Structural basis of human PCNA sliding on DNA.

abstract：:The experimental investigation of quantum devices incorporating mechanical resonators has opened up new frontiers in the study of quantum mechanics at a macroscopic level. It has recently been shown that surface acoustic waves (SAWs) can be piezoelectrically coupled to superconducting qubits, and confined in high-qual...

journal_title：Nature communications

authors： Manenti R,Kockum AF,Patterson A,Behrle T,Rahamim J,Tancredi G,Nori F,Leek PJ

更新日期：2017-10-17 00:00:00

abstract：:Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate of only 12% for patients with the metastatic disease. Checkpoint inhibitors, such as the antibodies inhibiting the PD-1/PD-L1 axis, are among the most promising immunotherapies for patients with advanced colon cancer, but their dur...

journal_title：Nature communications

authors： He C,Duan X,Guo N,Chan C,Poon C,Weichselbaum RR,Lin W

更新日期：2016-08-17 00:00:00

abstract：:Centromeres consist of specialized centrochromatin containing CENP-A nucleosomes intermingled with H3 nucleosomes carrying transcription-associated modifications. We have designed a novel synthetic biology 'in situ epistasis' analysis in which H3 dimethylated on lysine 4 (H3K4me2) demethylase LSD2 plus synthetic modul...

journal_title：Nature communications

authors： Molina O,Vargiu G,Abad MA,Zhiteneva A,Jeyaprakash AA,Masumoto H,Kouprina N,Larionov V,Earnshaw WC

更新日期：2016-11-14 00:00:00

abstract：:Cell-to-cell variability plays a critical role in cellular responses and decision-making in a population, and transcriptional bursting has been broadly studied by experimental and theoretical approaches as the potential source of cell-to-cell variability. Although molecular mechanisms of transcriptional bursting have ...

journal_title：Nature communications

authors： Fujita K,Iwaki M,Yanagida T

更新日期：2016-12-07 00:00:00

abstract：:Single-nucleotide variants that underlie phenotypic variation can affect chromatin occupancy of transcription factors (TFs). To delineate determinants of in vivo TF binding and chromatin accessibility, we introduce an approach that compares ChIP-seq and DNase-seq data sets from genetically divergent murine erythroid c...

journal_title：Nature communications

authors： Behera V,Evans P,Face CJ,Hamagami N,Sankaranarayanan L,Keller CA,Giardine B,Tan K,Hardison RC,Shi J,Blobel GA

更新日期：2018-02-22 00:00:00

abstract：:Helitrons are eukaryotic DNA transposons that have profoundly affected genome variability via capture and mobilization of host genomic sequences. Defining their mode of action is therefore important for understanding how genome landscapes evolve. Sequence similarities with certain prokaryotic mobile elements suggest a...

journal_title：Nature communications

authors： Grabundzija I,Hickman AB,Dyda F

更新日期：2018-03-29 00:00:00

abstract：:Proactive, that is, unsolicited, prosociality is a key component of our hyper-cooperation, which in turn has enabled the emergence of various uniquely human traits, including complex cognition, morality and cumulative culture and technology. However, the evolutionary foundation of the human prosocial sentiment remains...

journal_title：Nature communications

authors： Burkart JM,Allon O,Amici F,Fichtel C,Finkenwirth C,Heschl A,Huber J,Isler K,Kosonen ZK,Martins E,Meulman EJ,Richiger R,Rueth K,Spillmann B,Wiesendanger S,van Schaik CP

更新日期：2014-08-27 00:00:00

abstract：:It is known that temperature estimates of macroscopic systems in equilibrium are most precise when their energy fluctuations are large. However, for nanoscale systems deviations from standard thermodynamics arise due to their interactions with the environment. Here we include such interactions and, using quantum estim...

journal_title：Nature communications

authors： Miller HJD,Anders J

更新日期：2018-06-06 00:00:00

abstract：:Mechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical information: stress magnitu...

journal_title：Nature communications

authors： Hamant O,Inoue D,Bouchez D,Dumais J,Mjolsness E

更新日期：2019-05-29 00:00:00

abstract：:Cladodontomorph sharks are Palaeozoic stem chondrichthyans thought to go extinct at the end-Permian mass extinction. This extinction preceded the diversification of euselachians, including modern sharks. Here we describe an outer-platform cladodontomorph shark tooth assemblage from the Early Cretaceous of southern Fra...

