4D Visualization of replication foci in mammalian cells corresponding to individual replicons.

abstract：:How do descending inputs from the brain control leg motor circuits to change how an animal walks? Conceptually, descending neurons are thought to function either as command-type neurons, in which a single type of descending neuron exerts a high-level control to elicit a coordinated change in motor output, or through a...

journal_title：Nature communications

authors： Feng K,Sen R,Minegishi R,Dübbert M,Bockemühl T,Büschges A,Dickson BJ

更新日期：2020-12-02 00:00:00

abstract：:Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to tr...

journal_title：Nature communications

authors： Büchel C,Peters J,Banaschewski T,Bokde AL,Bromberg U,Conrod PJ,Flor H,Papadopoulos D,Garavan H,Gowland P,Heinz A,Walter H,Ittermann B,Mann K,Martinot JL,Paillère-Martinot ML,Nees F,Paus T,Pausova Z,Poustka L,Riets

更新日期：2017-02-21 00:00:00

abstract：:Full-carbon electronics at the scale of several angstroms is an expeimental challenge, which could be overcome by exploiting the versatility of carbon allotropes. Here, we investigate charge transport through graphene/single-fullerene/graphene hybrid junctions using a single-molecule manipulation technique. Such sub-n...

journal_title：Nature communications

authors： Tan Z,Zhang D,Tian HR,Wu Q,Hou S,Pi J,Sadeghi H,Tang Z,Yang Y,Liu J,Tan YZ,Chen ZB,Shi J,Xiao Z,Lambert C,Xie SY,Hong W

更新日期：2019-04-15 00:00:00

abstract：:Epigenomic data sets provide critical information about the dynamic role of chromatin states in gene regulation, but a key question of how chromatin state segmentations vary under different conditions across the genome has remained unaddressed. Here we present ChromDiff, a group-wise chromatin state comparison method ...

journal_title：Nature communications

authors： Yen A,Kellis M

更新日期：2015-08-18 00:00:00

abstract：:Polyps of the cnidarian Hydra maintain their adult anatomy through two developmental organizers, the head organizer located apically and the foot organizer basally. The head organizer is made of two antagonistic cross-reacting components, an activator, driving apical differentiation and an inhibitor, preventing ectopi...

journal_title：Nature communications

authors： Vogg MC,Beccari L,Iglesias Ollé L,Rampon C,Vriz S,Perruchoud C,Wenger Y,Galliot B

更新日期：2019-01-18 00:00:00

abstract：:The two-dimensional topological insulators host a full gap in the bulk band, induced by spin-orbit coupling (SOC) effect, together with the topologically protected gapless edge states. However, it is usually challenging to suppress the bulk conductance and thus to realize the quantum spin Hall (QSH) effect. In this st...

journal_title：Nature communications

authors： Song YH,Jia ZY,Zhang D,Zhu XY,Shi ZQ,Wang H,Zhu L,Yuan QQ,Zhang H,Xing DY,Li SC

更新日期：2018-10-04 00:00:00

abstract：:Neurons communicate through chemical synapses and electrical synapses (gap junctions). Although these two types of synapses often coexist between neurons, little is known about whether they interact, and whether any interactions between them are important to controlling synaptic strength and circuit functions. By stud...

journal_title：Nature communications

authors： Liu P,Chen B,Mailler R,Wang ZW

更新日期：2017-03-20 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： You X,Wu H,Zhang R,Su Y,Cao L,Yu Q,Yuan J,Xiao K,He M,Jiang Z

更新日期：2020-01-24 00:00:00

abstract：:Metal ions at the active site of an enzyme act as cofactors, and their dynamic fluctuations can potentially influence enzyme activity. Here, we use λ-exonuclease as a model enzyme with two Mg2+ binding sites and probe activity at various concentrations of magnesium by single-molecule-FRET. We find that while MgA2+ and...

journal_title：Nature communications

authors： Hwang W,Yoo J,Lee Y,Park S,Hoang PL,Cho H,Yu J,Hoa Vo TM,Shin M,Jin MS,Park D,Hyeon C,Lee G

更新日期：2018-10-23 00:00:00

abstract：:During meiosis, homologous chromosomes synapse and recombine at sites marked by the binding of the mismatch repair protein MLH1. In hexaploid wheat, the Ph1 locus has a major effect on whether crossover occurs between homologues or between related homoeologues. Here we report that--in wheat-rye hybrids where homologue...

journal_title：Nature communications

authors： Martín AC,Shaw P,Phillips D,Reader S,Moore G

更新日期：2014-08-06 00:00:00

abstract：:Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication. We analyse the cellular pathways in which human proviral genes are...

