Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank.

abstract：:Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a plasticity in L5 auditory cortex (ACtx) neurons that innervate the inferior colliculus (IC), thalamus, lateral amygdala and striatum. We track daily ch...

journal_title：Nature communications

authors： Asokan MM,Williamson RS,Hancock KE,Polley DB

更新日期：2018-06-25 00:00:00

abstract：:γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell recepto...

journal_title：Nature communications

authors： Davey MS,Willcox CR,Joyce SP,Ladell K,Kasatskaya SA,McLaren JE,Hunter S,Salim M,Mohammed F,Price DA,Chudakov DM,Willcox BE

更新日期：2017-03-01 00:00:00

abstract：:Endogenous opioid peptides and prescription opioid drugs modulate pain, anxiety and stress by activating opioid receptors, currently classified into four subtypes. Here we demonstrate that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines, is a broad-spectrum scavenger of opioid peptides. Ph...

journal_title：Nature communications

authors： Meyrath M,Szpakowska M,Zeiner J,Massotte L,Merz MP,Benkel T,Simon K,Ohnmacht J,Turner JD,Krüger R,Seutin V,Ollert M,Kostenis E,Chevigné A

更新日期：2020-06-19 00:00:00

abstract：:Cyanobacteria are model organisms for photosynthesis and are attractive for biotechnology applications. To aid investigation of genotype-phenotype relationships in cyanobacteria, we develop an inducible CRISPRi gene repression library in Synechocystis sp. PCC 6803, where we aim to target all genes for repression. We t...

journal_title：Nature communications

authors： Yao L,Shabestary K,Björk SM,Asplund-Samuelsson J,Joensson HN,Jahn M,Hudson EP

更新日期：2020-04-03 00:00:00

abstract：:There is large interspecific variation in the magnitude of population fluctuations, even among closely related species. The factors generating this variation are not well understood, primarily because of the challenges of separating the relative impact of variation in population size from fluctuations in the environme...

journal_title：Nature communications

authors： Sæther BE,Grøtan V,Engen S,Coulson T,Grant PR,Visser ME,Brommer JE,Rosemary Grant B,Gustafsson L,Hatchwell BJ,Jerstad K,Karell P,Pietiäinen H,Roulin A,Røstad OW,Weimerskirch H

更新日期：2016-06-22 00:00:00

abstract：:Providing high performance electrical nano-interconnects for micro-nano electronics that are robust in harsh environments is highly demanded. Today, electrical nano-interconnects based on metallic nanowires, e.g. Ag and Cu, are limited by their positive physicochemical reactivity and ductility under large strain (i.e....

journal_title：Nature communications

authors： Sun Y,Sun B,He J,Yang G,Wang C

更新日期：2020-01-31 00:00:00

abstract：:The development of high efficiency solar cells relies on the management of electronic and optical properties that need to be accurately measured. As the conversion efficiencies increase, there is a concomitant electronic and photonic contribution that affects the overall performances. Here we show an optical method to...

journal_title：Nature communications

authors： Bercegol A,Ory D,Suchet D,Cacovich S,Fournier O,Rousset J,Lombez L

更新日期：2019-04-08 00:00:00

abstract：:Spin-orbit torque has recently been intensively investigated for the purposes of manipulating the magnetization in magnetic nano-devices and understanding fundamental physics. Therefore, the search for novel materials or material combinations that exhibit a strong enough spin-torque effect has become one of the top pr...

journal_title：Nature communications

authors： Li P,Wu W,Wen Y,Zhang C,Zhang J,Zhang S,Yu Z,Yang SA,Manchon A,Zhang XX

更新日期：2018-09-28 00:00:00

abstract：:Alkali metal vapors enable access to single electron systems, suitable for demonstrating fundamental light-matter interactions and promising for quantum logic operations, storage and sensing. However, progress is hampered by the need for robust and repeatable control over the atomic vapor density and over the associat...

journal_title：Nature communications

authors： Rusimova KR,Slavov D,Pradaux-Caggiano F,Collins JT,Gordeev SN,Carbery DR,Wadsworth WJ,Mosley PJ,Valev VK

更新日期：2019-05-24 00:00:00

abstract：:Intentional doping is the core of semiconductor technologies to tune electrical and optical properties of semiconductors for electronic devices, however, it has shown to be a grand challenge for halide perovskites. Here, we show that some metal ions, such as silver, strontium, cerium ions, which exist in the precursor...

journal_title：Nature communications

authors： Lin Y,Shao Y,Dai J,Li T,Liu Y,Dai X,Xiao X,Deng Y,Gruverman A,Zeng XC,Huang J

更新日期：2021-01-04 00:00:00

abstract：:Molar tooth structures are ptygmatically folded and microspar-filled structures common in early- and mid-Proterozoic (∼2,500-750 million years ago, Ma) subtidal successions, but extremely rare in rocks <750 Ma. Here, on the basis of Mg and S isotopes, we show that molar tooth structures may have formed within sediment...

