Extreme multifunctional proteins identified from a human protein interaction network.

abstract：:Bryostatin is in clinical trials for Alzheimer's disease, cancer, and HIV/AIDS eradication. It binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C regulator, and plant-derived phorbol esters, but each ligand induces different activities. Determination of the structural origin f...

journal_title：Nature communications

authors： Ryckbosch SM,Wender PA,Pande VS

更新日期：2017-02-23 00:00:00

abstract：:Considering the rapid increase of CO2 emission, especially from power plants, there is a constant need for materials which can effectively eliminate post-combustion CO2 (the main component: CO2/N2 = 15/85). Here, we show the design and synthesis of a Cu(II) metal-organic framework (FJI-H14) with a high density of acti...

journal_title：Nature communications

authors： Liang L,Liu C,Jiang F,Chen Q,Zhang L,Xue H,Jiang HL,Qian J,Yuan D,Hong M

更新日期：2017-11-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Fryirs KA,Brierley GJ,Dixon T

更新日期：2019-11-08 00:00:00

abstract：:The ciliary kinase NEK8 plays a critical role in situs determination and cystic kidney disease, yet its exact function remains unknown. In this study, we identify ANKS6 as a target and activator of NEK8. ANKS6 requires NEK8 for localizing to the ciliary inversin compartment (IC) and activates NEK8 by binding to its ki...

journal_title：Nature communications

authors： Czarnecki PG,Gabriel GC,Manning DK,Sergeev M,Lemke K,Klena NT,Liu X,Chen Y,Li Y,San Agustin JT,Garnaas MK,Francis RJ,Tobita K,Goessling W,Pazour GJ,Lo CW,Beier DR,Shah JV

更新日期：2015-01-20 00:00:00

abstract：:The immunogenic heat shock proteins (HSPs) gp96, hsp70 and calreticulin (CRT) bind to CD91 on antigen-presenting cells (APCs) for cross-presentation of the HSP-chaperoned peptides. This event leads to priming of T-cell responses. Here we show that CD91 serves as a signalling receptor for these HSPs, allowing for the m...

journal_title：Nature communications

authors： Pawaria S,Binder RJ

更新日期：2011-11-01 00:00:00

abstract：:Modulation of epigenetic patterns has promising efficacy for treating cancer. 5-Hydroxymethylated cytosine (5-hmC) is an epigenetic mark potentially important in cancer. Here we report that 5-hmC is an epigenetic hallmark of prostate cancer (PCa) progression. A member of the ten-eleven translocation (TET) proteins, wh...

journal_title：Nature communications

authors： Takayama K,Misawa A,Suzuki T,Takagi K,Hayashizaki Y,Fujimura T,Homma Y,Takahashi S,Urano T,Inoue S

更新日期：2015-09-25 00:00:00

abstract：:Unusual features of the vibrational density of states D(ω) of glasses allow one to rationalize their peculiar low-temperature properties. Simulational studies of D(ω) have been restricted to studying poorly annealed glasses that may not be relevant to experiments. Here we report on D(ω) of zero-temperature glasses wit...

journal_title：Nature communications

authors： Wang L,Ninarello A,Guan P,Berthier L,Szamel G,Flenner E

更新日期：2019-01-03 00:00:00

abstract：:Nanofabricated and nanopatterned surfaces have revealed the sensitivity of cell adhesion to nanoscale variations in the spacing of adhesive ligands such as the tripeptide arginine-glycine-aspartic acid (RGD). To date, surface characterisation and cell adhesion are often examined in two separate experiments so that the...

journal_title：Nature communications

authors： Lu X,Nicovich PR,Zhao M,Nieves DJ,Mollazade M,Vivekchand SRC,Gaus K,Gooding JJ

更新日期：2018-08-20 00:00:00

abstract：:Topological insulators do not allow conduction in the bulk, yet they support edge modes that travel along the boundary only in one direction, determined by the carried electron spin, with inherent robustness to defects and disorder. Topological insulators have inspired analogues in photonics and optics, in which one-w...

journal_title：Nature communications

authors： Khanikaev AB,Fleury R,Mousavi SH,Alù A

更新日期：2015-10-06 00:00:00

abstract：:Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Phase I/II clinical trial investigations for non-small cell lung cancer...

journal_title：Nature communications

authors： Collier TL,Normandin MD,Stephenson NA,Livni E,Liang SH,Wooten DW,Esfahani SA,Stabin MG,Mahmood U,Chen J,Wang W,Maresca K,Waterhouse RN,El Fakhri G,Richardson P,Vasdev N

