FAK-heterozygous mice display enhanced tumour angiogenesis.

abstract：:Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that kidney function is  recovered after AKI despite substantial t...

journal_title：Nature communications

authors： Lazzeri E,Angelotti ML,Peired A,Conte C,Marschner JA,Maggi L,Mazzinghi B,Lombardi D,Melica ME,Nardi S,Ronconi E,Sisti A,Antonelli G,Becherucci F,De Chiara L,Guevara RR,Burger A,Schaefer B,Annunziato F,Anders HJ,La

更新日期：2018-04-09 00:00:00

abstract：:The need for active and stable oxidation catalysts is driven by the demands in production of valuable chemicals, remediation of hydrocarbon pollutants and energy sustainability. Traditional approaches focus on oxygen-activating oxides as support which provides the oxygen activation at the catalyst-support peripheral i...

journal_title：Nature communications

authors： Shan S,Li J,Maswadeh Y,O'Brien C,Kareem H,Tran DT,Lee IC,Wu ZP,Wang S,Yan S,Cronk H,Mott D,Yang L,Luo J,Petkov V,Zhong CJ

更新日期：2020-08-21 00:00:00

abstract：:Because maintenance of non-scalable cellular components--membranes and chromosomes--requires an increasing fraction of energy as cell size decreases, miniaturization comes at a considerable energetic cost for a phytoplanktonic cell. Consequently, if eukaryotes can use their superior energetic resources to acquire nutr...

journal_title：Nature communications

authors： Zubkov MV

更新日期：2014-04-29 00:00:00

abstract：:The CCCTC-binding zinc-finger protein (CTCF)-mediated network of long-range chromatin interactions is important for genome organization and function. Although this network has been considered largely invariant, we find that it exhibits extensive cell-type-specific interactions that contribute to cell identity. Here, w...

journal_title：Nature communications

authors： Kai Y,Andricovich J,Zeng Z,Zhu J,Tzatsos A,Peng W

更新日期：2018-10-11 00:00:00

abstract：:Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto t...

journal_title：Nature communications

authors： Kim HR,Mun Y,Lee KS,Park YJ,Park JS,Park JH,Jeon BN,Kim CH,Jun Y,Hyun YM,Kim M,Lee SM,Park CS,Im SH,Jun CD

更新日期：2018-09-07 00:00:00

abstract：:TorsinA is an ER-resident AAA + ATPase, whose deletion of glutamate E303 results in the genetic neuromuscular disease primary dystonia. TorsinA is an unusual AAA + ATPase that needs an external activator. Also, it likely does not thread a peptide substrate through a narrow central channel, in contrast to its closest s...

journal_title：Nature communications

authors： Demircioglu FE,Zheng W,McQuown AJ,Maier NK,Watson N,Cheeseman IM,Denic V,Egelman EH,Schwartz TU

更新日期：2019-07-22 00:00:00

abstract：:The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug resistance in clinical samples, and improvements in global surveillance. Here we show how de Bruijn graph representation of bacterial diversity can be used to identify species and resistance profiles of clinical isolates. W...

journal_title：Nature communications

authors： Bradley P,Gordon NC,Walker TM,Dunn L,Heys S,Huang B,Earle S,Pankhurst LJ,Anson L,de Cesare M,Piazza P,Votintseva AA,Golubchik T,Wilson DJ,Wyllie DH,Diel R,Niemann S,Feuerriegel S,Kohl TA,Ismail N,Omar SV,Smith E

更新日期：2015-12-21 00:00:00

abstract：:Parkinson's disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated α-synuclein. Little is known about how differences in α-synuclein aggregate structure affect disease phenotype. Here, we amplified α-synuclein aggregates from PD...

journal_title：Nature communications

authors： Strohäker T,Jung BC,Liou SH,Fernandez CO,Riedel D,Becker S,Halliday GM,Bennati M,Kim WS,Lee SJ,Zweckstetter M

更新日期：2019-12-04 00:00:00

abstract：:The mobility of drops on surfaces is important in many biological and industrial processes, but the phenomena governing their adhesion, which is dictated by the morphology of the three-phase contact line, remain unclear. Here we describe a technique for measuring the dynamic behaviour of the three-phase contact line a...

journal_title：Nature communications

authors： Paxson AT,Varanasi KK

更新日期：2013-01-01 00:00:00

abstract：:Microbial production of isoprene from renewable feedstock is a promising alternative to traditional petroleum-based processes. Currently, efforts to improve isoprenoid production in Saccharomyces cerevisiae mainly focus on cytoplasmic engineering, whereas comprehensive engineering of multiple subcellular compartments ...