journal_title：Nature communications

authors： Shen B,Dong L,Xiao S,Lang X,Huang K,Peng Y,Zhou C,Ke S,Liu P

更新日期：2016-01-07 00:00:00

abstract：:In the quantum Hall regime, near integer filling factors, electrons should only be transmitted through spatially separated edge states. However, in mesoscopic systems, electronic transmission turns out to be more complex, giving rise to a large spectrum of magnetoresistance oscillations. To explain these observations,...

journal_title：Nature communications

authors： Hackens B,Martins F,Faniel S,Dutu CA,Sellier H,Huant S,Pala M,Desplanque L,Wallart X,Bayot V

更新日期：2010-07-27 00:00:00

abstract：:Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune sign...

journal_title：Nature communications

authors： Singhania A,Graham CM,Gabryšová L,Moreira-Teixeira L,Stavropoulos E,Pitt JM,Chakravarty P,Warnatsch A,Branchett WJ,Conejero L,Lin JW,Davidson S,Wilson MS,Bancroft G,Langhorne J,Frickel E,Sesay AK,Priestnall SL,Herbert

更新日期：2019-06-28 00:00:00

abstract：:The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells....

journal_title：Nature communications

authors： Bunnik EM,Cook KB,Varoquaux N,Batugedara G,Prudhomme J,Cort A,Shi L,Andolina C,Ross LS,Brady D,Fidock DA,Nosten F,Tewari R,Sinnis P,Ay F,Vert JP,Noble WS,Le Roch KG

更新日期：2018-05-15 00:00:00

abstract：:Recent outbreaks of Zika, chikungunya and dengue highlight the importance of better understanding the spread of disease-carrying mosquitoes across multiple spatio-temporal scales. Traditional surveillance tools are limited by jurisdictional boundaries and cost constraints. Here we show how a scalable citizen science s...

journal_title：Nature communications

authors： Palmer JRB,Oltra A,Collantes F,Delgado JA,Lucientes J,Delacour S,Bengoa M,Eritja R,Bartumeus F

更新日期：2017-10-24 00:00:00

abstract：:The emergence of antimicrobial-resistant bacteria is an increasingly serious threat to global health, necessitating the development of innovative antimicrobials. Here we report the development of a series of CRISPR-Cas13a-based antibacterial nucleocapsids, termed CapsidCas13a(s), capable of sequence-specific killing o...

journal_title：Nature communications

authors： Kiga K,Tan XE,Ibarra-Chávez R,Watanabe S,Aiba Y,Sato'o Y,Li FY,Sasahara T,Cui B,Kawauchi M,Boonsiri T,Thitiananpakorn K,Taki Y,Azam AH,Suzuki M,Penadés JR,Cui L

更新日期：2020-06-10 00:00:00

abstract：:As an in-plane charge current flows in a heavy metal film with spin-orbit coupling, it produces a torque on and thereby switches the magnetization in a neighbouring ferromagnetic metal film. Such spin-orbit torque (SOT)-induced switching has been studied extensively in recent years and has shown higher efficiency than...

journal_title：Nature communications

authors： Li P,Liu T,Chang H,Kalitsov A,Zhang W,Csaba G,Li W,Richardson D,DeMann A,Rimal G,Dey H,Jiang JS,Porod W,Field SB,Tang J,Marconi MC,Hoffmann A,Mryasov O,Wu M

更新日期：2016-09-01 00:00:00

abstract：:The primary motor cortex has an important role in the precise execution of learned motor responses. During motor learning, synaptic efficacy between sensory and primary motor cortical neurons is enhanced, possibly involving long-term potentiation and N-methyl-D-aspartate (NMDA)-specific glutamate receptor function. To...

journal_title：Nature communications

authors： Hasan MT,Hernández-González S,Dogbevia G,Treviño M,Bertocchi I,Gruart A,Delgado-García JM

更新日期：2013-01-01 00:00:00

abstract：:Dynamics are fundamental to the functions of biomolecules and can occur on a wide range of time and length scales. Here we develop and apply high-speed AFM height spectroscopy (HS-AFM-HS), a technique whereby we monitor the sensing of a HS-AFM tip at a fixed position to directly detect the motions of unlabeled molecul...

journal_title：Nature communications

authors： Heath GR,Scheuring S

更新日期：2018-11-26 00:00:00

abstract：:In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane's insight that new beneficial alleles are lost...

journal_title：Nature communications

authors： Chelo IM,Nédli J,Gordo I,Teotónio H

更新日期：2013-01-01 00:00:00

abstract：:There is increasing evidence from genome-wide association studies for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children, yet the effects of protein-coding variants on ALL risk have not been systematically evaluated. Here we show a missense variant in CDKN2A associate...