更新日期：2017-06-08 00:00:00

abstract：:Device applications of graphene such as ultrafast transistors and photodetectors benefit from the combination of both high-quality p- and n-doped components prepared in a large-scale manner with spatial control and seamless connection. Here we develop a well-controlled chemical vapour deposition process for direct gro...

journal_title：Nature communications

authors： Yan K,Wu D,Peng H,Jin L,Fu Q,Bao X,Liu Z

更新日期：2012-01-01 00:00:00

abstract：:Triboelectrification is a well-known phenomenon that commonly occurs in nature and in our lives at any time and any place. Although each and every material exhibits triboelectrification, its quantification has not been standardized. A triboelectric series has been qualitatively ranked with regards to triboelectric pol...

journal_title：Nature communications

authors： Zou H,Zhang Y,Guo L,Wang P,He X,Dai G,Zheng H,Chen C,Wang AC,Xu C,Wang ZL

更新日期：2019-03-29 00:00:00

abstract：:The liquid and glass states of metal-organic frameworks (MOFs) have recently become of interest due to the potential for liquid-phase separations and ion transport, alongside the fundamental nature of the latter as a new, fourth category of melt-quenched glass. Here we show that the MOF liquid state can be blended wit...

journal_title：Nature communications

authors： Longley L,Collins SM,Zhou C,Smales GJ,Norman SE,Brownbill NJ,Ashling CW,Chater PA,Tovey R,Schönlieb CB,Headen TF,Terrill NJ,Yue Y,Smith AJ,Blanc F,Keen DA,Midgley PA,Bennett TD

更新日期：2018-06-15 00:00:00

abstract：:Diffusion is the result of repeated random scattering. It governs a wide range of phenomena from Brownian motion, to heat flow through window panes, neutron flux in fuel rods, dispersion of light in human tissue, and electronic conduction. It is universally acknowledged that the diffusion approach to describing wave t...

journal_title：Nature communications

authors： Shi Z,Genack AZ

更新日期：2018-05-10 00:00:00

abstract：:The insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) are highly related receptor tyrosine kinases with a disulfide-linked homodimeric architecture. Ligand binding to the receptor ectodomain triggers tyrosine autophosphorylation of the cytoplasmic domains, which stimulates catalytic activity and ...

journal_title：Nature communications

authors： Cabail MZ,Li S,Lemmon E,Bowen ME,Hubbard SR,Miller WT

更新日期：2015-03-11 00:00:00

abstract：:While main group elements have four valence orbitals accessible for bonding, quadruple bonding to main group elements is extremely rare. Here we report that main group element boron is able to form quadruple bonding interactions with iron in the BFe(CO)3- anion complex, which has been revealed by quantum chemical inve...

journal_title：Nature communications

authors： Chi C,Wang JQ,Hu HS,Zhang YY,Li WL,Meng L,Luo M,Zhou M,Li J

更新日期：2019-10-17 00:00:00

abstract：:Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-sign...

journal_title：Nature communications

authors： Benyamin B,Esko T,Ried JS,Radhakrishnan A,Vermeulen SH,Traglia M,Gögele M,Anderson D,Broer L,Podmore C,Luan J,Kutalik Z,Sanna S,van der Meer P,Tanaka T,Wang F,Westra HJ,Franke L,Mihailov E,Milani L,Hälldin J,Win

更新日期：2014-10-29 00:00:00

abstract：:Long-range chromatin interactions are important for transcriptional regulation of genes, many of which are related to complex agronomics traits. However, the pattern of three-dimensional chromatin interactions remains unclear in plants. Here we report the generation of chromatin interaction analysis by paired-end tag ...

journal_title：Nature communications

authors： Li E,Liu H,Huang L,Zhang X,Dong X,Song W,Zhao H,Lai J

更新日期：2019-06-14 00:00:00

abstract：:A crumpled sheet of paper displays an intricate pattern of creases and point-like singular structures, termed d-cones. It is typically assumed that elongated creases form when ridges connecting two d-cones fold beyond the material yielding threshold, and scarring is thus a by-product of the folding dynamics that seek ...

journal_title：Nature communications

authors： Gottesman O,Efrati E,Rubinstein SM

更新日期：2015-06-11 00:00:00

abstract：:Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor ce...

journal_title：Nature communications

authors： Duncan GJ,Manesh SB,Hilton BJ,Assinck P,Liu J,Moulson A,Plemel JR,Tetzlaff W

更新日期：2018-08-03 00:00:00

abstract：:By electrochemically coupling microbial and abiotic catalysts, bioelectrochemical systems such as microbial electrolysis cells and microbial electrosynthesis systems synthesize energy-rich chemicals from energy-poor precursors with unmatched efficiency. However, to circumvent chemical incompatibilities between the mic...

