Abstract:
:Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region for tumor foci emergence is and how this transformation occurs are still unclear. Here, hyperpolyploidization of hepatocytes around the centrilobular (CL) region is demonstrated to be closely linked with the development of HCC cells after diethylnitrosamine treatment. We identify the CL region as a dominant lobule for accumulation of hyperpolyploid hepatocytes and preneoplastic tumor foci formation. We also demonstrate that upregulation of Aurkb plays a critical role in promoting hyperpolyploidization. Increase of AURKB phosphorylation is detected on the midbody during cytokinesis, causing abscission failure and hyperpolyploidization. Pharmacological inhibition of AURKB dramatically reduces nucleus size and tumor foci number surrounding the CL region in diethylnitrosamine-treated liver. Our work reveals an intimate molecular link between pathological hyperpolyploidy of CL hepatocytes and transformation into HCC cells.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Lin H,Huang YS,Fustin JM,Doi M,Chen H,Lai HH,Lin SH,Lee YL,King PC,Hou HS,Chen HW,Young PY,Chao HWdoi
10.1038/s41467-020-20572-8subject
Has Abstractpub_date
2021-01-28 00:00:00pages
645issue
1issn
2041-1723pii
10.1038/s41467-020-20572-8journal_volume
12pub_type
杂志文章abstract::Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are unknown. Here we examine the role of upstream inputs to PCs-excitatory granule cells (GCs) and inhibitory molecular layer interneurons-in processing of whisking sign...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00312-1
更新日期:2017-08-10 00:00:00
abstract::The direct transformation of cellulose, which is the main component of lignocellulosic biomass, into building-block chemicals is the key to establishing biomass-based sustainable chemical processes. Only limited successes have been achieved for such transformations under mild conditions. Here we report the simple and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3141
更新日期:2013-01-01 00:00:00
abstract::Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated protein kinase pathw...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00758-3
更新日期:2017-09-21 00:00:00
abstract::In many dynamical systems and complex networks time delays appear naturally in feedback loops or coupling connections of individual elements. Moreover, in a whole class of systems, these delay times can depend on the state of the system. Nevertheless, so far the understanding of the impact of such state-dependent dela...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8425
更新日期:2015-06-17 00:00:00
abstract::Knowledge of cell type composition in disease relevant tissues is an important step towards the identification of cellular targets of disease. We present MuSiC, a method that utilizes cell-type specific gene expression from single-cell RNA sequencing (RNA-seq) data to characterize cell type compositions from bulk RNA-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08023-x
更新日期:2019-01-22 00:00:00
abstract::BKM120 (Buparlisib) is one of the most advanced phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of cancer, but it interferes as an off-target effect with microtubule polymerization. Here, we developed two chemical derivatives that differ from BKM120 by only one atom. We show that these minute changes sep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14683
更新日期:2017-03-09 00:00:00
abstract::Genetic ablation of endothelial focal adhesion kinase (FAK) can inhibit pathological angiogenesis, suggesting that loss of endothelial FAK is sufficient to reduce neovascularization. Here we show that reduced stromal FAK expression in FAK-heterozygous mice unexpectedly enhances both B16F0 and CMT19T tumour growth and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3020
更新日期:2013-01-01 00:00:00
abstract::In the nervous system, A→I RNA editing has an important role in regulating neuronal excitability. Ligand-gated membrane receptors, synaptic proteins, as well as ion channels, are targets for recoding by RNA editing. Although scores of editing sites have been identified in the mammalian brain, little is known about the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1446
更新日期:2011-08-16 00:00:00
abstract::The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discoverin...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/s41467-020-15706-x
更新日期:2020-05-21 00:00:00
abstract::Circular RNAs are non-coding RNAs, and are enriched in the CNS. Dorsal horn neurons of the spinal cord contribute to pain-like hypersensitivity after nerve injury in rodents. Here we show that spinal nerve ligation is associated with an increase in expression of circAnks1a in dorsal horn neurons, in both the cytoplasm...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12049-0
更新日期:2019-09-11 00:00:00
abstract::The spatial organization of chromosomes has key functional roles, yet how chromosomes fold remains poorly understood at the single-molecule level. Here, we employ models of polymer physics to investigate DNA loci in human HCT116 and IMR90 wild-type and cohesin depleted cells. Model predictions on single-molecule struc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17141-4
更新日期:2020-07-03 00:00:00
abstract::Liquid crystalline network (LCN) actuator normally deforms upon thermally or optically induced order-disorder phase transition, switching once between two shapes (shape 1 in LC phase and shape 2 in isotropic state) for each stimulation on/off cycle. Herein, we report an LCN actuator that deforms from shape 1 to shape ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-021-20938-6
更新日期:2021-01-27 00:00:00
abstract::Following the discovery of high-temperature superconductivity in the La-H system, we studied the formation of new chemical compounds in the barium-hydrogen system at pressures from 75 to 173 GPa. Using in situ generation of hydrogen from NH3BH3, we synthesized previously unknown superhydride BaH12 with a pseudocubic (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20103-5
更新日期:2021-01-11 00:00:00
