Experimental realization of two-dimensional Dirac nodal line fermions in monolayer Cu2Si.

abstract：:Sliding clamps encircle DNA and tether polymerases and other factors to the genomic template. However, the molecular mechanism of clamp sliding on DNA is unknown. Using crystallography, NMR and molecular dynamics simulations, here we show that the human clamp PCNA recognizes DNA through a double patch of basic residue...

journal_title：Nature communications

authors： De March M,Merino N,Barrera-Vilarmau S,Crehuet R,Onesti S,Blanco FJ,De Biasio A

更新日期：2017-01-10 00:00:00

abstract：:Long duration gamma-ray bursts (GRBs), the brightest events since the Big Bang itself, are believed to originate in an ultra-relativistic jet breaking out from a massive stellar envelope. Despite decades of study, there is still no consensus on their emission mechanism. One unresolved question is the origin of the tig...

journal_title：Nature communications

authors： Ito H,Matsumoto J,Nagataki S,Warren DC,Barkov MV,Yonetoku D

更新日期：2019-04-03 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity. A systematic characterization of the genomic landscape of Chinese ccRCC is lacking, and features of ccRCC associated with tumor thrombus (ccRCC-TT) remain poorly understood. Here, we applied whole-exome sequencing ...

journal_title：Nature communications

authors： Wang XM,Lu Y,Song YM,Dong J,Li RY,Wang GL,Wang X,Zhang SD,Dong ZH,Lu M,Wang SY,Ge LY,Luo GD,Ma RZ,George Rozen S,Bai F,Wu D,Ma LL

更新日期：2020-02-06 00:00:00

abstract：:Observing the crucial first few femtoseconds of photochemical reactions requires tools typically not available in the femtochemistry toolkit. Such dynamics are now within reach with the instruments provided by attosecond science. Here, we apply experimental and theoretical methods to assess the ultrafast nonadiabatic ...

journal_title：Nature communications

authors： Galbraith MCE,Scheit S,Golubev NV,Reitsma G,Zhavoronkov N,Despré V,Lépine F,Kuleff AI,Vrakking MJJ,Kornilov O,Köppel H,Mikosch J

更新日期：2017-10-18 00:00:00

abstract：:The low-energy electronic excitations in graphene are described by massless Dirac fermions that have a linear dispersion relation. Taking advantage of this 'optics-like' electron dynamics, generic optical elements like lenses and wave guides have been proposed for electrons in graphene. Tuning of these elements relies...

journal_title：Nature communications

authors： Rickhaus P,Maurand R,Liu MH,Weiss M,Richter K,Schönenberger C

更新日期：2013-01-01 00:00:00

abstract：:When assembling individual quantum components into a mesoscopic circuit, the interplay between Coulomb interaction and charge granularity breaks down the classical laws of electrical impedance composition. Here we explore experimentally the thermal consequences, and observe an additional quantum mechanism of electroni...

journal_title：Nature communications

authors： Sivre E,Duprez H,Anthore A,Aassime A,Parmentier FD,Cavanna A,Ouerghi A,Gennser U,Pierre F

更新日期：2019-12-10 00:00:00

abstract：:To perform their computational function, genetic circuits change states through a symphony of genetic parts that turn regulator expression on and off. Debugging is frustrated by an inability to characterize parts in the context of the circuit and identify the origins of failures. Here, we take snapshots of a large gen...

journal_title：Nature communications

authors： Espah Borujeni A,Zhang J,Doosthosseini H,Nielsen AAK,Voigt CA

更新日期：2020-10-05 00:00:00

abstract：:The central issues for understanding iron (Fe)-based superconductors are the symmetry and structure of the superconducting gap. So far the experimental data and theoretical models have been highly controversial. Some experiments favor two or more constant or nearly constant gaps, others indicate strong anisotropy and ...

journal_title：Nature communications

authors： Zeng B,Mu G,Luo HQ,Xiang T,Mazin II,Yang H,Shan L,Ren C,Dai PC,Wen HH

更新日期：2010-11-16 00:00:00

abstract：:Transposable elements constitute a substantial portion of eukaryotic genomes and contribute to genomic variation, function, and evolution. Miniature inverted-repeat transposable elements (MITEs), as DNA transposons, are widely distributed in plant and animal genomes. Previous studies have suggested that retrotransposo...

journal_title：Nature communications

authors： Shen J,Liu J,Xie K,Xing F,Xiong F,Xiao J,Li X,Xiong L

更新日期：2017-03-03 00:00:00

abstract：:COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electro...

journal_title：Nature communications

authors： Douangamath A,Fearon D,Gehrtz P,Krojer T,Lukacik P,Owen CD,Resnick E,Strain-Damerell C,Aimon A,Ábrányi-Balogh P,Brandão-Neto J,Carbery A,Davison G,Dias A,Downes TD,Dunnett L,Fairhead M,Firth JD,Jones SP,Keeley A,K

