Highly efficient RNA-guided base editing in rabbit.

abstract：:The Arctic marine biome, shrinking with increasing temperature and receding sea-ice cover, is tightly connected to lower latitudes through the North Atlantic. By flowing northward through the European Arctic Corridor (the main Arctic gateway where 80% of in- and outflow takes place), the North Atlantic Waters transpor...

journal_title：Nature communications

authors： Oziel L,Baudena A,Ardyna M,Massicotte P,Randelhoff A,Sallée JB,Ingvaldsen RB,Devred E,Babin M

更新日期：2020-04-06 00:00:00

abstract：:Break-induced replication (BIR) is a DNA double-strand break repair pathway that leads to genomic instabilities similar to those observed in cancer. BIR proceeds by a migrating bubble where asynchrony between leading and lagging strand synthesis leads to accumulation of long single-stranded DNA (ssDNA). It remains unk...

journal_title：Nature communications

authors： Elango R,Sheng Z,Jackson J,DeCata J,Ibrahim Y,Pham NT,Liang DH,Sakofsky CJ,Vindigni A,Lobachev KS,Ira G,Malkova A

更新日期：2017-11-27 00:00:00

abstract：:Ribosomes are essential intracellular machines composed of proteins and RNA molecules. The DNA sequences (rDNA) encoding ribosomal RNAs (rRNAs) are tandemly repeated and give origin to the nucleolus. Here we develop a computational method for estimating rDNA dosage (copy number) and mitochondrial DNA abundance using w...

journal_title：Nature communications

authors： Gibbons JG,Branco AT,Yu S,Lemos B

更新日期：2014-09-11 00:00:00

abstract：:Modern computation relies crucially on modular architectures, breaking a complex algorithm into self-contained subroutines. A client can then call upon a remote server to implement parts of the computation independently via an application programming interface (API). Present APIs relay only classical information. Here...

journal_title：Nature communications

authors： Zhang K,Thompson J,Zhang X,Shen Y,Lu Y,Zhang S,Ma J,Vedral V,Gu M,Kim K

更新日期：2019-10-16 00:00:00

abstract：:Early detection and accurate monitoring of chronic kidney disease (CKD) could improve care and retard progression to end-stage renal disease. Here, using untargeted metabolomics in 2155 participants including patients with stage 1-5 CKD and healthy controls, we identify five metabolites, including 5-methoxytryptophan ...

journal_title：Nature communications

authors： Chen DQ,Cao G,Chen H,Argyopoulos CP,Yu H,Su W,Chen L,Samuels DC,Zhuang S,Bayliss GP,Zhao S,Yu XY,Vaziri ND,Wang M,Liu D,Mao JR,Ma SX,Zhao J,Zhang Y,Shang YQ,Kang H,Ye F,Cheng XH,Li XR,Zhang L,Meng MX,G

更新日期：2019-04-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi) are approved for treating certain haematological malignancies, however, recent evidence also illustrates they are modulators of the immune system. In experimental models, HDACi are particularly potent against malignancies originating from the B-lymphocyte lineage. Here we examine...

journal_title：Nature communications

authors： Waibel M,Christiansen AJ,Hibbs ML,Shortt J,Jones SA,Simpson I,Light A,O'Donnell K,Morand EF,Tarlinton DM,Johnstone RW,Hawkins ED

更新日期：2015-04-27 00:00:00

abstract：:DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial-mesenchymal transition (EMT) regulators in breast cancer progress...

journal_title：Nature communications

authors： Cho MH,Park JH,Choi HJ,Park MK,Won HY,Park YJ,Lee CH,Oh SH,Song YS,Kim HS,Oh YH,Lee JY,Kong G

更新日期：2015-07-22 00:00:00

abstract：:Circadian rhythms are a nearly universal feature of living organisms and affect almost every biological process. Our innate preference for mornings or evenings is determined by the phase of our circadian rhythms. We conduct a genome-wide association analysis of self-reported morningness, followed by analyses of biolog...

journal_title：Nature communications

authors： Hu Y,Shmygelska A,Tran D,Eriksson N,Tung JY,Hinds DA

更新日期：2016-02-02 00:00:00

abstract：:Ligand-induced receptor dimerization has traditionally been viewed as the key event in transmembrane signalling by epidermal growth factor receptors (EGFRs). Here we show that the Caenorhabditis elegans EGFR orthologue LET-23 is constitutively dimeric, yet responds to its ligand LIN-3 without changing oligomerization ...

journal_title：Nature communications

authors： Freed DM,Alvarado D,Lemmon MA

更新日期：2015-06-10 00:00:00

abstract：:Precise manipulation and control of coherent lattice oscillations via nanostructuring and phonon-wave interference has the potential to significantly impact a broad array of technologies and research areas. Resolving the dynamics of individual phonons in defect-laden materials presents an enormous challenge, however, ...

