A cocktail of three virulent bacteriophages prevents Vibrio cholerae infection in animal models.

abstract：:The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. By combining highly purified, fully active bovine F-ATP synthase with preformed liposomes we show that Ca2+ dissipates the H+ gradient generated by ATP hydrolysis. Afte...

journal_title：Nature communications

authors： Urbani A,Giorgio V,Carrer A,Franchin C,Arrigoni G,Jiko C,Abe K,Maeda S,Shinzawa-Itoh K,Bogers JFM,McMillan DGG,Gerle C,Szabò I,Bernardi P

更新日期：2019-09-25 00:00:00

abstract：:Central spin decoherence caused by nuclear spin baths is often a critical issue in various quantum computing schemes, and it has also been used for sensing single-nuclear spins. Recent theoretical studies suggest that central spin decoherence can act as a probe of many-body physics in spin baths; however, identificati...

journal_title：Nature communications

authors： Ma WL,Wolfowicz G,Zhao N,Li SS,Morton JJ,Liu RB

更新日期：2014-09-10 00:00:00

abstract：:Granule cells are the dominant cell type of the olfactory bulb inhibiting mitral and tufted cells via dendrodendritic synapses; yet the factors regulating the strength of their inhibitory output, and, therefore, their impact on odour discrimination, remain unknown. Here we show that GABAAR β3-subunits are distributed ...

journal_title：Nature communications

authors： Nunes D,Kuner T

更新日期：2015-11-23 00:00:00

abstract：:Molecular spins have become key enablers for exploring magnetic interactions, quantum information processes and many-body effects in metals. Metal-organic molecules, in particular, let the spin state of the core metal ion to be modified according to its organic environment, allowing localized magnetic moments to emerg...

journal_title：Nature communications

authors： Atxabal A,Ribeiro M,Parui S,Urreta L,Sagasta E,Sun X,Llopis R,Casanova F,Hueso LE

更新日期：2016-12-12 00:00:00

abstract：:Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC) n -containing RNAs into poly-dipeptides can initiate in vivo without a 5'-cap. The pr...

journal_title：Nature communications

authors： Cheng W,Wang S,Mestre AA,Fu C,Makarem A,Xian F,Hayes LR,Lopez-Gonzalez R,Drenner K,Jiang J,Cleveland DW,Sun S

更新日期：2018-01-04 00:00:00

abstract：:A platform for highly parallel direct sequencing of native RNA strands was recently described by Oxford Nanopore Technologies, but despite initial efforts it remains crucial to further investigate the technology for quantification of complex transcriptomes. Here we undertake native RNA sequencing of polyA + RNA from t...

journal_title：Nature communications

authors： Soneson C,Yao Y,Bratus-Neuenschwander A,Patrignani A,Robinson MD,Hussain S

更新日期：2019-07-31 00:00:00

abstract：:In humans, males have lower recombination rates than females over the majority of the genome, but the opposite is usually true near the telomeres. These broad-scale differences have been known for decades, yet little is known about differences at the fine scale. By combining data sets, we have collected recombination ...

journal_title：Nature communications

authors： Bhérer C,Campbell CL,Auton A

更新日期：2017-04-25 00:00:00

abstract：:Ferroelectric materials exhibit a phase transition to a paraelectric state driven by temperature - called the Curie transition. In conventional ferroelectrics, the Curie transition is caused by a change in crystal symmetry, while the material itself remains a continuous three-dimensional solid crystal. However, ferroe...

journal_title：Nature communications

authors： Hafner J,Benaglia S,Richheimer F,Teuschel M,Maier FJ,Werner A,Wood S,Platz D,Schneider M,Hradil K,Castro FA,Garcia R,Schmid U

更新日期：2021-01-08 00:00:00

abstract：:The reconstruction of human-driven, Earth-shaping dynamics is important for understanding past human/environment interactions and for helping human societies that currently face global changes. However, it is often challenging to distinguish the effects of the climate from human activities on environmental changes. He...

journal_title：Nature communications

authors： Giguet-Covex C,Pansu J,Arnaud F,Rey PJ,Griggo C,Gielly L,Domaizon I,Coissac E,David F,Choler P,Poulenard J,Taberlet P

更新日期：2014-01-01 00:00:00

abstract：:Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of ...

journal_title：Nature communications

authors： Adhireksan Z,Palermo G,Riedel T,Ma Z,Muhammad R,Rothlisberger U,Dyson PJ,Davey CA

更新日期：2017-03-30 00:00:00

abstract：:Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in Drosophila DM1 model. Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cell...

journal_title：Nature communications

authors： Cerro-Herreros E,Sabater-Arcis M,Fernandez-Costa JM,Moreno N,Perez-Alonso M,Llamusi B,Artero R