更新日期：2020-10-07 00:00:00

abstract：:Covalently locking interacting proteins in situ is an attractive strategy for addressing the challenge of identifying weak and transient protein interactions, yet it is demanding to execute chemical reactions in live systems in a biocompatible, specific, and autonomous manner. Harnessing proximity-enabled reactivity o...

journal_title：Nature communications

authors： Yang B,Tang S,Ma C,Li ST,Shao GC,Dang B,DeGrado WF,Dong MQ,Wang PG,Ding S,Wang L

更新日期：2017-12-21 00:00:00

abstract：:Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of neurexin and is nee...

journal_title：Nature communications

authors： Muhammad K,Reddy-Alla S,Driller JH,Schreiner D,Rey U,Böhme MA,Hollmann C,Ramesh N,Depner H,Lützkendorf J,Matkovic T,Götz T,Bergeron DD,Schmoranzer J,Goettfert F,Holt M,Wahl MC,Hell SW,Scheiffele P,Walter AM,Loll B

更新日期：2015-10-16 00:00:00

abstract：:Thalamic inputs of cells in sensory cortices are outnumbered by local connections. Thus, it was suggested that robust sensory response in layer 4 emerges due to synchronized thalamic activity. To investigate the role of both inputs in the generation of correlated cortical activities, we isolated the thalamic excitator...

journal_title：Nature communications

authors： Cohen-Kashi Malina K,Mohar B,Rappaport AN,Lampl I

更新日期：2016-09-12 00:00:00

abstract：:Nonlinear spectroscopies are utilized extensively for selective measurements of chemical dynamics in the optical, infrared, and radio-frequency regimes. The development of these techniques for extreme ultraviolet (XUV) light sources facilitates measurements of electronic dynamics on attosecond timescales. Here, we elu...

journal_title：Nature communications

authors： Fidler AP,Camp SJ,Warrick ER,Bloch E,Marroux HJB,Neumark DM,Schafer KJ,Gaarde MB,Leone SR

更新日期：2019-03-27 00:00:00

abstract：:Studies on vesicle formation by the Coat Protein I (COPI) complex have contributed to a basic understanding of how vesicular transport is initiated. Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be required for the fission stage of COPI vesicle formation. Here, we find that PA with vary...

journal_title：Nature communications

authors： Park SY,Yang JS,Li Z,Deng P,Zhu X,Young D,Ericsson M,Andringa RLH,Minnaard AJ,Zhu C,Sun F,Moody DB,Morris AJ,Fan J,Hsu VW

更新日期：2019-07-30 00:00:00

abstract：:During animal cell division, the central spindle, an anti-parallel microtubule bundle structure formed between segregating chromosomes during anaphase, cooperates with astral microtubules to position the cleavage furrow. Because the central spindle is the only structure linking the two halves of the mitotic spindle, i...

journal_title：Nature communications

authors： Lee KY,Esmaeili B,Zealley B,Mishima M

更新日期：2015-06-19 00:00:00

abstract：:Models of visual attention postulate the existence of a saliency map whose function is to guide attention and gaze to the most conspicuous regions in a visual scene. Although cortical representations of saliency have been reported, there is mounting evidence for a subcortical saliency mechanism, which pre-dates the ev...

journal_title：Nature communications

authors： White BJ,Berg DJ,Kan JY,Marino RA,Itti L,Munoz DP

更新日期：2017-01-24 00:00:00

abstract：:The presence of a di-unsaturated highly branched isoprenoid (HBI) lipid biomarker (diene II) in Southern Ocean sediments has previously been proposed as a proxy measure of palaeo Antarctic sea ice. Here we show that a source of diene II is the sympagic diatom Berkeleya adeliensis Medlin. Furthermore, the propensity fo...

journal_title：Nature communications

authors： Belt ST,Smik L,Brown TA,Kim JH,Rowland SJ,Allen CS,Gal JK,Shin KH,Lee JI,Taylor KW

更新日期：2016-08-30 00:00:00

abstract：:The performance of conjugated polymer devices is largely dictated by charge transport processes. However, it is difficult to obtain a clear relationship between conjugated polymer structures and charge transport properties, due to the complexity of the structure and the dispersive nature of charge transport in conjuga...

journal_title：Nature communications

authors： Jiang Y,McNeill J

更新日期：2018-10-17 00:00:00

abstract：:Organic semiconductors are usually polycyclic aromatic hydrocarbons and their analogs containing heteroatom substitution. Bioinspired materials chemistry of organic electronics promises new charge transport mechanism and specific molecular recognition with biomolecules. We discover organic semiconductors from deoxyrib...

