Artificial van der Waals hybrid synapse and its application to acoustic pattern recognition.

Abstract:

:Brain-inspired parallel computing, which is typically performed using a hardware neural-network platform consisting of numerous artificial synapses, is a promising technology for effectively handling large amounts of informational data. However, the reported nonlinear and asymmetric conductance-update characteristics of artificial synapses prevent a hardware neural-network from delivering the same high-level training and inference accuracies as those delivered by a software neural-network. Here, we developed an artificial van-der-Waals hybrid synapse that features linear and symmetric conductance-update characteristics. Tungsten diselenide and molybdenum disulfide channels were used selectively to potentiate and depress conductance. Subsequently, via training and inference simulation, we demonstrated the feasibility of our hybrid synapse toward a hardware neural-network and also delivered high recognition rates that were comparable to those delivered using a software neural-network. This simulation involving the use of acoustic patterns was performed with a neural network that was theoretically formed with the characteristics of the hybrid synapses.

journal_name

Nat Commun

journal_title

Nature communications

authors

Seo S,Kang BS,Lee JJ,Ryu HJ,Kim S,Kim H,Oh S,Shim J,Heo K,Oh S,Park JH

doi

10.1038/s41467-020-17849-3

subject

Has Abstract

pub_date

2020-08-07 00:00:00

pages

3936

issue

1

issn

2041-1723

pii

10.1038/s41467-020-17849-3

journal_volume

11

pub_type

杂志文章
  • Noise reduction facilitated by dosage compensation in gene networks.

    abstract::Genetic noise together with genome duplication and volume changes during cell cycle are significant contributors to cell-to-cell heterogeneity. How can cells buffer the effects of these unavoidable epigenetic and genetic variations on phenotypes that are sensitive to such variations? Here we show that a simple network...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms12959

    authors: Peng W,Song R,Acar M

    更新日期:2016-10-03 00:00:00

  • Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury.

    abstract::Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that kidney function is  recovered after AKI despite substantial t...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-03753-4

    authors: Lazzeri E,Angelotti ML,Peired A,Conte C,Marschner JA,Maggi L,Mazzinghi B,Lombardi D,Melica ME,Nardi S,Ronconi E,Sisti A,Antonelli G,Becherucci F,De Chiara L,Guevara RR,Burger A,Schaefer B,Annunziato F,Anders HJ,La

    更新日期:2018-04-09 00:00:00

  • Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases.

    abstract::TP53 mutations are the most frequent genetic alterations in breast cancer and are associated with more aggressive disease and worse overall survival. We have created two conditional mutant Trp53 alleles in the mouse that allow expression of Trp53R172H or Trp53R245W missense mutations in single cells surrounded by a no...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06146-9

    authors: Zhang Y,Xiong S,Liu B,Pant V,Celii F,Chau G,Elizondo-Fraire AC,Yang P,You MJ,El-Naggar AK,Navin NE,Lozano G

    更新日期:2018-09-27 00:00:00

  • Redox reactions and weak buffering capacity lead to acidification in the Chesapeake Bay.

    abstract::The combined effects of anthropogenic and biological CO2 inputs may lead to more rapid acidification in coastal waters compared to the open ocean. It is less clear, however, how redox reactions would contribute to acidification. Here we report estuarine acidification dynamics based on oxygen, hydrogen sulfide (H2S), p...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-00417-7

    authors: Cai WJ,Huang WJ,Luther GW 3rd,Pierrot D,Li M,Testa J,Xue M,Joesoef A,Mann R,Brodeur J,Xu YY,Chen B,Hussain N,Waldbusser GG,Cornwell J,Kemp WM

    更新日期:2017-08-28 00:00:00

  • GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.

    abstract::GFI1 is a transcriptional regulator expressed in lymphoid cells, and an "oncorequisite" factor required for development and maintenance of T-lymphoid leukemia. GFI1 deletion causes hypersensitivity to ionizing radiation, for which the molecular mechanism remains unknown. Here, we demonstrate that GFI1 is required in T...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-03817-5

    authors: Vadnais C,Chen R,Fraszczak J,Yu Z,Boulais J,Pinder J,Frank D,Khandanpour C,Hébert J,Dellaire G,Côté JF,Richard S,Orthwein A,Drobetsky E,Möröy T

    更新日期:2018-04-12 00:00:00

  • Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing.

