Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases.

Abstract:

:TP53 mutations are the most frequent genetic alterations in breast cancer and are associated with more aggressive disease and worse overall survival. We have created two conditional mutant Trp53 alleles in the mouse that allow expression of Trp53R172H or Trp53R245W missense mutations in single cells surrounded by a normal stroma and immune system. Mice with Trp53 mutations in a few breast epithelial cells develop breast cancers with high similarity to human breast cancer including triple negative. p53R245W tumors are the most aggressive and exhibit metastases to lung and liver. Development of p53R172H breast tumors with some metastases requires additional hits. Sequencing of primary tumors and metastases shows p53R245W drives a parallel evolutionary pattern of metastases. These in vivo models most closely simulate the genesis of human breast cancer and will thus be invaluable in testing novel therapeutic options.

journal_name

Nat Commun

journal_title

Nature communications

authors

Zhang Y,Xiong S,Liu B,Pant V,Celii F,Chau G,Elizondo-Fraire AC,Yang P,You MJ,El-Naggar AK,Navin NE,Lozano G

doi

10.1038/s41467-018-06146-9

subject

Has Abstract

pub_date

2018-09-27 00:00:00

pages

3953

issue

1

issn

2041-1723

pii

10.1038/s41467-018-06146-9

journal_volume

9

pub_type

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