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The tumour suppressor CYLD regulates the p53 DNA damage response.

Abstract：

:The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-κB, MAP kinase and Wnt signalling. However, the tumour suppressing mechanisms of CYLD remain poorly understood. Here we show that loss of CYLD catalytic activity causes impaired DNA damage-induced p53 stabilization and activation in epithelial cells and sensitizes mice to chemical carcinogen-induced intestinal and skin tumorigenesis. Mechanistically, CYLD interacts with and deubiquitinates p53 facilitating its stabilization in response to genotoxic stress. Ubiquitin chain-restriction analysis provides evidence that CYLD removes K48 ubiquitin chains from p53 indirectly by cleaving K63 linkages, suggesting that p53 is decorated with complex K48/K63 chains. Moreover, CYLD deficiency also diminishes CEP-1/p53-dependent DNA damage-induced germ cell apoptosis in the nematode Caenorhabditis elegans. Collectively, our results identify CYLD as a deubiquitinase facilitating DNA damage-induced p53 activation and suggest that regulation of p53 responses to genotoxic stress contributes to the tumour suppressor function of CYLD.

journal_name

Nat Commun

journal_title

Nature communications

authors

Fernández-Majada V,Welz PS,Ermolaeva MA,Schell M,Adam A,Dietlein F,Komander D,Büttner R,Thomas RK,Schumacher B,Pasparakis M

doi

10.1038/ncomms12508

subject

Has Abstract

pub_date

2016-08-26 00:00:00

pages

12508

issn

2041-1723

pii

ncomms12508

journal_volume

7

pub_type

杂志文章

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