    abstract::Adeno-associated virus (AAV) capsid engineering is an emerging approach to advance gene therapy. However, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. Here we show proof-of-principle and successful application of a novel approach, termed AAV Barcode-Seq, th...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4075

    authors: Adachi K,Enoki T,Kawano Y,Veraz M,Nakai H

    更新日期:2014-01-01 00:00:00

  • Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism.

    abstract::Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholipid synthesis. In vertebrates, SREBP activation is mainly contr...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-09152-7

    authors: Bertolio R,Napoletano F,Mano M,Maurer-Stroh S,Fantuz M,Zannini A,Bicciato S,Sorrentino G,Del Sal G

    更新日期:2019-03-22 00:00:00

  • Local microRNA delivery targets Palladin and prevents metastatic breast cancer.

    abstract::Metastasis is the primary cause for mortality in breast cancer. MicroRNAs, gene expression master regulators, constitute an attractive candidate to control metastasis. Here we show that breast cancer metastasis can be prevented by miR-96 or miR-182 treatment, and decipher the mechanism of action. We found that miR-96/...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms12868

    authors: Gilam A,Conde J,Weissglas-Volkov D,Oliva N,Friedman E,Artzi N,Shomron N

    更新日期:2016-09-19 00:00:00

  • Disentangling the role of floral sensory stimuli in pollination networks.

    abstract::Despite progress in understanding pollination network structure, the functional roles of floral sensory stimuli (visual, olfactory) have never been addressed comprehensively in a community context, even though such traits are known to mediate plant-pollinator interactions. Here, we use a comprehensive dataset of flora...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-03448-w

    authors: Kantsa A,Raguso RA,Dyer AG,Olesen JM,Tscheulin T,Petanidou T

    更新日期:2018-03-12 00:00:00

  • Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue.

    abstract::The insulin/IGF-1 signalling pathway is a key regulator of metabolism and the rate of ageing. We previously documented that systemic inactivation of phosphoinositide 3-kinase (PI3K) p110α, the principal PI3K isoform that positively regulates insulin signalling, results in a beneficial metabolic effect in aged mice. He...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-09514-1

    authors: Araiz C,Yan A,Bettedi L,Samuelson I,Virtue S,McGavigan AK,Dani C,Vidal-Puig A,Foukas LC

    更新日期:2019-04-04 00:00:00

  • Characterizing rare fluctuations in soft particulate flows.

    abstract::Soft particulate media include a wide range of systems involving athermal dissipative particles both in non-living and biological materials. Characterization of flows of particulate media is of great practical and theoretical importance. A fascinating feature of these systems is the existence of a critical rigidity tr...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-00022-8

    authors: Rahbari SHE,Saberi AA,Park H,Vollmer J

    更新日期:2017-04-10 00:00:00

  • Origin and structure of polar domains in doped molecular crystals.

    abstract::Doping is a primary tool for the modification of the properties of materials. Occlusion of guest molecules in crystals generally reduces their symmetry by the creation of polar domains, which engender polarization and pyroelectricity in the doped crystals. Here we describe a molecular-level determination of the struct...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms13351

    authors: Meirzadeh E,Azuri I,Qi Y,Ehre D,Rappe AM,Lahav M,Kronik L,Lubomirsky I

    更新日期:2016-11-08 00:00:00

  • Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation.

    abstract::Cognitive performance in people varies according to time-of-day, with memory retrieval declining in the late afternoon-early evening. However, functional roles of local brain circadian clocks in memory performance remains unclear. Here, we show that hippocampal clock controlled by the circadian-dependent transcription...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-13554-y

    authors: Hasegawa S,Fukushima H,Hosoda H,Serita T,Ishikawa R,Rokukawa T,Kawahara-Miki R,Zhang Y,Ohta M,Okada S,Tanimizu T,Josselyn SA,Frankland PW,Kida S

    更新日期:2019-12-18 00:00:00

  • Modeling mitigation of influenza epidemics by baloxavir.

    abstract::Influenza viruses annually kill 290,000-650,000 people worldwide. Antivirals can reduce death tolls. Baloxavir, the recently approved influenza antiviral, inhibits initiation of viral mRNA synthesis, whereas oseltamivir, an older drug, inhibits release of virus progeny. Baloxavir blocks virus replication more rapidly ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-16585-y

    authors: Du Z,Nugent C,Galvani AP,Krug RM,Meyers LA

    更新日期:2020-06-02 00:00:00

  • Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma.

    abstract::Survival following a diagnosis of multiple myeloma (MM) varies between patients and some of these differences may be a consequence of inherited genetic variation. In this study, to identify genetic markers associated with MM overall survival (MM-OS), we conduct a meta-analysis of four patient series of European ancest...

