A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization.

abstract：:Transition metal oxides host a wealth of exotic phenomena ranging from charge, orbital and magnetic order to nontrivial topological phases and superconductivity. In order to translate these unique materials properties into device functionalities these materials must be doped; however, the nature of carriers and their ...

journal_title：Nature communications

authors： Verdi C,Caruso F,Giustino F

更新日期：2017-06-08 00:00:00

abstract：:A central question in stem cell biology is the relationship between stem cells and their niche. Although previous reports have uncovered how signaling molecules released by niche cells support stem cell function, the role of the extra-cellular matrix (ECM) within the niche is unclear. Here, we show that upon activatio...

journal_title：Nature communications

authors： Rayagiri SS,Ranaldi D,Raven A,Mohamad Azhar NIF,Lefebvre O,Zammit PS,Borycki AG

更新日期：2018-03-14 00:00:00

abstract：:Translation efficiency can be affected by mRNA stability and secondary structures, including G-quadruplex structures (G4s). The highly conserved DEAH-box helicase DHX36/RHAU resolves G4s on DNA and RNA in vitro, however a systems-wide analysis of DHX36 targets and function is lacking. We map globally DHX36 binding to ...

journal_title：Nature communications

authors： Sauer M,Juranek SA,Marks J,De Magis A,Kazemier HG,Hilbig D,Benhalevy D,Wang X,Hafner M,Paeschke K

更新日期：2019-06-03 00:00:00

abstract：:A major conundrum in climate science is how to account for dependence between climate models. This complicates interpretation of probabilistic projections derived from such models. Here we show that this problem can be addressed using a novel method to test multiple non-exclusive hypotheses, and to make predictions un...

journal_title：Nature communications

authors： Olson R,An SI,Fan Y,Chang W,Evans JP,Lee JY

更新日期：2019-07-09 00:00:00

abstract：:Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential role of SNX3-retromer assembly for ...

journal_title：Nature communications

authors： McGough IJ,de Groot REA,Jellett AP,Betist MC,Varandas KC,Danson CM,Heesom KJ,Korswagen HC,Cullen PJ

更新日期：2018-09-13 00:00:00

abstract：:Previous studies have utilized monoamine oxidase (MAO) and L-3,4-dihydroxyphenylalanine decarboxylase (DDC) for microbe-based production of tetrahydropapaveroline (THP), a benzylisoquinoline alkaloid (BIA) precursor to opioid analgesics. In the current study, a phylogenetically distinct Bombyx mori 3,4-dihydroxyphenyl...

journal_title：Nature communications

authors： Vavricka CJ,Yoshida T,Kuriya Y,Takahashi S,Ogawa T,Ono F,Agari K,Kiyota H,Li J,Ishii J,Tsuge K,Minami H,Araki M,Hasunuma T,Kondo A

更新日期：2019-05-01 00:00:00

abstract：:Controlling the structure of catalysts at the atomic level provides an opportunity to establish detailed understanding of the catalytic form-to-function and realize new, non-equilibrium catalytic structures. Here, advanced thin-film deposition is used to control the atomic structure of La2/3Sr1/3MnO3, a well-known cat...

journal_title：Nature communications

authors： Eom CJ,Kuo DY,Adamo C,Moon EJ,May SJ,Crumlin EJ,Schlom DG,Suntivich J

更新日期：2018-10-02 00:00:00

abstract：:Humans survive and thrive through social exchange. Yet, social dependency also comes at a cost. Perceived social isolation, or loneliness, affects physical and mental health, cognitive performance, overall life expectancy, and increases vulnerability to Alzheimer's disease-related dementias. Despite severe consequence...

journal_title：Nature communications

authors： Spreng RN,Dimas E,Mwilambwe-Tshilobo L,Dagher A,Koellinger P,Nave G,Ong A,Kernbach JM,Wiecki TV,Ge T,Li Y,Holmes AJ,Yeo BTT,Turner GR,Dunbar RIM,Bzdok D

更新日期：2020-12-15 00:00:00

abstract：:Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates that ADLumin-1 can efficien...

journal_title：Nature communications

authors： Yang J,Yin W,Van R,Yin K,Wang P,Zheng C,Zhu B,Ran K,Zhang C,Kumar M,Shao Y,Ran C

更新日期：2020-08-13 00:00:00

abstract：:Many glasses exhibit fractional power law (FPL) between the mean atomic volume va and the first diffraction peak position q1, i.e. [Formula: see text] with d ≃ 2.5 deviating from the space dimension D = 3, under compression or composition change. What structural change causes such FPL and whether the FPL and d are uni...

journal_title：Nature communications

authors： Zhang H,Qiao K,Han Y

更新日期：2020-04-24 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region for tumor foci emergence is and how this transformation occurs are still unclear. Here, hyperpolyploidization of ...

