Abstract:
:CD47 is a cell surface molecule that inhibits phagocytosis of cells that express it by binding to its receptor, SIRPα, on macrophages and other immune cells. CD47 is expressed at different levels by neoplastic and normal cells. Here, to reveal mechanisms by which different neoplastic cells generate this dominant 'don't eat me' signal, we analyse the CD47 regulatory genomic landscape. We identify two distinct super-enhancers (SEs) associated with CD47 in certain cancer cell types. We show that a set of active constituent enhancers, located within the two CD47 SEs, regulate CD47 expression in different cancer cell types and that disruption of CD47 SEs reduces CD47 gene expression. Finally we report that the TNF-NFKB1 signalling pathway directly regulates CD47 by interacting with a constituent enhancer located within a CD47-associated SE specific to breast cancer. These results suggest that cancers can evolve SE to drive CD47 overexpression to escape immune surveillance.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Betancur PA,Abraham BJ,Yiu YY,Willingham SB,Khameneh F,Zarnegar M,Kuo AH,McKenna K,Kojima Y,Leeper NJ,Ho P,Gip P,Swigut T,Sherwood RI,Clarke MF,Somlo G,Young RA,Weissman ILdoi
10.1038/ncomms14802subject
Has Abstractpub_date
2017-04-05 00:00:00pages
14802issn
2041-1723pii
ncomms14802journal_volume
8pub_type
杂志文章abstract::Considering the rapid increase of CO2 emission, especially from power plants, there is a constant need for materials which can effectively eliminate post-combustion CO2 (the main component: CO2/N2 = 15/85). Here, we show the design and synthesis of a Cu(II) metal-organic framework (FJI-H14) with a high density of acti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01166-3
更新日期:2017-11-01 00:00:00
abstract::Rabies virus (RABV) causes fatal encephalitis in more than 59,000 people yearly. Upon the bite of an infected animal, the development of clinical disease can be prevented with post-exposure prophylaxis (PEP), which includes the administration of Rabies immunoglobulin (RIG). However, the high cost and limited availabil...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14398-7
更新日期:2020-01-30 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00812-0
更新日期:2017-10-10 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14037
更新日期:2017-01-09 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09456-8
更新日期:2019-03-29 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13031-6
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journal_title:Nature communications
pub_type: 杂志文章
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05716-1
更新日期:2018-08-13 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20124-0
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17316-z
更新日期:2020-07-21 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11568
更新日期:2016-05-13 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
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更新日期:2019-11-26 00:00:00
abstract::Estimates of recent biodiversity change remain inconsistent, debated, and infrequently assessed for their functional implications. Here, we report that spatial scale and type of biodiversity measurement influence evidence of temporal biodiversity change. We show a pervasive scale dependence of temporal trends in taxon...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04889-z
更新日期:2018-07-02 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5686
更新日期:2014-08-26 00:00:00
abstract::Removal of internal transcribed spacer 2 (ITS2) from pre-ribosomal RNA is essential to make functional ribosomes. This complicated processing reaction begins with a single endonucleolytic cleavage followed by exonucleolytic trimming at both new cleavage sites to generate mature 5.8S and 25S rRNA. We reconstituted the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01786-9
更新日期:2017-11-27 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17849-3
更新日期:2020-08-07 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01131-0
更新日期:2017-10-24 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09380-x
更新日期:2019-03-29 00:00:00
abstract::EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell surface protein involved in homotypic cell-cell adhesion via intercellular oligomerization and proliferative signalling via proteolytic cleavage. Despite its use as a diagnostic marker and being a drug target, structural details of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5764
更新日期:2014-08-28 00:00:00
abstract::The pyridine ring is a potent pharmacophore in alkaloid natural products. Nonetheless, its biosynthetic pathways are poorly understood. Rubrolones A and B are tropolone alkaloid natural products possessing a unique tetra-substituted pyridine moiety. Here, we report the gene cluster and propose a biosynthetic pathway f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13083
更新日期:2016-10-07 00:00:00
abstract::Genetic ablation of endothelial focal adhesion kinase (FAK) can inhibit pathological angiogenesis, suggesting that loss of endothelial FAK is sufficient to reduce neovascularization. Here we show that reduced stromal FAK expression in FAK-heterozygous mice unexpectedly enhances both B16F0 and CMT19T tumour growth and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3020
更新日期:2013-01-01 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Nature communications
pub_type: 杂志文章
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更新日期:2020-03-11 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11092
更新日期:2016-03-29 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10489
更新日期:2016-02-04 00:00:00
abstract::Monomeric near-infrared (NIR) fluorescent proteins (FPs) are in high demand as protein tags and components of biosensors for deep-tissue imaging and multicolour microscopy. We report three bright and spectrally distinct monomeric NIR FPs, termed miRFPs, engineered from bacterial phytochrome, which can be used as easil...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12405
更新日期:2016-08-19 00:00:00
abstract::Because of the potential impact on agriculture and other key human activities, efforts have been dedicated to the local control of precipitation. The most common approach consists of dispersing small particles of dry ice, silver iodide, or other salts in the atmosphere. Here we show, using field experiments conducted ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1462
更新日期:2011-08-30 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04157-0
更新日期:2018-05-22 00:00:00
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journal_title:Nature communications
pub_type: 杂志文章
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更新日期:2015-10-09 00:00:00