Discovery of protein acetylation patterns by deconvolution of peptide isomer mass spectra.

abstract：:Akin to single-site homogeneous catalysis, a long sought-after goal is to achieve reaction site precision in heterogeneous catalysis for chemical control over patterns of activity, selectivity and stability. Herein, we report on metal phosphides as a class of material capable of realizing these attributes and unlock t...

journal_title：Nature communications

authors： Xu YF,Duchesne PN,Wang L,Tavasoli A,Jelle AA,Xia M,Liao JF,Kuang DB,Ozin GA

更新日期：2020-10-13 00:00:00

abstract：:The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends on the MCM ATPase function. Whether CMG translocation occurs on single- or double-stranded DNA and how ATP hydrolysis drives DNA unwinding remain open questions. Here we use cryo-electron ...

journal_title：Nature communications

authors： Abid Ali F,Renault L,Gannon J,Gahlon HL,Kotecha A,Zhou JC,Rueda D,Costa A

更新日期：2016-02-18 00:00:00

abstract：:NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible for sensing danger si...

journal_title：Nature communications

authors： Hafner-Bratkovič I,Sušjan P,Lainšček D,Tapia-Abellán A,Cerović K,Kadunc L,Angosto-Bazarra D,Pelegrin P,Jerala R

更新日期：2018-12-05 00:00:00

abstract：:Crystallization by particle attachment is impacting our understanding of natural mineralization processes and holds promise for novel materials design. When particles assemble in crystallographic alignment, expulsion of the intervening solvent and particle coalescence are enabled by near-perfect co-alignment via inter...

journal_title：Nature communications

authors： Zhang X,Shen Z,Liu J,Kerisit SN,Bowden ME,Sushko ML,De Yoreo JJ,Rosso KM

更新日期：2017-10-10 00:00:00

abstract：:Human height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been performed in European population. To investigate the rare and low-frequency variants associated with height, we construct a reference panel (N = 3,541) for genotype imputation by integrating t...

journal_title：Nature communications

authors： Akiyama M,Ishigaki K,Sakaue S,Momozawa Y,Horikoshi M,Hirata M,Matsuda K,Ikegawa S,Takahashi A,Kanai M,Suzuki S,Matsui D,Naito M,Yamaji T,Iwasaki M,Sawada N,Tanno K,Sasaki M,Hozawa A,Minegishi N,Wakai K,Tsugane S

更新日期：2019-09-27 00:00:00

abstract：:Cells couple growth with division and regulate size in response to nutrient availability. In rod-shaped fission yeast, cell-size control occurs at mitotic commitment. An important regulator is the DYRK-family kinase Pom1, which forms gradients from cell poles and inhibits the mitotic activator Cdr2, itself localized a...

journal_title：Nature communications

authors： Kelkar M,Martin SG

更新日期：2015-10-07 00:00:00

abstract：:Blue/deep-blue emission is crucial for organic optoelectronics but remains a formidable challenge in organic afterglow due to the difficulties in populating and stabilizing the high-energy triplet excited states. Here, a facile strategy to realize the efficient deep-blue organic afterglow is proposed via host molecule...

journal_title：Nature communications

authors： Xu S,Wang W,Li H,Zhang J,Chen R,Wang S,Zheng C,Xing G,Song C,Huang W

更新日期：2020-09-23 00:00:00

abstract：:Gfi1b is a transcriptional repressor expressed in hematopoietic stem cells (HSCs) and megakaryocytes (MKs). Gfi1b deficiency leads to expansion of both cell types and abrogates the ability of MKs to respond to integrin. Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtB...

journal_title：Nature communications

authors： Shooshtarizadeh P,Helness A,Vadnais C,Brouwer N,Beauchemin H,Chen R,Bagci H,Staal FJT,Coté JF,Möröy T

更新日期：2019-03-20 00:00:00

abstract：:In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additi...

journal_title：Nature communications

authors： Piedrafita G,Kostiou V,Wabik A,Colom B,Fernandez-Antoran D,Herms A,Murai K,Hall BA,Jones PH

更新日期：2020-03-18 00:00:00

abstract：:Although the chemistry of uranium-ligand multiple bonding is burgeoning, analogous complexes involving other actinides such as thorium remain rare and there are not yet any terminal thorium nitrides outside of cryogenic matrix isolation conditions. Here, we report evidence that reduction of a thorium-azide produces a ...

journal_title：Nature communications

authors： Du J,Alvarez-Lamsfus C,Wildman EP,Wooles AJ,Maron L,Liddle ST

更新日期：2019-09-13 00:00:00

abstract：:The transcription factor BMAL1 is a core component of the molecular clock, regulating biological pathways that drive 24 h (circadian) rhythms in behaviour and physiology. The molecular clock has a profound influence on innate immune function, and circadian disruption is linked with increased incidence of multiple scle...