    journal_title:Nature communications

    pub_type: 杂志文章,meta分析

    doi:10.1038/ncomms10290

    authors: Johnson DC,Weinhold N,Mitchell JS,Chen B,Kaiser M,Begum DB,Hillengass J,Bertsch U,Gregory WA,Cairns D,Jackson GH,Försti A,Nickel J,Hoffmann P,Nöethen MM,Stephens OW,Barlogie B,Davis FE,Hemminki K,Goldschmidt H,Hou

    更新日期:2016-01-08 00:00:00

  • Interpreting nanovoids in atom probe tomography data for accurate local compositional measurements.

    abstract::Quantifying chemical compositions around nanovoids is a fundamental task for research and development of various materials. Atom probe tomography (APT) and scanning transmission electron microscopy (STEM) are currently the most suitable tools because of their ability to probe materials at the nanoscale. Both technique...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-14832-w

    authors: Wang X,Hatzoglou C,Sneed B,Fan Z,Guo W,Jin K,Chen D,Bei H,Wang Y,Weber WJ,Zhang Y,Gault B,More KL,Vurpillot F,Poplawsky JD

    更新日期:2020-02-24 00:00:00

  • An artificial primitive mimic of the Gramicidin-A channel.

    abstract::Gramicidin A (gA) is the simplest known natural channel, and important progress in improving conduction activity has previously been obtained with modified natural gAs. However, simple artificial systems mimicking the gA functions are unknown. Here we show that gA can be mimicked using a simple synthetic triazole or '...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms5142

    authors: Barboiu M,Le Duc Y,Gilles A,Cazade PA,Michau M,Marie Legrand Y,van der Lee A,Coasne B,Parvizi P,Post J,Fyles T

    更新日期:2014-06-26 00:00:00

  • CORE GREML for estimating covariance between random effects in linear mixed models for complex trait analyses.

    abstract::As a key variance partitioning tool, linear mixed models (LMMs) using genome-based restricted maximum likelihood (GREML) allow both fixed and random effects. Classic LMMs assume independence between random effects, which can be violated, causing bias. Here we introduce a generalized GREML, named CORE GREML, that expli...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18085-5

    authors: Zhou X,Im HK,Lee SH

    更新日期:2020-08-21 00:00:00

  • Myogenin promotes myocyte fusion to balance fibre number and size.

    abstract::Each skeletal muscle acquires its unique size before birth, when terminally differentiating myocytes fuse to form a defined number of multinucleated myofibres. Although mice in which the transcription factor Myogenin is mutated lack most myogenesis and die perinatally, a specific cell biological role for Myogenin has ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06583-6

    authors: Ganassi M,Badodi S,Ortuste Quiroga HP,Zammit PS,Hinits Y,Hughes SM

    更新日期:2018-10-12 00:00:00

  • Resolving Dirac electrons with broadband high-resolution NMR.

    abstract::Detecting the metallic Dirac electronic states on the surface of Topological Insulators (TIs) is critical for the study of important surface quantum properties (SQPs), such as Majorana zero modes, where simultaneous probing of the bulk and edge electron states is required. However, there is a particular shortage of ex...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-14838-4

    authors: Papawassiliou W,Jaworski A,Pell AJ,Jang JH,Kim Y,Lee SC,Kim HJ,Alwahedi Y,Alhassan S,Subrati A,Fardis M,Karagianni M,Panopoulos N,Dolinšek J,Papavassiliou G

    更新日期:2020-03-09 00:00:00

  • Interactions with conspecific outsiders as drivers of cognitive evolution.

    abstract::The social intelligence hypothesis (SIH) posits that within-group interactions drive cognitive evolution, but it has received equivocal support. We argue the SIH overlooks a major component of social life: interactions with conspecific outsiders. Competition for vital resources means conspecific outsiders present myri...

    journal_title:Nature communications

    pub_type: 杂志文章,评审

    doi:10.1038/s41467-020-18780-3

    authors: Ashton BJ,Kennedy P,Radford AN

    更新日期:2020-10-06 00:00:00

  • Neurofilament sidearms modulate parallel and crossed-filament orientations inducing nematic to isotropic and re-entrant birefringent hydrogels.

    abstract::Neurofilaments are intermediate filaments assembled from the subunits neurofilament-low, neurofilament-medium and neurofilament-high. In axons, parallel neurofilaments form a nematic liquid-crystal hydrogel with network structure arising from interactions between the neurofilaments' C-terminal sidearms. Here we report...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms3224

    authors: Deek J,Chung PJ,Kayser J,Bausch AR,Safinya CR

    更新日期:2013-01-01 00:00:00

  • Voltage-induced spreading and superspreading of liquids.

