Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank.


:Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% on the liability scale. Genetic correlations with body mass index, alcohol intake, smoking, schizophrenia, anorexia nervosa and neuroticism are observed. Gene-based associations identify 173 genes, including DLEU7, MSRB3 and POC5, highlighting genes expressed in the brain, cerebellum, lungs, blood and oesophagus. We use polygenic scores (PGS) to predict recent snoring and probable obstructive sleep apnoea (OSA) in an independent Australian sample (n ~ 8000). Mendelian randomization analyses suggest a potential causal relationship between high BMI and snoring. Altogether, our results uncover insights into the aetiology of snoring as a complex sleep-related trait and its role in health and disease beyond it being a cardinal symptom of OSA.


Nat Commun


Nature communications


Campos AI,García-Marín LM,Byrne EM,Martin NG,Cuéllar-Partida G,Rentería ME




Has Abstract


2020-02-14 00:00:00












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    更新日期:2015-06-12 00:00:00

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    更新日期:2018-09-19 00:00:00

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    authors: Zeng B,Mu G,Luo HQ,Xiang T,Mazin II,Yang H,Shan L,Ren C,Dai PC,Wen HH

    更新日期:2010-11-16 00:00:00

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    authors: Schmitt-Engel C,Schultheis D,Schwirz J,Ströhlein N,Troelenberg N,Majumdar U,Dao VA,Grossmann D,Richter T,Tech M,Dönitz J,Gerischer L,Theis M,Schild I,Trauner J,Koniszewski ND,Küster E,Kittelmann S,Hu Y,Lehmann S,S

    更新日期:2015-07-28 00:00:00

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    authors: Lee W,Kim J,Yun JM,Ohn T,Gong Q

    更新日期:2020-06-19 00:00:00

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    abstract::Organic conjugated polymers demonstrate great potential in transistors, solar cells and light-emitting diodes, whose performances are fundamentally governed by charge transport. However, the morphology-property relationships and the underpinning charge transport mechanisms remain unclear. Particularly, whether the non...

    journal_title:Nature communications

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    authors: Wang J,Niu J,Shao B,Yang G,Lu C,Li M,Zhou Z,Chuai X,Chen J,Lu N,Huang B,Wang Y,Li L,Liu M

    更新日期:2021-01-04 00:00:00

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    authors: Sasaki Y,Jampani VSR,Tanaka C,Sakurai N,Sakane S,Le KV,Araoka F,Orihara H

    更新日期:2016-11-07 00:00:00

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    journal_title:Nature communications

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    authors: Honigmann A,Mueller V,Ta H,Schoenle A,Sezgin E,Hell SW,Eggeling C

    更新日期:2014-11-20 00:00:00

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    abstract::Many bacteria can exchange genetic material through horizontal gene transfer (HGT) mediated by plasmids and plasmid-borne transposable elements. Here, we study the population structure and dynamics of over 10,000 bacterial plasmids, by quantifying their genetic similarities and reconstructing a network based on their ...

    journal_title:Nature communications

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    authors: Acman M,van Dorp L,Santini JM,Balloux F

    更新日期:2020-05-15 00:00:00

  • Partially coherent radar unties range resolution from bandwidth limitations.

    abstract::It is widely believed that range resolution, the ability to distinguish between two closely situated targets, depends inversely on the bandwidth of the transmitted radar signal. Here we demonstrate a different type of ranging system, which possesses superior range resolution that is almost completely free of bandwidth...

    journal_title:Nature communications

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    authors: Komissarov R,Kozlov V,Filonov D,Ginzburg P

    更新日期:2019-03-29 00:00:00

  • Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations.

    abstract::Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an IBD detection algorithm that combines a fast heuristic search with accurate coalescent-based likelihood calculations. FastSMC enables biobank-s...

    journal_title:Nature communications

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    authors: Nait Saada J,Kalantzis G,Shyr D,Cooper F,Robinson M,Gusev A,Palamara PF

    更新日期:2020-11-30 00:00:00

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    journal_title:Nature communications

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    authors: Machida T,Kohsaka Y,Matsuoka K,Iwaya K,Hanaguri T,Tamegai T

    更新日期:2016-05-27 00:00:00

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    abstract::The mid-Pliocene Warm Period (mPWP) offers an opportunity to understand a warmer-than-present world and assess the predictive ability of numerical climate models. Environmental reconstruction and climate modelling are crucial for understanding the mPWP, and the synergy of these two, often disparate, fields has proven ...

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    authors: Haywood AM,Dowsett HJ,Dolan AM

    更新日期:2016-02-16 00:00:00

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    authors: Bratton BP,Shaevitz JW,Gitai Z,Morgenstein RM

    更新日期:2018-07-18 00:00:00

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    authors: Suzuki N,Hirano I,Pan X,Minegishi N,Yamamoto M

    更新日期:2013-01-01 00:00:00

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    abstract::Soliton microcombs constitute chip-scale optical frequency combs, and have the potential to impact a myriad of applications from frequency synthesis and telecommunications to astronomy. The demonstration of soliton formation via self-injection locking of the pump laser to the microresonator has significantly relaxed t...

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    authors: Voloshin AS,Kondratiev NM,Lihachev GV,Liu J,Lobanov VE,Dmitriev NY,Weng W,Kippenberg TJ,Bilenko IA

    更新日期:2021-01-11 00:00:00

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    authors: Bradac C,Gao W,Forneris J,Trusheim ME,Aharonovich I

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    authors: Manjavacas A,García de Abajo FJ

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    authors: Munck C,Albertsen M,Telke A,Ellabaan M,Nielsen PH,Sommer MOA

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    更新日期:2017-11-03 00:00:00

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    authors: Alcala N,Leblay N,Gabriel AAG,Mangiante L,Hervas D,Giffon T,Sertier AS,Ferrari A,Derks J,Ghantous A,Delhomme TM,Chabrier A,Cuenin C,Abedi-Ardekani B,Boland A,Olaso R,Meyer V,Altmuller J,Le Calvez-Kelm F,Durand G,V

    更新日期:2019-08-20 00:00:00

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    authors: Aghion S,Ahlén O,Amsler C,Ariga A,Ariga T,Belov AS,Berggren K,Bonomi G,Bräunig P,Bremer J,Brusa RS,Cabaret L,Canali C,Caravita R,Castelli F,Cerchiari G,Cialdi S,Comparat D,Consolati G,Derking H,Di Domizio S,Di N

    更新日期:2014-07-28 00:00:00

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    更新日期:2016-08-01 00:00:00

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    authors: Zhu Q,Sun X,Yang D,Ma J,Kang X,Zheng L,Zhang J,Wu Z,Han B

    更新日期:2019-08-26 00:00:00

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    authors: Shanmugasundaram K,Nayak BK,Friedrichs WE,Kaushik D,Rodriguez R,Block K

    更新日期:2017-10-19 00:00:00

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    authors: Boivin G,Faget J,Ancey PB,Gkasti A,Mussard J,Engblom C,Pfirschke C,Contat C,Pascual J,Vazquez J,Bendriss-Vermare N,Caux C,Vozenin MC,Pittet MJ,Gunzer M,Meylan E

    更新日期:2020-06-02 00:00:00

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    authors: Guixà-González R,Albasanz JL,Rodriguez-Espigares I,Pastor M,Sanz F,Martí-Solano M,Manna M,Martinez-Seara H,Hildebrand PW,Martín M,Selent J

    更新日期:2017-02-21 00:00:00