A mouse model of adult-onset anaemia due to erythropoietin deficiency.

abstract：:The resting-state human brain networks underlie fundamental cognitive functions and consist of complex interactions among brain regions. However, the level of complexity of the resting-state networks has not been quantified, which has prevented comprehensive descriptions of the brain activity as an integrative system....

journal_title：Nature communications

authors： Watanabe T,Hirose S,Wada H,Imai Y,Machida T,Shirouzu I,Konishi S,Miyashita Y,Masuda N

更新日期：2013-01-01 00:00:00

abstract：:Circadian clock mechanisms have been extensively investigated but the main rate-limiting step that determines circadian period remains unclear. Formation of a stable complex between clock proteins and CK1 is a conserved feature in eukaryotic circadian mechanisms. Here we show that the FRQ-CK1 interaction, but not FRQ ...

journal_title：Nature communications

authors： Liu X,Chen A,Caicedo-Casso A,Cui G,Du M,He Q,Lim S,Kim HJ,Hong CI,Liu Y

更新日期：2019-09-25 00:00:00

abstract：:The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthesis and widespread activation of muscle-spec...

journal_title：Nature communications

authors： Moretti I,Ciciliot S,Dyar KA,Abraham R,Murgia M,Agatea L,Akimoto T,Bicciato S,Forcato M,Pierre P,Uhlenhaut NH,Rigby PW,Carvajal JJ,Blaauw B,Calabria E,Schiaffino S

更新日期：2016-08-03 00:00:00

abstract：:The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-κB, MAP kinase and Wnt signalling. However, the tumour suppressing mechanisms of CYLD remain poorly understood. Here we show that loss of CYLD catalytic activity causes impaired DNA damage-induced p53 stabilization and activation in epitheli...

journal_title：Nature communications

authors： Fernández-Majada V,Welz PS,Ermolaeva MA,Schell M,Adam A,Dietlein F,Komander D,Büttner R,Thomas RK,Schumacher B,Pasparakis M

更新日期：2016-08-26 00:00:00

abstract：:Soliton microcombs constitute chip-scale optical frequency combs, and have the potential to impact a myriad of applications from frequency synthesis and telecommunications to astronomy. The demonstration of soliton formation via self-injection locking of the pump laser to the microresonator has significantly relaxed t...

journal_title：Nature communications

authors： Voloshin AS,Kondratiev NM,Lihachev GV,Liu J,Lobanov VE,Dmitriev NY,Weng W,Kippenberg TJ,Bilenko IA

更新日期：2021-01-11 00:00:00

abstract：:Human mesenchymal stromal cells (hMSCs) are a promising source for engineered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and install novel cellular functions. Here, we describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutagenesis and integrat...

journal_title：Nature communications

authors： Srifa W,Kosaric N,Amorin A,Jadi O,Park Y,Mantri S,Camarena J,Gurtner GC,Porteus M

更新日期：2020-05-18 00:00:00

abstract：:Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/r...

journal_title：Nature communications

authors： Siddiqi FH,Menzies FM,Lopez A,Stamatakou E,Karabiyik C,Ureshino R,Ricketts T,Jimenez-Sanchez M,Esteban MA,Lai L,Tortorella MD,Luo Z,Liu H,Metzakopian E,Fernandes HJR,Bassett A,Karran E,Miller BL,Fleming A,Rubinsztei

更新日期：2019-04-18 00:00:00

abstract：:Constitutive activation of Wnt/β-catenin inhibits oligodendrocyte myelination. Tcf7l2/Tcf4, a β-catenin transcriptional partner, is required for oligodendrocyte differentiation. How Tcf7l2 modifies β-catenin signalling and controls myelination remains elusive. Here we define a stage-specific Tcf7l2-regulated transcrip...

journal_title：Nature communications

authors： Zhao C,Deng Y,Liu L,Yu K,Zhang L,Wang H,He X,Wang J,Lu C,Wu LN,Weng Q,Mao M,Li J,van Es JH,Xin M,Parry L,Goldman SA,Clevers H,Lu QR

更新日期：2016-03-09 00:00:00

abstract：:Granule cells are the dominant cell type of the olfactory bulb inhibiting mitral and tufted cells via dendrodendritic synapses; yet the factors regulating the strength of their inhibitory output, and, therefore, their impact on odour discrimination, remain unknown. Here we show that GABAAR β3-subunits are distributed ...

journal_title：Nature communications

authors： Nunes D,Kuner T

更新日期：2015-11-23 00:00:00

abstract：:MicroRNAs (miRNAs) are critical to somatic cell reprogramming into induced pluripotent stem cells (iPSCs), however, exactly how miRNA expression changes support the transition to pluripotency requires further investigation. Here we use a murine secondary reprogramming system to sample cellular trajectories towards iPS...

