Abstract:
:Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Boer CG,Radjabzadeh D,Medina-Gomez C,Garmaeva S,Schiphof D,Arp P,Koet T,Kurilshikov A,Fu J,Ikram MA,Bierma-Zeinstra S,Uitterlinden AG,Kraaij R,Zhernakova A,van Meurs JBJdoi
10.1038/s41467-019-12873-4subject
Has Abstractpub_date
2019-10-25 00:00:00pages
4881issue
1issn
2041-1723pii
10.1038/s41467-019-12873-4journal_volume
10pub_type
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