Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus.

abstract：:PET hydrolase (PETase), which hydrolyzes polyethylene terephthalate (PET) into soluble building blocks, provides an attractive avenue for the bioconversion of plastics. Here we present the structures of a novel PETase from the PET-consuming microbe Ideonella sakaiensis in complex with substrate and product analogs. Th...

journal_title：Nature communications

authors： Han X,Liu W,Huang JW,Ma J,Zheng Y,Ko TP,Xu L,Cheng YS,Chen CC,Guo RT

更新日期：2017-12-13 00:00:00

abstract：:Biodiversity-ecosystem functioning (BEF) experiments have shown that local species richness promotes ecosystem functioning and stability. Whether this also applies under real-world conditions is still debated. Here, we focus on larger scales of space, time and ecological organization. We develop a quasi-experimental d...

journal_title：Nature communications

authors： Oehri J,Schmid B,Schaepman-Strub G,Niklaus PA

更新日期：2020-01-09 00:00:00

abstract：:Activation of the Hippo pathway effector Yap underlies many liver cancers, however no germline or somatic mutations have been identified. Autophagy maintains essential metabolic functions of the liver, and autophagy-deficient murine models develop benign adenomas and hepatomegaly, which have been attributed to activat...

journal_title：Nature communications

authors： Lee YA,Noon LA,Akat KM,Ybanez MD,Lee TF,Berres ML,Fujiwara N,Goossens N,Chou HI,Parvin-Nejad FP,Khambu B,Kramer EGM,Gordon R,Pfleger C,Germain D,John GR,Campbell KN,Yue Z,Yin XM,Cuervo AM,Czaja MJ,Fiel MI,Hosh

更新日期：2018-11-23 00:00:00

abstract：:Generation and recombination of electrons and holes in organic solar cells occurs via charge transfer states located at the donor/acceptor interface. The energy of these charge transfer states is a crucial factor for the attainable open-circuit voltage and its correct determination is thus of utmost importance for a d...

journal_title：Nature communications

authors： List M,Sarkar T,Perkhun P,Ackermann J,Luo C,Würfel U

更新日期：2018-09-07 00:00:00

abstract：:SecB chaperones assist protein export by binding both unfolded proteins and the SecA motor. Certain SecB homologs can also control toxin-antitoxin (TA) systems known to modulate bacterial growth in response to stress. In such TA-chaperone (TAC) systems, SecB assists the folding and prevents degradation of the antitoxi...

journal_title：Nature communications

authors： Guillet V,Bordes P,Bon C,Marcoux J,Gervais V,Sala AJ,Dos Reis S,Slama N,Mares-Mejía I,Cirinesi AM,Maveyraud L,Genevaux P,Mourey L

更新日期：2019-02-15 00:00:00

abstract：:Macrophages serve multiple functions including immune regulation, morphogenesis, tissue homeostasis and healing reactions. The current paradigm holds that mammary gland macrophages first arise postnatally during the prepubertal period from the bone marrow-derived monocytes. Here we delineate the origins of tissue-resi...

journal_title：Nature communications

authors： Jäppinen N,Félix I,Lokka E,Tyystjärvi S,Pynttäri A,Lahtela T,Gerke H,Elima K,Rantakari P,Salmi M

更新日期：2019-01-17 00:00:00

abstract：:Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and o...

journal_title：Nature communications

authors： Boer CG,Radjabzadeh D,Medina-Gomez C,Garmaeva S,Schiphof D,Arp P,Koet T,Kurilshikov A,Fu J,Ikram MA,Bierma-Zeinstra S,Uitterlinden AG,Kraaij R,Zhernakova A,van Meurs JBJ

更新日期：2019-10-25 00:00:00

abstract：:The diploid nature of the human genome is neglected in many analyses done today, where a genome is perceived as a set of unphased variants with respect to a reference genome. This lack of haplotype-level analyses can be explained by a lack of methods that can produce dense and accurate chromosome-length haplotypes at ...

journal_title：Nature communications

authors： Porubsky D,Garg S,Sanders AD,Korbel JO,Guryev V,Lansdorp PM,Marschall T

更新日期：2017-11-03 00:00:00

abstract：:In nature, individual cells contain multiple isolated compartments in which cascade enzymatic reactions occur to form essential biological products with high efficiency. Here, we report a cell-inspired design of functional hydrogel particles with multiple compartments, in which different enzymes are spatially immobili...

journal_title：Nature communications

authors： Tan H,Guo S,Dinh ND,Luo R,Jin L,Chen CH

更新日期：2017-09-22 00:00:00

abstract：:Solid organic matter (OM) plays an essential role in the generation, migration, storage, and production of hydrocarbons from economically important shale rock formations. Electron microscopy images have documented spatial heterogeneity in the porosity of OM at nanoscale, and bulk spectroscopy measurements have documen...

