Global patterns of the leaf economics spectrum in wetlands.

abstract：:The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available. Here we report cyclic peptide inhibitors of the KDM4A-C with selectivity over other KDMs/2OG oxygenases, including closely related KDM4D/E ...

journal_title：Nature communications

authors： Kawamura A,Münzel M,Kojima T,Yapp C,Bhushan B,Goto Y,Tumber A,Katoh T,King ON,Passioura T,Walport LJ,Hatch SB,Madden S,Müller S,Brennan PE,Chowdhury R,Hopkinson RJ,Suga H,Schofield CJ

更新日期：2017-04-06 00:00:00

abstract：:Much controversy exists regarding the structural organization of the yeast centromeric nucleosome and the role of the nonhistone protein, Scm3, in its assembly and architecture. Here we show that the substitution of H3 with its centromeric variant Cse4 results in octameric nucleosomes that organize DNA in a left-hande...

journal_title：Nature communications

authors： Dechassa ML,Wyns K,Li M,Hall MA,Wang MD,Luger K

更新日期：2011-01-01 00:00:00

abstract：:Ultra-small, magic-sized metal nanoclusters represent an important new class of materials with properties between molecules and particles. However, their small size challenges the conventional methods for structure characterization. Here we present the structure of ultra-stable Au144(SR)60 magic-sized nanoclusters obt...

journal_title：Nature communications

authors： Jensen KM,Juhas P,Tofanelli MA,Heinecke CL,Vaughan G,Ackerson CJ,Billinge SJ

更新日期：2016-06-14 00:00:00

abstract：:Cellular events that occur across the seminiferous epithelium in the mammalian testis during spermatogenesis are tightly coordinated by biologically active peptides released from laminin chains. Laminin-γ3 domain IV is released at the apical ectoplasmic specialization during spermiation and mediates restructuring of t...

journal_title：Nature communications

authors： Su L,Mruk DD,Lie PP,Silvestrini B,Cheng CY

更新日期：2012-01-01 00:00:00

abstract：:The power conversion efficiency of hybrid solid-state solar cells has more than doubled from 7 to 15% over the past year. This is largely as a result of the incorporation of organometallic trihalide perovskite absorbers into these devices. But, as promising as this development is, long-term operational stability is ju...

journal_title：Nature communications

authors： Leijtens T,Eperon GE,Pathak S,Abate A,Lee MM,Snaith HJ

更新日期：2013-01-01 00:00:00

abstract：:Here we report a rational strategy to orthogonally control assembly and disassembly of DNA-based nanostructures using specific IgG antibodies as molecular inputs. We first demonstrate that the binding of a specific antibody to a pair of antigen-conjugated split DNA input-strands induces their co-localization and recon...

journal_title：Nature communications

authors： Ranallo S,Sorrentino D,Ricci F

更新日期：2019-12-03 00:00:00

abstract：:Carbon forms one of nature's strongest chemical bonds; its allotropes having provided some of the most exciting scientific discoveries in recent times. The possibility of inter-allotropic transformations/hybridization of carbon is hence a topic of immense fundamental and technological interest. Such modifications usua...

journal_title：Nature communications

authors： Jung HY,Araujo PT,Kim YL,Jung SM,Jia X,Hong S,Ahn CW,Kong J,Dresselhaus MS,Kar S,Jung YJ

更新日期：2014-09-15 00:00:00

abstract：:Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, cone snails can rapidly switch between distinct venoms in response to predatory or defensive stimuli. Here, we show that the d...

journal_title：Nature communications

authors： Dutertre S,Jin AH,Vetter I,Hamilton B,Sunagar K,Lavergne V,Dutertre V,Fry BG,Antunes A,Venter DJ,Alewood PF,Lewis RJ

更新日期：2014-03-24 00:00:00

abstract：:A number of marine organisms use muscle-controlled surface structures to achieve rapid changes in colour and transparency with outstanding reversibility. Inspired by these display tactics, we develop analogous deformation-controlled surface-engineering approaches via strain-dependent cracks and folds to realize the fo...

journal_title：Nature communications

authors： Zeng S,Zhang D,Huang W,Wang Z,Freire SG,Yu X,Smith AT,Huang EY,Nguon H,Sun L

更新日期：2016-07-08 00:00:00

abstract：:The Schrödinger equation is a fundamental equation to describe the wave function of a quantum-mechanical system. The similar forms between the Schrödinger equation and the paraxial wave equation allow a paradigm shift from the quantum mechanics to classical fields, opening up a plethora of interesting phenomena includ...

journal_title：Nature communications

authors： Shen YX,Peng YG,Cai F,Huang K,Zhao DG,Qiu CW,Zheng H,Zhu XF

更新日期：2019-07-30 00:00:00

abstract：:Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging. We conducted a chemical biology screen and identified a subset of neuroendocrine tumors displaying a striking pattern of sensitivity to inhibition of the choles...