journal_title：Nature communications

authors： Karlas A,Berre S,Couderc T,Varjak M,Braun P,Meyer M,Gangneux N,Karo-Astover L,Weege F,Raftery M,Schönrich G,Klemm U,Wurzlbauer A,Bracher F,Merits A,Meyer TF,Lecuit M

更新日期：2016-05-12 00:00:00

abstract：:Hydrogen can facilitate the detachment of protective oxide layer off metals and alloys. The degradation is usually exacerbated at elevated temperatures in many industrial applications; however, its origin remains poorly understood. Here by heating hydrogenated aluminium inside an environmental transmission electron mi...

journal_title：Nature communications

authors： Li M,Xie DG,Ma E,Li J,Zhang XX,Shan ZW

更新日期：2017-02-20 00:00:00

abstract：:Cancer is caused by the accumulation of multiple genetic mutations, but their cooperative effects are poorly understood. Using a genome-wide analysis of all the somatic mutations in colorectal cancer patients in a large-scale molecular interaction network, here we find that a giant cluster of mutation-propagating modu...

journal_title：Nature communications

authors： Shin D,Lee J,Gong JR,Cho KH

更新日期：2017-11-02 00:00:00

abstract：:New capabilities at X-ray free-electron laser facilities allow the generation of two-colour femtosecond X-ray pulses, opening the possibility of performing ultrafast studies of X-ray-induced phenomena. Particularly, the experimental realization of hetero-site-specific X-ray-pump/X-ray-probe spectroscopy is of special ...

journal_title：Nature communications

authors： Picón A,Lehmann CS,Bostedt C,Rudenko A,Marinelli A,Osipov T,Rolles D,Berrah N,Bomme C,Bucher M,Doumy G,Erk B,Ferguson KR,Gorkhover T,Ho PJ,Kanter EP,Krässig B,Krzywinski J,Lutman AA,March AM,Moonshiram D,Ray D,

更新日期：2016-05-23 00:00:00

abstract：:Porous coordination polymers are well known for their easily tailored framework structures and corresponding properties. Although systematic modulations of pore sizes of binary prototypes have gained great success, simultaneous adjustment of both pore size and shape of ternary prototypes remains unexplored, owing to t...

journal_title：Nature communications

authors： Zhang YB,Zhou HL,Lin RB,Zhang C,Lin JB,Zhang JP,Chen XM

更新日期：2012-01-24 00:00:00

abstract：:A central paradigm in conservation biology is that population bottlenecks reduce genetic diversity and population viability. In an era of biodiversity loss and climate change, understanding the determinants and consequences of bottlenecks is therefore an important challenge. However, as most studies focus on single sp...

journal_title：Nature communications

authors： Stoffel MA,Humble E,Paijmans AJ,Acevedo-Whitehouse K,Chilvers BL,Dickerson B,Galimberti F,Gemmell NJ,Goldsworthy SD,Nichols HJ,Krüger O,Negro S,Osborne A,Pastor T,Robertson BC,Sanvito S,Schultz JK,Shafer ABA,Wolf JBW

更新日期：2018-11-16 00:00:00

abstract：:Metal-organic frameworks (MOFs) are well known for their tunable structure and porosity. Many studies have shown they are promising for various important applications, for which their performance can be further enhanced by encapsulating functional species, such as luminescent guest molecules, within the frameworks. Al...

journal_title：Nature communications

authors： Sun CY,Wang XL,Zhang X,Qin C,Li P,Su ZM,Zhu DX,Shan GG,Shao KZ,Wu H,Li J

更新日期：2013-01-01 00:00:00

abstract：:Antibodies conjugated to bioactive compounds allow targeted delivery of therapeutics to cell types of choice based on that antibody's specificity. Here we develop a new type of conjugate that consists of a nanobody and a peptidic ligand for a G protein-coupled receptor (GPCR), fused via their C-termini. We address act...

journal_title：Nature communications

authors： Cheloha RW,Fischer FA,Woodham AW,Daley E,Suminski N,Gardella TJ,Ploegh HL

更新日期：2020-04-29 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alternative strategies ...

journal_title：Nature communications

authors： Krarup A,Truan D,Furmanova-Hollenstein P,Bogaert L,Bouchier P,Bisschop IJM,Widjojoatmodjo MN,Zahn R,Schuitemaker H,McLellan JS,Langedijk JPM

更新日期：2015-09-03 00:00:00

abstract：:Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs signaling is reported to enhance fa...

journal_title：Nature communications

authors： Xu H,Zhao Q,Song N,Yan Z,Lin R,Wu S,Jiang L,Hong S,Xie J,Zhou H,Wang R,Jiang X

更新日期：2020-11-16 00:00:00

abstract：:Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance...

