MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis.

abstract：:Droplet interactions with compliant materials are familiar, but surprisingly complex processes of importance to the manufacturing, chemical, and garment industries. Despite progress-previous research indicates that mesoscopic substrate deformations can enhance droplet drying or slow down spreading dynamics-our underst...

journal_title：Nature communications

authors： Gerber J,Lendenmann T,Eghlidi H,Schutzius TM,Poulikakos D

更新日期：2019-10-21 00:00:00

abstract：:Chromosomal regions of identical or nearly identical DNA sequence can preferentially associate with one another in the apparent absence of DNA breakage. Molecular mechanism(s) underlying such homology-dependent pairing phenomena remain(s) unknown. Using Neurospora crassa repeat-induced point mutation (RIP) as a model ...

journal_title：Nature communications

authors： Gladyshev E,Kleckner N

更新日期：2014-04-03 00:00:00

abstract：:The vimentin network displays remarkable plasticity to support basic cellular functions and reorganizes during cell division. Here, we show that in several cell types vimentin filaments redistribute to the cell cortex during mitosis, forming a robust framework interwoven with cortical actin and affecting its organizat...

journal_title：Nature communications

authors： Duarte S,Viedma-Poyatos Á,Navarro-Carrasco E,Martínez AE,Pajares MA,Pérez-Sala D

更新日期：2019-09-13 00:00:00

abstract：:The mixed layer of modern oceans is a zone of fully homogenized sediment resulting from bioturbation. The mixed layer is host to complex biogeochemical cycles that directly impact ecosystem functioning, affecting ocean productivity and marine biodiversity. The timing of origin of the mixed layer has been controversial...

journal_title：Nature communications

authors： Gougeon RC,Mángano MG,Buatois LA,Narbonne GM,Laing BA

更新日期：2018-05-15 00:00:00

abstract：:Mesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether action potentials are converted to dopamine output in the striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. Here, we address the roles for mechanisms governing rel...

journal_title：Nature communications

authors： Condon MD,Platt NJ,Zhang YF,Roberts BM,Clements MA,Vietti-Michelina S,Tseu MY,Brimblecombe KR,Threlfell S,Mann EO,Cragg SJ

更新日期：2019-09-19 00:00:00

abstract：:Chronic bacterial infections on medical devices, including catheter-associated urinary tract infections (CAUTI), are associated with bacterial biofilm communities that are refractory to antibiotic therapy and resistant to host immunity. Previously, we have shown that Pseudomonas aeruginosa can cause CAUTI by forming a...

journal_title：Nature communications

authors： Cole SJ,Hall CL,Schniederberend M,Farrow Iii JM,Goodson JR,Pesci EC,Kazmierczak BI,Lee VT

更新日期：2018-10-25 00:00:00

abstract：:Do completely unpredictable events exist? Classical physics excludes fundamental randomness. Although quantum theory makes probabilistic predictions, this does not imply that nature is random, as randomness should be certified without relying on the complete structure of the theory being used. Bell tests approach the ...

journal_title：Nature communications

authors： Gallego R,Masanes L,De La Torre G,Dhara C,Aolita L,Acín A

更新日期：2013-01-01 00:00:00

abstract：:The sensory cortex participates in emotional memory but its role is poorly understood. Here we show that inactivation of the higher order auditory cortex Te2 in rats during early memory consolidation impairs remote first- and second-order fear memories but not the association between two neutral cues. Furthermore, Te2...

journal_title：Nature communications

authors： Grosso A,Cambiaghi M,Renna A,Milano L,Roberto Merlo G,Sacco T,Sacchetti B

更新日期：2015-12-01 00:00:00

abstract：:Gluconeogenesis is a fundamental feature of hepatocytes. Whether this gluconeogenic activity is also present in malignant hepatocytes remains unexplored. A better understanding of this biological process may lead to novel therapeutic strategies. Here we show that gluconeogenesis is not present in mouse or human malign...

journal_title：Nature communications

authors： Ma R,Zhang W,Tang K,Zhang H,Zhang Y,Li D,Li Y,Xu P,Luo S,Cai W,Ji T,Katirai F,Ye D,Huang B

更新日期：2013-01-01 00:00:00

abstract：:One primary reason that makes single-cell RNA-seq analysis challenging is dropouts, where the data only captures a small fraction of the transcriptome of each cell. Almost all computational algorithms developed for single-cell RNA-seq adopted gene selection, dimension reduction or imputation to address the dropouts. H...

journal_title：Nature communications

authors： Qiu P

更新日期：2020-03-03 00:00:00

abstract：:Single-atom catalysts (SACs) have sparked broad interest recently while the low metal loading poses a big challenge for further applications. Herein, a dual protection strategy has been developed to give high-content SACs by nanocasting SiO2 into porphyrinic metal-organic frameworks (MOFs). The pyrolysis of SiO2@MOF c...