journal_title：Nature communications

authors： Mahoney CE,Pirman D,Chubukov V,Sleger T,Hayes S,Fan ZP,Allen EL,Chen Y,Huang L,Liu M,Zhang Y,McDonald G,Narayanaswamy R,Choe S,Chen Y,Gross S,Cianchetta G,Padyana AK,Murray S,Liu W,Marks KM,Murtie J,Dorsch M,

更新日期：2019-01-09 00:00:00

abstract：:Efficient charge separation is of crucial importance for the improvement of photocatalytic activity for solar hydrogen evolution. Here we report efficient photo-generated charge separation by twin-induced one-dimensional homojunctions with type-II staggered band alignment, using a ternary chalcogenate, i.e. Cd0.5Zn0.5...

journal_title：Nature communications

authors： Liu M,Jing D,Zhou Z,Guo L

更新日期：2013-01-01 00:00:00

abstract：:Chemical synthesis of amino acids from renewable sources is an alternative route to the current processes based on fermentation. Here, we report visible-light-driven amination of biomass-derived α-hydroxyl acids and glucose into amino acids using NH3 at 50 °C. Ultrathin CdS nanosheets are identified as an efficient an...

journal_title：Nature communications

authors： Song S,Qu J,Han P,Hülsey MJ,Zhang G,Wang Y,Wang S,Chen D,Lu J,Yan N

更新日期：2020-09-29 00:00:00

abstract：:Somatic mutations contribute to tumorigenesis. Although these mutations occur in all proliferating cells, their accumulation under non-malignant conditions, such as in autoimmune disorders, has not been investigated. Here, we show that patients with newly diagnosed rheumatoid arthritis have expanded CD8+ T-cell clones...

journal_title：Nature communications

authors： Savola P,Kelkka T,Rajala HL,Kuuliala A,Kuuliala K,Eldfors S,Ellonen P,Lagström S,Lepistö M,Hannunen T,Andersson EI,Khajuria RK,Jaatinen T,Koivuniemi R,Repo H,Saarela J,Porkka K,Leirisalo-Repo M,Mustjoki S

更新日期：2017-06-21 00:00:00

abstract：:Understanding and predicting radiation damage evolution in complex materials is crucial for developing next-generation nuclear energy sources. Here, using a combination of ion beam irradiation, transmission electron microscopy and X-ray diffraction, we show that, contrary to the behaviour observed in pyrochlores, the ...

journal_title：Nature communications

authors： Uberuaga BP,Tang M,Jiang C,Valdez JA,Smith R,Wang Y,Sickafus KE

更新日期：2015-10-29 00:00:00

abstract：:Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) with minimized RNA off-target activities display constrained editing scopes with efficient editing...

journal_title：Nature communications

authors： Li S,Yuan B,Cao J,Chen J,Chen J,Qiu J,Zhao XM,Wang X,Qiu Z,Cheng TL

更新日期：2020-11-17 00:00:00

abstract：:Deep subsurface formations (for example, high-temperature oil reservoirs) are candidate sites for carbon capture and storage technology. However, very little is known about how the subsurface microbial community would respond to an increase in CO2 pressure resulting from carbon capture and storage. Here we construct m...

journal_title：Nature communications

authors： Mayumi D,Dolfing J,Sakata S,Maeda H,Miyagawa Y,Ikarashi M,Tamaki H,Takeuchi M,Nakatsu CH,Kamagata Y

更新日期：2013-01-01 00:00:00

abstract：:A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are thought less likely to be determinants of critical functions. Here we train a machine learning model using functional, mutational an...

journal_title：Nature communications

authors： Wells A,Heckerman D,Torkamani A,Yin L,Sebat J,Ren B,Telenti A,di Iulio J

更新日期：2019-11-20 00:00:00

abstract：:There is increasing evidence from genome-wide association studies for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children, yet the effects of protein-coding variants on ALL risk have not been systematically evaluated. Here we show a missense variant in CDKN2A associate...

journal_title：Nature communications

authors： Xu H,Zhang H,Yang W,Yadav R,Morrison AC,Qian M,Devidas M,Liu Y,Perez-Andreu V,Zhao X,Gastier-Foster JM,Lupo PJ,Neale G,Raetz E,Larsen E,Bowman WP,Carroll WL,Winick N,Williams R,Hansen T,Holm JC,Mardis E,Fulton

更新日期：2015-06-24 00:00:00

abstract：:Human chromosomes are captured along microtubule walls (lateral attachment) and then tethered to microtubule-ends (end-on attachment) through a multi-step end-on conversion process. Upstream regulators that orchestrate this remarkable change in the plane of kinetochore-microtubule attachment in human cells are not kno...

journal_title：Nature communications

authors： Shrestha RL,Conti D,Tamura N,Braun D,Ramalingam RA,Cieslinski K,Ries J,Draviam VM

