Orthogonal regulation of DNA nanostructure self-assembly and disassembly using antibodies.

abstract：:Sequencing of a single-cell genome requires DNA amplification, a process prone to introducing bias and errors into the amplified genome. Here we introduce a novel multiple displacement amplification (MDA) method based on the unique DNA primase features of Thermus thermophilus (Tth) PrimPol. TthPrimPol displays a poten...

journal_title：Nature communications

authors： Picher ÁJ,Budeus B,Wafzig O,Krüger C,García-Gómez S,Martínez-Jiménez MI,Díaz-Talavera A,Weber D,Blanco L,Schneider A

更新日期：2016-11-29 00:00:00

abstract：:Granule cells are the dominant cell type of the olfactory bulb inhibiting mitral and tufted cells via dendrodendritic synapses; yet the factors regulating the strength of their inhibitory output, and, therefore, their impact on odour discrimination, remain unknown. Here we show that GABAAR β3-subunits are distributed ...

journal_title：Nature communications

authors： Nunes D,Kuner T

更新日期：2015-11-23 00:00:00

abstract：:Bacterial contamination of biological channels, catheters or water resources is a major threat to public health, which can be amplified by the ability of bacteria to swim upstream. The mechanisms of this 'rheotaxis', the reorientation with respect to flow gradients, are still poorly understood. Here, we follow individ...

journal_title：Nature communications

authors： Mathijssen AJTM,Figueroa-Morales N,Junot G,Clément É,Lindner A,Zöttl A

更新日期：2019-07-31 00:00:00

abstract：:When two periodic potentials compete in materials, one may adopt the other, which straightforwardly generates topological defects. Of particular interest are domain walls in charge-, dipole-, and spin-ordered systems, which govern macroscopic properties and important functionality. However, detailed atomic and electro...

journal_title：Nature communications

authors： Park JW,Cho GY,Lee J,Yeom HW

更新日期：2019-09-06 00:00:00

abstract：:Membranes with nano-apertures are versatile templates that possess a wide range of electronic, optical and biomedical applications. However, such membranes have been limited to silicon-based inorganic materials to utilize standard semiconductor processes. Here we report a new type of flexible and free-standing polymer...

journal_title：Nature communications

authors： Cho H,Kim J,Park H,Won Bang J,Seop Hyun M,Bae Y,Ha L,Yoon Kim D,Min Kang S,Jung Park T,Seo S,Choi M,Suh KY

更新日期：2014-01-01 00:00:00

abstract：:How rapidly natural selection sorts genome-wide standing genetic variation during adaptation remains largely unstudied experimentally. Here, we present a genomic release-recapture experiment using paired threespine stickleback fish populations adapted to selectively different lake and stream habitats. First, we use po...

journal_title：Nature communications

authors： Laurentino TG,Moser D,Roesti M,Ammann M,Frey A,Ronco F,Kueng B,Berner D

更新日期：2020-04-21 00:00:00

abstract：:Everyone experiences common events differently. This leads to personal memories that presumably provide neural signatures of individual identity when events are reimagined. We present initial evidence that these signatures can be read from brain activity. To do this, we progress beyond previous work that has deployed ...

journal_title：Nature communications

authors： Anderson AJ,McDermott K,Rooks B,Heffner KL,Dodell-Feder D,Lin FV

更新日期：2020-11-20 00:00:00

abstract：:HIV infection causes bone loss. We previously reported that immunosuppression-mediated B-cell production of receptor activator of NF-κB ligand (RANKL) coupled with decline in osteoprotegerin correlate with decreased bone mineral density (BMD) in untreated HIV infection. Paradoxically, antiretroviral therapy (ART) wors...

journal_title：Nature communications

authors： Ofotokun I,Titanji K,Vikulina T,Roser-Page S,Yamaguchi M,Zayzafoon M,Williams IR,Weitzmann MN

更新日期：2015-09-22 00:00:00

abstract：:Many ecological responses to climate change have been documented. However, due to indirect effects, some responses can be complex and difficult to predict. For example, our understanding of effects on consumers involving responses on several trophic levels is limited. Here, combining the knowledge of trophic interacti...

journal_title：Nature communications

authors： Jonsson T,Setzer M

更新日期：2015-01-14 00:00:00

abstract：:Paternal epigenetic inheritance is gaining attention for its growing medical relevance. However, the form in which paternal epigenetic information is transmitted to offspring and how it influences offspring development remain poorly understood. Here we show that in C. elegans, sperm-inherited chromatin states transmit...

journal_title：Nature communications

authors： Kaneshiro KR,Rechtsteiner A,Strome S

更新日期：2019-03-20 00:00:00

abstract：:Nature has developed striking light-powered proteins such as bacteriorhodopsin, which can convert light energy into conformational changes for biological functions. Such natural machines are a great source of inspiration for creation of their synthetic analogues. However, synthetic molecular machines typically operate...