journal_title：Nature communications

authors： Sutton CE,Finlay CM,Raverdeau M,Early JO,DeCourcey J,Zaslona Z,O'Neill LAJ,Mills KHG,Curtis AM

更新日期：2017-12-12 00:00:00

abstract：:Anthropogenic CO2 emissions are causing ocean acidification, which can affect the physiology of marine organisms. Here we assess the possible effects of ocean acidification on the metabolic potential of sponge symbionts, inferred by metagenomic analyses of the microbiomes of two sponge species sampled at a shallow vol...

journal_title：Nature communications

authors： Botté ES,Nielsen S,Abdul Wahab MA,Webster J,Robbins S,Thomas T,Webster NS

更新日期：2019-09-12 00:00:00

abstract：:Stacking faults are known as defective structures in crystalline materials that typically lower the structural quality of the material. Here, we show that a particular type of defect, that is, stacking fault tetrahedra (SFTs), exhibits pronounced quantized electronic behaviour, revealing a potential synthetic route to...

journal_title：Nature communications

authors： Schouteden K,Amin-Ahmadi B,Li Z,Muzychenko D,Schryvers D,Van Haesendonck C

更新日期：2016-12-23 00:00:00

abstract：:Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compression. TEBVs maintain mechanical strength, vasoactivity, and nitric oxide...

journal_title：Nature communications

authors： Zhang X,Bishawi M,Zhang G,Prasad V,Salmon E,Breithaupt JJ,Zhang Q,Truskey GA

更新日期：2020-10-27 00:00:00

abstract：:Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural and functional properties of lymph nodes (LNs). Here we show that YAP and TAZ (YAP/TAZ), the final effectors of Hippo signaling, regulate FRC commitment and maturation. S...

journal_title：Nature communications

authors： Choi SY,Bae H,Jeong SH,Park I,Cho H,Hong SP,Lee DH,Lee CK,Park JS,Suh SH,Choi J,Yang MJ,Jang JY,Onder L,Moon JH,Jeong HS,Adams RH,Kim JM,Ludewig B,Song JH,Lim DS,Koh GY

更新日期：2020-01-24 00:00:00

abstract：:A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19868-6. ...

journal_title：Nature communications

authors： Heimbucher T,Hog J,Gupta P,Murphy CT

更新日期：2020-11-20 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alternative strategies ...

journal_title：Nature communications

authors： Krarup A,Truan D,Furmanova-Hollenstein P,Bogaert L,Bouchier P,Bisschop IJM,Widjojoatmodjo MN,Zahn R,Schuitemaker H,McLellan JS,Langedijk JPM

更新日期：2015-09-03 00:00:00

abstract：:Myoblast fusion is an indispensable step for skeletal muscle development, postnatal growth, and regeneration. Myeloid differentiation primary response gene 88 (MyD88) is an adaptor protein that mediates Toll-like receptors and interleukin-1 receptor signaling. Here we report a cell-autonomous role of MyD88 in the regu...

journal_title：Nature communications

authors： Hindi SM,Shin J,Gallot YS,Straughn AR,Simionescu-Bankston A,Hindi L,Xiong G,Friedland RP,Kumar A

更新日期：2017-11-20 00:00:00

abstract：:In cancer metastasis, various environmental stressors attack the disseminating cells. The successful colonization of cancer cells in secondary sites therefore requires the ability of the cells to avoid the consequences of such exposure to the stressors. Here we show that orthotopic transplantation of a CD44 variant is...

journal_title：Nature communications

authors： Yae T,Tsuchihashi K,Ishimoto T,Motohara T,Yoshikawa M,Yoshida GJ,Wada T,Masuko T,Mogushi K,Tanaka H,Osawa T,Kanki Y,Minami T,Aburatani H,Ohmura M,Kubo A,Suematsu M,Takahashi K,Saya H,Nagano O

更新日期：2012-06-06 00:00:00

abstract：:Topological insulators exhibit a metallic surface state in which the directions of the carriers' momentum and spin are locked together. This characteristic property, which lies at the heart of proposed applications of topological insulators, protects carriers in the surface state from back-scattering unless the scatte...

journal_title：Nature communications

authors： Nam MS,Williams BH,Chen Y,Contera S,Yao S,Lu M,Chen YF,Timco GA,Muryn CA,Winpenny REP,Ardavan A

更新日期：2018-01-04 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating resid...

