltamivir, an older drug, inhibits release of virus progeny. Baloxavir blocks virus replication more rapidly ...

journal_title：Nature communications

authors： Du Z,Nugent C,Galvani AP,Krug RM,Meyers LA

更新日期：2020-06-02 00:00:00

abstract：:SMC (structural maintenance of chromosomes) family members play essential roles in chromosome condensation, sister chromatid cohesion and DNA repair. It remains unclear how SMCs structure chromosomes and how their mechanochemical cycle regulates their interactions with DNA. Here we used single-molecule fluorescence mi...

journal_title：Nature communications

authors： Kim H,Loparo JJ

更新日期：2016-01-04 00:00:00

abstract：:Solar radio observations provide a unique diagnostic of the outer solar atmosphere. However, the inhomogeneous turbulent corona strongly affects the propagation of the emitted radio waves, so decoupling the intrinsic properties of the emitting source from the effects of radio wave propagation has long been a major cha...

journal_title：Nature communications

authors： Kontar EP,Yu S,Kuznetsov AA,Emslie AG,Alcock B,Jeffrey NLS,Melnik VN,Bian NH,Subramanian P

更新日期：2017-11-15 00:00:00

abstract：:Mutators represent a successful strategy in rapidly adapting asexual populations, but theory predicts their eventual extinction due to their unsustainably large deleterious load. While antimutator invasions have been documented experimentally, important discrepancies among studies remain currently unexplained. Here we...

journal_title：Nature communications

authors： Couce A,Tenaillon O

更新日期：2019-07-15 00:00:00

abstract：:Alkenes are fundamental functionalities in nature and highly useful intermediates in organic synthesis, medicinal chemistry and material sciences. Transition-metal-catalyzed Heck couplings with organic halides as electrophiles have been established as a powerful protocol for the synthesis of this valuable building blo...

journal_title：Nature communications

authors： Lv L,Zhu D,Li CJ

更新日期：2019-02-12 00:00:00

abstract：:The c-Jun/AP-1 transcription factor controls key cellular behaviours, including proliferation and apoptosis, in response to JNK and Ras/MAPK signalling. While the JNK pathway has been well characterized, the mechanism of activation by Ras was elusive. Here we identify the uncharacterized ubiquitin ligase Trim7 as a cr...

journal_title：Nature communications

authors： Chakraborty A,Diefenbacher ME,Mylona A,Kassel O,Behrens A

更新日期：2015-04-08 00:00:00

abstract：:While plasmonic designs have dominated recent trends in structural color, schemes using localized surface plasmon resonances and surface plasmon polaritons that simultaneously achieve high color vibrancy at ultrahigh resolution have been elusive because of tradeoffs between size and performance. Herein we demonstrate ...

journal_title：Nature communications

authors： Lee JS,Park JY,Kim YH,Jeon S,Ouellette O,Sargent EH,Kim DH,Hyun JK

更新日期：2019-10-21 00:00:00

abstract：:Detecting the metallic Dirac electronic states on the surface of Topological Insulators (TIs) is critical for the study of important surface quantum properties (SQPs), such as Majorana zero modes, where simultaneous probing of the bulk and edge electron states is required. However, there is a particular shortage of ex...

journal_title：Nature communications

authors： Papawassiliou W,Jaworski A,Pell AJ,Jang JH,Kim Y,Lee SC,Kim HJ,Alwahedi Y,Alhassan S,Subrati A,Fardis M,Karagianni M,Panopoulos N,Dolinšek J,Papavassiliou G

更新日期：2020-03-09 00:00:00

abstract：:Type I modular polyketide synthases assemble diverse bioactive natural products. Such multienzymes typically use malonyl and methylmalonyl-CoA building blocks for polyketide chain assembly. However, in several cases more exotic alkylmalonyl-CoA extender units are also known to be incorporated. In all examples studied ...

