Scanning superlens microscopy for non-invasive large field-of-view visible light nanoscale imaging.

abstract：:Hereditary retinal degenerations (HRDs) are Mendelian diseases characterized by progressive blindness and caused by ultra-rare mutations. In a genomic screen of 331 unrelated Japanese patients, we identify a disruptive Alu insertion and a nonsense variant (p.Arg1933*) in the ciliary gene RP1, neither of which are rare...

journal_title：Nature communications

authors： Nikopoulos K,Cisarova K,Quinodoz M,Koskiniemi-Kuendig H,Miyake N,Farinelli P,Rehman AU,Khan MI,Prunotto A,Akiyama M,Kamatani Y,Terao C,Miya F,Ikeda Y,Ueno S,Fuse N,Murakami A,Wada Y,Terasaki H,Sonoda KH,Ishibashi

更新日期：2019-06-28 00:00:00

abstract：:Prompt identification of acute coronary syndrome is a challenge in clinical practice. The 12-lead electrocardiogram (ECG) is readily available during initial patient evaluation, but current rule-based interpretation approaches lack sufficient accuracy. Here we report machine learning-based methods for the prediction o...

journal_title：Nature communications

authors： Al-Zaiti S,Besomi L,Bouzid Z,Faramand Z,Frisch S,Martin-Gill C,Gregg R,Saba S,Callaway C,Sejdić E

更新日期：2020-08-07 00:00:00

abstract：:A fascinating but uncharacterized action of antimitotic chemotherapy is to collectively prime cancer cells to apoptotic mitochondrial outer membrane permeabilization (MOMP), while impacting only on cycling cell subsets. Here, we show that a proapoptotic secretory phenotype is induced by activation of cGAS/STING in can...

journal_title：Nature communications

authors： Lohard S,Bourgeois N,Maillet L,Gautier F,Fétiveau A,Lasla H,Nguyen F,Vuillier C,Dumont A,Moreau-Aubry A,Frapin M,David L,Loussouarn D,Kerdraon O,Campone M,Jézéquel P,Juin PP,Barillé-Nion S

更新日期：2020-01-14 00:00:00

abstract：:Myoblast fusion (MF) is required for muscle growth and repair, and its alteration contributes to muscle diseases. The mechanisms governing this process are incompletely understood, and no epigenetic regulator has been previously described. Ash1L is an epigenetic activator belonging to the Trithorax group of proteins a...

journal_title：Nature communications

authors： Castiglioni I,Caccia R,Garcia-Manteiga JM,Ferri G,Caretti G,Molineris I,Nishioka K,Gabellini D

更新日期：2018-11-28 00:00:00

abstract：:New exotic phenomena have recently been discovered in oxides of paramagnetic Ir(4+) ions, widely known as 'iridates'. Their remarkable properties originate from concerted effects of the crystal field, magnetic interactions and strong spin-orbit coupling, characteristic of 5d metal ions. Despite numerous experimental r...

journal_title：Nature communications

authors： Pedersen KS,Bendix J,Tressaud A,Durand E,Weihe H,Salman Z,Morsing TJ,Woodruff DN,Lan Y,Wernsdorfer W,Mathonière C,Piligkos S,Klokishner SI,Ostrovsky S,Ollefs K,Wilhelm F,Rogalev A,Clérac R

更新日期：2016-07-20 00:00:00

abstract：:Manipulation of proteins by chemical modification is a powerful way to decipher their function. However, most ribosome-dependent and semi-synthetic methods have limitations in the number and type of modifications that can be introduced, especially in live cells. Here, we present an approach to incorporate single or mu...

journal_title：Nature communications

authors： Khoo KK,Galleano I,Gasparri F,Wieneke R,Harms H,Poulsen MH,Chua HC,Wulf M,Tampé R,Pless SA

更新日期：2020-05-08 00:00:00

abstract：:Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop ...