更新日期：2018-06-26 00:00:00

abstract：:Infrared light detection and sensing is deeply embedded in modern technology and human society and its development has always been benefitting from the discovery of various photoelectric materials. The rise of two-dimensional materials, thanks to their distinct electronic structures, extreme dimensional confinement an...

journal_title：Nature communications

authors： Yin J,Tan Z,Hong H,Wu J,Yuan H,Liu Y,Chen C,Tan C,Yao F,Li T,Chen Y,Liu Z,Liu K,Peng H

更新日期：2018-08-17 00:00:00

abstract：:CRISPR/Cas9 has demonstrated a high-efficiency in site-specific gene targeting. However, potential off-target effects of the Cas9 nuclease represent a major safety concern for any therapeutic application. Here, we knock out the Tafazzin gene by CRISPR/Cas9 in human-induced pluripotent stem cells with 54% efficiency. W...

journal_title：Nature communications

authors： Yang L,Grishin D,Wang G,Aach J,Zhang CZ,Chari R,Homsy J,Cai X,Zhao Y,Fan JB,Seidman C,Seidman J,Pu W,Church G

更新日期：2014-11-26 00:00:00

abstract：:Understanding the behaviour of thermally excited many-particle systems, composed of a single particle type having a well-defined shape and size, is important in condensed matter, notably protein crystallization. Here we observe and explain the origin of local chiral symmetry breaking in a surprisingly simple system of...

journal_title：Nature communications

authors： Zhao K,Bruinsma R,Mason TG

更新日期：2012-05-01 00:00:00

abstract：:Circadian clocks generate reliable ~24-h rhythms despite being based on stochastic biochemical reactions. The circadian clock in Synechococcus elongatus uses a post-translational oscillator that cycles deterministically in a test tube. Because the volume of a single bacterial cell is much smaller than a macroscopic re...

journal_title：Nature communications

authors： Chew J,Leypunskiy E,Lin J,Murugan A,Rust MJ

更新日期：2018-08-01 00:00:00

abstract：:The superconducting gap structure in iron-based high-temperature superconductors (Fe-HTSs) is non-universal. In contrast to other unconventional superconductors, in the Fe-HTSs both d-wave and extended s-wave pairing symmetries are close in energy. Probing the proximity between these very different superconducting sta...

journal_title：Nature communications

authors： Guguchia Z,Amato A,Kang J,Luetkens H,Biswas PK,Prando G,von Rohr F,Bukowski Z,Shengelaya A,Keller H,Morenzoni E,Fernandes RM,Khasanov R

更新日期：2015-11-09 00:00:00

abstract：:Sustainable food production in the context of climate change necessitates diversification of agriculture and a more efficient utilization of plant genetic resources. Fonio millet (Digitaria exilis) is an orphan African cereal crop with a great potential for dryland agriculture. Here, we establish high-quality genomic ...

journal_title：Nature communications

authors： Abrouk M,Ahmed HI,Cubry P,Šimoníková D,Cauet S,Pailles Y,Bettgenhaeuser J,Gapa L,Scarcelli N,Couderc M,Zekraoui L,Kathiresan N,Čížková J,Hřibová E,Doležel J,Arribat S,Bergès H,Wieringa JJ,Gueye M,Kane NA,Leclerc C

更新日期：2020-09-08 00:00:00

abstract：:The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (E...

journal_title：Nature communications

authors： Cardenas A,Sordillo JE,Rifas-Shiman SL,Chung W,Liang L,Coull BA,Hivert MF,Lai PS,Forno E,Celedón JC,Litonjua AA,Brennan KJ,DeMeo DL,Baccarelli AA,Oken E,Gold DR

更新日期：2019-07-12 00:00:00

abstract：:Understanding how rock-forming minerals transform under shock loading is critical for modeling collisions between planetary bodies, interpreting the significance of shock features in minerals and for using them as diagnostic indicators of impact conditions, such as shock pressure. To date, our understanding of the for...

journal_title：Nature communications

authors： Gleason AE,Bolme CA,Lee HJ,Nagler B,Galtier E,Kraus RG,Sandberg R,Yang W,Langenhorst F,Mao WL

更新日期：2017-11-14 00:00:00

abstract：:Huntington's Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery by heat shock transcription factor 1 (HSF1) ameliorates biochemical and neurobiological defec...

journal_title：Nature communications

authors： Gomez-Pastor R,Burchfiel ET,Neef DW,Jaeger AM,Cabiscol E,McKinstry SU,Doss A,Aballay A,Lo DC,Akimov SS,Ross CA,Eroglu C,Thiele DJ

更新日期：2017-02-13 00:00:00

abstract：:Materials genomics represents a research mode for materials development, for which reliable methods for efficient materials construction are essential. Here we present a methodology for high-throughput construction of covalent organic frameworks (COFs) based on materials genomics strategy, in which a gene partition me...

