Long-range interactions between proximal and distal regulatory regions in maize.

Abstract:

:Long-range chromatin interactions are important for transcriptional regulation of genes, many of which are related to complex agronomics traits. However, the pattern of three-dimensional chromatin interactions remains unclear in plants. Here we report the generation of chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) data and the construction of extensive H3K4me3- and H3K27ac-centered chromatin interaction maps in maize. Results show that the interacting patterns between proximal and distal regulatory regions of genes are highly complex and dynamic. Genes with chromatin interactions have higher expression levels than those without interactions. Genes with proximal-proximal interactions prefer to be transcriptionally coordinated. Tissue-specific proximal-distal interactions are associated with tissue-specific expression of genes. Interactions between proximal and distal regulatory regions further interweave into organized network communities that are enriched in specific biological functions. The high-resolution chromatin interaction maps will help to understand the transcription regulation of genes associated with complex agronomic traits of maize.

journal_name

Nat Commun

journal_title

Nature communications

authors

Li E,Liu H,Huang L,Zhang X,Dong X,Song W,Zhao H,Lai J

doi

10.1038/s41467-019-10603-4

subject

Has Abstract

pub_date

2019-06-14 00:00:00

pages

2633

issue

1

issn

2041-1723

pii

10.1038/s41467-019-10603-4

journal_volume

10

pub_type

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