Abstract:
:Mechanosensitive ion channels transduce physical force into electrochemical signaling that underlies an array of fundamental physiological processes, including hearing, touch, proprioception, osmoregulation, and morphogenesis. The mechanosensitive channels of small conductance (MscS) constitute a remarkably diverse superfamily of channels critical for management of osmotic pressure. Here, we present cryo-electron microscopy structures of a MscS homolog from Arabidopsis thaliana, MSL1, presumably in both the closed and open states. The heptameric MSL1 channel contains an unusual bowl-shaped transmembrane region, which is reminiscent of the evolutionarily and architecturally unrelated mechanosensitive Piezo channels. Upon channel opening, the curved transmembrane domain of MSL1 flattens and expands. Our structures, in combination with functional analyses, delineate a structural mechanism by which mechanosensitive channels open under increased membrane tension. Further, the shared structural feature between unrelated channels suggests the possibility of a unified mechanical gating mechanism stemming from membrane deformation induced by a non-planar transmembrane domain.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Deng Z,Maksaev G,Schlegel AM,Zhang J,Rau M,Fitzpatrick JAJ,Haswell ES,Yuan Pdoi
10.1038/s41467-020-17538-1subject
Has Abstractpub_date
2020-07-23 00:00:00pages
3690issue
1issn
2041-1723pii
10.1038/s41467-020-17538-1journal_volume
11pub_type
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