Diffusion in translucent media.

abstract：:Vibrio parahaemolyticus is the leading cause of seafood-borne diarrheal diseases. Experimental overproduction of a type 3 secretion system (T3SS1) in this pathogen leads to decreased intestinal colonization, which suggests that T3SS1 repression is required for maximal virulence. However, the mechanisms by which T3SS1 ...

journal_title：Nature communications

authors： Gu D,Zhang Y,Wang Q,Zhou X

更新日期：2020-11-13 00:00:00

abstract：:Mantle plumes are thought to play a key role in transferring heat from the core-mantle boundary to the lithosphere, where it can significantly influence plate tectonics. On impinging on the lithosphere at spreading ridges or in intra-plate settings, mantle plumes may generate hotspots, large igneous provinces and henc...

journal_title：Nature communications

authors： Chang SJ,Ferreira AM,Faccenda M

更新日期：2016-02-29 00:00:00

abstract：:Three-dimensional graphene network is a promising structure for improving both the mechanical properties and functional capabilities of reinforced polymer and ceramic matrix composites. However, direct application in a metal matrix remains difficult due to the reason that wetting is usually unfavorable in the carbon/m...

journal_title：Nature communications

authors： Zhang X,Xu Y,Wang M,Liu E,Zhao N,Shi C,Lin D,Zhu F,He C

更新日期：2020-06-02 00:00:00

abstract：:Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the last West African outbreak, a median of 23 months (IQR [18-25]) after discharge from treatment center. Compared with healthy donors, EBOV_S exhi...

journal_title：Nature communications

authors： Wiedemann A,Foucat E,Hocini H,Lefebvre C,Hejblum BP,Durand M,Krüger M,Keita AK,Ayouba A,Mély S,Fernandez JC,Touré A,Fourati S,Lévy-Marchal C,Raoul H,Delaporte E,Koivogui L,Thiébaut R,Lacabaratz C,Lévy Y,PostEboGui

更新日期：2020-07-24 00:00:00

abstract：:R-loops are stable nucleic acid structures that have important physiological functions, but which also pose a significant threat to genomic stability. Increased R-loops cause replication stress and chromosome fragility and have been associated with diseases such as neurodegeneration and cancer. Although excessive R-lo...

journal_title：Nature communications

authors： Chakraborty P,Huang JTJ,Hiom K

更新日期：2018-10-19 00:00:00

abstract：:We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outcome. An APOBEC mutat...

journal_title：Nature communications

authors： Walker BA,Wardell CP,Murison A,Boyle EM,Begum DB,Dahir NM,Proszek PZ,Melchor L,Pawlyn C,Kaiser MF,Johnson DC,Qiang YW,Jones JR,Cairns DA,Gregory WM,Owen RG,Cook G,Drayson MT,Jackson GH,Davies FE,Morgan GJ

更新日期：2015-04-23 00:00:00

abstract：:Structural DNA nanotechnology seeks to build synthetic molecular machinery from DNA. DNA nanomachines are artificially designed assemblies that switch between defined conformations in response to an external cue. Though it has proved possible to create DNA machines and rudimentary walkers, the function of such autonom...

journal_title：Nature communications

authors： Surana S,Bhat JM,Koushika SP,Krishnan Y

更新日期：2011-06-07 00:00:00

abstract：:Geminiviruses are major plant pathogens that threaten food security globally. They have a unique architecture built from two incomplete icosahedral particles, fused to form a geminate capsid. However, despite their importance to agricultural economies and fundamental biological interest, the details of how this is rea...

journal_title：Nature communications

authors： Hesketh EL,Saunders K,Fisher C,Potze J,Stanley J,Lomonossoff GP,Ranson NA

更新日期：2018-06-18 00:00:00

abstract：:After stroke, peripheral immune cells are activated and these systemic responses may amplify brain damage, but how the injured brain sends out signals to trigger systemic inflammation remains unclear. Here we show that a brain-to-cervical lymph node (CLN) pathway is involved. In rats subjected to focal cerebral ischem...

journal_title：Nature communications

authors： Esposito E,Ahn BJ,Shi J,Nakamura Y,Park JH,Mandeville ET,Yu Z,Chan SJ,Desai R,Hayakawa A,Ji X,Lo EH,Hayakawa K

更新日期：2019-11-22 00:00:00

abstract：:Phosphorylation is a major post-translational mechanism of regulation that frequently targets disordered protein domains, but it remains unclear how phosphorylation modulates disordered states of proteins. Here we determine the kinetics and energetics of a disordered protein domain the kinase-inducible domain (KID) of...