journal_title：Nature communications

authors： Yang J,Hatcherian J,Hackley PC,Pomerantz AE

更新日期：2017-12-19 00:00:00

abstract：:Van der Waals (vdW) forces act ubiquitously in condensed matter. Despite being weak on an atomic level, they substantially influence molecular and biological systems due to their long range and system-size scaling. The difficulty to isolate and measure vdW forces on a single-molecule level causes our present understan...

journal_title：Nature communications

authors： Wagner C,Fournier N,Ruiz VG,Li C,Müllen K,Rohlfing M,Tkatchenko A,Temirov R,Tautz FS

更新日期：2014-11-26 00:00:00

abstract：:Emerging evidence supports roles of enhancer RNAs (eRNAs) in regulating target gene. Here, we study eRNA regulation and function during skeletal myoblast differentiation. We provide a panoramic view of enhancer transcription and categorization of eRNAs. Master transcription factor MyoD is crucial in activating eRNA pr...

journal_title：Nature communications

authors： Zhao Y,Zhou J,He L,Li Y,Yuan J,Sun K,Chen X,Bao X,Esteban MA,Sun H,Wang H

更新日期：2019-12-19 00:00:00

abstract：:Iron (Fe) is essential for life, but in excess can cause oxidative cytotoxicity through the generation of Fe-catalyzed reactive oxygen species. It is yet unknown which genes and mechanisms can provide Fe-toxicity tolerance. Here, we identify S-nitrosoglutathione-reductase (GSNOR) variants underlying a major quantitati...

journal_title：Nature communications

authors： Li B,Sun L,Huang J,Göschl C,Shi W,Chory J,Busch W

更新日期：2019-08-29 00:00:00

abstract：:Layer-by-layer-stacked chemical vapour deposition (CVD) graphene films find applications as transparent and conductive electrodes in solar cells, organic light-emitting diodes and touch panels. Common to lamellar-type systems with anisotropic electron delocalization, the plane-to-plane (vertical) conductivity in such ...

journal_title：Nature communications

authors： Liu Y,Yuan L,Yang M,Zheng Y,Li L,Gao L,Nerngchamnong N,Nai CT,Sangeeth CS,Feng YP,Nijhuis CA,Loh KP

更新日期：2014-11-20 00:00:00

abstract：:The principles governing the recruitment of interneurons during acceleration in vertebrate locomotion are unknown. In the mouse, the V2a spinal interneurons are dispensable for left-right coordination at low locomotor frequencies, but their function is essential for maintaining left-right coordination at high frequenc...

journal_title：Nature communications

authors： Zhong G,Sharma K,Harris-Warrick RM

更新日期：2011-01-01 00:00:00

abstract：:The challenge of monitoring in planta dynamic changes of NADP(H) and NAD(H) redox states at the subcellular level is considered a major obstacle in plant bioenergetics studies. Here, we introduced two circularly permuted yellow fluorescent protein sensors, iNAP and SoNar, into Arabidopsis thaliana to monitor the dynam...

journal_title：Nature communications

authors： Lim SL,Voon CP,Guan X,Yang Y,Gardeström P,Lim BL

更新日期：2020-06-26 00:00:00

abstract：:The development of transistors with high gain is essential for applications ranging from switching elements and drivers to transducers for chemical and biological sensing. Organic transistors have become well-established based on their distinct advantages, including ease of fabrication, synthetic freedom for chemical ...

journal_title：Nature communications

authors： Khodagholy D,Rivnay J,Sessolo M,Gurfinkel M,Leleux P,Jimison LH,Stavrinidou E,Herve T,Sanaur S,Owens RM,Malliaras GG

更新日期：2013-01-01 00:00:00

abstract：:Defect-free monolayers of graphene and hexagonal boron nitride are surprisingly permeable to thermal protons, despite being completely impenetrable to all gases. It remains untested whether small ions can permeate through the two-dimensional crystals. Here we show that mechanically exfoliated graphene and hexagonal bo...

journal_title：Nature communications

authors： Mogg L,Zhang S,Hao GP,Gopinadhan K,Barry D,Liu BL,Cheng HM,Geim AK,Lozada-Hidalgo M

更新日期：2019-09-18 00:00:00

abstract：:Many phenomena occurring in strongly correlated quantum systems still await conclusive explanations. The absence of isolated free quarks in nature is an example. It is attributed to quark confinement, whose origin is not yet understood. The phase diagram for nuclear matter at general temperatures and densities, studie...

journal_title：Nature communications

authors： Tagliacozzo L,Celi A,Orland P,Mitchell MW,Lewenstein M

更新日期：2013-01-01 00:00:00

abstract：:RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral fitness is not well characterized. Here we report the X-ray crystal structure of the receptor-binding domain (RBD) of the human coronavirus, HCoV-229E, in comple...

