The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni.

abstract：:The concept of spin-torque-driven high-frequency magnetization dynamics, allows the potential construction of complex networks of non-linear dynamical nanoscale systems, combining the field of spintronics and the study of non-linear systems. In the few previous demonstrations of synchronization of several spin-torque ...

journal_title：Nature communications

authors： Lebrun R,Tsunegi S,Bortolotti P,Kubota H,Jenkins AS,Romera M,Yakushiji K,Fukushima A,Grollier J,Yuasa S,Cros V

更新日期：2017-06-12 00:00:00

abstract：:Regulatory T (Treg) cells derived from the thymus (tTreg) and periphery (pTreg) have central and distinct functions in immunosuppression, but mechanisms for the generation and activation of Treg subsets in vivo are unclear. Here, we show that mechanistic target of rapamycin (mTOR) unexpectedly supports the homeostasis...

journal_title：Nature communications

authors： Chapman NM,Zeng H,Nguyen TM,Wang Y,Vogel P,Dhungana Y,Liu X,Neale G,Locasale JW,Chi H

更新日期：2018-05-29 00:00:00

abstract：:POT1 and TPP1 are part of the shelterin complex and are essential for telomere length regulation and maintenance. Naturally occurring mutations of the telomeric POT1-TPP1 complex are implicated in familial glioma, melanoma and chronic lymphocytic leukaemia. Here we report the atomic structure of the interacting portio...

journal_title：Nature communications

authors： Rice C,Shastrula PK,Kossenkov AV,Hills R,Baird DM,Showe LC,Doukov T,Janicki S,Skordalakes E

更新日期：2017-04-10 00:00:00

abstract：:Recent studies suggest the emerging roles of armadillo (ARM) family proteins in tumor progression. However, the functions and underlying mechanisms of ARM members in tumorigenesis and aggressiveness of neuroblastoma (NB) remain to be determined. Herein, we identify armadillo repeat containing 12 (ARMC12) as an ARM mem...

journal_title：Nature communications

authors： Li D,Song H,Mei H,Fang E,Wang X,Yang F,Li H,Chen Y,Huang K,Zheng L,Tong Q

更新日期：2018-07-19 00:00:00

abstract：:Circadian clock mechanisms have been extensively investigated but the main rate-limiting step that determines circadian period remains unclear. Formation of a stable complex between clock proteins and CK1 is a conserved feature in eukaryotic circadian mechanisms. Here we show that the FRQ-CK1 interaction, but not FRQ ...

journal_title：Nature communications

authors： Liu X,Chen A,Caicedo-Casso A,Cui G,Du M,He Q,Lim S,Kim HJ,Hong CI,Liu Y

更新日期：2019-09-25 00:00:00

abstract：:Leptin stimulates the sympathetic nervous system (SNS), energy expenditure, and weight loss; however, the underlying molecular mechanism remains elusive. Here, we uncover Sh2b1 in leptin receptor (LepR) neurons as a critical component of a SNS/brown adipose tissue (BAT)/thermogenesis axis. LepR neuron-specific deletio...

journal_title：Nature communications

authors： Jiang L,Su H,Wu X,Shen H,Kim MH,Li Y,Myers MG Jr,Owyang C,Rui L

更新日期：2020-03-23 00:00:00

abstract：:Clonal heterogeneity and evolution has major implications for disease progression and relapse in acute myeloid leukemia (AML). To model clonal dynamics in vivo, we serially transplanted 23 AML cases to immunodeficient mice and followed clonal composition for up to 15 months by whole-exome sequencing of 84 xenografts a...

journal_title：Nature communications

authors： Sandén C,Lilljebjörn H,Orsmark Pietras C,Henningsson R,Saba KH,Landberg N,Thorsson H,von Palffy S,Peña-Martinez P,Högberg C,Rissler M,Gisselsson D,Lazarevic V,Juliusson G,Ågerstam H,Fioretos T

更新日期：2020-02-05 00:00:00

abstract：:Monolayer chalcogenide semiconductors with both luminescent and ferromagnetic properties are dreamed for simultaneous polarization and detection of the valley degree of freedom in valleytronics. However, a conventional chalcogenide monolayer lacks these coexisting properties due to their mutually exclusive origins. He...

journal_title：Nature communications

authors： Duan H,Guo P,Wang C,Tan H,Hu W,Yan W,Ma C,Cai L,Song L,Zhang W,Sun Z,Wang L,Zhao W,Yin Y,Li X,Wei S

更新日期：2019-04-05 00:00:00

abstract：:Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more than 2,000 human lncRNAs, we identify numerous lncRNAs involved in key steps of cell division su...