journal_title：Nature communications

authors： Boudewijns R,Thibaut HJ,Kaptein SJF,Li R,Vergote V,Seldeslachts L,Van Weyenbergh J,De Keyzer C,Bervoets L,Sharma S,Liesenborghs L,Ma J,Jansen S,Van Looveren D,Vercruysse T,Wang X,Jochmans D,Martens E,Roose K,De Vlie

更新日期：2020-11-17 00:00:00

abstract：:Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes. We report here a cryo-electron microscopy structure of a single insulin bound to a physiologically relevant, high-affinity version of the receptor ectodomain, th...

journal_title：Nature communications

authors： Weis F,Menting JG,Margetts MB,Chan SJ,Xu Y,Tennagels N,Wohlfart P,Langer T,Müller CW,Dreyer MK,Lawrence MC

更新日期：2018-10-24 00:00:00

abstract：:The cost of whole-genome bisulfite sequencing (WGBS) remains a bottleneck for many studies and it is therefore imperative to extract as much information as possible from a given dataset. This is particularly important because even at the recommend 30X coverage for reference methylomes, up to 50% of high-resolution fea...

journal_title：Nature communications

authors： Libertini E,Heath SC,Hamoudi RA,Gut M,Ziller MJ,Czyz A,Ruotti V,Stunnenberg HG,Frontini M,Ouwehand WH,Meissner A,Gut IG,Beck S

更新日期：2016-06-27 00:00:00

abstract：:The temperature-jump technique, in which the sample is rapidly heated by a powerful laser pulse, has been widely used to probe the fast dynamics of folding of proteins and nucleic acids. However, the existing temperature-jump setups tend to involve sophisticated and expensive instrumentation, while providing only mode...

journal_title：Nature communications

authors： Polinkovsky ME,Gambin Y,Banerjee PR,Erickstad MJ,Groisman A,Deniz AA

更新日期：2014-12-17 00:00:00

abstract：:Spatial correlations in environmental stochasticity can synchronize populations over wide areas, a phenomenon known as the Moran effect. The Moran effect has been confirmed in field, laboratory and theoretical investigations. Little is known, however, about the Moran effect in a common ecological case, when environmen...

journal_title：Nature communications

authors： Massie TM,Weithoff G,Kuckländer N,Gaedke U,Blasius B

更新日期：2015-01-09 00:00:00

abstract：:Blood vessel expansion is driven by sprouting angiogenesis of endothelial cells, and is essential for development, wound healing and disease. Membrane-localized vascular endothelial growth factor receptor-1 (mVEGFR1) is an endothelial cell-intrinsic decoy receptor that negatively modulates blood vessel morphogenesis. ...

journal_title：Nature communications

authors： Boucher JM,Clark RP,Chong DC,Citrin KM,Wylie LA,Bautch VL

更新日期：2017-06-07 00:00:00

abstract：:Despite centuries of research, much about the barbarian migrations that took place between the fourth and sixth centuries in Europe remains hotly debated. To better understand this key era that marks the dawn of modern European societies, we obtained ancient genomic DNA from 63 samples from two cemeteries (from Hungar...

journal_title：Nature communications

authors： Amorim CEG,Vai S,Posth C,Modi A,Koncz I,Hakenbeck S,La Rocca MC,Mende B,Bobo D,Pohl W,Baricco LP,Bedini E,Francalacci P,Giostra C,Vida T,Winger D,von Freeden U,Ghirotto S,Lari M,Barbujani G,Krause J,Caramelli D

更新日期：2018-09-11 00:00:00

abstract：:The Sun's activity cycle governs the radiation, particle and magnetic flux in the heliosphere creating hazardous space weather. Decadal-scale variations define space climate and force the Earth's atmosphere. However, predicting the solar cycle is challenging. Current understanding indicates a short window for predicti...

