Massive mining of publicly available RNA-seq data from human and mouse.

abstract：:Post-translational protein modification by tyrosine sulfation has an important role in extracellular protein-protein interactions. The protein tyrosine sulfation reaction is catalysed by the Golgi enzyme called the tyrosylprotein sulfotransferase. To date, no crystal structure is available for tyrosylprotein sulfotran...

journal_title：Nature communications

authors： Teramoto T,Fujikawa Y,Kawaguchi Y,Kurogi K,Soejima M,Adachi R,Nakanishi Y,Mishiro-Sato E,Liu MC,Sakakibara Y,Suiko M,Kimura M,Kakuta Y

更新日期：2013-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are endogenous small RNAs of ∼21 nt that regulate multiple biological pathways in multicellular organisms. They derive from longer transcripts that harbor an imperfect stem-loop structure. In plants, the ribonuclease type III DICER-LIKE1 assisted by accessory proteins cleaves the precursor to releas...

journal_title：Nature communications

authors： Rojas AML,Drusin SI,Chorostecki U,Mateos JL,Moro B,Bologna NG,Bresso EG,Schapire A,Rasia RM,Moreno DM,Palatnik JF

更新日期：2020-10-21 00:00:00

abstract：:Any experienced event may be encoded and retained in detail as part of our episodic memory, and may also refer and contribute to our generalized knowledge stored in semantic memory. The beginnings of this declarative memory formation are only poorly understood. Even less is known about the interrelation between episod...

journal_title：Nature communications

authors： Friedrich M,Mölle M,Friederici AD,Born J

更新日期：2020-03-10 00:00:00

abstract：:Oxygen defect control has long been considered an important route to functionalizing complex oxide films. However, the nature of oxygen defects in thin films is often not investigated beyond basic redox chemistry. One of the model examples for oxygen-defect studies is the layered Ruddlesden-Popper phase La2-xSr x CuO4...

journal_title：Nature communications

authors： Meyer TL,Jacobs R,Lee D,Jiang L,Freeland JW,Sohn C,Egami T,Morgan D,Lee HN

更新日期：2018-01-08 00:00:00

abstract：:Previous studies have reported that chromosome synteny in Lepidoptera has been well conserved, yet the number of haploid chromosomes varies widely from 5 to 223. Here we report the genome (393 Mb) of the Glanville fritillary butterfly (Melitaea cinxia; Nymphalidae), a widely recognized model species in metapopulation ...

journal_title：Nature communications

authors： Ahola V,Lehtonen R,Somervuo P,Salmela L,Koskinen P,Rastas P,Välimäki N,Paulin L,Kvist J,Wahlberg N,Tanskanen J,Hornett EA,Ferguson LC,Luo S,Cao Z,de Jong MA,Duplouy A,Smolander OP,Vogel H,McCoy RC,Qian K,Chong W

更新日期：2014-09-05 00:00:00

abstract：:Cardiac voltage-gated sodium channels (Nav1.5) play an essential role in regulating cardiac electric activity by initiating and propagating action potentials in the heart. Altered Nav1.5 function is associated with multiple cardiac diseases including long-QT3 and Brugada syndrome. Here, we show that Nav1.5 is subject ...

journal_title：Nature communications

authors： Pei Z,Xiao Y,Meng J,Hudmon A,Cummins TR

更新日期：2016-06-23 00:00:00

abstract：:Seismic tomography provides unique constraints on the morphology, the deformation, and (indirectly) the rheology of subducting slabs. We use teleseismic double-difference P-wave tomography to image with unprecedented clarity the structural complexity of the Izu-Bonin slab. We resolve a tear in the slab in the mantle t...

journal_title：Nature communications

authors： Zhang H,Wang F,Myhill R,Guo H

更新日期：2019-03-21 00:00:00

abstract：:The nitrogen-vacancy (NV) centre in diamond is emerging as a promising platform for solid-state quantum information processing and nanoscale metrology. Of interest in these applications is the manipulation of the NV charge, which can be attained by optical excitation. Here, we use two-colour optical microscopy to inve...

journal_title：Nature communications

authors： Jayakumar H,Henshaw J,Dhomkar S,Pagliero D,Laraoui A,Manson NB,Albu R,Doherty MW,Meriles CA

更新日期：2016-08-30 00:00:00

abstract：:Predictable stereoselective formation of supramolecular assembly is generally believed to be an important but complicated process. Here, we show that point chirality of a ligand decisively influences its supramolecular assembly behavior. We designed three closely related chiral ligands with different point chiralities...

journal_title：Nature communications

authors： Yeung CT,Yim KH,Wong HY,Pal R,Lo WS,Yan SC,Yee-Man Wong M,Yufit D,Smiles DE,McCormick LJ,Teat SJ,Shuh DK,Wong WT,Law GL

