Abstract:
:To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Jin K,Sam IH,Po KHL,Lin D,Ghazvini Zadeh EH,Chen S,Yuan Y,Li Xdoi
10.1038/ncomms12394subject
Has Abstractpub_date
2016-08-03 00:00:00pages
12394issn
2041-1723pii
ncomms12394journal_volume
7pub_type
杂志文章abstract::Multiferroic bismuth ferrite, BiFeO3, offers a vast landscape to study the interplay between different ferrroic orders. Another aspect which is equally exciting, and yet underutilized, is the possibility of large-scale ordering of domains. Along with symmetry-driven bulk photovoltaic effect, BiFeO3 presents opportunit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20446-z
更新日期:2021-01-12 00:00:00
abstract::When assembling individual quantum components into a mesoscopic circuit, the interplay between Coulomb interaction and charge granularity breaks down the classical laws of electrical impedance composition. Here we explore experimentally the thermal consequences, and observe an additional quantum mechanism of electroni...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13566-8
更新日期:2019-12-10 00:00:00
abstract::The manipulation of crystal orientation from the thermodynamic equilibrium states is desired in layered hybrid perovskite films to direct charge transport and enhance the perovskite devices performance. Here we report a templated growth mechanism of layered perovskites from 3D-like perovskites which can be a general d...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13856-1
更新日期:2020-01-29 00:00:00
abstract::In recent years, there has been marked increase in research aimed to introduce alkali vapours into guided-wave configurations. Owing to the significant reduction in device dimensions, the increase in density of states, the interaction with surfaces and primarily the high intensities carried along the structure, a plet...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14461
更新日期:2017-02-09 00:00:00
abstract::Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to tr...
journal_title:Nature communications
pub_type: 杂志文章,多中心研究
doi:10.1038/ncomms14140
更新日期:2017-02-21 00:00:00
abstract::Electrochemical water splitting requires efficient water oxidation catalysts to accelerate the sluggish kinetics of water oxidation reaction. Here, we report a promisingly dendritic core-shell nickel-iron-copper metal/metal oxide electrode, prepared via dealloying with an electrodeposited nickel-iron-copper alloy as a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02429-9
更新日期:2018-01-26 00:00:00
abstract::Self-assembly of large multi-component systems is a common strategy for the bottom-up construction of discrete, well-defined, nanoscopic-sized cages. Icosahedral or pseudospherical viral capsids, built up from hundreds of identical proteins, constitute typical examples of the complexity attained by biological self-ass...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1793
更新日期:2012-04-17 00:00:00
abstract::Biologists have long been fascinated by the amazing diversity of animal colour patterns. Despite much interest, the underlying evolutionary and developmental mechanisms contributing to their rich variety remain largely unknown, especially the vivid and complex colour patterns seen in vertebrates. Here, we show that co...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1071
更新日期:2010-09-07 00:00:00
abstract::The preparation of α-functionalized organic acids can be greatly simplified by adopting a protocol involving the catalytic assembly of achiral building blocks. However, the enzymatic assembly of small amino acids and aldehydes to form numerous α-functionalized organic acids is highly desired and remains a significant ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06241-x
更新日期:2018-09-19 00:00:00
abstract::Nano-ordered intermetallic compounds have generated great interest in fuel cell applications. However, the synthesis of non-preciousearly transition metal intermetallic nanoparticles remains a formidable challenge owing to the extremely oxyphilic nature and very negative reduction potentials. Here, we have successfull...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12509-7
更新日期:2019-10-04 00:00:00
abstract::Intramolecular photostabilization via triple-state quenching was recently revived as a tool to impart synthetic organic fluorophores with 'self-healing' properties. To date, utilization of such fluorophore derivatives is rare due to their elaborate multi-step synthesis. Here we present a general strategy to covalently...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10144
更新日期:2016-01-11 00:00:00
abstract::Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2580
更新日期:2013-01-01 00:00:00
abstract::The downstream consequences of inflammation in the adult mammalian heart are formation of a non-functional scar, pathological remodelling and heart failure. In zebrafish, hydrogen peroxide released from a wound is the initial instructive chemotactic cue for the infiltration of inflammatory cells, however, the identity...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3081
更新日期:2013-01-01 00:00:00
abstract::It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10512
更新日期:2016-01-27 00:00:00
abstract::Organic semiconductors enable the fabrication of a range of lightweight and mechanically flexible optoelectronic devices. Most organic semiconductor lasers, however, have remained rigid until now, predominantly due to the need for a support substrate. Here, we use a simple fabrication process to make membrane-based, s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03874-w
更新日期:2018-05-01 00:00:00