journal_title：Nature communications

authors： Bhowmik P,Nandy D

更新日期：2018-12-06 00:00:00

abstract：:Animals promote their survival by avoiding rapidly approaching objects that indicate threats. In mice, looming-evoked defensive responses are triggered by the superior colliculus (SC) which receives direct retinal inputs. However, the specific neural circuits that begin in the retina and mediate this important behavio...

journal_title：Nature communications

authors： Huang L,Yuan T,Tan M,Xi Y,Hu Y,Tao Q,Zhao Z,Zheng J,Han Y,Xu F,Luo M,Sollars PJ,Pu M,Pickard GE,So KF,Ren C

更新日期：2017-03-31 00:00:00

abstract：:Semaphorins and their transmembrane receptors, Plexins, are key regulators of axon guidance and development of neuronal connectivity. B-type Plexins respond to Class IV semaphorins and mediate a variety of developmental functions. Here we report that the expression of Plexin-B2 and its high-affinity ligand, Sema4C, pe...

journal_title：Nature communications

authors： Paldy E,Simonetti M,Worzfeld T,Bali KK,Vicuña L,Offermanns S,Kuner R

更新日期：2017-08-02 00:00:00

abstract：:The continued development of novel drugs, proteins, and advanced materials strongly rely on our ability to self-assemble molecules in solids with the most suitable structure (polymorph) in order to exhibit desired functionalities. The search for new polymorphs remains a scientific challenge, that is at the core of cry...

journal_title：Nature communications

authors： Potticary J,Terry LR,Bell C,Papanikolopoulos AN,Christianen PC,Engelkamp H,Collins AM,Fontanesi C,Kociok-Köhn G,Crampin S,Da Como E,Hall SR

更新日期：2016-05-10 00:00:00

abstract：:The ionic conductance through a nanometer-sized pore in a membrane changes when a biopolymer slides through it, making nanopores sensitive to single molecules in solution. Their possible use for sequencing has motivated numerous studies on how DNA, a semi-flexible polymer, translocates nanopores. Here we study voltage...

journal_title：Nature communications

authors： McMullen A,de Haan HW,Tang JX,Stein D

更新日期：2014-06-16 00:00:00

abstract：:Cryo-electron microscopy can determine the structure of biological matter in vitrified liquids. However, structure alone is insufficient to understand the function of native and engineered biomolecules. So far, their mechanical properties have mainly been probed at room temperature using tens of pico-newton forces wit...

journal_title：Nature communications

authors： Pawlak R,Vilhena JG,Hinaut A,Meier T,Glatzel T,Baratoff A,Gnecco E,Pérez R,Meyer E

更新日期：2019-02-08 00:00:00

abstract：:Hepatocellular-cholangiocarcinoma (H-ChC) is a rare subtype of liver cancer with clinicopathological features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). To date, molecular mechanisms underlying the co-existence of HCC and iCCA components in a single tumor remain elusive. Here, w...

journal_title：Nature communications

authors： Wang A,Wu L,Lin J,Han L,Bian J,Wu Y,Robson SC,Xue L,Ge Y,Sang X,Wang W,Zhao H

更新日期：2018-03-01 00:00:00

abstract：:Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune responses. Using allele-specific expression analysi...

journal_title：Nature communications

authors： Litchfield K,Reading JL,Lim EL,Xu H,Liu P,Al-Bakir M,Wong YNS,Rowan A,Funt SA,Merghoub T,Perkins D,Lauss M,Svane IM,Jönsson G,Herrero J,Larkin J,Quezada SA,Hellmann MD,Turajlic S,Swanton C

更新日期：2020-07-30 00:00:00

abstract：:Some bacteria can feed on fungi, a phenomenon known as mycophagy. Here we show that a prophage tail-like protein (Bg_9562) is essential for mycophagy in Burkholderia gladioli strain NGJ1. The purified protein causes hyphal disintegration and inhibits growth of several fungal species. Disruption of the Bg_9562 gene abo...