journal_title：Nature communications

authors： Guinot G,Adnet S,Cavin L,Cappetta H

更新日期：2013-01-01 00:00:00

abstract：:Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine modification, N(6)-methyladenine (6mA), has recently been found in mammalian cells. However, the presence and function(s) of 6mA in the mammalian brain remain ...

journal_title：Nature communications

authors： Yao B,Cheng Y,Wang Z,Li Y,Chen L,Huang L,Zhang W,Chen D,Wu H,Tang B,Jin P

更新日期：2017-10-24 00:00:00

abstract：:Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time...

journal_title：Nature communications

authors： Galenkamp NS,Soskine M,Hermans J,Wloka C,Maglia G

更新日期：2018-10-05 00:00:00

abstract：:Large single-crystal graphene is highly desired and important for the applications of graphene in electronics, as grain boundaries between graphene grains markedly degrade its quality and properties. Here we report the growth of millimetre-sized hexagonal single-crystal graphene and graphene films joined from such gra...

journal_title：Nature communications

authors： Gao L,Ren W,Xu H,Jin L,Wang Z,Ma T,Ma LP,Zhang Z,Fu Q,Peng LM,Bao X,Cheng HM

更新日期：2012-02-28 00:00:00

abstract：:The mechanisms underlying how cells subjected to genotoxic stress reestablish reduction-oxidation (redox) homeostasis to scavenge genotoxic stress-induced reactive oxygen species (ROS), which maintains the physiological function of cellular processes and cell survival, remain unclear. Herein, we report that, via a TCF...

journal_title：Nature communications

authors： Cao L,Wu G,Zhu J,Tan Z,Shi D,Wu X,Tang M,Li Z,Hu Y,Zhang S,Yu R,Mo S,Wu J,Song E,Li M,Song L,Li J

更新日期：2019-08-21 00:00:00

abstract：:Circular RNAs (circRNAs) have recently gained substantial attention in the cancer research field where most, including the putative oncogene ciRS-7 (CDR1as), have been proposed to function as competitive endogenous RNAs (ceRNAs) by sponging specific microRNAs. Here, we report the first spatially resolved cellular expr...

journal_title：Nature communications

authors： Kristensen LS,Ebbesen KK,Sokol M,Jakobsen T,Korsgaard U,Eriksen AC,Hansen TB,Kjems J,Hager H

更新日期：2020-09-11 00:00:00

abstract：:Chirality is an intriguing property of certain molecules, materials or artificial nanostructures, which allows them to interact with the spin angular momentum of the impinging light field. Due to their chiral geometry, they can distinguish between left- and right-hand circular polarization states or convert them into ...

journal_title：Nature communications

authors： Banzer P,Woźniak P,Mick U,De Leon I,Boyd RW

更新日期：2016-10-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Ma X,Liang H,Cui X,Liu Y,Lu H,Ning W,Poon NY,Ho B,Zhou K

更新日期：2019-08-21 00:00:00

abstract：:The Greenland ice sheet has become one of the main contributors to global sea level rise, predominantly through increased meltwater runoff. The main drivers of Greenland ice sheet runoff, however, remain poorly understood. Here we show that clouds enhance meltwater runoff by about one-third relative to clear skies, us...

journal_title：Nature communications

authors： Van Tricht K,Lhermitte S,Lenaerts JT,Gorodetskaya IV,L'Ecuyer TS,Noël B,van den Broeke MR,Turner DD,van Lipzig NP

更新日期：2016-01-12 00:00:00

abstract：:Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin αMβ2, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for injury responses in diverse disease models. However, the role of Mac-1 i...

journal_title：Nature communications

authors： Wang Y,Gao H,Shi C,Erhardt PW,Pavlovsky A,A Soloviev D,Bledzka K,Ustinov V,Zhu L,Qin J,Munday AD,Lopez J,Plow E,Simon DI

更新日期：2017-05-30 00:00:00

abstract：:Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are unknown. Here we examine the role of upstream inputs to PCs-excitatory granule cells (GCs) and inhibitory molecular layer interneurons-in processing of whisking sign...