journal_title：Nature communications

authors： Zhang F,Lemaur V,Choi W,Kafle P,Seki S,Cornil J,Beljonne D,Diao Y

更新日期：2019-09-16 00:00:00

abstract：:Lithium metal is an ideal anode for lithium batteries due to its low electrochemical potential and high theoretical capacity. However, safety issues arising from lithium dendrite growth have significantly reduced the practical applicability of lithium metal batteries. Here, we report the addition of octaphenyl polyoxy...

journal_title：Nature communications

authors： Dai H,Gu X,Dong J,Wang C,Lai C,Sun S

更新日期：2020-01-31 00:00:00

abstract：:Graphene nanoscrolls are Archimedean-type spirals formed by rolling single-layer graphene sheets. Their unique structure makes them conceptually interesting and understanding their formation gives important information on the manipulation and characteristics of various carbon nanostructures. Here we report a 100% effi...

journal_title：Nature communications

authors： Sharifi T,Gracia-Espino E,Barzegar HR,Jia X,Nitze F,Hu G,Nordblad P,Tai CW,Wågberg T

更新日期：2013-01-01 00:00:00

abstract：:Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and obs...

journal_title：Nature communications

authors： Fernandez-Cuesta L,Peifer M,Lu X,Sun R,Ozretić L,Seidal D,Zander T,Leenders F,George J,Müller C,Dahmen I,Pinther B,Bosco G,Konrad K,Altmüller J,Nürnberg P,Achter V,Lang U,Schneider PM,Bogus M,Soltermann A,Brustu

更新日期：2014-03-27 00:00:00

abstract：:Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the ability to select appropriate responses from a vast behavioral repertoire. Modulation by the prefrontal cortex (PFC) is thought to be key for both processes, but the precise role of specific circuits remains unclear. We examined th...

journal_title：Nature communications

authors： Huda R,Sipe GO,Breton-Provencher V,Cruz KG,Pho GN,Adam E,Gunter LM,Sullins A,Wickersham IR,Sur M

更新日期：2020-11-26 00:00:00

abstract：:Peptide-major histocompatibility complex class II (pMHCII)-based nanomedicines displaying tissue-specific autoantigenic epitopes can blunt specific autoimmune conditions by re-programming cognate antigen-experienced CD4+ T-cells into disease-suppressing T-regulatory type 1 (TR1) cells. Here, we show that single pMHCII...

journal_title：Nature communications

authors： Umeshappa CS,Singha S,Blanco J,Shao K,Nanjundappa RH,Yamanouchi J,Parés A,Serra P,Yang Y,Santamaria P

更新日期：2019-05-14 00:00:00

abstract：:Niemann-Pick type C disease is a fatal, progressive neurodegenerative disorder caused by loss-of-function mutations in NPC1, a multipass transmembrane glycoprotein essential for intracellular lipid trafficking. We sought to define the cellular machinery controlling degradation of the most common disease-causing mutant...

journal_title：Nature communications

authors： Schultz ML,Krus KL,Kaushik S,Dang D,Chopra R,Qi L,Shakkottai VG,Cuervo AM,Lieberman AP

更新日期：2018-09-10 00:00:00

abstract：:'Ideal' transparent p-type semiconductors are required for the integration of high-performance thin-film transistors (TFTs) and circuits. Although CuI has recently attracted attention owing to its excellent opto-electrical properties, solution processability, and low-temperature synthesis, the uncontrolled copper vaca...

journal_title：Nature communications

authors： Liu A,Zhu H,Park WT,Kim SJ,Kim H,Kim MG,Noh YY

更新日期：2020-08-27 00:00:00

abstract：:Express delivery services are booming in both developed and emerging economies due to their low cost, convenience, and the fast growth in online shopping. The increasing environmental impacts of express delivery services and mitigation potentials, however, remain largely unexplored. Here we addressed such a gap for Ch...

journal_title：Nature communications

authors： Kang P,Song G,Xu M,Miller TR,Wang H,Zhang H,Liu G,Zhou Y,Ren J,Zhong R,Duan H

更新日期：2021-01-19 00:00:00

abstract：:Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in Drosophila DM1 model. Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cell...

journal_title：Nature communications

authors： Cerro-Herreros E,Sabater-Arcis M,Fernandez-Costa JM,Moreno N,Perez-Alonso M,Llamusi B,Artero R

更新日期：2018-06-26 00:00:00

abstract：:The atmosphere plays a fundamental role in the transport of microbes across the planet but it is often neglected as a microbial habitat. Although the ocean represents two thirds of the Earth's surface, there is little information on the atmospheric microbial load over the open ocean. Here we provide a global estimate ...

journal_title：Nature communications

authors： Mayol E,Arrieta JM,Jiménez MA,Martínez-Asensio A,Garcias-Bonet N,Dachs J,González-Gaya B,Royer SJ,Benítez-Barrios VM,Fraile-Nuez E,Duarte CM

更新日期：2017-08-04 00:00:00