journal_title：Nature communications

authors： Swain DM,Yadav SK,Tyagi I,Kumar R,Kumar R,Ghosh S,Das J,Jha G

更新日期：2017-09-01 00:00:00

abstract：:The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effect...

journal_title：Nature communications

authors： Kim JH,Matsubara T,Lee J,Fenollar-Ferrer C,Han K,Kim D,Jia S,Chang CJ,Yang H,Nagano T,Krausz KW,Yim SH,Gonzalez FJ

更新日期：2021-01-12 00:00:00

abstract：:Neuronal reward valuations provide the physiological basis for economic behaviour. Yet, how such valuations are converted to economic decisions remains unclear. Here we show that the dorsolateral prefrontal cortex (DLPFC) implements a flexible value code based on object-specific valuations by single neurons. As monkey...

journal_title：Nature communications

authors： Tsutsui KI,Grabenhorst F,Kobayashi S,Schultz W

更新日期：2016-09-13 00:00:00

abstract：:Oxidation of bromide in aqueous environments initiates the formation of molecular halogen compounds, which is important for the global tropospheric ozone budget. In the aqueous bulk, oxidation of bromide by ozone involves a [Br•OOO-] complex as intermediate. Here we report liquid jet X-ray photoelectron spectroscopy m...

journal_title：Nature communications

authors： Artiglia L,Edebeli J,Orlando F,Chen S,Lee MT,Corral Arroyo P,Gilgen A,Bartels-Rausch T,Kleibert A,Vazdar M,Andres Carignano M,Francisco JS,Shepson PB,Gladich I,Ammann M

更新日期：2017-09-26 00:00:00

abstract：:Climate change is impacting fisheries worldwide with uncertain outcomes for food and nutritional security. Using management strategy evaluations for key US fisheries in the eastern Bering Sea we find that Ecosystem Based Fisheries Management (EBFM) measures forestall future declines under climate change over non-EBFM ...

journal_title：Nature communications

authors： Holsman KK,Haynie AC,Hollowed AB,Reum JCP,Aydin K,Hermann AJ,Cheng W,Faig A,Ianelli JN,Kearney KA,Punt AE

更新日期：2020-09-11 00:00:00

abstract：:Biomechanical energy harvesting textiles based on nanogenerators that convert mechanical energy into electricity have broad application prospects in next-generation wearable electronic devices. However, the difficult-to-weave structure, limited flexibility and stretchability, small device size and poor weatherability ...

journal_title：Nature communications

authors： Gong W,Hou C,Zhou J,Guo Y,Zhang W,Li Y,Zhang Q,Wang H

更新日期：2019-02-20 00:00:00

abstract：:ATP-dependent chromatin remodellers are mutated in more than 20% of human cancers. The consequences of these mutations on enzyme function are poorly understood. Here, we characterise the effects of CHD4 mutations identified in endometrial carcinoma on the remodelling properties of dMi-2, the highly conserved Drosophil...

journal_title：Nature communications

authors： Kovač K,Sauer A,Mačinković I,Awe S,Finkernagel F,Hoffmeister H,Fuchs A,Müller R,Rathke C,Längst G,Brehm A

更新日期：2018-05-29 00:00:00

abstract：:Polymorphism is a remarkable concept in chemistry, materials science, computer science, and biology. Whether it is the ability of a material to exist in two or more crystal structures, a single interface connecting to two different entities, or alternative phenotypes of an organism, polymorphism determines function an...

journal_title：Nature communications

authors： Li L,Salamończyk M,Shadpour S,Zhu C,Jákli A,Hegmann T

更新日期：2018-02-19 00:00:00

abstract：:Structural rearrangements govern the various properties of disordered systems and visualization of these dynamical processes can provide critical information on structural deformation and phase transformation of the systems. However, direct imaging of individual atoms or molecules in a disordered state is quite challe...

journal_title：Nature communications

authors： Choe J,Lee Y,Park J,Kim Y,Kim CU,Kim K

更新日期：2019-09-27 00:00:00