Bulk tissue cell type deconvolution with multi-subject single-cell expression reference.

abstract：:Laboratory spectroscopy of atomic hydrogen in a magnetic flux density of 10(5) T (1 gigagauss), the maximum observed on high-field magnetic white dwarfs, is impossible because practically available fields are about a thousand times less. In this regime, the cyclotron and binding energies become equal. Here we demonstr...

journal_title：Nature communications

authors： Murdin BN,Li J,Pang ML,Bowyer ET,Litvinenko KL,Clowes SK,Engelkamp H,Pidgeon CR,Galbraith I,Abrosimov NV,Riemann H,Pavlov SG,Hübers HW,Murdin PG

更新日期：2013-01-01 00:00:00

abstract：:The central phenomenon in the field of organic spintronics is the large magnetoresistance in thick organic spin valves. A prerequisite for understanding the magnetoresistance is a reliable description of the device resistance, or the I-V characteristics. Here I show that the observed I-V characteristics in the organic...

journal_title：Nature communications

authors： Yu ZG

更新日期：2014-09-09 00:00:00

abstract：:Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective, transient or lack specificity. Here we report that neutrophil...

journal_title：Nature communications

authors： Boivin G,Faget J,Ancey PB,Gkasti A,Mussard J,Engblom C,Pfirschke C,Contat C,Pascual J,Vazquez J,Bendriss-Vermare N,Caux C,Vozenin MC,Pittet MJ,Gunzer M,Meylan E

更新日期：2020-06-02 00:00:00

abstract：:Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2-7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer seeds revealing a preference for guanine in positions 1 and 2 and a high overall G or C content in the seed of the most toxic siRNAs for four ...

journal_title：Nature communications

authors： Gao QQ,Putzbach WE,Murmann AE,Chen S,Sarshad AA,Peter JM,Bartom ET,Hafner M,Peter ME

更新日期：2018-10-29 00:00:00

abstract：:Mechanosensitive ion channels transduce physical force into electrochemical signaling that underlies an array of fundamental physiological processes, including hearing, touch, proprioception, osmoregulation, and morphogenesis. The mechanosensitive channels of small conductance (MscS) constitute a remarkably diverse su...

journal_title：Nature communications

authors： Deng Z,Maksaev G,Schlegel AM,Zhang J,Rau M,Fitzpatrick JAJ,Haswell ES,Yuan P

更新日期：2020-07-23 00:00:00

abstract：:At photonic Dirac points, electromagnetic waves are governed by the same equations as two-component massless relativistic fermions. However, photonic Dirac points are known to occur in pairs in "photonic graphene" and other similar photonic crystals, which necessitates special precautions to excite only one valley sta...

journal_title：Nature communications

authors： Liu GG,Zhou P,Yang Y,Xue H,Ren X,Lin X,Sun HX,Bi L,Chong Y,Zhang B

更新日期：2020-04-20 00:00:00

abstract：:Dendrimers are well-defined macromolecules whose highly branched structure is reminiscent of many natural structures, such as trees, dendritic cells, neurons or the networks of kidneys and lungs. Nature has privileged such branched structures for increasing the efficiency of exchanges with the external medium; thus, t...

journal_title：Nature communications

authors： Caminade AM,Fruchon S,Turrin CO,Poupot M,Ouali A,Maraval A,Garzoni M,Maly M,Furer V,Kovalenko V,Majoral JP,Pavan GM,Poupot R

更新日期：2015-07-14 00:00:00

abstract：:The original version of this Article contained an error in the last sentence of the second paragraph of the 'Atmospheric rarefaction effects' section of the Results, which incorrectly read 'The other one emulates the rarefied, CO2-rich Martian atmosphere (μ♂ = 1.3 × 10-5 N s m-2) at 6.9 mbar and 210 K, which gives ρ♂ ...

journal_title：Nature communications

authors： Di Renzo M,Urzay J

更新日期：2018-05-21 00:00:00

abstract：:Single-cell RNA-sequencing (scRNA-Seq) is a compelling approach to directly and simultaneously measure cellular composition and state, which can otherwise only be estimated by applying deconvolution methods to bulk RNA-Seq estimates. However, it has not yet become a widely used tool in population-scale analyses, due t...

journal_title：Nature communications

authors： Mandric I,Schwarz T,Majumdar A,Hou K,Briscoe L,Perez R,Subramaniam M,Hafemeister C,Satija R,Ye CJ,Pasaniuc B,Halperin E

更新日期：2020-10-30 00:00:00

abstract：:Activation of autophagy and elevation of glutamine synthesis represent key adaptations to maintain amino acid balance during starvation. In this study, we investigate the role of autophagy and glutamine on the regulation of mTORC1, a critical kinase that regulates cell growth and proliferation. We report that suppleme...