journal_title：Nature communications

authors： Cremons DR,Plemmons DA,Flannigan DJ

更新日期：2016-04-15 00:00:00

abstract：:Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, cone snails can rapidly switch between distinct venoms in response to predatory or defensive stimuli. Here, we show that the d...

journal_title：Nature communications

authors： Dutertre S,Jin AH,Vetter I,Hamilton B,Sunagar K,Lavergne V,Dutertre V,Fry BG,Antunes A,Venter DJ,Alewood PF,Lewis RJ

更新日期：2014-03-24 00:00:00

abstract：:The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibr...

journal_title：Nature communications

authors： Cazet AS,Hui MN,Elsworth BL,Wu SZ,Roden D,Chan CL,Skhinas JN,Collot R,Yang J,Harvey K,Johan MZ,Cooper C,Nair R,Herrmann D,McFarland A,Deng N,Ruiz-Borrego M,Rojo F,Trigo JM,Bezares S,Caballero R,Lim E,Timpson P

更新日期：2018-07-24 00:00:00

abstract：:In carrier multiplication, the absorption of a single photon results in two or more electron-hole pairs. Quantum dots are promising materials for implementing carrier multiplication principles in real-life technologies. So far, however, most of research in this area has focused on optical studies of solution samples w...

journal_title：Nature communications

authors： Gao J,Fidler AF,Klimov VI

更新日期：2015-09-08 00:00:00

abstract：:Yeast lacks dedicated photoreceptors; however, blue light still causes pronounced oscillations of the transcription factor Msn2 into and out of the nucleus. Here we show that this poorly understood phenomenon is initiated by a peroxisomal oxidase, which converts light into a hydrogen peroxide (H2O2) signal that is sen...

journal_title：Nature communications

authors： Bodvard K,Peeters K,Roger F,Romanov N,Igbaria A,Welkenhuysen N,Palais G,Reiter W,Toledano MB,Käll M,Molin M

更新日期：2017-03-24 00:00:00

abstract：:CRISPR-Cas immunity is at the forefront of antivirus defense in bacteria and archaea and specifically targets viruses carrying protospacers matching the spacers catalogued in the CRISPR arrays. Here, we perform deep sequencing of the CRISPRome-all spacers contained in a microbiome-associated with hyperthermophilic arc...

journal_title：Nature communications

authors： Medvedeva S,Liu Y,Koonin EV,Severinov K,Prangishvili D,Krupovic M

更新日期：2019-11-15 00:00:00

abstract：:Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains unclear. We investigated the effect of the risk variant, rs7665090G, located near NFKB1, on astrocytes. We demonst...

journal_title：Nature communications

authors： Ponath G,Lincoln MR,Levine-Ritterman M,Park C,Dahlawi S,Mubarak M,Sumida T,Airas L,Zhang S,Isitan C,Nguyen TD,Raine CS,Hafler DA,Pitt D

更新日期：2018-12-17 00:00:00

abstract：:Selective activation of dopamine D1 receptors (D1Rs) has been pursued for 40 years as a therapeutic strategy for neurologic and psychiatric diseases due to the fundamental role of D1Rs in motor function, reward processing, and cognition. All known D1R-selective agonists are catechols, which are rapidly metabolized and...

journal_title：Nature communications

authors： Gray DL,Allen JA,Mente S,O'Connor RE,DeMarco GJ,Efremov I,Tierney P,Volfson D,Davoren J,Guilmette E,Salafia M,Kozak R,Ehlers MD

更新日期：2018-02-14 00:00:00

abstract：:Bacterial Type III Secretion Systems deliver effectors into host cells to manipulate cellular processes to the advantage of the pathogen. Many host targets of these effectors are found on membranes. Therefore, to identify their targets, effectors often use specialized membrane-localization domains to localize to appro...

journal_title：Nature communications

authors： Salomon D,Guo Y,Kinch LN,Grishin NV,Gardner KH,Orth K

更新日期：2013-01-01 00:00:00

abstract：:Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex vasculature of the kidney remains a daunting task. The molecular pathways that specify and sustain functional, phenotypic and structural heterogeneity of the kidney vasculature are unknown. Here, we employ high-throughput bulk and...

journal_title：Nature communications

authors： Barry DM,McMillan EA,Kunar B,Lis R,Zhang T,Lu T,Daniel E,Yokoyama M,Gomez-Salinero JM,Sureshbabu A,Cleaver O,Di Lorenzo A,Choi ME,Xiang J,Redmond D,Rabbany SY,Muthukumar T,Rafii S

更新日期：2019-12-13 00:00:00

abstract：:Insight into crumpling or compaction of one-dimensional objects is important for understanding biopolymer packaging and designing innovative technological devices. By compacting various types of wires in rigid confinements and characterizing the morphology of the resulting crumpled structures, here, we report how fric...

journal_title：Nature communications

authors： Shaebani MR,Najafi J,Farnudi A,Bonn D,Habibi M

更新日期：2017-06-06 00:00:00

abstract：:GABAB receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs. Of the three in...