journal_title：Nature communications

authors： Chen S,Augustine GJ,Chadderton P

更新日期：2017-08-10 00:00:00

abstract：:International corporations in an increasingly globalized economy exert a major influence on the planet's land use and resources through their product design and material sourcing decisions. Many companies use life cycle assessment (LCA) to evaluate their sustainability, yet commonly-used LCA methodologies lack the spa...

journal_title：Nature communications

authors： Chaplin-Kramer R,Sim S,Hamel P,Bryant B,Noe R,Mueller C,Rigarlsford G,Kulak M,Kowal V,Sharp R,Clavreul J,Price E,Polasky S,Ruckelshaus M,Daily G

更新日期：2017-04-21 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Mattesen TB,Rasmussen MH,Sandoval J,Ongen H,Árnadóttir SS,Gladov J,Martinez-Cardus A,de Moura MC,Madsen AH,Laurberg S,Dermitzakis ET,Esteller M,Andersen CL,Bramsen JB

更新日期：2020-06-03 00:00:00

abstract：:The gravitational collapse of eruption columns generates ground-hugging pyroclastic density currents (PDCs) with highly variable temperatures, high enough to be a threat for communities surrounding volcanoes. The reasons for such great temperature variability are debated in terms of eruptive versus transport and empla...

journal_title：Nature communications

authors： Trolese M,Cerminara M,Esposti Ongaro T,Giordano G

更新日期：2019-06-06 00:00:00

abstract：:Mappings of classical computation onto statistical mechanics models have led to remarkable successes in addressing some complex computational problems. However, such mappings display thermodynamic phase transitions that may prevent reaching solution even for easy problems known to be solvable in polynomial time. Here ...

journal_title：Nature communications

authors： Chamon C,Mucciolo ER,Ruckenstein AE,Yang ZC

更新日期：2017-05-12 00:00:00

abstract：:Novel methods for information processing are highly desired in our information-driven society. Inspired by the brain's ability to process information, the recently introduced paradigm known as 'reservoir computing' shows that complex networks can efficiently perform computation. Here we introduce a novel architecture ...

journal_title：Nature communications

authors： Appeltant L,Soriano MC,Van der Sande G,Danckaert J,Massar S,Dambre J,Schrauwen B,Mirasso CR,Fischer I

更新日期：2011-09-13 00:00:00

abstract：:The ability to identify cause-effect relations is an essential component of the scientific method. The identification of causal relations is generally accomplished through statistical trials where alternative hypotheses are tested against each other. Traditionally, such trials have been based on classical statistics. ...

journal_title：Nature communications

authors： Chiribella G,Ebler D

更新日期：2019-04-01 00:00:00

abstract：:Rosemary extracts containing the phenolic diterpenes carnosic acid and its derivative carnosol are approved food additives used in an increasingly wide range of products to enhance shelf-life, thanks to their high anti-oxidant activity. We describe here the elucidation of the complete biosynthetic pathway of carnosic ...

journal_title：Nature communications

authors： Scheler U,Brandt W,Porzel A,Rothe K,Manzano D,Božić D,Papaefthimiou D,Balcke GU,Henning A,Lohse S,Marillonnet S,Kanellis AK,Ferrer A,Tissier A

更新日期：2016-10-05 00:00:00

abstract：:The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alterna...

journal_title：Nature communications

authors： Wang B,Tan XF,Thurmond S,Zhang ZM,Lin A,Hai R,Song J

更新日期：2017-03-27 00:00:00

abstract：:The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibr...

journal_title：Nature communications

authors： Cazet AS,Hui MN,Elsworth BL,Wu SZ,Roden D,Chan CL,Skhinas JN,Collot R,Yang J,Harvey K,Johan MZ,Cooper C,Nair R,Herrmann D,McFarland A,Deng N,Ruiz-Borrego M,Rojo F,Trigo JM,Bezares S,Caballero R,Lim E,Timpson P

更新日期：2018-07-24 00:00:00

abstract：:Photoluminescence phenomena normally obey Stokes' law of luminescence according to which the emitted photon energy is typically lower than its excitation counterparts. Here we show that carbon nanotubes break this rule under one-photon excitation conditions. We found that the carbon nanotubes exhibit efficient near-in...

journal_title：Nature communications

authors： Akizuki N,Aota S,Mouri S,Matsuda K,Miyauchi Y

更新日期：2015-11-16 00:00:00