journal_title：Nature communications

authors： Tan HWS,Sim AYL,Long YC

更新日期：2017-08-24 00:00:00

abstract：:We show how the kinetics of a fast and irreversible chemical reaction in a nanocrystalline material at high temperature can be studied using nanosecond electron pulses in an electron microscope. Infrared laser pulses first heat a nanocrystalline oxide layer on a carbon film, then single nanosecond electron pulses allo...

journal_title：Nature communications

authors： Sinha SK,Khammari A,Picher M,Roulland F,Viart N,LaGrange T,Banhart F

更新日期：2019-08-13 00:00:00

abstract：:O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its function in liver tumorigenesis is not clear. Here, we demonstrate that O-GlcNAcylation can enhance the expression, stability and function of Yes-associated protein (YAP), the downstream transcriptional regulator of the Hippo p...

journal_title：Nature communications

authors： Zhang X,Qiao Y,Wu Q,Chen Y,Zou S,Liu X,Zhu G,Zhao Y,Chen Y,Yu Y,Pan Q,Wang J,Sun F

更新日期：2017-05-05 00:00:00

abstract：:One of the primary contributors to forgetting is interference from overlapping memories. Intuitively, this suggests-and prominent theoretical models argue-that memory interference is best avoided by encoding overlapping memories as if they were unrelated. It is therefore surprising that reactivation of older memories ...

journal_title：Nature communications

authors： Chanales AJH,Dudukovic NM,Richter FR,Kuhl BA

更新日期：2019-11-25 00:00:00

abstract：:Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we sho...

journal_title：Nature communications

authors： Liu T,Song T,Zhang X,Yuan H,Su L,Li W,Xu J,Liu S,Chen L,Chen T,Zhang M,Gu L,Zhang B,Dou D

更新日期：2014-08-26 00:00:00

abstract：:NaK and other non-selective channels are able to conduct both sodium (Na+) and potassium (K+) with equally high efficiency. In contrast to previous crystallographic results, we show that the selectivity filter (SF) of NaK in native-like lipid membranes adopts two distinct conformations that are stabilized by either Na...

journal_title：Nature communications

authors： Shi C,He Y,Hendriks K,de Groot BL,Cai X,Tian C,Lange A,Sun H

更新日期：2018-02-19 00:00:00

abstract：:To prevent new infections with human immunodeficiency virus type 1 (HIV-1) in sub-Saharan Africa, UNAIDS recommends targeting interventions to populations that are at high risk of acquiring and passing on the virus. Yet it is often unclear who and where these 'source' populations are. Here we demonstrate how viral dee...

journal_title：Nature communications

authors： Ratmann O,Grabowski MK,Hall M,Golubchik T,Wymant C,Abeler-Dörner L,Bonsall D,Hoppe A,Brown AL,de Oliveira T,Gall A,Kellam P,Pillay D,Kagaayi J,Kigozi G,Quinn TC,Wawer MJ,Laeyendecker O,Serwadda D,Gray RH,Fraser C

更新日期：2019-03-29 00:00:00

abstract：:Molecules can efficiently and selectively convert light energy into other degrees of freedom. Disentangling the underlying ultrafast motion of electrons and nuclei of the photoexcited molecule presents a challenge to current spectroscopic approaches. Here we explore the photoexcited dynamics of molecules by an interac...

journal_title：Nature communications

authors： McFarland BK,Farrell JP,Miyabe S,Tarantelli F,Aguilar A,Berrah N,Bostedt C,Bozek JD,Bucksbaum PH,Castagna JC,Coffee RN,Cryan JP,Fang L,Feifel R,Gaffney KJ,Glownia JM,Martinez TJ,Mucke M,Murphy B,Natan A,Osipov T,

更新日期：2014-06-23 00:00:00

abstract：:Scanning probe microscopy has emerged as a primary tool for exploring and controlling the nanoworld. A critical part of scanning probe measurements is the information transfer from the tip-surface junction to the measurement system. This process reduces responses at multiple degrees of freedom of the probe to relative...

journal_title：Nature communications

authors： Belianinov A,Kalinin SV,Jesse S

更新日期：2015-03-13 00:00:00

abstract：:Zea mays is an important genetic model for elucidating transcriptional networks. Uncertainties about the complete structure of mRNA transcripts limit the progress of research in this system. Here, using single-molecule sequencing technology, we produce 111,151 transcripts from 6 tissues capturing ∼70% of the genes ann...

journal_title：Nature communications

authors： Wang B,Tseng E,Regulski M,Clark TA,Hon T,Jiao Y,Lu Z,Olson A,Stein JC,Ware D

更新日期：2016-06-24 00:00:00

abstract：:Causal reasoning can shed new light on the major challenges in machine learning for medical imaging: scarcity of high-quality annotated data and mismatch between the development dataset and the target environment. A causal perspective on these issues allows decisions about data collection, annotation, preprocessing, a...