journal_title：Nature communications

authors： Lin H,Huang YS,Fustin JM,Doi M,Chen H,Lai HH,Lin SH,Lee YL,King PC,Hou HS,Chen HW,Young PY,Chao HW

更新日期：2021-01-28 00:00:00

abstract：:Hypoxia is a main driver of sprouting angiogenesis, but how tip endothelial cells are directed to hypoxic regions remains poorly understood. Here, we show that an endothelial MST1-FOXO1 cascade is essential for directional migration of tip cells towards hypoxic regions. In mice, endothelial-specific deletion of either...

journal_title：Nature communications

authors： Kim YH,Choi J,Yang MJ,Hong SP,Lee CK,Kubota Y,Lim DS,Koh GY

更新日期：2019-02-19 00:00:00

abstract：:High-index dielectric nanoparticles supporting a distinct series of Mie resonances have enabled a new class of optical antennas with unprecedented functionalities. The great wealth of multipolar responses has not only brought in new physical insight but also spurred practical applications. However, how to make such a ...

journal_title：Nature communications

authors： Tian J,Luo H,Yang Y,Ding F,Qu Y,Zhao D,Qiu M,Bozhevolnyi SI

更新日期：2019-01-23 00:00:00

abstract：:Marine low clouds play an important role in the climate system, and their properties are sensitive to cloud condensation nuclei concentrations. While new particle formation represents a major source of cloud condensation nuclei globally, the prevailing view is that new particle formation rarely occurs in remote marine...

journal_title：Nature communications

authors： Zheng G,Wang Y,Wood R,Jensen MP,Kuang C,McCoy IL,Matthews A,Mei F,Tomlinson JM,Shilling JE,Zawadowicz MA,Crosbie E,Moore R,Ziemba L,Andreae MO,Wang J

更新日期：2021-01-22 00:00:00

abstract：:Genomic changes observed across treatment may result from either clonal evolution or geographically disparate sampling of heterogeneous tumors. Here we use computational modeling based on analysis of fifteen primary breast tumors and find that apparent clonal change between two tumor samples can frequently be explaine...

journal_title：Nature communications

authors： Caswell-Jin JL,McNamara K,Reiter JG,Sun R,Hu Z,Ma Z,Ding J,Suarez CJ,Tilk S,Raghavendra A,Forte V,Chin SF,Bardwell H,Provenzano E,Caldas C,Lang J,West R,Tripathy D,Press MF,Curtis C

更新日期：2019-02-08 00:00:00

abstract：:Mountains are plant biodiversity hotspots considered particularly vulnerable to multiple environmental changes. Here, we quantify population changes and range-shift dynamics along elevational gradients over the last three decades for c. two-thirds of the orchid species of the European Alps. Local extinctions were more...

journal_title：Nature communications

authors： Geppert C,Perazza G,Wilson RJ,Bertolli A,Prosser F,Melchiori G,Marini L

更新日期：2020-11-17 00:00:00

abstract：:Carbon and hydrogen are fundamental components of organic molecules and a fascinating plethora of functions can be generated using these two elements. Yet, realizing attractive electronic structures only by using carbon and hydrogen remains challenging. Herein, we report the synthesis and properties of the C70 fragmen...

journal_title：Nature communications

authors： Tanaka Y,Fukui N,Shinokubo H

更新日期：2020-08-03 00:00:00

abstract：:There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of ris...

journal_title：Nature communications

authors： Taylor JL,Debost JPG,Morton SU,Wigdor EM,Heyne HO,Lal D,Howrigan DP,Bloemendal A,Larsen JT,Kosmicki JA,Weiner DJ,Homsy J,Seidman JG,Seidman CE,Agerbo E,McGrath JJ,Mortensen PB,Petersen L,Daly MJ,Robinson EB

更新日期：2019-07-10 00:00:00

abstract：:Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL). Persisting CAR-T cells generate sustained pressure against CD19 that may drive unique mechanisms of resistanc...

journal_title：Nature communications

authors： Jacoby E,Nguyen SM,Fountaine TJ,Welp K,Gryder B,Qin H,Yang Y,Chien CD,Seif AE,Lei H,Song YK,Khan J,Lee DW,Mackall CL,Gardner RA,Jensen MC,Shern JF,Fry TJ

更新日期：2016-07-27 00:00:00

abstract：:Benzoxaboroles are effective against bacterial, fungal and protozoan pathogens. We report potent activity of the benzoxaborole AN3661 against Plasmodium falciparum laboratory-adapted strains (mean IC50 32 nM), Ugandan field isolates (mean ex vivo IC50 64 nM), and murine P. berghei and P. falciparum infections (day 4 E...