更新日期：2017-07-28 00:00:00

abstract：:The elastic-to-plastic transition during the deformation of a dislocation-free nanoscale volume is accompanied by displacement bursts associated with dislocation nucleation. The dislocations that nucleate during the so-called "pop-in" burst take the form of prismatic dislocation loops (PDLs) and exhibit characteristic...

journal_title：Nature communications

authors： Lee S,Vaid A,Im J,Kim B,Prakash A,Guénolé J,Kiener D,Bitzek E,Oh SH

更新日期：2020-05-12 00:00:00

abstract：:Choroidal neovascularization (CNV) is a major cause of visual impairment in patients suffering from wet age-related macular degeneration (AMD), particularly when refractory to intraocular anti-VEGF injections. Here we report that treatment with the oral mineralocorticoid receptor (MR) antagonist spironolactone reduces...

journal_title：Nature communications

authors： Zhao M,Mantel I,Gelize E,Li X,Xie X,Arboleda A,Seminel M,Levy-Boukris R,Dernigoghossian M,Prunotto A,Andrieu-Soler C,Rivolta C,Canonica J,Naud MC,Lechner S,Farman N,Bravo-Osuna I,Herrero-Vanrell R,Jaisser F,Behar-Co

更新日期：2019-01-21 00:00:00

abstract：:Quasicrystals, materials with aperiodic long-range order, have been found in intermetallics, soft materials such as colloids and supermolecules, and also in two-dimensional monolayer films. Here we present the first example of three-dimensional growth of a single-element quasicrystalline film. Using a hitherto unexplo...

journal_title：Nature communications

authors： Sharma HR,Nozawa K,Smerdon JA,Nugent PJ,McLeod I,Dhanak VR,Shimoda M,Ishii Y,Tsai AP,McGrath R

更新日期：2013-01-01 00:00:00

abstract：:Sensitive detection of protein interactions and post-translational modifications of native proteins is a challenge for research and diagnostic purposes. A method for this, which could be used in point-of-care devices and high-throughput screening, should be reliable, cost effective and robust. To achieve this, here we...

journal_title：Nature communications

authors： Koos B,Cane G,Grannas K,Löf L,Arngården L,Heldin J,Clausson CM,Klaesson A,Hirvonen MK,de Oliveira FM,Talibov VO,Pham NT,Auer M,Danielson UH,Haybaeck J,Kamali-Moghaddam M,Söderberg O

更新日期：2015-06-12 00:00:00

abstract：:Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is termed clonal hematopoiesis of indeterminate potential (CHIP) and is a...

journal_title：Nature communications

authors： Mouhieddine TH,Sperling AS,Redd R,Park J,Leventhal M,Gibson CJ,Manier S,Nassar AH,Capelletti M,Huynh D,Bustoros M,Sklavenitis-Pistofidis R,Tahri S,Hornburg K,Dumke H,Itani MM,Boehner CJ,Liu CJ,AlDubayan SH,Reardon B

更新日期：2020-06-12 00:00:00

abstract：:Crystalline solids are generally known as excellent heat conductors, amorphous materials or glasses as thermal insulators. It has thus come as a surprise that certain crystal structures defy this paradigm. A prominent example are type-I clathrates and other materials with guest-host structures. They sustain low-energy...

journal_title：Nature communications

authors： Ikeda MS,Euchner H,Yan X,Tomeš P,Prokofiev A,Prochaska L,Lientschnig G,Svagera R,Hartmann S,Gati E,Lang M,Paschen S

更新日期：2019-02-21 00:00:00

abstract：:The successful mitigation of emerging wildlife diseases may involve controversial host culling. For livestock, 'preemptive host culling' is an accepted practice involving the removal of herds with known contact to infected populations. When applied to wildlife, this proactive approach comes in conflict with biodiversi...

journal_title：Nature communications

authors： Mysterud A,Hopp P,Alvseike KR,Benestad SL,Nilsen EB,Rolandsen CM,Strand O,Våge J,Viljugrein H

更新日期：2020-09-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Tebo AG,Gautier A

更新日期：2019-08-14 00:00:00

abstract：:Studies on vesicle formation by the Coat Protein I (COPI) complex have contributed to a basic understanding of how vesicular transport is initiated. Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be required for the fission stage of COPI vesicle formation. Here, we find that PA with vary...

journal_title：Nature communications

authors： Park SY,Yang JS,Li Z,Deng P,Zhu X,Young D,Ericsson M,Andringa RLH,Minnaard AJ,Zhu C,Sun F,Moody DB,Morris AJ,Fan J,Hsu VW

更新日期：2019-07-30 00:00:00

abstract：:Thalamic inputs of cells in sensory cortices are outnumbered by local connections. Thus, it was suggested that robust sensory response in layer 4 emerges due to synchronized thalamic activity. To investigate the role of both inputs in the generation of correlated cortical activities, we isolated the thalamic excitator...

journal_title：Nature communications

authors： Cohen-Kashi Malina K,Mohar B,Rappaport AN,Lampl I

更新日期：2016-09-12 00:00:00