journal_title：Nature communications

authors： Wong AHM,Tomlinson ACA,Zhou D,Satkunarajah M,Chen K,Sharon C,Desforges M,Talbot PJ,Rini JM

更新日期：2017-11-23 00:00:00

abstract：:Deep understanding of the genomic and immunological differences between Chinese and Western lung cancer patients is of great importance for target therapy selection and development for Chinese patients. Here we report an extensive molecular and immune profiling study of 245 Chinese patients with non-small cell lung ca...

journal_title：Nature communications

authors： Zhang XC,Wang J,Shao GG,Wang Q,Qu X,Wang B,Moy C,Fan Y,Albertyn Z,Huang X,Zhang J,Qiu Y,Platero S,Lorenzi MV,Zudaire E,Yang J,Cheng Y,Xu L,Wu YL

更新日期：2019-04-16 00:00:00

abstract：:Analysis of potentially interconnected residential water and energy demand is sparse. In a 1-in-10 random sample of Singapore households living in apartments, water use per capita declines over the socioeconomic distribution, whereas electricity use rises. Here I show that in this leading Asian city and tropical clima...

journal_title：Nature communications

authors： Salvo A

更新日期：2018-12-20 00:00:00

abstract：:Telomere maintenance is a universal hallmark of cancer. Most tumors including low-grade oligodendrogliomas use telomerase reverse transcriptase (TERT) expression for telomere maintenance while astrocytomas use the alternative lengthening of telomeres (ALT) pathway. Although TERT and ALT are hallmarks of tumor prolifer...

journal_title：Nature communications

authors： Viswanath P,Batsios G,Mukherjee J,Gillespie AM,Larson PEZ,Luchman HA,Phillips JJ,Costello JF,Pieper RO,Ronen SM

更新日期：2021-01-04 00:00:00

abstract：:Whether and how fracture mechanics needs to be modified for small length scales and in systems of reduced dimensionality remains an open debate. Here, employing in situ transmission electron microscopy, atomic structures and dislocation dynamics in the crack tip zone of a propagating crack in two-dimensional (2D) mono...

journal_title：Nature communications

authors： Ly TH,Zhao J,Cichocka MO,Li LJ,Lee YH

更新日期：2017-01-18 00:00:00

abstract：:Topological quantum matter can be realized by subjecting engineered systems to time-periodic modulations. In analogy with static systems, periodically driven quantum matter can be topologically classified by topological invariants, whose non-zero value guarantees the presence of robust edge modes. In the high-frequenc...

journal_title：Nature communications

authors： Mukherjee S,Spracklen A,Valiente M,Andersson E,Öhberg P,Goldman N,Thomson RR

更新日期：2017-01-04 00:00:00

abstract：:Single-nucleotide substitutions are a defining characteristic of cancer genomes. Many single-nucleotide substitutions in cancer genomes arise because of errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA replication patterns help shape the mutational landscapes of normal and can...

journal_title：Nature communications

authors： Liu L,De S,Michor F

更新日期：2013-01-01 00:00:00

abstract：:Evidence from animal and human studies has suggested that the amygdala plays a role in detecting threat and in directing attention to the eyes. Nevertheless, there has been no systematic investigation of whether the amygdala specifically facilitates attention to the eyes or whether other features can also drive attent...

journal_title：Nature communications

authors： Dal Monte O,Costa VD,Noble PL,Murray EA,Averbeck BB

更新日期：2015-12-14 00:00:00

abstract：:Inspired by mammalian skins, soft hybrids integrating the merits of elastomers and hydrogels have potential applications in diverse areas including stretchable and bio-integrated electronics, microfluidics, tissue engineering, soft robotics and biomedical devices. However, existing hydrogel-elastomer hybrids have limi...

journal_title：Nature communications

authors： Yuk H,Zhang T,Parada GA,Liu X,Zhao X

更新日期：2016-06-27 00:00:00

abstract：:Pulsars are rotating neutron stars emitting lighthouse-like beams. Owing to their unique properties, pulsars are a unique astrophysical tool to test general relativity, inform on matter in extreme conditions, and probe galactic magnetic fields. Understanding pulsar physics and emission mechanisms is critical to these ...

journal_title：Nature communications

authors： Gueroult R,Shi Y,Rax JM,Fisch NJ

更新日期：2019-07-19 00:00:00

abstract：:Large-scale climate patterns control variability in the global carbon sink. In Europe, the North-Atlantic Oscillation (NAO) influences vegetation activity, however the East-Atlantic (EA) pattern is known to modulate NAO strength and location. Using observation-driven and modelled data sets, we show that multi-annual v...

journal_title：Nature communications

authors： Bastos A,Janssens IA,Gouveia CM,Trigo RM,Ciais P,Chevallier F,Peñuelas J,Rödenbeck C,Piao S,Friedlingstein P,Running SW

更新日期：2016-01-18 00:00:00