journal_title：Nature communications

authors： Cornejo JA,Sheng H,Edri E,M Ajo-Franklin C,Frei H

更新日期：2018-06-11 00:00:00

abstract：:Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines. The fusion of immun...

journal_title：Nature communications

authors： Liu WL,Zou MZ,Liu T,Zeng JY,Li X,Yu WY,Li CX,Ye JJ,Song W,Feng J,Zhang XZ

更新日期：2019-07-19 00:00:00

abstract：:Socioeconomic challenges continue to mount for half a billion residents of central India because of a decline in the total rainfall and a concurrent rise in the magnitude and frequency of extreme rainfall events. Alongside a weakening monsoon circulation, the locally available moisture and the frequency of moisture-la...

journal_title：Nature communications

authors： Roxy MK,Ghosh S,Pathak A,Athulya R,Mujumdar M,Murtugudde R,Terray P,Rajeevan M

更新日期：2017-10-03 00:00:00

abstract：:To date, the vast preponderance of somatic variants observed in the cancer genome have been rare variants, and it is common in practice to encounter in a new tumor variants that have not been observed previously. Here we focus on probability estimation for encountering such hitherto unseen variants. We draw upon stati...

journal_title：Nature communications

authors： Chakraborty S,Arora A,Begg CB,Shen R

更新日期：2019-12-03 00:00:00

abstract：:In budding yeast, overcoming of a critical size to enter S phase and the mitosis/mating switch--two central cell fate events--take place in the G1 phase of the cell cycle. Here we present a mathematical model of the basic molecular mechanism controlling the G1/S transition, whose major regulatory feature is multisite ...

journal_title：Nature communications

authors： Palumbo P,Vanoni M,Cusimano V,Busti S,Marano F,Manes C,Alberghina L

更新日期：2016-04-20 00:00:00

abstract：:Over the last century the North Anatolian Fault Zone in Turkey has produced a remarkable sequence of large earthquakes. These events have now left an earthquake gap south of Istanbul and beneath the Marmara Sea, a gap that has not been filled for 250 years. Here we investigate the nature of the eastern end of this gap...

journal_title：Nature communications

authors： Bohnhoff M,Bulut F,Dresen G,Malin PE,Eken T,Aktar M

更新日期：2013-01-01 00:00:00

abstract：:Serial X-ray crystallography allows macromolecular structure determination at both X-ray free electron lasers (XFELs) and, more recently, synchrotron sources. The time resolution for serial synchrotron crystallography experiments has been limited to millisecond timescales with monochromatic beams. The polychromatic, "...

journal_title：Nature communications

authors： Meents A,Wiedorn MO,Srajer V,Henning R,Sarrou I,Bergtholdt J,Barthelmess M,Reinke PYA,Dierksmeyer D,Tolstikova A,Schaible S,Messerschmidt M,Ogata CM,Kissick DJ,Taft MH,Manstein DJ,Lieske J,Oberthuer D,Fischetti RF,C

更新日期：2017-11-03 00:00:00

abstract：:Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for the synthesis of glycerolipids, interacts with and is a direct sub...

journal_title：Nature communications

authors： Song L,Liu Z,Hu HH,Yang Y,Li TY,Lin ZZ,Ye J,Chen J,Huang X,Liu DT,Zhou J,Shi Y,Zhao H,Xie C,Chen L,Song E,Lin SY,Lin SC

更新日期：2020-11-17 00:00:00

abstract：:Ocean ventilation is the integrated effect of various processes that exchange surface properties with the ocean interior and is essential for oxygen supply, storage of anthropogenic carbon and the heat budget of the ocean, for instance. Current observational methods utilise transient tracers, e.g. tritium, SF6, CFCs a...

journal_title：Nature communications

authors： Ebser S,Kersting A,Stöven T,Feng Z,Ringena L,Schmidt M,Tanhua T,Aeschbach W,Oberthaler MK

更新日期：2018-11-28 00:00:00

abstract：:Deregulation of mitochondrial network in terminally differentiated cells contributes to a broad spectrum of disorders. Methylmalonic acidemia (MMA) is one of the most common inherited metabolic disorders, due to deficiency of the mitochondrial methylmalonyl-coenzyme A mutase (MMUT). How MMUT deficiency triggers cell d...

journal_title：Nature communications

authors： Luciani A,Schumann A,Berquez M,Chen Z,Nieri D,Failli M,Debaix H,Festa BP,Tokonami N,Raimondi A,Cremonesi A,Carrella D,Forny P,Kölker S,Diomedi Camassei F,Diaz F,Moraes CT,Di Bernardo D,Baumgartner MR,Devuyst O

更新日期：2020-02-20 00:00:00