journal_title：Nature communications

authors： Kuzyk A,Yang Y,Duan X,Stoll S,Govorov AO,Sugiyama H,Endo M,Liu N

更新日期：2016-02-02 00:00:00

abstract：:Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on ART combination therapies (ACTs). Decreased sensitivity to ARTs is emerging, making it critically important to understand the mechan...

journal_title：Nature communications

authors： Bridgford JL,Xie SC,Cobbold SA,Pasaje CFA,Herrmann S,Yang T,Gillett DL,Dick LR,Ralph SA,Dogovski C,Spillman NJ,Tilley L

更新日期：2018-09-18 00:00:00

abstract：:Urban residential buildings make large contributions to energy consumption. Energy consumption per square meter is most widely used to measure energy efficiency in urban residential buildings. This study aims to explore whether it is an appropriate indicator. An extended STIRPAT model was used based on the survey data...

journal_title：Nature communications

authors： Gao J,Zhong X,Cai W,Ren H,Huo T,Wang X,Mi Z

更新日期：2019-10-30 00:00:00

abstract：:Application of force on biomolecules has been instrumental in understanding biofunctional behaviour from single molecules to complex collections of cells. Current approaches, for example, those based on atomic force microscopy or magnetic or optical tweezers, are powerful but limited in their applicability as integrat...

journal_title：Nature communications

authors： Webster A,Vollmer F,Sato Y

更新日期：2014-10-21 00:00:00

abstract：:Fibrosis due to extracellular matrix (ECM) secretion from myofibroblasts complicates many chronic liver diseases causing scarring and organ failure. Integrin-dependent interaction with scar ECM promotes pro-fibrotic features. However, the pathological intracellular mechanism in liver myofibroblasts is not completely u...

journal_title：Nature communications

authors： Martin K,Pritchett J,Llewellyn J,Mullan AF,Athwal VS,Dobie R,Harvey E,Zeef L,Farrow S,Streuli C,Henderson NC,Friedman SL,Hanley NA,Piper Hanley K

更新日期：2016-08-18 00:00:00

abstract：:CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs systemically. Here, we report a generalizable methodology that allows en...

journal_title：Nature communications

authors： Wei T,Cheng Q,Min YL,Olson EN,Siegwart DJ

更新日期：2020-06-26 00:00:00

abstract：:Modern ab initio calculations predict ionic and superionic states in highly compressed water and ammonia. The prediction apparently contradicts state-of-the-art experimentally established phase diagrams overwhelmingly dominated by molecular phases. Here we present experimental evidence that the threshold pressure of ~...

journal_title：Nature communications

authors： Palasyuk T,Troyan I,Eremets M,Drozd V,Medvedev S,Zaleski-Ejgierd P,Magos-Palasyuk E,Wang H,Bonev SA,Dudenko D,Naumov P

更新日期：2014-03-24 00:00:00

abstract：:Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signalling modulates sys...

journal_title：Nature communications

authors： Uno K,Yamada T,Ishigaki Y,Imai J,Hasegawa Y,Sawada S,Kaneko K,Ono H,Asano T,Oka Y,Katagiri H

更新日期：2015-08-13 00:00:00

abstract：:Biocatalytic cyclization is highly desirable for efficient synthesis of biologically derived chemical substances, such as the commodity chemicals ε-caprolactam and δ-valerolactam. To identify biocatalysts in lactam biosynthesis, we develop a caprolactam-detecting genetic enzyme screening system (CL-GESS). The Alcalige...

journal_title：Nature communications

authors： Yeom SJ,Kim M,Kwon KK,Fu Y,Rha E,Park SH,Lee H,Kim H,Lee DH,Kim DM,Lee SG

更新日期：2018-11-29 00:00:00

abstract：:Theory, simulations and experimental results have suggested an important role of internal friction in the kinetics of protein folding. Recent experiments on spectrin domains provided the first evidence for a pronounced contribution of internal friction in proteins that fold on the millisecond timescale. However, it ha...

journal_title：Nature communications

authors： Borgia A,Wensley BG,Soranno A,Nettels D,Borgia MB,Hoffmann A,Pfeil SH,Lipman EA,Clarke J,Schuler B

更新日期：2012-01-01 00:00:00

abstract：:Chromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosome(s). Considered as an early event in tumour development, this form of genome instability plays a prominent role in tumour onset. Chromothri...