journal_title：Nature communications

authors： Lv X,Wang F,Zhou P,Ye L,Xie W,Xu H,Yu H

更新日期：2016-09-21 00:00:00

abstract：:Mei (Prunus mume) is an ornamental woody plant that has been domesticated in East Asia for thousands of years. High diversity in floral traits, along with its recent genome sequence, makes mei an ideal model system for studying the evolution of woody plants. Here, we investigate the genetic architecture of floral trai...

journal_title：Nature communications

authors： Zhang Q,Zhang H,Sun L,Fan G,Ye M,Jiang L,Liu X,Ma K,Shi C,Bao F,Guan R,Han Y,Fu Y,Pan H,Chen Z,Li L,Wang J,Lv M,Zheng T,Yuan C,Zhou Y,Lee SM,Yan X,Xu X,Wu R,Chen W,Cheng T

更新日期：2018-04-27 00:00:00

abstract：:During centriole duplication, a single daughter centriole is formed next to the mother centriole. The molecular mechanism that determines a single duplication site remains a long-standing question. Here, we show that intrinsic self-organization of Plk4 is implicated in symmetry breaking in the process of centriole dup...

journal_title：Nature communications

authors： Yamamoto S,Kitagawa D

更新日期：2019-04-18 00:00:00

abstract：:Liquid sensors composed of ionic liquids are rising as alternatives to solid semiconductors for flexible and self-healing electronics. However, the fluidic nature may give rise to leakage problems in cases of accidental damages. Here, we proposed a liquid sensor based on a binary ionic liquid system, in which a flowin...

journal_title：Nature communications

authors： Gao N,He Y,Tao X,Xu XQ,Wu X,Wang Y

更新日期：2019-02-01 00:00:00

abstract：:The negative-capacitance field-effect transistor(NC-FET) has attracted tremendous research efforts. However, the lack of a clear physical picture and design rule for this device has led to numerous invalid fabrications. In this work, we address this issue based on an unexpectedly concise and insightful analytical form...

journal_title：Nature communications

authors： Cao W,Banerjee K

更新日期：2020-01-10 00:00:00

abstract：:Domain walls can be driven by current at very high speeds in nanowires formed from ultra-thin, perpendicularly magnetized cobalt layers and cobalt/nickel multilayers deposited on platinum underlayers due to a chiral spin torque. An important feature of this torque is a magnetic chiral exchange field that each domain w...

journal_title：Nature communications

authors： Ryu KS,Yang SH,Thomas L,Parkin SS

更新日期：2014-05-23 00:00:00

abstract：:Under hypoxia, most of glucose is converted to secretory lactate, which leads to the overuse of glutamine-carbon. However, under such a condition how glutamine nitrogen is disposed to avoid over-accumulating ammonia remains to be determined. Here we identify a metabolic flux of glutamine to secretory dihydroorotate, w...

journal_title：Nature communications

authors： Wang Y,Bai C,Ruan Y,Liu M,Chu Q,Qiu L,Yang C,Li B

更新日期：2019-01-14 00:00:00

abstract：:Topological insulators exhibit a metallic surface state in which the directions of the carriers' momentum and spin are locked together. This characteristic property, which lies at the heart of proposed applications of topological insulators, protects carriers in the surface state from back-scattering unless the scatte...

journal_title：Nature communications

authors： Nam MS,Williams BH,Chen Y,Contera S,Yao S,Lu M,Chen YF,Timco GA,Muryn CA,Winpenny REP,Ardavan A

更新日期：2018-01-04 00:00:00

abstract：:Mass extinctions have profoundly impacted the evolution of life through not only reducing taxonomic diversity but also reshaping ecosystems and biogeographic patterns. In particular, they are considered to have driven increased biogeographic cosmopolitanism, but quantitative tests of this hypothesis are rare and have ...

journal_title：Nature communications

authors： Button DJ,Lloyd GT,Ezcurra MD,Butler RJ

更新日期：2017-10-10 00:00:00

abstract：:The insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) are highly related receptor tyrosine kinases with a disulfide-linked homodimeric architecture. Ligand binding to the receptor ectodomain triggers tyrosine autophosphorylation of the cytoplasmic domains, which stimulates catalytic activity and ...

journal_title：Nature communications

authors： Cabail MZ,Li S,Lemmon E,Bowen ME,Hubbard SR,Miller WT

更新日期：2015-03-11 00:00:00

abstract：:Hybrid quantum systems are essential for the realization of distributed quantum networks. In particular, piezo-mechanics operating at typical superconducting qubit frequencies features low thermal excitations, and offers an appealing platform to bridge superconducting quantum processors and optical telecommunication c...

journal_title：Nature communications

authors： Han X,Fu W,Zhong C,Zou CL,Xu Y,Sayem AA,Xu M,Wang S,Cheng R,Jiang L,Tang HX

