Brain-to-cervical lymph node signaling after stroke.

abstract：:Cytidine base editors (CBEs) and adenine base editors (ABEs), composed of a cytidine deaminase or an evolved adenine deaminase fused to Cas9 nickase, enable the conversion of C·G to T·A or A·T to G·C base pair in organisms, respectively. Here, we show that BE3 and ABE7.10 systems can achieve a targeted mutation effici...

journal_title：Nature communications

authors： Liu Z,Chen M,Chen S,Deng J,Song Y,Lai L,Li Z

更新日期：2018-07-13 00:00:00

abstract：:Atmospheric iron affects the global carbon cycle by modulating ocean biogeochemistry through the deposition of soluble iron to the ocean. Iron emitted by anthropogenic (fossil fuel) combustion is a source of soluble iron that is currently considered less important than other soluble iron sources, such as mineral dust ...

journal_title：Nature communications

authors： Matsui H,Mahowald NM,Moteki N,Hamilton DS,Ohata S,Yoshida A,Koike M,Scanza RA,Flanner MG

更新日期：2018-04-23 00:00:00

abstract：:Heterozygous germline mutations in BRCA2 predispose to breast and ovarian cancer. Contrary to non-cancerous cells, where BRCA2 deletion causes cell cycle arrest or cell death, tumors carrying BRCA2 inactivation continue to proliferate. Here we set out to investigate adaptation to loss of BRCA2 focusing on genome-wide ...

journal_title：Nature communications

authors： Reisländer T,Lombardi EP,Groelly FJ,Miar A,Porru M,Di Vito S,Wright B,Lockstone H,Biroccio A,Harris A,Londoño-Vallejo A,Tarsounas M

更新日期：2019-07-17 00:00:00

abstract：:Processing of interleukin RNAs must be tightly controlled during the immune response. Here we report that a subnuclear body called the interleukin-6 and -10 splicing activating compartment (InSAC) is a nuclear site of cytokine RNA production and stability. Tat-activating regulatory DNA-binding protein-43 (TDP-43) acts...

journal_title：Nature communications

authors： Lee S,Lee TA,Lee E,Kang S,Park A,Kim SW,Park HJ,Yoon JH,Ha SJ,Park T,Lee JS,Cheon JH,Park B

更新日期：2015-01-05 00:00:00

abstract：:Neural crest migration is critical to its physiological function. Mechanisms controlling mammalian neural crest migration are comparatively unknown, due to difficulties accessing this cell population in vivo. Here we report requirements of glycogen synthase kinase 3 (GSK3) in regulating the neural crest in Xenopus and...

journal_title：Nature communications

authors： Gonzalez Malagon SG,Lopez Muñoz AM,Doro D,Bolger TG,Poon E,Tucker ER,Adel Al-Lami H,Krause M,Phiel CJ,Chesler L,Liu KJ

更新日期：2018-03-19 00:00:00

abstract：:Visualization and exploration of high-dimensional data is a ubiquitous challenge across disciplines. Widely used techniques such as principal component analysis (PCA) aim to identify dominant trends in one dataset. However, in many settings we have datasets collected under different conditions, e.g., a treatment and a...

journal_title：Nature communications

authors： Abid A,Zhang MJ,Bagaria VK,Zou J

更新日期：2018-05-30 00:00:00

abstract：:Human Ebp1 is a member of the proliferation-associated 2G4 (PA2G4) family and plays an important role in cancer regulation. Ebp1 shares the methionine aminopeptidase (MetAP) fold and binds to mature 80S ribosomes for translational control. Here, we present a cryo-EM single particle analysis reconstruction of Ebp1 boun...

journal_title：Nature communications

authors： Wild K,Aleksić M,Lapouge K,Juaire KD,Flemming D,Pfeffer S,Sinning I

更新日期：2020-02-07 00:00:00

abstract：:A key question of theoretical ecology is which properties of ecosystems favour their stability and help maintaining biodiversity. This question recently reconsidered mutualistic systems, generating intense controversy about the role of mutualistic interactions and their network architecture. Here we show analytically ...

journal_title：Nature communications

authors： Pascual-García A,Bastolla U

更新日期：2017-02-24 00:00:00

abstract：:A long-standing and profound problem in astronomy is the difficulty in obtaining deep near-infrared observations due to the extreme brightness and variability of the night sky at these wavelengths. A solution to this problem is crucial if we are to obtain the deepest possible observations of the early Universe, as red...

journal_title：Nature communications

authors： Bland-Hawthorn J,Ellis SC,Leon-Saval SG,Haynes R,Roth MM,Löhmannsröben HG,Horton AJ,Cuby JG,Birks TA,Lawrence JS,Gillingham P,Ryder SD,Trinh C

更新日期：2011-12-06 00:00:00

abstract：:In eukaryotes, adventitious oxidation of erythrose-4-phosphate, an intermediate of the pentose phosphate pathway (PPP), generates 4-phosphoerythronate (4PE), which inhibits 6-phosphogluconate dehydrogenase. 4PE is detoxified by metabolite-proofreading phosphatases such as yeast Pho13. Here, we report that a similar fu...