journal_title：Nature communications

authors： Ray L,Valentic TR,Miyazawa T,Withall DM,Song L,Milligan JC,Osada H,Takahashi S,Tsai SC,Challis GL

更新日期：2016-12-21 00:00:00

abstract：:Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto t...

journal_title：Nature communications

authors： Kim HR,Mun Y,Lee KS,Park YJ,Park JS,Park JH,Jeon BN,Kim CH,Jun Y,Hyun YM,Kim M,Lee SM,Park CS,Im SH,Jun CD

更新日期：2018-09-07 00:00:00

abstract：:Deep long-period (DLP) earthquakes observed beneath active volcanoes are sometimes considered as precursors to eruptions. Their origin remains, however, unclear. Here, we present a possible DLP generating mechanism related to the rapid growth of gas bubbles in response to the slow decompression of over-saturated magma...

journal_title：Nature communications

authors： Melnik O,Lyakhovsky V,Shapiro NM,Galina N,Bergal-Kuvikas O

更新日期：2020-08-06 00:00:00

abstract：:Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic mark...

journal_title：Nature communications

authors： Preston MD,Campino S,Assefa SA,Echeverry DF,Ocholla H,Amambua-Ngwa A,Stewart LB,Conway DJ,Borrmann S,Michon P,Zongo I,Ouédraogo JB,Djimde AA,Doumbo OK,Nosten F,Pain A,Bousema T,Drakeley CJ,Fairhurst RM,Sutherland CJ

更新日期：2014-06-13 00:00:00

abstract：:Circadian clock mechanisms have been extensively investigated but the main rate-limiting step that determines circadian period remains unclear. Formation of a stable complex between clock proteins and CK1 is a conserved feature in eukaryotic circadian mechanisms. Here we show that the FRQ-CK1 interaction, but not FRQ ...

journal_title：Nature communications

authors： Liu X,Chen A,Caicedo-Casso A,Cui G,Du M,He Q,Lim S,Kim HJ,Hong CI,Liu Y

更新日期：2019-09-25 00:00:00

abstract：:In the central nervous system, most synapses show a fast mode of neurotransmitter release known as synchronous release followed by a phase of asynchronous release, which extends over tens of milliseconds to seconds. Synapsin II (SYN2) is a member of the multigene synapsin family (SYN1/2/3) of synaptic vesicle phosphop...

journal_title：Nature communications

authors： Medrihan L,Cesca F,Raimondi A,Lignani G,Baldelli P,Benfenati F

更新日期：2013-01-01 00:00:00

abstract：:The amniote middle ear is a classical example of the evolutionary novelty. Although paleontological evidence supports the view that mammals and diapsids (modern reptiles and birds) independently acquired the middle ear after divergence from their common ancestor, the developmental bases of these transformations remain...

journal_title：Nature communications

authors： Kitazawa T,Takechi M,Hirasawa T,Adachi N,Narboux-Nême N,Kume H,Maeda K,Hirai T,Miyagawa-Tomita S,Kurihara Y,Hitomi J,Levi G,Kuratani S,Kurihara H

更新日期：2015-04-22 00:00:00

abstract：:Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Phase I/II clinical trial investigations for non-small cell lung cancer...

journal_title：Nature communications

authors： Collier TL,Normandin MD,Stephenson NA,Livni E,Liang SH,Wooten DW,Esfahani SA,Stabin MG,Mahmood U,Chen J,Wang W,Maresca K,Waterhouse RN,El Fakhri G,Richardson P,Vasdev N

更新日期：2017-06-08 00:00:00

abstract：:While many tools exist for identifying and quantifying individual cell types, few methods are available to assess the relationships between cell types in organs and tissues and how these relationships change during aging or disease states. We present a quantitative method for evaluating cellular organization, using th...

journal_title：Nature communications

authors： Sornborger A,Li J,Timmons C,Lupu F,Eggenschwiler J,Takahama Y,Manley NR

更新日期：2017-05-30 00:00:00