更新日期：2020-06-26 00:00:00

abstract：:Organic semiconductors are usually polycyclic aromatic hydrocarbons and their analogs containing heteroatom substitution. Bioinspired materials chemistry of organic electronics promises new charge transport mechanism and specific molecular recognition with biomolecules. We discover organic semiconductors from deoxyrib...

journal_title：Nature communications

authors： Zhang F,Lemaur V,Choi W,Kafle P,Seki S,Cornil J,Beljonne D,Diao Y

更新日期：2019-09-16 00:00:00

abstract：:The leaf economics spectrum (LES) describes consistent correlations among a variety of leaf traits that reflect a gradient from conservative to acquisitive plant strategies. So far, whether the LES holds in wetland plants at a global scale has been unclear. Using data on 365 wetland species from 151 studies, we find t...

journal_title：Nature communications

authors： Pan Y,Cieraad E,Armstrong J,Armstrong W,Clarkson BR,Colmer TD,Pedersen O,Visser EJW,Voesenek LACJ,van Bodegom PM

更新日期：2020-09-09 00:00:00

abstract：:Methods for site-selective chemistry on proteins are in high demand for the synthesis of chemically modified biopharmaceuticals, as well as for applications in chemical biology, biosensors and more. Inadvertent N-terminal gluconoylation has been reported during expression of proteins with an N-terminal His tag. Here w...

journal_title：Nature communications

authors： Martos-Maldonado MC,Hjuler CT,Sørensen KK,Thygesen MB,Rasmussen JE,Villadsen K,Midtgaard SR,Kol S,Schoffelen S,Jensen KJ

更新日期：2018-08-17 00:00:00

abstract：:Circadian rhythms are a nearly universal feature of living organisms and affect almost every biological process. Our innate preference for mornings or evenings is determined by the phase of our circadian rhythms. We conduct a genome-wide association analysis of self-reported morningness, followed by analyses of biolog...

journal_title：Nature communications

authors： Hu Y,Shmygelska A,Tran D,Eriksson N,Tung JY,Hinds DA

更新日期：2016-02-02 00:00:00

abstract：:Whispering-gallery-mode resonators have been extensively used in conjunction with different materials for the development of a variety of photonic devices. Among the latter, hybrid structures, consisting of dielectric microspheres and colloidal core/shell semiconductor nanocrystals as gain media, have attracted intere...

journal_title：Nature communications

authors： Grivas C,Li C,Andreakou P,Wang P,Ding M,Brambilla G,Manna L,Lagoudakis P

更新日期：2013-01-01 00:00:00

abstract：:The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells, oscillates spontaneously in a wide variety of systems. Although much of the signal cascade regulating myosin activity has been characterized, the origin of such oscillatory behavior is still unclear. Here, we show that basal myosin II oscill...

journal_title：Nature communications

authors： Qin X,Hannezo E,Mangeat T,Liu C,Majumder P,Liu J,Choesmel-Cadamuro V,McDonald JA,Liu Y,Yi B,Wang X

更新日期：2018-03-23 00:00:00

abstract：:Nuclear factor-κB (NFκB) and peroxisome proliferator activated receptor-γ (PPARγ) are both transcription factors that perform distinct but overlapping roles in cellular regulation. Here we report that PPARγ acts as an E3 ubiquitin ligase, physically interacting with p65 to induce its ubiquitination and degradation. Th...

journal_title：Nature communications

authors： Hou Y,Moreau F,Chadee K

更新日期：2012-01-01 00:00:00

abstract：:The synergistic interaction among different components in complex catalysts is one of the crucial factors in determining catalytic performance. Here we report the interactions among the three components in controlling the catalytic performance of Cu-ZnO-ZrO2 (CZZ) catalyst for CO2 hydrogenation to methanol. The in sit...

journal_title：Nature communications

authors： Wang Y,Kattel S,Gao W,Li K,Liu P,Chen JG,Wang H

更新日期：2019-03-11 00:00:00

abstract：:A key question in materials science is how fast properties evolve, which relates to the kinetics of phase transformations. In metals, kinetics is primarily connected to diffusion, which for substitutional elements is enabled via mobile atomic-lattice vacancies. In fact, non-equilibrium vacancies are often required for...

journal_title：Nature communications

authors： Dumitraschkewitz P,Uggowitzer PJ,Gerstl SSA,Löffler JF,Pogatscher S

更新日期：2019-10-18 00:00:00

abstract：:Theoretical and experimental results have revealed that the lithium-ion storage capacity for nitrogen-doped graphene largely depends on the nitrogen-doping level. However, most nitrogen-doped carbon materials used for lithium-ion batteries are reported to have a nitrogen content of approximately 10 wt% because a highe...

journal_title：Nature communications

authors： Zheng F,Yang Y,Chen Q

更新日期：2014-11-06 00:00:00