journal_title：Nature communications

authors： Jiao L,Zhang R,Wan G,Yang W,Wan X,Zhou H,Shui J,Yu SH,Jiang HL

更新日期：2020-06-05 00:00:00

abstract：:Models of visual attention postulate the existence of a saliency map whose function is to guide attention and gaze to the most conspicuous regions in a visual scene. Although cortical representations of saliency have been reported, there is mounting evidence for a subcortical saliency mechanism, which pre-dates the ev...

journal_title：Nature communications

authors： White BJ,Berg DJ,Kan JY,Marino RA,Itti L,Munoz DP

更新日期：2017-01-24 00:00:00

abstract：:Main group elements usually assume a typical oxidation state while forming compounds with other species. Group I elements are usually in the +1 state in inorganic materials. Our recent work reveals that pressure may make the inner shell 5p electrons of Cs reactive, causing Cs to expand beyond the +1 oxidation state. H...

journal_title：Nature communications

authors： Botana J,Miao MS

更新日期：2014-09-10 00:00:00

abstract：:Centromeres are specified epigenetically through the deposition of the centromere-specific histone H3 variant CENP-A. However, how additional epigenetic features are involved in centromere specification is unknown. Here, we find that histone H4 Lys5 and Lys12 acetylation (H4K5ac and H4K12ac) primarily occur within the...

journal_title：Nature communications

authors： Shang WH,Hori T,Westhorpe FG,Godek KM,Toyoda A,Misu S,Monma N,Ikeo K,Carroll CW,Takami Y,Fujiyama A,Kimura H,Straight AF,Fukagawa T

更新日期：2016-11-04 00:00:00

abstract：:The continuum hypothesis states that both deterministic and stochastic processes contribute to the assembly of ecological communities. However, the contextual dependency of these processes remains an open question that imposes strong limitations on predictions of community responses to environmental change. Here we me...

journal_title：Nature communications

authors： Powell JR,Karunaratne S,Campbell CD,Yao H,Robinson L,Singh BK

更新日期：2015-10-05 00:00:00

abstract：:Thermal melanism theory states that dark-colored ectotherm organisms are at an advantage at low temperature due to increased warming. This theory is generally supported for ectotherm animals, however, the function of colors in the fungal kingdom is largely unknown. Here, we test whether the color lightness of mushroom...

journal_title：Nature communications

authors： Krah FS,Büntgen U,Schaefer H,Müller J,Andrew C,Boddy L,Diez J,Egli S,Freckleton R,Gange AC,Halvorsen R,Heegaard E,Heideroth A,Heibl C,Heilmann-Clausen J,Høiland K,Kar R,Kauserud H,Kirk PM,Kuyper TW,Krisai-Greilhub

更新日期：2019-06-28 00:00:00

abstract：:Colloidal quantum dots have emerged as a material platform for low-cost high-performance optoelectronics. At the heart of optoelectronic devices lies the formation of a junction, which requires the intimate contact of n-type and p-type semiconductors. Doping in bulk semiconductors has been largely deployed for many de...

journal_title：Nature communications

authors： Stavrinadis A,Rath AK,de Arquer FP,Diedenhofen SL,Magén C,Martinez L,So D,Konstantatos G

更新日期：2013-01-01 00:00:00

abstract：:Nucleosomes containing the histone H3 variant CENP-A are the epigenetic mark of centromeres, the kinetochore assembly sites required for chromosome segregation. HJURP is the CENP-A chaperone, which associates with Mis18α, Mis18β, and M18BP1 to target centromeres and deposit new CENP-A. How these proteins interact to p...

journal_title：Nature communications

authors： Pan D,Walstein K,Take A,Bier D,Kaiser N,Musacchio A

更新日期：2019-09-06 00:00:00

abstract：:Spinel transition metal oxides (TMOs) have emerged as promising anode materials for lithium-ion batteries. It has been shown that reducing their particle size to nanoscale dimensions benefits overall electrochemical performance. Here, we use in situ transmission electron microscopy to probe the lithiation behavior of ...

journal_title：Nature communications

authors： Li J,Meng Q,Zhang Y,Peng L,Yu G,Marschilok AC,Wu L,Su D,Takeuchi KJ,Takeuchi ES,Zhu Y,Stach EA

更新日期：2019-01-09 00:00:00

abstract：:Changing climate will impact species' ranges only when environmental variability directly impacts the demography of local populations. However, measurement of demographic responses to climate change has largely been limited to single species and locations. Here we show that amphibian communities are responsive to clim...

