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A helitron-induced RabGDIα variant causes quantitative recessive resistance to maize rough dwarf disease.

Abstract：

:Maize rough dwarf disease (MRDD), caused by various species of the genus Fijivirus, threatens maize production worldwide. We previously identified a quantitative locus qMrdd1 conferring recessive resistance to one causal species, rice black-streaked dwarf virus (RBSDV). Here, we show that Rab GDP dissociation inhibitor alpha (RabGDIα) is the host susceptibility factor for RBSDV. The viral P7-1 protein binds tightly to the exon-10 and C-terminal regions of RabGDIα to recruit it for viral infection. Insertion of a helitron transposon into RabGDIα intron 10 creates alternative splicing to replace the wild-type exon 10 with a helitron-derived exon 10. The resultant splicing variant RabGDIα-hel has difficulty being recruited by P7-1, thus leading to quantitative recessive resistance to MRDD. All naturally occurring resistance alleles may have arisen from a recent single helitron insertion event. These resistance alleles are valuable to improve maize resistance to MRDD and potentially to engineer RBSDV resistance in other crops.

journal_name

Nat Commun

journal_title

Nature communications

authors

Liu Q,Deng S,Liu B,Tao Y,Ai H,Liu J,Zhang Y,Zhao Y,Xu M

doi

10.1038/s41467-020-14372-3

subject

Has Abstract

pub_date

2020-01-24 00:00:00

pages

495

issue

1

issn

2041-1723

pii

10.1038/s41467-020-14372-3

journal_volume

11

pub_type

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