journal_title：Nature communications

authors： Sachla AJ,Helmann JD

更新日期：2019-04-04 00:00:00

abstract：:Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography is recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present a specific deep-learning-based model trained on 1,177 digital subtraction angiography verified bone-removal co...

journal_title：Nature communications

authors： Shi Z,Miao C,Schoepf UJ,Savage RH,Dargis DM,Pan C,Chai X,Li XL,Xia S,Zhang X,Gu Y,Zhang Y,Hu B,Xu W,Zhou C,Luo S,Wang H,Mao L,Liang K,Wen L,Zhou L,Yu Y,Lu GM,Zhang LJ

更新日期：2020-11-30 00:00:00

abstract：:Streptomycetes are notable for their complex life cycle and production of most clinically important antibiotics. A key factor that controls entry into development and the onset of antibiotic production is the 68-residue protein, BldC. BldC is a putative DNA-binding protein related to MerR regulators, but lacks coiled-...

journal_title：Nature communications

authors： Schumacher MA,den Hengst CD,Bush MJ,Le TBK,Tran NT,Chandra G,Zeng W,Travis B,Brennan RG,Buttner MJ

更新日期：2018-03-19 00:00:00

abstract：:Antarctic Bottom Water (AABW) is a critical component of the global climate system, occupying the abyssal layer of the World Ocean and driving the lower limb of the global meridional overturning circulation. Around East Antarctica, the dense shelf water (DSW) precursor to AABW is predominantly formed by enhanced sea i...

journal_title：Nature communications

authors： Kusahara K,Hasumi H,Williams GD

更新日期：2011-01-18 00:00:00

abstract：:It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct ske...

journal_title：Nature communications

authors： Li M,Wu H,Luo Z,Xia Y,Guan J,Wang T,Gu Y,Chen L,Zhang K,Ma J,Liu Y,Zhong Z,Nie J,Zhou S,Mu Z,Wang X,Qu J,Jing L,Wang H,Huang S,Yi N,Wang Z,Xi D,Wang J,Yin G,Wang L,Li N,Jiang Z,Lang Q,Xiao H,Ji

更新日期：2012-05-22 00:00:00

abstract：:Since the pioneering proposal of the replicon model of DNA replication 50 years ago, the predicted replicons have not been identified and quantified at the cellular level. Here, we combine conventional and super-resolution microscopy of replication sites in live and fixed cells with computational image analysis. We co...

journal_title：Nature communications

authors： Chagin VO,Casas-Delucchi CS,Reinhart M,Schermelleh L,Markaki Y,Maiser A,Bolius JJ,Bensimon A,Fillies M,Domaing P,Rozanov YM,Leonhardt H,Cardoso MC

更新日期：2016-04-07 00:00:00

abstract：:G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between different G4 structures are rare. Here, we describe DC-34, a small molec...

journal_title：Nature communications

authors： Calabrese DR,Chen X,Leon EC,Gaikwad SM,Phyo Z,Hewitt WM,Alden S,Hilimire TA,He F,Michalowski AM,Simmons JK,Saunders LB,Zhang S,Connors D,Walters KJ,Mock BA,Schneekloth JS Jr

更新日期：2018-10-12 00:00:00

abstract：:In certain regions of the predominantly nitrogen limited ocean, microbes can become co-limited by phosphorus. Within such regions, a proportion of the dissolved organic phosphorus pool can be accessed by microbes employing a variety of alkaline phosphatase (APase) enzymes. In contrast to the PhoA family of APases that...

journal_title：Nature communications

authors： Browning TJ,Achterberg EP,Yong JC,Rapp I,Utermann C,Engel A,Moore CM

更新日期：2017-05-19 00:00:00

abstract：:Current approaches to monitor and quantify cell division in live cells, and reliably distinguish between acytokinesis and endoreduplication, are limited and complicate determination of stem cell pool identities. Here we overcome these limitations by generating an in vivo reporter system using the scaffolding protein a...

journal_title：Nature communications

authors： Hesse M,Raulf A,Pilz GA,Haberlandt C,Klein AM,Jabs R,Zaehres H,Fügemann CJ,Zimmermann K,Trebicka J,Welz A,Pfeifer A,Röll W,Kotlikoff MI,Steinhäuser C,Götz M,Schöler HR,Fleischmann BK

更新日期：2012-01-01 00:00:00

abstract：:Metabolic reprogramming greatly contributes to the regulation of macrophage activation. However, the mechanism of lipid accumulation and the corresponding function in tumor-associated macrophages (TAMs) remain unclear. With primary investigation in colon cancer and confirmation in other cancer models, here we determin...

journal_title：Nature communications

authors： Xiang W,Shi R,Kang X,Zhang X,Chen P,Zhang L,Hou A,Wang R,Zhao Y,Zhao K,Liu Y,Ma Y,Luo H,Shang S,Zhang J,He F,Yu S,Gan L,Shi C,Li Y,Yang W,Liang H,Miao H

更新日期：2018-07-03 00:00:00

abstract：:The development of efficient reactions for the one-pot construction of bicyclic ring systems bearing two quaternary carbon centres at their bridgehead positions represents a significant challenge to synthetic chemistry. The development of new methods capable of overcoming this challenge is highly desirable, because th...