journal_title：Nature communications

authors： Miller DAW,Grant EHC,Muths E,Amburgey SM,Adams MJ,Joseph MB,Waddle JH,Johnson PTJ,Ryan ME,Schmidt BR,Calhoun DL,Davis CL,Fisher RN,Green DM,Hossack BR,Rittenhouse TAG,Walls SC,Bailey LL,Cruickshank SS,Fellers GM,G

更新日期：2018-09-25 00:00:00

abstract：:Recent studies suggest the emerging roles of armadillo (ARM) family proteins in tumor progression. However, the functions and underlying mechanisms of ARM members in tumorigenesis and aggressiveness of neuroblastoma (NB) remain to be determined. Herein, we identify armadillo repeat containing 12 (ARMC12) as an ARM mem...

journal_title：Nature communications

authors： Li D,Song H,Mei H,Fang E,Wang X,Yang F,Li H,Chen Y,Huang K,Zheng L,Tong Q

更新日期：2018-07-19 00:00:00

abstract：:Single-cell analysis reveals aspects of cellular physiology not evident from population-based studies, particularly in the case of highly multiplexed methods such as mass cytometry (CyTOF) able to correlate the levels of multiple signalling, differentiation and cell fate markers. Immunofluorescence (IF) microscopy add...

journal_title：Nature communications

authors： Lin JR,Fallahi-Sichani M,Sorger PK

更新日期：2015-09-24 00:00:00

abstract：:As a major CO2 sink, the North Atlantic, especially its subpolar gyre region, is essential for the global carbon cycle. Decadal fluctuations of CO2 uptake in the North Atlantic subpolar gyre region are associated with the evolution of the North Atlantic Oscillation, the Atlantic meridional overturning circulation, oce...

journal_title：Nature communications

authors： Li H,Ilyina T,Müller WA,Sienz F

更新日期：2016-03-30 00:00:00

abstract：:Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of 'extreme mu...

journal_title：Nature communications

authors： Chapple CE,Robisson B,Spinelli L,Guien C,Becker E,Brun C

更新日期：2015-06-09 00:00:00

abstract：:Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts project has generated a data set of 3,781 whole genomes sequenced at low depth (average 7x), aimi...

journal_title：Nature communications

authors： Huang J,Howie B,McCarthy S,Memari Y,Walter K,Min JL,Danecek P,Malerba G,Trabetti E,Zheng HF,UK10K Consortium.,Gambaro G,Richards JB,Durbin R,Timpson NJ,Marchini J,Soranzo N

更新日期：2015-09-14 00:00:00

abstract：:COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electro...

journal_title：Nature communications

authors： Douangamath A,Fearon D,Gehrtz P,Krojer T,Lukacik P,Owen CD,Resnick E,Strain-Damerell C,Aimon A,Ábrányi-Balogh P,Brandão-Neto J,Carbery A,Davison G,Dias A,Downes TD,Dunnett L,Fairhead M,Firth JD,Jones SP,Keeley A,K

更新日期：2020-10-07 00:00:00

abstract：:In conventional computers, wiring between transistors is required to enable the execution of Boolean logic functions. This has resulted in processors in which billions of transistors are physically interconnected, which limits integration densities, gives rise to huge power consumption and restricts processing speeds....

journal_title：Nature communications

authors： Mahboob I,Flurin E,Nishiguchi K,Fujiwara A,Yamaguchi H

更新日期：2011-02-15 00:00:00

abstract：:In the original version of this Article, an incorrect sample size was provided for the number of relict species (443 instead of 442) and the number of relict forests (423 instead of 422). These errors have been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Tang CQ,Matsui T,Ohashi H,Dong YF,Momohara A,Herrando-Moraira S,Qian S,Yang Y,Ohsawa M,Luu HT,Grote PJ,Krestov PV,LePage B,Werger M,Robertson K,Hobohm C,Wang CY,Peng MC,Chen X,Wang HC,Su WH,Zhou R,Li S,He LY

更新日期：2018-12-04 00:00:00

abstract：:Nematode neurons generally produce graded potentials instead of action potentials. It is unclear how the graded potentials control postsynaptic cells under physiological conditions. Here we show that postsynaptic currents frequently occur in bursts at the neuromuscular junction of Caenorhabditis elegans. Cholinergic b...

journal_title：Nature communications

authors： Liu P,Chen B,Wang ZW

更新日期：2013-01-01 00:00:00

abstract：:Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown...

journal_title：Nature communications

authors： Kim DH,Park ES,Lee AR,Park S,Park YK,Ahn SH,Kang HS,Won JH,Ha YN,Jae B,Kim DS,Chung WC,Song MJ,Kim KH,Park SH,Kim SH,Kim KH

更新日期：2018-08-16 00:00:00