Rotator side chains trigger cooperative transition for shape and function memory effect in organic semiconductors.

abstract：:The costs for solar photovoltaics, wind, and battery storage have dropped markedly since 2010, however, many recent studies and reports around the world have not adequately captured such dramatic decrease. Those costs are projected to decline further in the near future, bringing new prospects for the widespread penetr...

journal_title：Nature communications

authors： He G,Lin J,Sifuentes F,Liu X,Abhyankar N,Phadke A

更新日期：2020-05-19 00:00:00

abstract：:Shaping ceramics into complex and intricate geometries using cost-effective processes is desirable in many applications but still remains an open challenge. Inspired by plant seed dispersal units that self-fold on differential swelling, we demonstrate that self-shaping can be implemented in ceramics by programming the...

journal_title：Nature communications

authors： Bargardi FL,Le Ferrand H,Libanori R,Studart AR

更新日期：2016-12-23 00:00:00

abstract：:The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly impacts physical autonomy and survival. Here, we compare genome-wide transcriptional changes of sarcopen...

journal_title：Nature communications

authors： Migliavacca E,Tay SKH,Patel HP,Sonntag T,Civiletto G,McFarlane C,Forrester T,Barton SJ,Leow MK,Antoun E,Charpagne A,Seng Chong Y,Descombes P,Feng L,Francis-Emmanuel P,Garratt ES,Giner MP,Green CO,Karaz S,Kothandaram

更新日期：2019-12-20 00:00:00

abstract：:A subset of transcription factors classified as neural crest 'specifiers' are also core epithelial-mesenchymal transition regulatory factors, both in the neural crest and in tumour progression. The bHLH factor Twist is among the least well studied of these factors. Here we demonstrate that Twist is required for crania...

journal_title：Nature communications

authors： Lander R,Nasr T,Ochoa SD,Nordin K,Prasad MS,Labonne C

更新日期：2013-01-01 00:00:00

abstract：:During stress, prompt export of stress-inducible transcripts is critical for cell survival. Here, we characterize a function of the SAGA (Spt-Ada-Gcn5 acetyltransferase) deubiquitylating module (DUBm) in monitoring messenger ribonucleoprotein (mRNP) biogenesis to regulate non-canonical mRNA export of stress-inducible ...

journal_title：Nature communications

authors： Kim M,Choi Y,Kim H,Lee D

更新日期：2019-06-05 00:00:00

abstract：:CD47 is a cell surface molecule that inhibits phagocytosis of cells that express it by binding to its receptor, SIRPα, on macrophages and other immune cells. CD47 is expressed at different levels by neoplastic and normal cells. Here, to reveal mechanisms by which different neoplastic cells generate this dominant 'don'...

journal_title：Nature communications

authors： Betancur PA,Abraham BJ,Yiu YY,Willingham SB,Khameneh F,Zarnegar M,Kuo AH,McKenna K,Kojima Y,Leeper NJ,Ho P,Gip P,Swigut T,Sherwood RI,Clarke MF,Somlo G,Young RA,Weissman IL

更新日期：2017-04-05 00:00:00

abstract：:Coordination of outer membrane constriction with septation is critical to faithful division in Gram-negative bacteria and vital to the barrier function of the membrane. This coordination requires the recruitment of the peptidoglycan-binding outer-membrane lipoprotein Pal at division sites by the Tol system. Here, we s...

journal_title：Nature communications

authors： Szczepaniak J,Holmes P,Rajasekar K,Kaminska R,Samsudin F,Inns PG,Rassam P,Khalid S,Murray SM,Redfield C,Kleanthous C

更新日期：2020-03-11 00:00:00

abstract：:Pulses of tree mortality caused by drought have been reported recently in forests around the globe, but large-scale quantitative evidence is lacking for Europe. Analyzing high-resolution annual satellite-based canopy mortality maps from 1987 to 2016 we here show that excess forest mortality (i.e., canopy mortality exc...

journal_title：Nature communications

authors： Senf C,Buras A,Zang CS,Rammig A,Seidl R

更新日期：2020-12-03 00:00:00

abstract：:Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterise the DNA methylomes of zebrafish PGCs at four devel...

journal_title：Nature communications

authors： Skvortsova K,Tarbashevich K,Stehling M,Lister R,Irimia M,Raz E,Bogdanovic O

更新日期：2019-07-11 00:00:00

abstract：:Mycobacterium tuberculosis (MTB) infects 30% of all humans and kills someone every 20-30 s. Here we report genome-wide binding for ~80% of all predicted MTB transcription factors (TFs), and assayed global expression following induction of each TF. The MTB DNA-binding network consists of ~16,000 binding events from 154...

journal_title：Nature communications

authors： Minch KJ,Rustad TR,Peterson EJ,Winkler J,Reiss DJ,Ma S,Hickey M,Brabant W,Morrison B,Turkarslan S,Mawhinney C,Galagan JE,Price ND,Baliga NS,Sherman DR