journal_title：Nature communications

authors： Voronina N,Wong JKL,Hübschmann D,Hlevnjak M,Uhrig S,Heilig CE,Horak P,Kreutzfeldt S,Mock A,Stenzinger A,Hutter B,Fröhlich M,Brors B,Jahn A,Klink B,Gieldon L,Sieverling L,Feuerbach L,Chudasama P,Beck K,Kroiss M,H

更新日期：2020-05-08 00:00:00

abstract：:Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma. To explore the mechanism by which Ca(2+) blocks intercellular communication during tissue injury, we determined the X-ray crystal structures of...

journal_title：Nature communications

authors： Bennett BC,Purdy MD,Baker KA,Acharya C,McIntire WE,Stevens RC,Zhang Q,Harris AL,Abagyan R,Yeager M

更新日期：2016-01-12 00:00:00

abstract：:Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is mostly unknown. Here, we show that increased osteoclastic miR-214-...

journal_title：Nature communications

authors： Li D,Liu J,Guo B,Liang C,Dang L,Lu C,He X,Cheung HY,Xu L,Lu C,He B,Liu B,Shaikh AB,Li F,Wang L,Yang Z,Au DW,Peng S,Zhang Z,Zhang BT,Pan X,Qian A,Shang P,Xiao L,Jiang B,Wong CK,Xu J,Bian Z,Liang Z,

更新日期：2016-03-07 00:00:00

abstract：:The occurrence of Oceanic Anoxic Event 2 (OAE2) 94 million years ago is considered to be one of the largest carbon cycle perturbations in the Earth's history. The marked increase in the spatial extent of the anoxic conditions in the world's oceans associated with OAE2 resulted in the mass accumulation of organic-rich ...

journal_title：Nature communications

authors： Takashima R,Nishi H,Yamanaka T,Tomosugi T,Fernando AG,Tanabe K,Moriya K,Kawabe F,Hayashi K

更新日期：2011-01-01 00:00:00

abstract：:Erythropoietin regulates erythropoiesis in a hypoxia-inducible manner. Here we generate inherited super-anaemic mice (ISAM) as a mouse model of adult-onset anaemia caused by erythropoietin deficiency. ISAM express erythropoietin in the liver but lack erythropoietin production in the kidney. Around weaning age, when th...

journal_title：Nature communications

authors： Yamazaki S,Souma T,Hirano I,Pan X,Minegishi N,Suzuki N,Yamamoto M

更新日期：2013-01-01 00:00:00

abstract：:Electrodynamic responses from three-dimensional topological insulators are characterized by the universal magnetoelectric term constituent of the Lagrangian formalism. The quantized magnetoelectric coupling, which is generally referred to as topological magnetoelectric effect, has been predicted to induce exotic pheno...

journal_title：Nature communications

authors： Okada KN,Takahashi Y,Mogi M,Yoshimi R,Tsukazaki A,Takahashi KS,Ogawa N,Kawasaki M,Tokura Y

更新日期：2016-07-20 00:00:00

abstract：:Artificial photosynthesis is a vibrant field of research aiming at converting abundant, low energy molecules such as water, nitrogen or carbon dioxide into fuels or useful chemicals by means of solar energy input. Photo-electrochemical reduction of carbon dioxide is an appealing strategy, aiming at reducing the greenh...

journal_title：Nature communications

authors： Pati PB,Wang R,Boutin E,Diring S,Jobic S,Barreau N,Odobel F,Robert M

更新日期：2020-07-13 00:00:00

abstract：:Semaphorins and their transmembrane receptors, Plexins, are key regulators of axon guidance and development of neuronal connectivity. B-type Plexins respond to Class IV semaphorins and mediate a variety of developmental functions. Here we report that the expression of Plexin-B2 and its high-affinity ligand, Sema4C, pe...

journal_title：Nature communications

authors： Paldy E,Simonetti M,Worzfeld T,Bali KK,Vicuña L,Offermanns S,Kuner R

更新日期：2017-08-02 00:00:00

abstract：:The actin-like protein MreB has been proposed to coordinate the synthesis of the cell wall to determine cell shape in bacteria. MreB is preferentially localized to areas of the cell with specific curved geometries, avoiding the cell poles. It remains unclear whether MreB's curvature preference is regulated by addition...

journal_title：Nature communications

authors： Bratton BP,Shaevitz JW,Gitai Z,Morgenstein RM

更新日期：2018-07-18 00:00:00

abstract：:For over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemb...

journal_title：Nature communications

authors： Laine VN,Gossmann TI,Schachtschneider KM,Garroway CJ,Madsen O,Verhoeven KJ,de Jager V,Megens HJ,Warren WC,Minx P,Crooijmans RP,Corcoran P,Great Tit HapMap Consortium.,Sheldon BC,Slate J,Zeng K,van Oers K,Visser ME,Gro

更新日期：2016-01-25 00:00:00