journal_title：Nature communications

authors： Castro DC,Walker I,Glocker B

更新日期：2020-07-22 00:00:00

abstract：:Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (~35,000 samples) with the population-specific reference panel created by the Genome of T...

journal_title：Nature communications

authors： van Leeuwen EM,Karssen LC,Deelen J,Isaacs A,Medina-Gomez C,Mbarek H,Kanterakis A,Trompet S,Postmus I,Verweij N,van Enckevort DJ,Huffman JE,White CC,Feitosa MF,Bartz TM,Manichaikul A,Joshi PK,Peloso GM,Deelen P,van D

更新日期：2015-03-09 00:00:00

abstract：:Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs). However, Notch1 can be stochastically activated to promote carcinogenesis in murine models of SCC. Activat...

journal_title：Nature communications

authors： Natsuizaka M,Whelan KA,Kagawa S,Tanaka K,Giroux V,Chandramouleeswaran PM,Long A,Sahu V,Darling DS,Que J,Yang Y,Katz JP,Wileyto EP,Basu D,Kita Y,Natsugoe S,Naganuma S,Klein-Szanto AJ,Diehl JA,Bass AJ,Wong KK,Rust

更新日期：2017-11-24 00:00:00

abstract：:Island systems generally have fewer species than continental areas due to their small size and geographical isolation. Low island diversity reduces the possibility of exportation of island lineages and island systems are not thought to have a major influence on the build-up of continental diversity. However, the view ...

journal_title：Nature communications

authors： Jønsson KA,Holt BG

更新日期：2015-10-05 00:00:00

abstract：:Problematic microfossils dominate the palaeontological record between the Great Oxidation Event 2.4 billion years ago (Ga) and the last Palaeoproterozoic iron formations, deposited 500-600 million years later. These fossils are often associated with iron-rich sedimentary rocks, but their affinities, metabolism, and, h...

journal_title：Nature communications

authors： Lepot K,Addad A,Knoll AH,Wang J,Troadec D,Béché A,Javaux EJ

更新日期：2017-03-23 00:00:00

abstract：:Formation of domain walls in ferroelectrics is not energetically favourable in low-dimensional systems. Instead, vortex-type structures are formed that are driven by depolarization fields occurring in such systems. Consequently, polarization vortices have only been experimentally found in systems in which these fields...

journal_title：Nature communications

authors： Peters JJP,Apachitei G,Beanland R,Alexe M,Sanchez AM

更新日期：2016-11-16 00:00:00

abstract：:Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell subset, with a unique expression profile including chemokine receptors consistent with migration to target tissues, is expanded in SLE patients,...

journal_title：Nature communications

authors： Wang S,Wang J,Kumar V,Karnell JL,Naiman B,Gross PS,Rahman S,Zerrouki K,Hanna R,Morehouse C,Holoweckyj N,Liu H,Autoimmunity Molecular Medicine Team.,Manna Z,Goldbach-Mansky R,Hasni S,Siegel R,Sanjuan M,Streicher K,Ca

更新日期：2018-05-01 00:00:00

abstract：:Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear receptor RORγ, compared to estrogen receptor-positive breast cancer. G...

journal_title：Nature communications

authors： Cai D,Wang J,Gao B,Li J,Wu F,Zou JX,Xu J,Jiang Y,Zou H,Huang Z,Borowsky AD,Bold RJ,Lara PN,Li JJ,Chen X,Lam KS,To KF,Kung HJ,Fiehn O,Zhao R,Evans RM,Chen HW

更新日期：2019-10-11 00:00:00

abstract：:Understanding catalysts strain dynamic behaviours is crucial for the development of cost-effective, efficient, stable and long-lasting catalysts. Here, we reveal in situ three-dimensional strain evolution of single gold nanocrystals during a catalytic CO oxidation reaction under operando conditions with coherent X-ray...

journal_title：Nature communications

authors： Passos AR,Rochet A,Manente LM,Suzana AF,Harder R,Cha W,Meneau F

更新日期：2020-09-18 00:00:00

abstract：:Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain undergoes epig...

journal_title：Nature communications

authors： Perone Y,Farrugia AJ,Rodríguez-Meira A,Győrffy B,Ion C,Uggetti A,Chronopoulos A,Marrazzo P,Faronato M,Shousha S,Davies C,Steel JH,Patel N,Del Rio Hernandez A,Coombes C,Pruneri G,Lim A,Calvo F,Magnani L

更新日期：2019-05-09 00:00:00

abstract：:Zero-energy particles (such as Majorana fermions) are newly predicted quasiparticles and are expected to play an important role in fault-tolerant quantum computation. In conventional Hermitian quantum systems, however, such zero states are vulnerable and even become vanishing if couplings with surroundings are of the ...

journal_title：Nature communications

authors： Pan M,Zhao H,Miao P,Longhi S,Feng L

更新日期：2018-04-03 00:00:00