更新日期：2015-01-12 00:00:00

abstract：:Post-translational protein modification by tyrosine sulfation has an important role in extracellular protein-protein interactions. The protein tyrosine sulfation reaction is catalysed by the Golgi enzyme called the tyrosylprotein sulfotransferase. To date, no crystal structure is available for tyrosylprotein sulfotran...

journal_title：Nature communications

authors： Teramoto T,Fujikawa Y,Kawaguchi Y,Kurogi K,Soejima M,Adachi R,Nakanishi Y,Mishiro-Sato E,Liu MC,Sakakibara Y,Suiko M,Kimura M,Kakuta Y

更新日期：2013-01-01 00:00:00

abstract：:Constitutive activation of Wnt/β-catenin inhibits oligodendrocyte myelination. Tcf7l2/Tcf4, a β-catenin transcriptional partner, is required for oligodendrocyte differentiation. How Tcf7l2 modifies β-catenin signalling and controls myelination remains elusive. Here we define a stage-specific Tcf7l2-regulated transcrip...

journal_title：Nature communications

authors： Zhao C,Deng Y,Liu L,Yu K,Zhang L,Wang H,He X,Wang J,Lu C,Wu LN,Weng Q,Mao M,Li J,van Es JH,Xin M,Parry L,Goldman SA,Clevers H,Lu QR

更新日期：2016-03-09 00:00:00

abstract：:In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of acquired drug resistance through the tumor microenvironment, which is mediated by human tumor-associated B ...

journal_title：Nature communications

authors： Somasundaram R,Zhang G,Fukunaga-Kalabis M,Perego M,Krepler C,Xu X,Wagner C,Hristova D,Zhang J,Tian T,Wei Z,Liu Q,Garg K,Griss J,Hards R,Maurer M,Hafner C,Mayerhöfer M,Karanikas G,Jalili A,Bauer-Pohl V,Weihsengru

更新日期：2017-09-19 00:00:00

abstract：:Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically independent from each other. We report that, upon developmental maturation, in mice 3...

journal_title：Nature communications

authors： Jean P,Anttonen T,Michanski S,de Diego AMG,Steyer AM,Neef A,Oestreicher D,Kroll J,Nardis C,Pangršič T,Möbius W,Ashmore J,Wichmann C,Moser T

更新日期：2020-06-25 00:00:00

abstract：:Artificial photosynthesis is a vibrant field of research aiming at converting abundant, low energy molecules such as water, nitrogen or carbon dioxide into fuels or useful chemicals by means of solar energy input. Photo-electrochemical reduction of carbon dioxide is an appealing strategy, aiming at reducing the greenh...

journal_title：Nature communications

authors： Pati PB,Wang R,Boutin E,Diring S,Jobic S,Barreau N,Odobel F,Robert M

更新日期：2020-07-13 00:00:00

abstract：:RNA sequencing (RNA-seq) is the leading technology for genome-wide transcript quantification. However, publicly available RNA-seq data is currently provided mostly in raw form, a significant barrier for global and integrative retrospective analyses. ARCHS4 is a web resource that makes the majority of published RNA-seq...

journal_title：Nature communications

authors： Lachmann A,Torre D,Keenan AB,Jagodnik KM,Lee HJ,Wang L,Silverstein MC,Ma'ayan A

更新日期：2018-04-10 00:00:00

abstract：:Hepatocellular-cholangiocarcinoma (H-ChC) is a rare subtype of liver cancer with clinicopathological features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). To date, molecular mechanisms underlying the co-existence of HCC and iCCA components in a single tumor remain elusive. Here, w...

journal_title：Nature communications

authors： Wang A,Wu L,Lin J,Han L,Bian J,Wu Y,Robson SC,Xue L,Ge Y,Sang X,Wang W,Zhao H

更新日期：2018-03-01 00:00:00

abstract：:Chemotherapy remains a mainstay of cancer treatment but its use is often limited by the development of adverse reactions. Severe loss of body weight (cachexia) is a frequent cause of death in cancer patients and is exacerbated by chemotherapy. We show that genetic inactivation of vascular endothelial growth factor (VE...

journal_title：Nature communications

authors： Klose R,Krzywinska E,Castells M,Gotthardt D,Putz EM,Kantari-Mimoun C,Chikdene N,Meinecke AK,Schrödter K,Helfrich I,Fandrey J,Sexl V,Stockmann C

更新日期：2016-08-19 00:00:00

abstract：:Interaction between light and matter results in new quantum states whose energetics can modify chemical kinetics. In the regime of ensemble vibrational strong coupling (VSC), a macroscopic number [Formula: see text] of molecular transitions couple to each resonant cavity mode, yielding two hybrid light-matter (polarit...

journal_title：Nature communications

authors： Campos-Gonzalez-Angulo JA,Ribeiro RF,Yuen-Zhou J

更新日期：2019-10-15 00:00:00

abstract：:High strength and high ductility are often mutually exclusive properties for structural metallic materials. This is particularly important for aluminum (Al)-based alloys which are widely commercially employed. Here, we introduce a hierarchical nanostructured Al alloy with a structure of Al nanograins surrounded by nan...