journal_title：Nature communications

authors： Dallari S,Macal M,Loureiro ME,Jo Y,Swanson L,Hesser C,Ghosh P,Zuniga EI

更新日期：2017-04-03 00:00:00

abstract：:Although chemically very simple, Fe2O3 is known to undergo a series of enigmatic structural, electronic and magnetic transformations at high pressures and high temperatures. So far, these transformations have neither been correctly described nor understood because of the lack of structural data. Here we report a syste...

journal_title：Nature communications

authors： Bykova E,Dubrovinsky L,Dubrovinskaia N,Bykov M,McCammon C,Ovsyannikov SV,Liermann HP,Kupenko I,Chumakov AI,Rüffer R,Hanfland M,Prakapenka V

更新日期：2016-02-11 00:00:00

abstract：:To avoid dangerous climate change, new technologies must remove billions of tonnes of CO2 from the atmosphere every year by mid-century. Here we detail a land-based enhanced weathering cycle utilizing magnesite (MgCO3) feedstock to repeatedly capture CO2 from the atmosphere. In this process, MgCO3 is calcined, produci...

journal_title：Nature communications

authors： McQueen N,Kelemen P,Dipple G,Renforth P,Wilcox J

更新日期：2020-07-03 00:00:00

abstract：:dDsk2 is a conserved extraproteasomal ubiquitin receptor that targets ubiquitylated proteins for degradation. Here we report that dDsk2 plays a nonproteolytic function in transcription regulation. dDsk2 interacts with the dHP1c complex, localizes at promoters of developmental genes and is required for transcription. T...

journal_title：Nature communications

authors： Kessler R,Tisserand J,Font-Burgada J,Reina O,Coch L,Attolini CS,Garcia-Bassets I,Azorín F

更新日期：2015-04-28 00:00:00

abstract：:Efficient engulfment of apoptotic cells is critical for maintaining tissue homoeostasis. When phagocytes recognize 'eat me' signals presented on the surface of apoptotic cells, this subsequently induces cytoskeletal rearrangement of phagocytes for the engulfment through Rac1 activation. However, the intracellular sign...

journal_title：Nature communications

authors： Nakaya M,Tajima M,Kosako H,Nakaya T,Hashimoto A,Watari K,Nishihara H,Ohba M,Komiya S,Tani N,Nishida M,Taniguchi H,Sato Y,Matsumoto M,Tsuda M,Kuroda M,Inoue K,Kurose H

更新日期：2013-01-01 00:00:00

abstract：:Neuronal reward valuations provide the physiological basis for economic behaviour. Yet, how such valuations are converted to economic decisions remains unclear. Here we show that the dorsolateral prefrontal cortex (DLPFC) implements a flexible value code based on object-specific valuations by single neurons. As monkey...

journal_title：Nature communications

authors： Tsutsui KI,Grabenhorst F,Kobayashi S,Schultz W

更新日期：2016-09-13 00:00:00

abstract：:Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be cost-ineffective and time-consuming. Here we report ImReP, a computational method for rapid and accurate profiling of the Ig repertoire, including the complementary-determining region 3 (CDR3), using regular RNA sequencing data such as t...

journal_title：Nature communications

authors： Mandric I,Rotman J,Yang HT,Strauli N,Montoya DJ,Van Der Wey W,Ronas JR,Statz B,Yao D,Petrova V,Zelikovsky A,Spreafico R,Shifman S,Zaitlen N,Rossetti M,Ansel KM,Eskin E,Mangul S

更新日期：2020-06-19 00:00:00

abstract：:Pathological amino-acid substitutions in the amyloid precursor protein (APP) and chemical γ-secretase modulators affect the processing of APP by the γ-secretase complex and the production of the amyloid-beta peptide Aβ42, the accumulation of which is considered causative of Alzheimer's disease. Here we demonstrate tha...

journal_title：Nature communications

authors： Dimitrov M,Alattia JR,Lemmin T,Lehal R,Fligier A,Houacine J,Hussain I,Radtke F,Dal Peraro M,Beher D,Fraering PC

更新日期：2013-01-01 00:00:00

abstract：:Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% on the liability sca...

journal_title：Nature communications

authors： Campos AI,García-Marín LM,Byrne EM,Martin NG,Cuéllar-Partida G,Rentería ME

更新日期：2020-02-14 00:00:00

abstract：:Erythropoietin (Epo) supports both primitive erythropoiesis in the yolk sac and definitive erythropoiesis in the fetal liver and bone marrow. Although definitive erythropoiesis requires kidney- and liver-secreted Epo, it is unclear which cells produce Epo for primitive erythropoiesis. Here we find neural Epo-producing...

journal_title：Nature communications

authors： Suzuki N,Hirano I,Pan X,Minegishi N,Yamamoto M

更新日期：2013-01-01 00:00:00