journal_title：Nature communications

authors： Stanley N,Esteban-Martín S,De Fabritiis G

更新日期：2014-10-28 00:00:00

abstract：:Rabi oscillations describe the process whereby electromagnetic radiation interacts coherently with spin states in a non-equilibrium interaction. To date, Rabi oscillations have not been studied in one of the most common spin ensembles in nature: spins in ferromagnets. Here, using a combination of femtosecond laser pul...

journal_title：Nature communications

authors： Capua A,Rettner C,Yang SH,Phung T,Parkin SSP

更新日期：2017-06-28 00:00:00

abstract：:In all of the diverse areas of science where waves play an important role, one of the most fundamental solutions of the corresponding wave equation is a stationary wave with constant intensity. The most familiar example is that of a plane wave propagating in free space. In the presence of any Hermitian potential, a wa...

journal_title：Nature communications

authors： Makris KG,Musslimani ZH,Christodoulides DN,Rotter S

更新日期：2015-07-08 00:00:00

abstract：:Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) significantly increase loading o...

journal_title：Nature communications

authors： Qi R,Wang Y,Bruno PM,Xiao H,Yu Y,Li T,Lauffer S,Wei W,Chen Q,Kang X,Song H,Yang X,Huang X,Detappe A,Matulonis U,Pepin D,Hemann MT,Birrer MJ,Ghoroghchian PP

更新日期：2017-12-18 00:00:00

abstract：:Protein-protein interactions featuring intricate binding epitopes remain challenging targets for synthetic inhibitors. Interactions of NEMO, a scaffolding protein central to NF-κB signaling, exemplify this challenge. Various regulators are known to interact with different coiled coil regions of NEMO, but the topologic...

journal_title：Nature communications

authors： Sadek J,Wuo MG,Rooklin D,Hauenstein A,Hong SH,Gautam A,Wu H,Zhang Y,Cesarman E,Arora PS

更新日期：2020-04-14 00:00:00

abstract：:Reliable prediction of seasonal precipitation in the southwestern US (SWUS) remains a challenge with significant implications for the economy, water security and ecosystem management of the region. Winter precipitation in the SWUS has been linked to several climate modes, including the El Niño-Southern Oscillation (EN...

journal_title：Nature communications

authors： Mamalakis A,Yu JY,Randerson JT,AghaKouchak A,Foufoula-Georgiou E

更新日期：2018-06-13 00:00:00

abstract：:Nuclear factor-κB (NFκB) and peroxisome proliferator activated receptor-γ (PPARγ) are both transcription factors that perform distinct but overlapping roles in cellular regulation. Here we report that PPARγ acts as an E3 ubiquitin ligase, physically interacting with p65 to induce its ubiquitination and degradation. Th...

journal_title：Nature communications

authors： Hou Y,Moreau F,Chadee K

更新日期：2012-01-01 00:00:00

abstract：:Pseudomonas aeruginosa, an opportunistic pathogen of humans, uses quorum sensing (QS) to regulate the production of extracellular products that can benefit all members of the population. P. aeruginosa can police QS-deficient cheaters by producing hydrogen cyanide, which is also QS regulated; however, the mechanism by ...

journal_title：Nature communications

authors： Yan H,Asfahl KL,Li N,Sun F,Xiao J,Shen D,Dandekar AA,Wang M

更新日期：2019-11-01 00:00:00

abstract：:With the development of ultrafast electron and X-ray sources it is becoming possible to study structural dynamics with atomic-level spatial and temporal resolution. Because of their short mean free path, electrons are particularly well suited for investigating surfaces and thin films, such as the challenging and impor...

journal_title：Nature communications

authors： Engelen WJ,van der Heijden MA,Bakker DJ,Vredenbregt EJ,Luiten OJ

更新日期：2013-01-01 00:00:00

abstract：:Hepatocellular-cholangiocarcinoma (H-ChC) is a rare subtype of liver cancer with clinicopathological features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). To date, molecular mechanisms underlying the co-existence of HCC and iCCA components in a single tumor remain elusive. Here, w...

journal_title：Nature communications

authors： Wang A,Wu L,Lin J,Han L,Bian J,Wu Y,Robson SC,Xue L,Ge Y,Sang X,Wang W,Zhao H

更新日期：2018-03-01 00:00:00

abstract：:Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically and industrially important compounds, and are often clustered on chromosomes. Here, we study genomic clustering in the benzylisoquinoline alkaloid (BIA) pathway in opium poppy (Papaver somniferum), exploring relationships between g...

journal_title：Nature communications

authors： Li Q,Ramasamy S,Singh P,Hagel JM,Dunemann SM,Chen X,Chen R,Yu L,Tucker JE,Facchini PJ,Yeaman S

更新日期：2020-03-04 00:00:00

abstract：:Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads to resistance in Streptococcus sanguis. To reveal this stalling mechanism we obtained 3.6-Å-resolution cryo-EM structures of ErmBL-stalled...