    abstract::The ability to quickly spread a liquid across a surface and form a film is fundamental for a diverse range of technological processes, including printing, painting and spraying. Here we show that liquid dielectrophoresis or electrowetting can produce wetting on normally non-wetting surfaces, without needing modificati...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2619

    authors: McHale G,Brown CV,Sampara N

    更新日期:2013-01-01 00:00:00

  • Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.

    abstract::RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and consumption and di...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-05870-6

    authors: Zhang C,Seo J,Murakami K,Salem ESB,Bernhard E,Borra VJ,Choi K,Yuan CL,Chan CC,Chen X,Huang T,Weirauch MT,Divanovic S,Qi NR,Thomas HE,Mercer CA,Siomi H,Nakamura T

    更新日期:2018-09-10 00:00:00

  • Memory phototransistors based on exponential-association photoelectric conversion law.

    abstract::Ultraweak light detectors have wide-ranging important applications such as astronomical observation, remote sensing, laser ranging, and night vision. Current commercial ultraweak light detectors are commonly based on a photomultiplier tube or an avalanche photodiode, and they are incompatible with microelectronic devi...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-09206-w

    authors: Shao Z,Jiang T,Zhang X,Zhang X,Wu X,Xia F,Xiong S,Lee ST,Jie J

    更新日期:2019-03-20 00:00:00

  • Electron-vibration coupling induced renormalization in the photoemission spectrum of diamondoids.

    abstract::The development of theories and methods devoted to the accurate calculation of the electronic quasi-particle states and levels of molecules, clusters and solids is of prime importance to interpret the experimental data. These quantum systems are often modelled by using the Born-Oppenheimer approximation where the coup...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms11327

    authors: Gali A,Demján T,Vörös M,Thiering G,Cannuccia E,Marini A

    更新日期:2016-04-22 00:00:00

  • Electronic components embedded in a single graphene nanoribbon.

    abstract::The use of graphene in electronic devices requires a band gap, which can be achieved by creating nanostructures such as graphene nanoribbons. A wide variety of atomically precise graphene nanoribbons can be prepared through on-surface synthesis, bringing the concept of graphene nanoribbon electronics closer to reality...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-00195-2

    authors: Jacobse PH,Kimouche A,Gebraad T,Ervasti MM,Thijssen JM,Liljeroth P,Swart I

    更新日期:2017-07-25 00:00:00

  • Skin-inspired hydrogel-elastomer hybrids with robust interfaces and functional microstructures.

    abstract::Inspired by mammalian skins, soft hybrids integrating the merits of elastomers and hydrogels have potential applications in diverse areas including stretchable and bio-integrated electronics, microfluidics, tissue engineering, soft robotics and biomedical devices. However, existing hydrogel-elastomer hybrids have limi...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms12028

    authors: Yuk H,Zhang T,Parada GA,Liu X,Zhao X

    更新日期:2016-06-27 00:00:00

  • Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum.

    abstract::Multidrug resistant Plasmodium falciparum in Southeast Asia endangers regional malaria elimination and threatens to spread to other malaria endemic areas. Understanding mechanisms of piperaquine (PPQ) resistance is crucial for tracking its emergence and spread, and to develop effective strategies for overcoming it. He...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04104-z

    authors: Bopp S,Magistrado P,Wong W,Schaffner SF,Mukherjee A,Lim P,Dhorda M,Amaratunga C,Woodrow CJ,Ashley EA,White NJ,Dondorp AM,Fairhurst RM,Ariey F,Menard D,Wirth DF,Volkman SK

    更新日期:2018-05-02 00:00:00

  • Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.

    abstract::High-dose ionizing radiation induces severe DNA damage in the epithelial stem cells in small intestinal crypts and causes gastrointestinal syndrome (GIS). Although the tumour suppressor p53 is a primary factor inducing death of crypt cells with DNA damage, its essential role in maintaining genome stability means inhib...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4492

    authors: Takemura N,Kawasaki T,Kunisawa J,Sato S,Lamichhane A,Kobiyama K,Aoshi T,Ito J,Mizuguchi K,Karuppuchamy T,Matsunaga K,Miyatake S,Mori N,Tsujimura T,Satoh T,Kumagai Y,Kawai T,Standley DM,Ishii KJ,Kiyono H,Akira S,

    更新日期:2014-03-18 00:00:00