journal_title：Nature communications

authors： Long R,Huang J,Shao W,Liu S,Lan Y,Gong J,Yang Z

更新日期：2014-12-08 00:00:00

abstract：:Neuroimaging modalities such as MRI and EEG are able to record from the whole brain, but this comes at the price of either limited spatiotemporal resolution or limited sensitivity. Here, we show that functional ultrasound imaging (fUS) of the brain is able to assess local changes in cerebral blood volume during cognit...

journal_title：Nature communications

authors： Dizeux A,Gesnik M,Ahnine H,Blaize K,Arcizet F,Picaud S,Sahel JA,Deffieux T,Pouget P,Tanter M

更新日期：2019-03-28 00:00:00

abstract：:Low-damping magnetic materials have been widely used in microwave and spintronic applications because of their low energy loss and high sensitivity. While the Gilbert damping constant can reach 10-4 to 10-5 in some insulating ferromagnets, metallic ferromagnets generally have larger damping due to magnon scattering by...

journal_title：Nature communications

authors： Lee AJ,Brangham JT,Cheng Y,White SP,Ruane WT,Esser BD,McComb DW,Hammel PC,Yang F

更新日期：2017-08-10 00:00:00

abstract：:In magnetic materials, the Pauli exclusion principle typically drives anti-alignment between electron spins on neighbouring species resulting in antiferromagnetic behaviour. Ferromagnetism exhibiting spontaneous spin alignment is a fairly rare behaviour, but once materialized is often associated with itinerant electro...

journal_title：Nature communications

authors： Bristowe NC,Varignon J,Fontaine D,Bousquet E,Ghosez P

更新日期：2015-03-25 00:00:00

abstract：:In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additi...

journal_title：Nature communications

authors： Piedrafita G,Kostiou V,Wabik A,Colom B,Fernandez-Antoran D,Herms A,Murai K,Hall BA,Jones PH

更新日期：2020-03-18 00:00:00

abstract：:Standard optical tweezers rely on optical forces arising when a focused laser beam interacts with a microscopic particle: scattering forces, pushing the particle along the beam direction, and gradient forces, attracting it towards the high-intensity focal spot. Importantly, the incoming laser beam is not affected by t...

journal_title：Nature communications

authors： Kalantarifard F,Elahi P,Makey G,Maragò OM,Ilday FÖ,Volpe G

更新日期：2019-06-18 00:00:00

abstract：:The interaction of lipids and proteins plays an important role in plasma membrane bioactivity, and much can be learned from their diffusion characteristics. Here we present the combination of super-resolution STED microscopy with scanning fluorescence correlation spectroscopy (scanning STED-FCS, sSTED-FCS) to characte...

journal_title：Nature communications

authors： Honigmann A,Mueller V,Ta H,Schoenle A,Sezgin E,Hell SW,Eggeling C

更新日期：2014-11-20 00:00:00

abstract：:Antibiotics that interfere with translation, when combined, interact in diverse and difficult-to-predict ways. Here, we explain these interactions by "translation bottlenecks": points in the translation cycle where antibiotics block ribosomal progression. To elucidate the underlying mechanisms of drug interactions bet...

journal_title：Nature communications

authors： Kavčič B,Tkačik G,Bollenbach T

更新日期：2020-08-11 00:00:00

abstract：:Seismic tomography provides unique constraints on the morphology, the deformation, and (indirectly) the rheology of subducting slabs. We use teleseismic double-difference P-wave tomography to image with unprecedented clarity the structural complexity of the Izu-Bonin slab. We resolve a tear in the slab in the mantle t...

journal_title：Nature communications

authors： Zhang H,Wang F,Myhill R,Guo H

更新日期：2019-03-21 00:00:00

abstract：:Pladienolide, herboxidiene and spliceostatin have been identified as splicing modulators that target SF3B1 in the SF3b subcomplex. Here we report that PHF5A, another component of this subcomplex, is also targeted by these compounds. Mutations in PHF5A-Y36, SF3B1-K1071, SF3B1-R1074 and SF3B1-V1078 confer resistance to ...

journal_title：Nature communications

authors： Teng T,Tsai JH,Puyang X,Seiler M,Peng S,Prajapati S,Aird D,Buonamici S,Caleb B,Chan B,Corson L,Feala J,Fekkes P,Gerard B,Karr C,Korpal M,Liu X,T Lowe J,Mizui Y,Palacino J,Park E,Smith PG,Subramanian V,Wu ZJ

更新日期：2017-05-25 00:00:00

abstract：:Biodiversity changes are lagging behind current climate warming. The underlying determinants of this climatic debt are unknown and yet critical to understand the impacts of climate change on the present biota and improve forecasts of biodiversity changes. Here we assess determinants of climatic debt accumulated in Fre...

journal_title：Nature communications

authors： Bertrand R,Riofrío-Dillon G,Lenoir J,Drapier J,de Ruffray P,Gégout JC,Loreau M

更新日期：2016-08-26 00:00:00