journal_title：Nature communications

authors： Tapper W,Jones AV,Kralovics R,Harutyunyan AS,Zoi K,Leung W,Godfrey AL,Guglielmelli P,Callaway A,Ward D,Aranaz P,White HE,Waghorn K,Lin F,Chase A,Baxter EJ,Maclean C,Nangalia J,Chen E,Evans P,Short M,Jack A,Wal

更新日期：2015-04-07 00:00:00

abstract：:For the state-of-the-art quantum dot light-emitting diodes, while the ZnO nanoparticle layers can provide effective electron injections into quantum dots layers, the hole transporting materials usually cannot guarantee sufficient hole injection owing to the deep valence band of quantum dots. Developing proper hole tra...

journal_title：Nature communications

authors： Cao W,Xiang C,Yang Y,Chen Q,Chen L,Yan X,Qian L

更新日期：2018-07-04 00:00:00

abstract：:With its light weight, low cost and high efficiency even at low operation frequency, the triboelectric nanogenerator is considered a potential solution for self-powered sensor networks and large-scale renewable blue energy. As an energy harvester, its output power density and efficiency are dictated by the triboelectr...

journal_title：Nature communications

authors： Wang J,Wu C,Dai Y,Zhao Z,Wang A,Zhang T,Wang ZL

更新日期：2017-07-20 00:00:00

abstract：:Although many animals have evolved intrinsic transparency for the purpose of concealment, the development of dynamic, that is, controllable and reversible, transparency for living human cells and tissues has remained elusive to date. Here, by drawing inspiration from the structures and functionalities of adaptive ceph...

journal_title：Nature communications

authors： Chatterjee A,Cerna Sanchez JA,Yamauchi T,Taupin V,Couvrette J,Gorodetsky AA

更新日期：2020-06-02 00:00:00

abstract：:Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs are constitutively active, so a major focus has been to identify fusion clamps that regulate their activity in synapses: the primary candidates are synaptotagmin (syt) 1 and complexin I/II. Syt1 is a Ca2+ sensor for SV release that bi...

journal_title：Nature communications

authors： Courtney NA,Bao H,Briguglio JS,Chapman ER

更新日期：2019-09-09 00:00:00

abstract：:The host-guest recognition between two macrocycles to form hierarchical non-intertwined ring-in-ring assemblies remains an interesting and challenging target in noncovalent synthesis. Herein, we report the design and characterization of a box-in-box assembly on the basis of host-guest radical-pairing interactions betw...

journal_title：Nature communications

authors： Cai K,Lipke MC,Liu Z,Nelson J,Cheng T,Shi Y,Cheng C,Shen D,Han JM,Vemuri S,Feng Y,Stern CL,Goddard WA 3rd,Wasielewski MR,Stoddart JF

更新日期：2018-12-10 00:00:00

abstract：:Enhancement of optical emission on plasmonic nanostructures is intrinsically limited by the distance between the emitter and nanostructure surface, owing to a tightly-confined and exponentially-decaying electromagnetic field. This fundamental limitation prevents efficient application of plasmonic fluorescence enhancem...

journal_title：Nature communications

authors： Kumar S,Park H,Cho H,Siddique RH,Narasimhan V,Yang D,Choo H

更新日期：2020-06-10 00:00:00

abstract：:Transcription of eukaryotic protein-coding genes requires passage of RNA polymerase II (Pol II) through nucleosomes, but it is unclear how this is achieved. Here we report the cryo-EM structure of transcribing Saccharomyces cerevisiae Pol II engaged with a downstream nucleosome core particle at an overall resolution o...

journal_title：Nature communications

authors： Farnung L,Vos SM,Cramer P

更新日期：2018-12-21 00:00:00

abstract：:Epithelial barrier function is maintained by coordination of cell proliferation and cell loss, whereas barrier dysfunction can lead to disease and organismal death. JNK signalling is a conserved stress signalling pathway activated by bacterial infection and tissue damage, often leading to apoptotic cell death and comp...

journal_title：Nature communications

authors： Zhou J,Edgar BA,Boutros M

更新日期：2017-03-08 00:00:00

abstract：:Reversible acetylation of α-tubulin is an evolutionarily conserved modification in microtubule networks. Despite its prevalence, the physiological function and regulation of microtubule acetylation remain poorly understood. Here we report that macrophages challenged by bacterial lipopolysaccharides (LPS) undergo exten...

journal_title：Nature communications

authors： Wang B,Rao YH,Inoue M,Hao R,Lai CH,Chen D,McDonald SL,Choi MC,Wang Q,Shinohara ML,Yao TP

更新日期：2014-03-17 00:00:00