journal_title：Nature communications

authors： Clancy JL,Patel HR,Hussein SM,Tonge PD,Cloonan N,Corso AJ,Li M,Lee DS,Shin JY,Wong JJ,Bailey CG,Benevento M,Munoz J,Chuah A,Wood D,Rasko JE,Heck AJ,Grimmond SM,Rogers IM,Seo JS,Wells CA,Puri MC,Nagy A,Preiss

更新日期：2014-12-10 00:00:00

abstract：:Genome replication is highly regulated in time and space, but the rules governing the remodeling of these programs during evolution remain largely unknown. We generated genome-wide replication timing profiles for ten Lachancea yeasts, covering a continuous evolutionary range from closely related to more divergent spec...

journal_title：Nature communications

authors： Agier N,Delmas S,Zhang Q,Fleiss A,Jaszczyszyn Y,van Dijk E,Thermes C,Weigt M,Cosentino-Lagomarsino M,Fischer G

更新日期：2018-06-06 00:00:00

abstract：:Accurate pathogenicity prediction of missense variants is critically important in genetic studies and clinical diagnosis. Previously published prediction methods have facilitated the interpretation of missense variants but have limited performance. Here, we describe MVP (Missense Variant Pathogenicity prediction), a n...

journal_title：Nature communications

authors： Qi H,Zhang H,Zhao Y,Chen C,Long JJ,Chung WK,Guan Y,Shen Y

更新日期：2021-01-21 00:00:00

abstract：:The original version of this Article contained errors in Figs. 1a, 2a, 3a, and 4b, in which the units on the scale bars incorrectly read 'µm' rather than the correct 'nm.' This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Babakhanova G,Turiv T,Guo Y,Hendrikx M,Wei QH,Schenning APHJ,Broer DJ,Lavrentovich OD

更新日期：2018-03-14 00:00:00

abstract：:High harmonics generated by counter-rotating laser fields at the fundamental and second harmonic frequencies have raised important interest as a table-top source of circularly polarized ultrashort extreme-ultraviolet light. However, this emission has not yet been fully characterized: in particular it was assumed to be...

journal_title：Nature communications

authors： Barreau L,Veyrinas K,Gruson V,Weber SJ,Auguste T,Hergott JF,Lepetit F,Carré B,Houver JC,Dowek D,Salières P

更新日期：2018-11-09 00:00:00

abstract：:Starting from the gas phase, small clusters can be produced and deposited with huge flexibility with regard to composition, materials choice and cluster size. Despite many advances in experimental characterization, a detailed morphology of such clusters is still lacking. Here we present an atomic scale observation as ...

journal_title：Nature communications

authors： Bals S,Van Aert S,Romero CP,Lauwaet K,Van Bael MJ,Schoeters B,Partoens B,Yücelen E,Lievens P,Van Tendeloo G

更新日期：2012-06-12 00:00:00

abstract：:Glacier retreat is a worldwide phenomenon with important consequences for the hydrological cycle and downstream ecosystem structure and functioning. To determine the effects of glacier retreat on aquatic communities, we conducted a 4-year flow manipulation in a tropical glacier-fed stream. Compared with an adjacent re...

journal_title：Nature communications

authors： Cauvy-Fraunié S,Andino P,Espinosa R,Calvez R,Jacobsen D,Dangles O

更新日期：2016-06-24 00:00:00

abstract：:Transition metal oxides host a wealth of exotic phenomena ranging from charge, orbital and magnetic order to nontrivial topological phases and superconductivity. In order to translate these unique materials properties into device functionalities these materials must be doped; however, the nature of carriers and their ...

journal_title：Nature communications

authors： Verdi C,Caruso F,Giustino F

更新日期：2017-06-08 00:00:00

abstract：:Epitaxy is widely employed to create highly oriented crystalline films. A less appreciated, but nonetheless powerful means of creating such films is via topotactic transformation, in which a chemical reaction transforms a single crystal of one phase into a single crystal of a different phase, which inherits its orient...

journal_title：Nature communications

authors： Mairoser T,Mundy JA,Melville A,Hodash D,Cueva P,Held R,Glavic A,Schubert J,Muller DA,Schlom DG,Schmehl A

更新日期：2015-07-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Maury MM,Bracq-Dieye H,Huang L,Vales G,Lavina M,Thouvenot P,Disson O,Leclercq A,Brisse S,Lecuit M

更新日期：2019-08-06 00:00:00

abstract：:Silk and silk fibroin, the biomaterial from nature, nowadays are being widely utilized in many cutting-edge micro/nanodevices/systems via advanced micro/nanofabrication techniques. Herein, for the first time to our knowledge, we report aqueous multiphoton lithography of diversiform-regenerated-silk-fibroin-centric ink...

journal_title：Nature communications

authors： Sun YL,Li Q,Sun SM,Huang JC,Zheng BY,Chen QD,Shao ZZ,Sun HB

更新日期：2015-10-16 00:00:00

abstract：:Coordination of ciliary beating is essential to ensure mucus clearance in the airway tract. The orientation and synchronization of ciliary motion responds in part to the organization of the underlying cytoskeletal networks. Using electron tomography on mouse trachea, we show that basal bodies are collectively hooked a...