journal_title：Nature communications

authors： Arenz S,Bock LV,Graf M,Innis CA,Beckmann R,Grubmüller H,Vaiana AC,Wilson DN

更新日期：2016-07-06 00:00:00

abstract：:Black phosphorus, a fast emerging two-dimensional material, has been configured as field effect transistors, showing a hole-transport-dominated ambipolar characteristic. Here we report an effective modulation on ambipolar characteristics of few-layer black phosphorus transistors through in situ surface functionalizati...

journal_title：Nature communications

authors： Xiang D,Han C,Wu J,Zhong S,Liu Y,Lin J,Zhang XA,Ping Hu W,Özyilmaz B,Neto AH,Wee AT,Chen W

更新日期：2015-03-12 00:00:00

abstract：:Modulation of epigenetic patterns has promising efficacy for treating cancer. 5-Hydroxymethylated cytosine (5-hmC) is an epigenetic mark potentially important in cancer. Here we report that 5-hmC is an epigenetic hallmark of prostate cancer (PCa) progression. A member of the ten-eleven translocation (TET) proteins, wh...

journal_title：Nature communications

authors： Takayama K,Misawa A,Suzuki T,Takagi K,Hayashizaki Y,Fujimura T,Homma Y,Takahashi S,Urano T,Inoue S

更新日期：2015-09-25 00:00:00

abstract：:Monitoring of protein oligomerization has benefited greatly from Förster Resonance Energy Transfer (FRET) measurements. Although donors and acceptors are typically fluorescent molecules with different spectra, homo-FRET can occur between fluorescent molecules of the same type if the emission spectrum overlaps with the...

journal_title：Nature communications

authors： Ojha N,Rainey KH,Patterson GH

更新日期：2020-01-07 00:00:00

abstract：:Ensuring that protected areas (PAs) maintain the biodiversity within their boundaries is fundamental in achieving global conservation goals. Despite this objective, wildlife abundance changes in PAs are patchily documented and poorly understood. Here, we use linear mixed effect models to explore correlates of populati...

journal_title：Nature communications

authors： Barnes MD,Craigie ID,Harrison LB,Geldmann J,Collen B,Whitmee S,Balmford A,Burgess ND,Brooks T,Hockings M,Woodley S

更新日期：2016-09-01 00:00:00

abstract：:Topological superconductor is attracting growing interest for its potential application to topological quantum computation. The superconducting proximity effect on the topological insulator surface state is one promising way to yield topological superconductivity. The superconductivity realized at the interface betwee...

journal_title：Nature communications

authors： Yasuda K,Yasuda H,Liang T,Yoshimi R,Tsukazaki A,Takahashi KS,Nagaosa N,Kawasaki M,Tokura Y

更新日期：2019-06-21 00:00:00

abstract：:Highly regio- and enantioselective intermolecular hydroamination of alkenes is a challenging process potentially leading to valuable chiral amines. Hydroamination of alkenes via metal-catalyzed hydrogen atom transfer (HAT) with good regioselectivity and functional group tolerance has been reported, however, high enant...

journal_title：Nature communications

authors： Shen X,Chen X,Chen J,Sun Y,Cheng Z,Lu Z

更新日期：2020-02-07 00:00:00

abstract：:Optical spectroscopy is a fundamental tool in numerous areas of science and technology. Much effort has focused on miniaturizing spectrometers, but thus far at the cost of spectral resolution and broad operating range. Here we describe a compact spectrometer that achieves both high spectral resolution and broad bandwi...

journal_title：Nature communications

authors： Wan NH,Meng F,Schröder T,Shiue RJ,Chen EH,Englund D

更新日期：2015-07-23 00:00:00

abstract：:We propose the concept of universal fiducials based on a set of pre-made semi-synthetic antibodies (sABs) generated by customized phage display selections against the fusion protein BRIL, an engineered variant of apocytochrome b562a. These sABs can bind to BRIL fused either into the loops or termini of different GPCRs...

journal_title：Nature communications

authors： Mukherjee S,Erramilli SK,Ammirati M,Alvarez FJD,Fennell KF,Purdy MD,Skrobek BM,Radziwon K,Coukos J,Kang Y,Dutka P,Gao X,Qiu X,Yeager M,Eric Xu H,Han S,Kossiakoff AA

更新日期：2020-03-27 00:00:00

abstract：:WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid plexus (ChP) of the developing hi...

journal_title：Nature communications

authors： Kaiser K,Gyllborg D,Procházka J,Salašová A,Kompaníková P,Molina FL,Laguna-Goya R,Radaszkiewicz T,Harnoš J,Procházková M,Potěšil D,Barker RA,Casado ÁG,Zdráhal Z,Sedláček R,Arenas E,Villaescusa JC,Bryja V

更新日期：2019-04-02 00:00:00