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Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation.

Abstract：

:Trypanosoma brucei is a protozoan parasite that evades its host's adaptive immune response by repeatedly replacing its dense variant surface glycoprotein (VSG) coat from its large genomic VSG repertoire. While the mechanisms regulating VSG gene expression and diversification have been examined extensively, the dynamics of VSG coat replacement at the protein level, and the impact of this process on successful immune evasion, remain unclear. Here we evaluate the rate of VSG replacement at the trypanosome surface following a genetic VSG switch, and show that full coat replacement requires several days to complete. Using in vivo infection assays, we demonstrate that parasites undergoing coat replacement are only vulnerable to clearance via early IgM antibodies for a limited time. Finally, we show that IgM loses its ability to mediate trypanosome clearance at unexpectedly early stages of coat replacement based on a critical density threshold of its cognate VSGs on the parasite surface. Trypanosoma brucei evades the host immune system through replacement of a variant surface glycoprotein (VSG) coat. Here, the authors show that VSG replacement takes several days to complete, and the parasite is vulnerable to the host immune system for a short period of time during the process.

journal_name

Nat Commun

journal_title

Nature communications

authors

Pinger J,Chowdhury S,Papavasiliou FN

doi

10.1038/s41467-017-00959-w

subject

Has Abstract

pub_date

2017-10-10 00:00:00

pages

828

issue

1

issn

2041-1723

pii

10.1038/s41467-017-00959-w

journal_volume

8

pub_type

杂志文章

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