journal_title：Nature communications

authors： Sonoiki E,Ng CL,Lee MC,Guo D,Zhang YK,Zhou Y,Alley MR,Ahyong V,Sanz LM,Lafuente-Monasterio MJ,Dong C,Schupp PG,Gut J,Legac J,Cooper RA,Gamo FJ,DeRisi J,Freund YR,Fidock DA,Rosenthal PJ

更新日期：2017-03-06 00:00:00

abstract：:Do completely unpredictable events exist? Classical physics excludes fundamental randomness. Although quantum theory makes probabilistic predictions, this does not imply that nature is random, as randomness should be certified without relying on the complete structure of the theory being used. Bell tests approach the ...

journal_title：Nature communications

authors： Gallego R,Masanes L,De La Torre G,Dhara C,Aolita L,Acín A

更新日期：2013-01-01 00:00:00

abstract：:Scintillation based X-ray detection has received great attention for its application in a wide range of areas from security to healthcare. Here, we report highly efficient X-ray scintillators with state-of-the-art performance based on an organic metal halide, ethylenebis-triphenylphosphonium manganese (II) bromide ((C...

journal_title：Nature communications

authors： Xu LJ,Lin X,He Q,Worku M,Ma B

更新日期：2020-08-28 00:00:00

abstract：:Cyclophanes are a venerable class of macrocyclic and/or cage compounds that often feature high strain, unusual conformations and quite surprising properties, many of which are legendary in physical organic chemistry. However, the discovery of new, diverse cyclophanes and derivatives has been hindered by syntheses that...

journal_title：Nature communications

authors： Collins MS,Carnes ME,Nell BP,Zakharov LN,Johnson DW

更新日期：2016-04-04 00:00:00

abstract：:Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. To determine the role of GRP in sensory neurons, we generated a floxed Grp mouse line. We found that conditional knockout of Grp in sensory neurons ...

journal_title：Nature communications

authors： Barry DM,Liu XT,Liu B,Liu XY,Gao F,Zeng X,Liu J,Yang Q,Wilhelm S,Yin J,Tao A,Chen ZF

更新日期：2020-03-13 00:00:00

abstract：:Volcanoes are increasingly recognized as agents and recorders of global climate variability, although deciphering the linkages between planetary climate and volcanism is still in its infancy. The growth and emergence of subaqueous volcanoes produce passage zones, which are stratigraphic surfaces marking major transiti...

journal_title：Nature communications

authors： Russell JK,Edwards BR,Porritt LA

更新日期：2013-01-01 00:00:00

abstract：:Biochemical investigation of protein phosphorylation events is limited by inefficient production of the phosphorylated and non-phosphorylated forms of full-length proteins. Here using a genomically recoded strain of E. coli with a flexible UAG codon we produce site-specific serine- or phosphoserine-containing proteins...

journal_title：Nature communications

authors： Pirman NL,Barber KW,Aerni HR,Ma NJ,Haimovich AD,Rogulina S,Isaacs FJ,Rinehart J

更新日期：2015-09-09 00:00:00

abstract：:Controlling the domain size and degree of crystallization in organic films is highly important for electronic applications such as organic photovoltaics, but suitable nanoscale mapping is very difficult. Here we apply infrared-spectroscopic nano-imaging to directly determine the local crystallinity of organic thin fil...

journal_title：Nature communications

authors： Westermeier C,Cernescu A,Amarie S,Liewald C,Keilmann F,Nickel B

更新日期：2014-06-11 00:00:00

abstract：:Non-symmorphic chiral topological crystals host exotic multifold fermions, and their associated Fermi arcs helically wrap around and expand throughout the Brillouin zone between the high-symmetry center and surface-corner momenta. However, Fermi-arc splitting and realization of the theoretically proposed maximal Chern...

journal_title：Nature communications

authors： Yao M,Manna K,Yang Q,Fedorov A,Voroshnin V,Valentin Schwarze B,Hornung J,Chattopadhyay S,Sun Z,Guin SN,Wosnitza J,Borrmann H,Shekhar C,Kumar N,Fink J,Sun Y,Felser C

更新日期：2020-04-27 00:00:00

abstract：:Microglia, the brain-resident macrophages, exhibit highly dynamic functions in neurodevelopment and neurodegeneration. Human microglia possess unique features as compared to mouse microglia, but our understanding of human microglial functions is largely limited by an inability to obtain human microglia under homeostat...

journal_title：Nature communications

authors： Xu R,Li X,Boreland AJ,Posyton A,Kwan K,Hart RP,Jiang P

更新日期：2020-03-27 00:00:00

abstract：:Intricate biomineralization processes in molluscs engineer hierarchical structures with meso-, nano- and atomic architectures that give the final composite material exceptional mechanical strength and optical iridescence on the macroscale. This multiscale biological assembly inspires new synthetic routes to complex ma...

journal_title：Nature communications

authors： Hovden R,Wolf SE,Holtz ME,Marin F,Muller DA,Estroff LA

更新日期：2015-12-03 00:00:00