更新日期：2017-10-24 00:00:00

abstract：:Liquid crystalline network (LCN) actuator normally deforms upon thermally or optically induced order-disorder phase transition, switching once between two shapes (shape 1 in LC phase and shape 2 in isotropic state) for each stimulation on/off cycle. Herein, we report an LCN actuator that deforms from shape 1 to shape ...

journal_title：Nature communications

authors： Xiao YY,Jiang ZC,Hou JB,Zhao Y

更新日期：2021-01-27 00:00:00

abstract：:Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behaving biologics is di...

journal_title：Nature communications

authors： Ebo JS,Saunders JC,Devine PWA,Gordon AM,Warwick AS,Schiffrin B,Chin SE,England E,Button JD,Lloyd C,Bond NJ,Ashcroft AE,Radford SE,Lowe DC,Brockwell DJ

更新日期：2020-04-14 00:00:00

abstract：:COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electro...

journal_title：Nature communications

authors： Douangamath A,Fearon D,Gehrtz P,Krojer T,Lukacik P,Owen CD,Resnick E,Strain-Damerell C,Aimon A,Ábrányi-Balogh P,Brandão-Neto J,Carbery A,Davison G,Dias A,Downes TD,Dunnett L,Fairhead M,Firth JD,Jones SP,Keeley A,K

更新日期：2020-10-07 00:00:00

abstract：:Superchiral light, generated by the interference of two counter-propagating circularly polarized light (CPL) with same frequency, opposite handedness and different intensity, exhibits enhanced dissymmetry in its interaction with chiral molecules, and has the potential for ultrasensitive detection and characterization ...

journal_title：Nature communications

authors： He C,Yang G,Kuai Y,Shan S,Yang L,Hu J,Zhang D,Zhang Q,Zou G

更新日期：2018-11-30 00:00:00

abstract：:Numerous examples of biosynthetic gene clusters (BGCs), including for compounds of agricultural and medicinal importance, have now been discovered in plant genomes. However, little is known about how these complex traits are assembled and diversified. Here, we examine a large number of variants within and between spec...

journal_title：Nature communications

authors： Liu Z,Cheema J,Vigouroux M,Hill L,Reed J,Paajanen P,Yant L,Osbourn A

更新日期：2020-10-23 00:00:00

abstract：:Peptide macrocycles are promising therapeutic molecules because they are protease resistant, structurally rigid, membrane permeable, and capable of modulating protein-protein interactions. Here, we report the characterization of the dual function macrocyclase-peptidase enzyme involved in the biosynthesis of the highly...

journal_title：Nature communications

authors： Czekster CM,Ludewig H,McMahon SA,Naismith JH

更新日期：2017-10-19 00:00:00

abstract：:Pentacyclic triterpenoids (PTs) constitute one of the biggest families of natural products, many with higher oxidation state at the D/E rings possess a wide spectrum of biological activties but are poorly accessible. Here we report a site-selective C-H hydroxylation at the D/E rings of PTs paving a way toward these im...

journal_title：Nature communications

authors： Mu T,Wei B,Zhu D,Yu B

更新日期：2020-09-01 00:00:00

abstract：:Effective prevention strategies will be essential in reducing disease burden due to bacterial infections. Here we harness the specificity and rapid-acting properties of bacteriophages as a potential prophylaxis therapy for cholera, a severely dehydrating disease caused by Vibrio cholerae. To this end, we test a cockta...

journal_title：Nature communications

authors： Yen M,Cairns LS,Camilli A

更新日期：2017-02-01 00:00:00

abstract：:Thin films comprising semiconductor nanocrystals are emerging for applications in electronic and optoelectronic devices including light emitting diodes and solar cells. Achieving high charge carrier mobility in these films requires the identification and elimination of electronic traps on the nanocrystal surfaces. Her...

journal_title：Nature communications

authors： Thimsen E,Johnson M,Zhang X,Wagner AJ,Mkhoyan KA,Kortshagen UR,Aydil ES

更新日期：2014-12-19 00:00:00

abstract：:Mammalian and Drosophila genomes are partitioned into topologically associating domains (TADs). Although this partitioning has been reported to be functionally relevant, it is unclear whether TADs represent true physical units located at the same genomic positions in each cell nucleus or emerge as an average of numero...

journal_title：Nature communications

authors： Ulianov SV,Zakharova VV,Galitsyna AA,Kos PI,Polovnikov KE,Flyamer IM,Mikhaleva EA,Khrameeva EE,Germini D,Logacheva MD,Gavrilov AA,Gorsky AS,Nechaev SK,Gelfand MS,Vassetzky YS,Chertovich AV,Shevelyov YY,Razin SV

更新日期：2021-01-04 00:00:00

abstract：:Crystal structures of G protein-coupled receptor (GPCR) ligand complexes allow a rational design of novel molecular probes and drugs. Here we report the structure-guided design, chemical synthesis and biological investigations of bivalent ligands for dopamine D2 receptor/neurotensin NTS1 receptor (D2R/NTS1R) heterodim...

journal_title：Nature communications

authors： Hübner H,Schellhorn T,Gienger M,Schaab C,Kaindl J,Leeb L,Clark T,Möller D,Gmeiner P