journal_title：Nature communications

authors： Xu H,Zhang H,Yang W,Yadav R,Morrison AC,Qian M,Devidas M,Liu Y,Perez-Andreu V,Zhao X,Gastier-Foster JM,Lupo PJ,Neale G,Raetz E,Larsen E,Bowman WP,Carroll WL,Winick N,Williams R,Hansen T,Holm JC,Mardis E,Fulton

更新日期：2015-06-24 00:00:00

abstract：:Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. TOP1 is also a major driver of endogenous genome instability, particularly when its catalytic intermediate-a covalent TOP1-DNA adduct known as a TOP1 cleavage complex (TOP1cc)-is stabilised. TOP1ccs are high...

journal_title：Nature communications

authors： Fielden J,Wiseman K,Torrecilla I,Li S,Hume S,Chiang SC,Ruggiano A,Narayan Singh A,Freire R,Hassanieh S,Domingo E,Vendrell I,Fischer R,Kessler BM,Maughan TS,El-Khamisy SF,Ramadan K

更新日期：2020-03-09 00:00:00

abstract：:Low-damping magnetic materials have been widely used in microwave and spintronic applications because of their low energy loss and high sensitivity. While the Gilbert damping constant can reach 10-4 to 10-5 in some insulating ferromagnets, metallic ferromagnets generally have larger damping due to magnon scattering by...

journal_title：Nature communications

authors： Lee AJ,Brangham JT,Cheng Y,White SP,Ruane WT,Esser BD,McComb DW,Hammel PC,Yang F

更新日期：2017-08-10 00:00:00

abstract：:Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating, a process critical for cellular motility and extracellular fluid flow. Axonemal dyneins are evolutionarily and biochemically distinct from cytoplasmic dyneins that transport cargo, and the mechanisms regulating their localizat...

journal_title：Nature communications

authors： Walton T,Wu H,Brown A

更新日期：2021-01-20 00:00:00

abstract：:Multiple hypotheses propose an ostensibly disparate array of drivers of food chain length (FCL), with contradictory support from natural settings. Here we posit that the magnitude of vertical energy flux in food webs underlies several drivers of FCL. We show that rising energy flux fuels top-heavy biomass pyramids, pr...

journal_title：Nature communications

authors： Ward CL,McCann KS

更新日期：2017-12-11 00:00:00

abstract：:Three-dimensional graphene network is a promising structure for improving both the mechanical properties and functional capabilities of reinforced polymer and ceramic matrix composites. However, direct application in a metal matrix remains difficult due to the reason that wetting is usually unfavorable in the carbon/m...

journal_title：Nature communications

authors： Zhang X,Xu Y,Wang M,Liu E,Zhao N,Shi C,Lin D,Zhu F,He C

更新日期：2020-06-02 00:00:00

abstract：:Fire emissions generate air pollutants ozone (O3) and aerosols that influence the land carbon cycle. Surface O3 damages vegetation photosynthesis through stomatal uptake, while aerosols influence photosynthesis by increasing diffuse radiation. Here we combine several state-of-the-art models and multiple measurement da...

journal_title：Nature communications

authors： Yue X,Unger N

更新日期：2018-12-21 00:00:00

abstract：:Affiliation 4 incorrectly read 'University of the Basque Country (Ikerbasque), University of the Basque Country and Donostia International Physics Center, San Sebastian 20018, Spain.'Also, the affiliations of Ignacio Arganda-Carreras with 'IKERBASQUE, Basque Foundation for Science, Bilbao, 48013, Spain' and 'Donostia ...

journal_title：Nature communications

authors： Abdeladim L,Matho KS,Clavreul S,Mahou P,Sintes JM,Solinas X,Arganda-Carreras I,Turney SG,Lichtman JW,Chessel A,Bemelmans AP,Loulier K,Supatto W,Livet J,Beaurepaire E

更新日期：2019-05-09 00:00:00

abstract：:TorsinA is an ER-resident AAA + ATPase, whose deletion of glutamate E303 results in the genetic neuromuscular disease primary dystonia. TorsinA is an unusual AAA + ATPase that needs an external activator. Also, it likely does not thread a peptide substrate through a narrow central channel, in contrast to its closest s...

journal_title：Nature communications

authors： Demircioglu FE,Zheng W,McQuown AJ,Maier NK,Watson N,Cheeseman IM,Denic V,Egelman EH,Schwartz TU

更新日期：2019-07-22 00:00:00

abstract：:Multiphoton absorption processes enable many technologically important applications, such as in vivo imaging, photodynamic therapy and optical limiting, and so on. Specifically, higher-order nonlinear absorption such as five-photon absorption offers significant advantages of greater spatial confinement, increased pene...

journal_title：Nature communications

authors： Chen W,Bhaumik S,Veldhuis SA,Xing G,Xu Q,Grätzel M,Mhaisalkar S,Mathews N,Sum TC

更新日期：2017-05-12 00:00:00