abstract::The isolation of the two-dimensional semiconductor molybdenum disulphide introduced a new optically active material possessing a band gap that can be facilely tuned via elastic strain. As an atomically thin membrane with exceptional strength, monolayer molybdenum disulphide subjected to biaxial strain can embed wide b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8381
更新日期:2015-06-19 00:00:00
abstract::Essential components of animal behaviour are modulated by dopaminergic (DA) and noradrenergic circuitry. In this study, we reveal at cellular resolution the complete set of projections ('projectome') of every single type of DA and noradrenergio neurons in the central nervous system of zebrafish larvae. The most extens...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1171
更新日期:2011-01-25 00:00:00
abstract::Isolators, or optical diodes, are devices enabling unidirectional light propagation by using non-reciprocal optical materials, namely materials able to break Lorentz reciprocity. The realization of isolators at terahertz frequencies is a very important open challenge made difficult by the intrinsically lossy propagati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11216
更新日期:2016-04-06 00:00:00
abstract::To expand the toolbox of imaging in living cells, we have engineered a single-chain variable fragment binding the linear HA epitope with high affinity and specificity in vivo. The resulting probe, called the HA frankenbody, can light up in multiple colors HA-tagged nuclear, cytoplasmic, membrane, and mitochondrial pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10846-1
更新日期:2019-07-03 00:00:00
abstract::The original version of this article contained an error in the spelling of the author Christian A.M. Wilson, which was incorrectly given as Christian M.A. Wilson. This has now been corrected in both the PDF and HTML versions of the article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-017-02384-5
更新日期:2017-12-14 00:00:00
abstract::Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin α in emphysema remains unclear. Here we show that prothymosin α contributes to the pathogenesis of emphysema by in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2906
更新日期:2013-01-01 00:00:00
abstract::Different thresholds of Wnt signalling are thought to drive stem cell maintenance, regeneration, differentiation and cancer. However, the principle that oncogenic Wnt signalling could be specifically targeted remains controversial. Here we examine the requirement of BCL9/9l, constituents of the Wnt-enhanceosome, for i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08586-3
更新日期:2019-02-13 00:00:00
abstract::Solid-state quantum acoustodynamic (QAD) systems provide a compact platform for quantum information storage and processing by coupling acoustic phonon sources with superconducting or spin qubits. The multi-mode composite high-overtone bulk acoustic wave resonator (HBAR) is a popular phonon source well suited for QAD. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15472-w
更新日期:2020-05-08 00:00:00
abstract::The plasma membrane is uniquely enriched in phosphatidylserine (PtdSer). This anionic phospholipid is restricted almost exclusively to the inner leaflet of the plasmalemma. Because of their high density, the headgroups of anionic lipids experience electrostatic repulsion that, being exerted asymmetrically, is predicte...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01554-9
更新日期:2017-11-09 00:00:00
abstract::High-angle grain boundaries are always the preferential fatigue cracking sites, while the intrinsic fatigue cracking mechanism of coherent twin boundary remains elusive. Here we systematically investigate the fatigue cracking behaviours of copper bicrystals with a coherent twin boundary as their sole internal boundary...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4536
更新日期:2014-03-26 00:00:00
abstract::Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7691
更新日期:2015-04-07 00:00:00
abstract::Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritability of 0.39 (SE = 0.0...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07862-y
更新日期:2018-12-20 00:00:00
abstract::Alkali metal vapors enable access to single electron systems, suitable for demonstrating fundamental light-matter interactions and promising for quantum logic operations, storage and sensing. However, progress is hampered by the need for robust and repeatable control over the atomic vapor density and over the associat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10158-4
更新日期:2019-05-24 00:00:00
abstract::Gene transfer agents (GTAs) are thought to be ancient bacteriophages that have been co-opted into serving their host and can now transfer any gene between bacteria. Production of GTAs is controlled by several global regulators through unclear mechanisms. In Rhodobacter capsulatus, gene rcc01865 encodes a putative regu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08526-1
更新日期:2019-02-05 00:00:00
abstract::The unusual electronic properties of diamondoids, the nanoscale relatives of diamond, make them attractive for applications ranging from drug delivery to field emission displays. Identifying the fundamental origin of these properties has proven highly challenging, with even the most advanced quantum many-body calculat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3006
更新日期:2013-01-01 00:00:00
abstract::Targeting the vasculature remains a promising approach for treating solid tumours; however, the mechanisms of tumour neovascularization are diverse and complex. Here we uncover a new subpopulation of melanoma cells that express the vascular cell adhesion molecule PECAM1, but not VEGFR-2, and participate in a PECAM1-de...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6200
更新日期:2014-10-22 00:00:00
abstract::The resting-state human brain networks underlie fundamental cognitive functions and consist of complex interactions among brain regions. However, the level of complexity of the resting-state networks has not been quantified, which has prevented comprehensive descriptions of the brain activity as an integrative system....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2388
更新日期:2013-01-01 00:00:00