journal_title：Nature communications

authors： Lan Y,Han X,Tong M,Huang H,Yang Q,Liu D,Zhao X,Zhong C

更新日期：2018-12-10 00:00:00

abstract：:Cytokinesis mediates the physical separation of dividing cells and, in 3D epithelia, provides a spatial landmark for lumen formation. Here, we unravel an unexpected role in cytokinesis for proteins of the intraflagellar transport (IFT) machinery, initially characterized for their ciliary role and their link to polycys...

journal_title：Nature communications

authors： Taulet N,Vitre B,Anguille C,Douanier A,Rocancourt M,Taschner M,Lorentzen E,Echard A,Delaval B

更新日期：2017-12-04 00:00:00

abstract：:The development of high efficiency solar cells relies on the management of electronic and optical properties that need to be accurately measured. As the conversion efficiencies increase, there is a concomitant electronic and photonic contribution that affects the overall performances. Here we show an optical method to...

journal_title：Nature communications

authors： Bercegol A,Ory D,Suchet D,Cacovich S,Fournier O,Rousset J,Lombez L

更新日期：2019-04-08 00:00:00

abstract：:The insulator-to-metal transition continues to be a challenging subject, especially when electronic correlations are strong. In layered compounds, such as La2-xSrxNiO4 and La2-xBaxCuO4, the doped charge carriers can segregate into periodically spaced charge stripes separating narrow domains of antiferromagnetic order....

journal_title：Nature communications

authors： Anissimova S,Parshall D,Gu GD,Marty K,Lumsden MD,Chi S,Fernandez-Baca JA,Abernathy DL,Lamago D,Tranquada JM,Reznik D

更新日期：2014-03-17 00:00:00

abstract：:The development of thymic regulatory T cells (Treg) is mediated by Aire-regulated self-antigen presentation on medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), but the cooperation between these cells is still poorly understood. Here we show that signaling through Toll-like receptors (TLR) expressed...

journal_title：Nature communications

authors： Vobořil M,Brabec T,Dobeš J,Šplíchalová I,Březina J,Čepková A,Dobešová M,Aidarova A,Kubovčiak J,Tsyklauri O,Štěpánek O,Beneš V,Sedláček R,Klein L,Kolář M,Filipp D

更新日期：2020-05-12 00:00:00

abstract：:Oxygen contamination is a problem which inevitably occurs during severe plastic deformation of metallic powders by exposure to air. Although this contamination can change the morphology and properties of the consolidated materials, there is a lack of detailed information about the behavior of oxygen in nanocrystalline...

journal_title：Nature communications

authors： Guo J,Haberfehlner G,Rosalie J,Li L,Duarte MJ,Kothleitner G,Dehm G,He Y,Pippan R,Zhang Z

更新日期：2018-03-05 00:00:00

abstract：:Long-range chromatin interactions are important for transcriptional regulation of genes, many of which are related to complex agronomics traits. However, the pattern of three-dimensional chromatin interactions remains unclear in plants. Here we report the generation of chromatin interaction analysis by paired-end tag ...

journal_title：Nature communications

authors： Li E,Liu H,Huang L,Zhang X,Dong X,Song W,Zhao H,Lai J

更新日期：2019-06-14 00:00:00

abstract：:Shear-wave anisotropy in Earth's mantle helps constrain the lattice-preferred orientation of anisotropic minerals due to viscous flow. Previous studies at the Japan Trench subduction zone using land-based seismic networks identified strong anisotropy in the mantle wedge, reflecting viscous flow induced by the subducti...

journal_title：Nature communications

authors： Uchida N,Nakajima J,Wang K,Takagi R,Yoshida K,Nakayama T,Hino R,Okada T,Asano Y

更新日期：2020-11-10 00:00:00

abstract：:Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues either during nervous system development or the establishment of the vascular system. This was clearly demonstrated for netrin-1 via its interaction with the receptors DCC and UNC5s. However, mainly based on shared homologies wi...

journal_title：Nature communications

authors： Reuten R,Patel TR,McDougall M,Rama N,Nikodemus D,Gibert B,Delcros JG,Prein C,Meier M,Metzger S,Zhou Z,Kaltenberg J,McKee KK,Bald T,Tüting T,Zigrino P,Djonov V,Bloch W,Clausen-Schaumann H,Poschl E,Yurchenco PD,Eh

更新日期：2016-11-30 00:00:00

abstract：:Clustering of arc volcanoes in subduction zones indicates along-arc variation in the physical condition of the underlying mantle where majority of arc magmas are generated. The sub-arc mantle is brought in from the back-arc largely by slab-driven mantle wedge flow. Dynamic processes in the back-arc, such as small-scal...

journal_title：Nature communications

authors： Lee C,Wada I

更新日期：2017-06-29 00:00:00