abstract::Enterobacteria, especially Escherichia coli, are abundant in patients with inflammatory bowel disease or colorectal cancer (CRC). However, it is unclear whether cancer is promoted by inflammation-induced expansion of E. coli and/or changes in expression of specific microbial genes. Here we use longitudinal (2, 12 and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5724
更新日期:2014-09-03 00:00:00
abstract::A major challenge in environmental policymaking is determining whether and how fast our society should adopt sustainable management methods. These decisions may have long-lasting effects on the environment, and therefore, they depend critically on the discount factor, which determines the relative values given to futu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09246-2
更新日期:2019-03-29 00:00:00
abstract::Machines that simultaneously process and store multistate data at one and the same location can provide a new class of fast, powerful and efficient general-purpose computers. We demonstrate the central element of an all-optical calculator, a photonic abacus, which provides multistate compute-and-store operation by int...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01506-3
更新日期:2017-11-02 00:00:00
abstract::BRCA2 is essential for maintaining genomic integrity. BRCA2-deficient primary cells are either not viable or exhibit severe proliferation defects. Yet, BRCA2 deficiency contributes to tumorigenesis. It is believed that mutations in genes such as TRP53 allow BRCA2 heterozygous cells to overcome growth arrest when they ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03020-6
更新日期:2018-02-07 00:00:00
abstract::Granule cells are the dominant cell type of the olfactory bulb inhibiting mitral and tufted cells via dendrodendritic synapses; yet the factors regulating the strength of their inhibitory output, and, therefore, their impact on odour discrimination, remain unknown. Here we show that GABAAR β3-subunits are distributed ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9950
更新日期:2015-11-23 00:00:00
abstract::The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly impacts physical autonomy and survival. Here, we compare genome-wide transcriptional changes of sarcopen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13694-1
更新日期:2019-12-20 00:00:00
abstract::Autophagosomes are double-membrane vesicles that sequester cytoplasmic material for lysosomal degradation. Their biogenesis is initiated by recruitment of Atg9-vesicles to the phagophore assembly site. This process depends on the regulated activation of the Atg1-kinase complex. However, the underlying molecular mechan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10338
更新日期:2016-01-12 00:00:00
abstract::Telomere maintenance is a universal hallmark of cancer. Most tumors including low-grade oligodendrogliomas use telomerase reverse transcriptase (TERT) expression for telomere maintenance while astrocytomas use the alternative lengthening of telomeres (ALT) pathway. Although TERT and ALT are hallmarks of tumor prolifer...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20312-y
更新日期:2021-01-04 00:00:00
abstract::Human activities are transforming grassland biomass via changing climate, elemental nutrients, and herbivory. Theory predicts that food-limited herbivores will consume any additional biomass stimulated by nutrient inputs ('consumer-controlled'). Alternatively, nutrient supply is predicted to increase biomass where her...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19870-y
更新日期:2020-11-27 00:00:00
abstract::Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian brain. However, little is known about how metabolic signals instruct gene expression to control NPC homeostasis. Here, we show that methylglyoxa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15941-2
更新日期:2020-04-24 00:00:00
abstract::Central spin decoherence caused by nuclear spin baths is often a critical issue in various quantum computing schemes, and it has also been used for sensing single-nuclear spins. Recent theoretical studies suggest that central spin decoherence can act as a probe of many-body physics in spin baths; however, identificati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5822
更新日期:2014-09-10 00:00:00
abstract::Volcanoes are increasingly recognized as agents and recorders of global climate variability, although deciphering the linkages between planetary climate and volcanism is still in its infancy. The growth and emergence of subaqueous volcanoes produce passage zones, which are stratigraphic surfaces marking major transiti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2829
更新日期:2013-01-01 00:00:00
abstract::A long-standing and profound problem in astronomy is the difficulty in obtaining deep near-infrared observations due to the extreme brightness and variability of the night sky at these wavelengths. A solution to this problem is crucial if we are to obtain the deepest possible observations of the early Universe, as red...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1584
更新日期:2011-12-06 00:00:00
abstract::Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that kidney function is recovered after AKI despite substantial t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03753-4
更新日期:2018-04-09 00:00:00
abstract::Mappings of classical computation onto statistical mechanics models have led to remarkable successes in addressing some complex computational problems. However, such mappings display thermodynamic phase transitions that may prevent reaching solution even for easy problems known to be solvable in polynomial time. Here ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15303
更新日期:2017-05-12 00:00:00