journal_title：Nature communications

authors： Clare DK,Magescas J,Piolot T,Dumoux M,Vesque C,Pichard E,Dang T,Duvauchelle B,Poirier F,Delacour D

更新日期：2014-09-12 00:00:00

abstract：:The Lyme disease agent, Borrelia burgdorferi, colonizes the gut of the tick Ixodes scapularis, which transmits the pathogen to vertebrate hosts including humans. Here we show that B. burgdorferi colonization increases the expression of several tick gut genes including pixr, encoding a secreted gut protein with a Reele...

journal_title：Nature communications

authors： Narasimhan S,Schuijt TJ,Abraham NM,Rajeevan N,Coumou J,Graham M,Robson A,Wu MJ,Daffre S,Hovius JW,Fikrig E

更新日期：2017-08-04 00:00:00

abstract：:Oxygenic photosynthetic organisms perform solar energy conversion of water and CO2 to O2 and sugar at a broad range of wavelengths and light intensities. These cells also metabolize sugars using a respiratory system that functionally overlaps the photosynthetic apparatus. In this study, we describe the harvesting of p...

journal_title：Nature communications

authors： Saper G,Kallmann D,Conzuelo F,Zhao F,Tóth TN,Liveanu V,Meir S,Szymanski J,Aharoni A,Schuhmann W,Rothschild A,Schuster G,Adir N

更新日期：2018-06-04 00:00:00

abstract：:Spinal cord injury (SCI) often causes severe and permanent disabilities due to the regenerative failure of severed axons. Here we report significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This is achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hy...

journal_title：Nature communications

authors： Leibinger M,Zeitler C,Gobrecht P,Andreadaki A,Gisselmann G,Fischer D

更新日期：2021-01-15 00:00:00

abstract：:Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers....

journal_title：Nature communications

authors： Seki R,Li C,Fang Q,Hayashi S,Egawa S,Hu J,Xu L,Pan H,Kondo M,Sato T,Matsubara H,Kamiyama N,Kitajima K,Saito D,Liu Y,Gilbert MT,Zhou Q,Xu X,Shiroishi T,Irie N,Tamura K,Zhang G

更新日期：2017-02-06 00:00:00

abstract：:Molecular machines carry out their function by equilibrium mechanical motions in environments that are far from thermodynamic equilibrium. The mechanically equilibrated character of the trajectories of the macromolecule has allowed development of a powerful theoretical description, reminiscent of Onsager's trajectory ...

journal_title：Nature communications

authors： Astumian RD

更新日期：2019-08-23 00:00:00

abstract：:The nitrogen-vacancy (NV) centre in diamond is emerging as a promising platform for solid-state quantum information processing and nanoscale metrology. Of interest in these applications is the manipulation of the NV charge, which can be attained by optical excitation. Here, we use two-colour optical microscopy to inve...

journal_title：Nature communications

authors： Jayakumar H,Henshaw J,Dhomkar S,Pagliero D,Laraoui A,Manson NB,Albu R,Doherty MW,Meriles CA

更新日期：2016-08-30 00:00:00

abstract：:Astrocytic endfeet cover the entire cerebral vasculature and serve as exchange sites for ions, metabolites and energy substrates from the blood to the brain. They maintain endothelial tight junctions that form the blood-brain barrier (BBB) and release vasoactive molecules that regulate vascular tone. Malignant gliomas...

journal_title：Nature communications

authors： Watkins S,Robel S,Kimbrough IF,Robert SM,Ellis-Davies G,Sontheimer H

更新日期：2014-06-19 00:00:00

abstract：:Many applications proposed for graphene require multiple sheets be assembled into a monolithic structure. The ability to maintain structural integrity upon large deformation is essential to ensure a macroscopic material which functions reliably. However, it has remained a great challenge to achieve high elasticity in ...

journal_title：Nature communications

authors： Qiu L,Liu JZ,Chang SL,Wu Y,Li D

更新日期：2012-01-01 00:00:00

abstract：:A central paradigm in conservation biology is that population bottlenecks reduce genetic diversity and population viability. In an era of biodiversity loss and climate change, understanding the determinants and consequences of bottlenecks is therefore an important challenge. However, as most studies focus on single sp...

journal_title：Nature communications

authors： Stoffel MA,Humble E,Paijmans AJ,Acevedo-Whitehouse K,Chilvers BL,Dickerson B,Galimberti F,Gemmell NJ,Goldsworthy SD,Nichols HJ,Krüger O,Negro S,Osborne A,Pastor T,Robertson BC,Sanvito S,Schultz JK,Shafer ABA,Wolf JBW

更新日期：2018-11-16 00:00:00