更新日期：2016-07-26 00:00:00

abstract：:Thermal conductivity of two-dimensional (2D) materials is of interest for energy storage, nanoelectronics and optoelectronics. Here, we report that the thermal conductivity of molybdenum disulfide can be modified by electrochemical intercalation. We observe distinct behaviour for thin films with vertically aligned bas...

journal_title：Nature communications

authors： Zhu G,Liu J,Zheng Q,Zhang R,Li D,Banerjee D,Cahill DG

更新日期：2016-10-21 00:00:00

abstract：:Type I interferon (IFN) is a key driver of immunity to infections and cancer. Plasmacytoid dendritic cells (pDCs) are uniquely equipped to produce large quantities of type I IFN but the mechanisms that control this process are poorly understood. Here we report on a droplet-based microfluidic platform to investigate ty...

journal_title：Nature communications

authors： Wimmers F,Subedi N,van Buuringen N,Heister D,Vivié J,Beeren-Reinieren I,Woestenenk R,Dolstra H,Piruska A,Jacobs JFM,van Oudenaarden A,Figdor CG,Huck WTS,de Vries IJM,Tel J

更新日期：2018-08-20 00:00:00

abstract：:The cycling of carbon between Earth's surface and interior governs the long-term habitability of the planet. But how carbon migrates in the deep Earth is not well understood. In particular, the potential role of hydrocarbon fluids in the deep carbon cycle has long been controversial. Here we show that immiscible isobu...

journal_title：Nature communications

authors： Huang F,Daniel I,Cardon H,Montagnac G,Sverjensky DA

更新日期：2017-06-12 00:00:00

abstract：:The Middle Eocene Climatic Optimum (MECO) represents a ~500-kyr period of global warming ~40 million years ago and is associated with a rise in atmospheric CO2 concentrations, but the cause of this CO2 rise remains enigmatic. Here we show, based on osmium isotope ratios (187Os/188Os) of marine sediments and published ...

journal_title：Nature communications

authors： van der Ploeg R,Selby D,Cramwinckel MJ,Li Y,Bohaty SM,Middelburg JJ,Sluijs A

更新日期：2018-07-23 00:00:00

abstract：:The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that...

journal_title：Nature communications

authors： Ogrodnik M,Miwa S,Tchkonia T,Tiniakos D,Wilson CL,Lahat A,Day CP,Burt A,Palmer A,Anstee QM,Grellscheid SN,Hoeijmakers JHJ,Barnhoorn S,Mann DA,Bird TG,Vermeij WP,Kirkland JL,Passos JF,von Zglinicki T,Jurk D

更新日期：2017-06-13 00:00:00

abstract：:Three-dimensional topological Dirac semimetals (TDSs) are a new kind of Dirac materials that exhibit linear energy dispersion in the bulk and can be viewed as three-dimensional graphene. It has been proposed that TDSs can be driven to other exotic phases like Weyl semimetals, topological insulators and topological sup...

journal_title：Nature communications

authors： Cao J,Liang S,Zhang C,Liu Y,Huang J,Jin Z,Chen ZG,Wang Z,Wang Q,Zhao J,Li S,Dai X,Zou J,Xia Z,Li L,Xiu F

更新日期：2015-07-13 00:00:00

abstract：:Topological insulators interacting with magnetic impurities have been reported to host several unconventional effects. These phenomena are described within the framework of gapping Dirac quasiparticles due to broken time-reversal symmetry. However, the overwhelming majority of studies demonstrate the presence of a fin...

journal_title：Nature communications

authors： Sessi P,Biswas RR,Bathon T,Storz O,Wilfert S,Barla A,Kokh KA,Tereshchenko OE,Fauth K,Bode M,Balatsky AV

更新日期：2016-06-27 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Jiang L,Shen Y,Guo D,Yang D,Liu J,Fei X,Yang Y,Zhang B,Lin Z,Yang F,Wang X,Wang K,Wang J,Cai Z

更新日期：2020-07-16 00:00:00

abstract：:Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to redundant functions of individual cytokines. Searching for better cardiac inflammation targets, here we link T cells with HF developmen...

journal_title：Nature communications

authors： Kallikourdis M,Martini E,Carullo P,Sardi C,Roselli G,Greco CM,Vignali D,Riva F,Ormbostad Berre AM,Stølen TO,Fumero A,Faggian G,Di Pasquale E,Elia L,Rumio C,Catalucci D,Papait R,Condorelli G

更新日期：2017-03-06 00:00:00

abstract：:Complex behaviours may be viewed as sequences of modular actions, each elicited by specific sensory cues in their characteristic timescales. From this perspective, we can construct models in which unitary behavioural modules are hierarchically placed in context of related actions. Here, we analyse antennal positioning...

journal_title：Nature communications

authors： Natesan D,Saxena N,Ekeberg Ö,Sane SP

更新日期：2019-12-06 00:00:00