journal_title：Nature communications

authors： Dinamarca MC,Raveh A,Schneider A,Fritzius T,Früh S,Rem PD,Stawarski M,Lalanne T,Turecek R,Choo M,Besseyrias V,Bildl W,Bentrop D,Staufenbiel M,Gassmann M,Fakler B,Schwenk J,Bettler B

更新日期：2019-03-22 00:00:00

abstract：:Enhancers are DNA sequences that enable complex temporal and tissue-specific regulation of genes in higher eukaryotes. Although it is not entirely clear how enhancer-promoter interactions can increase gene expression, this proximity has been observed in multiple systems at multiple loci and is thought to be essential ...

journal_title：Nature communications

authors： Crump NT,Ballabio E,Godfrey L,Thorne R,Repapi E,Kerry J,Tapia M,Hua P,Lagerholm C,Filippakopoulos P,Davies JOJ,Milne TA

更新日期：2021-01-11 00:00:00

abstract：:The time-dependent response of structural materials dominates our aging infrastructure's life expectancy and has important resilience implications. For calcium-silicate-hydrates, the glue of cement, nanoscale mechanisms underlying time-dependent phenomena are complex and remain poorly understood. This complexity origi...

journal_title：Nature communications

authors： Morshedifard A,Masoumi S,Abdolhosseini Qomi MJ

更新日期：2018-05-03 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Chen S,Wang Q,Yu H,Capitano ML,Vemula S,Nabinger SC,Gao R,Yao C,Kobayashi M,Geng Z,Fahey A,Henley D,Liu SZ,Barajas S,Cai W,Wolf ER,Ramdas B,Cai Z,Gao H,Luo N,Sun Y,Wong TN,Link DC,Liu Y,Boswell HS,Mayo L

更新日期：2020-07-28 00:00:00

abstract：:Parkinson's disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated α-synuclein. Little is known about how differences in α-synuclein aggregate structure affect disease phenotype. Here, we amplified α-synuclein aggregates from PD...

journal_title：Nature communications

authors： Strohäker T,Jung BC,Liou SH,Fernandez CO,Riedel D,Becker S,Halliday GM,Bennati M,Kim WS,Lee SJ,Zweckstetter M

更新日期：2019-12-04 00:00:00

abstract：:The Lyme disease agent, Borrelia burgdorferi, colonizes the gut of the tick Ixodes scapularis, which transmits the pathogen to vertebrate hosts including humans. Here we show that B. burgdorferi colonization increases the expression of several tick gut genes including pixr, encoding a secreted gut protein with a Reele...

journal_title：Nature communications

authors： Narasimhan S,Schuijt TJ,Abraham NM,Rajeevan N,Coumou J,Graham M,Robson A,Wu MJ,Daffre S,Hovius JW,Fikrig E

更新日期：2017-08-04 00:00:00

abstract：:Van der Waals materials and heterostructures that manifest strongly bound exciton states at room temperature also exhibit emergent physical phenomena and are of great promise for optoelectronic applications. Here, we demonstrate that nanostructured, multilayer transition metal dichalcogenides (TMDCs) by themselves pro...

journal_title：Nature communications

authors： Zhang H,Abhiraman B,Zhang Q,Miao J,Jo K,Roccasecca S,Knight MW,Davoyan AR,Jariwala D

更新日期：2020-07-15 00:00:00

abstract：:Photoluminescence phenomena normally obey Stokes' law of luminescence according to which the emitted photon energy is typically lower than its excitation counterparts. Here we show that carbon nanotubes break this rule under one-photon excitation conditions. We found that the carbon nanotubes exhibit efficient near-in...

journal_title：Nature communications

authors： Akizuki N,Aota S,Mouri S,Matsuda K,Miyauchi Y

更新日期：2015-11-16 00:00:00

abstract：:Holocene summer temperature reconstructions from northern Europe based on sedimentary pollen records suggest an onset of peak summer warmth around 9,000 years ago. However, pollen-based temperature reconstructions are largely driven by changes in the proportions of tree taxa, and thus the early-Holocene warming signal...

journal_title：Nature communications

authors： Väliranta M,Salonen JS,Heikkilä M,Amon L,Helmens K,Klimaschewski A,Kuhry P,Kultti S,Poska A,Shala S,Veski S,Birks HH

更新日期：2015-04-10 00:00:00

abstract：:Recent studies show that the D'' layer, just above the Earth's core-mantle boundary, is composed of MgSiO3 post-perovskite and has significant lateral inhomogeneity. Here we consider the D'' diversity as related to the single-crystal elasticity of the post-perovskite phase. We measure the single-crystal elasticity of ...

journal_title：Nature communications

authors： Yoneda A,Fukui H,Xu F,Nakatsuka A,Yoshiasa A,Seto Y,Ono K,Tsutsui S,Uchiyama H,Baron AQ

更新日期：2014-03-27 00:00:00