journal_title：Nature communications

authors： Wu G,Liu C,Sun L,Wang Q,Sun B,Han B,Kai JJ,Luan J,Liu CT,Cao K,Lu Y,Cheng L,Lu J

更新日期：2019-11-08 00:00:00

abstract：:Trypanosoma brucei is a protozoan parasite that evades its host's adaptive immune response by repeatedly replacing its dense variant surface glycoprotein (VSG) coat from its large genomic VSG repertoire. While the mechanisms regulating VSG gene expression and diversification have been examined extensively, the dynamic...

journal_title：Nature communications

authors： Pinger J,Chowdhury S,Papavasiliou FN

更新日期：2017-10-10 00:00:00

abstract：:Distinct subtypes of ionotropic glutamate receptors can segregate to specific synaptic inputs in a given neuron. Using functional mapping by focal glutamate uncaging in CA3 pyramidal cells (PCs), we observe that kainate receptors (KARs) are strictly confined to the postsynaptic elements of mossy fibre (mf) synapses an...

journal_title：Nature communications

authors： Fièvre S,Carta M,Chamma I,Labrousse V,Thoumine O,Mulle C

更新日期：2016-09-27 00:00:00

abstract：:Rather than targeting tumour cells directly, elements of the tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here we report a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death. Using gain-and-loss of f...

journal_title：Nature communications

authors： Wilson R,Espinosa-Diez C,Kanner N,Chatterjee N,Ruhl R,Hipfinger C,Advani SJ,Li J,Khan OF,Franovic A,Weis SM,Kumar S,Coussens LM,Anderson DG,Chen CC,Cheresh DA,Anand S

更新日期：2016-11-25 00:00:00

abstract：:Staphylococcal pathogens adhere to their human targets with exceptional resilience to mechanical stress, some propagating force to the bacterium via small, Ig-like folds called B domains. We examine the mechanical stability of these folds using atomic force microscopy-based single-molecule force spectroscopy. The forc...

journal_title：Nature communications

authors： Milles LF,Unterauer EM,Nicolaus T,Gaub HE

更新日期：2018-11-12 00:00:00

abstract：:A phase transition is often accompanied by the appearance of an order parameter and symmetry breaking. Certain magnetic materials exhibit exotic hidden-order phases, in which the order parameters are not directly accessible to conventional magnetic measurements. Thus, experimental identification and theoretical unders...

journal_title：Nature communications

authors： Shen Y,Liu C,Qin Y,Shen S,Li YD,Bewley R,Schneidewind A,Chen G,Zhao J

更新日期：2019-10-08 00:00:00

abstract：:Human APOBEC3A (A3A) cytidine deaminase is a host enzyme that can introduce mutations into chromosomal DNA. As APOBEC3B (A3B) encodes a C-terminal catalytic domain ~91% identical to A3A, we examined its genotoxic potential as well as that of a highly prevalent chimaeric A3A-A3B deletion allele (ΔA3B), which is linked ...

journal_title：Nature communications

authors： Caval V,Suspène R,Shapira M,Vartanian JP,Wain-Hobson S

更新日期：2014-10-09 00:00:00

abstract：:Epithelial-to-mesenchymal transition-like (EMT-like) is a critical process allowing initiation of metastases during tumour progression. Here, to investigate its role in intestinal cancer, we combine computational network-based and experimental approaches to create a mouse model with high metastatic potential. Construc...

journal_title：Nature communications

authors： Chanrion M,Kuperstein I,Barrière C,El Marjou F,Cohen D,Vignjevic D,Stimmer L,Paul-Gilloteaux P,Bièche I,Tavares Sdos R,Boccia GF,Cacheux W,Meseure D,Fre S,Martignetti L,Legoix-Né P,Girard E,Fetler L,Barillot E,Louva

更新日期：2014-10-08 00:00:00

abstract：:While distinct stages of natural killer (NK) cell development have been defined, the molecular interactions that shape human NK cell maturation are poorly understood. Here we define intercellular interactions between developing NK cells and stromal cells which, through contact-dependent mechanisms, promote the generat...

journal_title：Nature communications

authors： Mace EM,Gunesch JT,Dixon A,Orange JS

更新日期：2016-07-20 00:00:00

abstract：:Defects can greatly influence the properties of oxide materials; however, facile defect engineering of oxides at room temperature remains challenging. The generation of defects in oxides is difficult to control by conventional chemical reduction methods that usually require high temperatures and are time consuming. He...

journal_title：Nature communications

authors： Ou G,Xu Y,Wen B,Lin R,Ge B,Tang Y,Liang Y,Yang C,Huang K,Zu D,Yu R,Chen W,Li J,Wu H,Liu LM,Li Y

更新日期：2018-04-03 00:00:00

abstract：:In humans, males have lower recombination rates than females over the majority of the genome, but the opposite is usually true near the telomeres. These broad-scale differences have been known for decades, yet little is known about differences at the fine scale. By combining data sets, we have collected recombination ...

journal_title：Nature communications

authors： Bhérer C,Campbell CL,Auton A

更新日期：2017-04-25 00:00:00