Abstract:
:Chronic bacterial infections on medical devices, including catheter-associated urinary tract infections (CAUTI), are associated with bacterial biofilm communities that are refractory to antibiotic therapy and resistant to host immunity. Previously, we have shown that Pseudomonas aeruginosa can cause CAUTI by forming a device-associated biofilm that is independent of known biofilm exopolysaccharides. Here, we show by RNA-seq that host urine alters the transcriptome of P. aeruginosa by suppressing quorum sensing regulated genes. P. aeruginosa produces acyl homoserine lactones (AHLs) in the presence of urea, but cannot perceive AHLs. Repression of quorum sensing by urine implies that quorum sensing should be dispensable during infection of the urinary tract. Indeed, mutants defective in quorum sensing are able to colonize similarly to wild-type in a murine model of CAUTI. Quorum sensing-regulated processes in clinical isolates are also inhibited by urea. These data show that urea in urine is a natural anti-quorum sensing mechanism in mammals.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Cole SJ,Hall CL,Schniederberend M,Farrow Iii JM,Goodson JR,Pesci EC,Kazmierczak BI,Lee VTdoi
10.1038/s41467-018-06882-ysubject
Has Abstractpub_date
2018-10-25 00:00:00pages
4436issue
1issn
2041-1723pii
10.1038/s41467-018-06882-yjournal_volume
9pub_type
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