journal_title：Nature communications

authors： Stojic L,Lun ATL,Mascalchi P,Ernst C,Redmond AM,Mangei J,Barr AR,Bousgouni V,Bakal C,Marioni JC,Odom DT,Gergely F

更新日期：2020-04-15 00:00:00

abstract：:The mega-diversity of herbivorous insects is attributed to their co-evolutionary associations with plants. Despite abundant studies on insect-plant interactions, we do not know whether host-plant shifts have impacted both genomic adaptation and species diversification over geological times. We show that the antagonist...

journal_title：Nature communications

authors： Allio R,Nabholz B,Wanke S,Chomicki G,Pérez-Escobar OA,Cotton AM,Clamens AL,Kergoat GJ,Sperling FAH,Condamine FL

更新日期：2021-01-13 00:00:00

abstract：:Magnetic skyrmion, a topologically stable spin-swirling object, can host emergent electromagnetism, as exemplified by the topological Hall effect and electric-current-driven skyrmion motion. To achieve efficient manipulation of nano-sized functional spin textures, it is imperative to exploit the resonant motion of sky...

journal_title：Nature communications

authors： Okamura Y,Kagawa F,Mochizuki M,Kubota M,Seki S,Ishiwata S,Kawasaki M,Onose Y,Tokura Y

更新日期：2013-01-01 00:00:00

abstract：:Familial hemiplegic migraine is an episodic neurological disorder characterized by transient sensory and motor symptoms and signs. Mutations of the ion pump α2-Na/K ATPase cause familial hemiplegic migraine, but the mechanisms by which α2-Na/K ATPase mutations lead to the migraine phenotype remain incompletely underst...

journal_title：Nature communications

authors： Smith SE,Chen X,Brier LM,Bumstead JR,Rensing NR,Ringel AE,Shin H,Oldenborg A,Crowley JR,Bice AR,Dikranian K,Ippolito JE,Haigis MC,Papouin T,Zhao G,Wong M,Culver JP,Bonni A

更新日期：2020-12-02 00:00:00

abstract：:Electrically pumped organic lasing is one of the most challenging issues in organic optoelectronics. We present a systematic theoretical investigation to screen out electrical pumping lasing molecules over a wide range of organic materials. With the electronic structure information obtained from time-dependent density...

journal_title：Nature communications

authors： Ou Q,Peng Q,Shuai Z

更新日期：2020-09-08 00:00:00

abstract：:Solid substrates often induce non-uniform strain and doping in graphene monolayer, therefore altering the intrinsic properties of graphene, reducing its charge carrier mobilities and, consequently, the overall electrical performance. Here, we exploit confocal Raman spectroscopy to study graphene directly free-floating...

journal_title：Nature communications

authors： Belyaeva LA,Jiang L,Soleimani A,Methorst J,Risselada HJ,Schneider GF

更新日期：2020-02-14 00:00:00

abstract：:Tomatoes come in a multitude of shapes and flavors despite a narrow genetic pool. Here, we leverage whole-genome resequencing data available for 602 cultivated and wild accessions to determine the contribution of transposable elements (TEs) to tomato diversity. We identify 6,906 TE insertions polymorphisms (TIPs), whi...

journal_title：Nature communications

authors： Domínguez M,Dugas E,Benchouaia M,Leduque B,Jiménez-Gómez JM,Colot V,Quadrana L

更新日期：2020-08-13 00:00:00

abstract：:Extrachromosomal telomeric circles are commonly invoked as important players in telomere maintenance, but their origin has remained elusive. Using electron microscopy analysis on purified telomeres we show that, apart from known structures, telomeric repeats accumulate internal loops (i-loops) that occur in the proxim...

journal_title：Nature communications

authors： Mazzucco G,Huda A,Galli M,Piccini D,Giannattasio M,Pessina F,Doksani Y

更新日期：2020-10-20 00:00:00

abstract：:Visual brain areas exhibit tuning characteristics well suited for image statistics present in our natural environment. However, visual sensation is an active process, and if there are any brain areas that ought to be particularly in tune with natural scene statistics, it would be sensory-motor areas critical for guidi...

journal_title：Nature communications

authors： Chen CY,Sonnenberg L,Weller S,Witschel T,Hafed ZM

更新日期：2018-07-20 00:00:00

abstract：:Daily-life foldable items, such as popup tents, the curved origami sculptures exhibited in the Museum of Modern Art of New York, overstrained bicycle wheels, released bilayered microrings and strained cyclic macromolecules, are made of rings buckled or folded in tridimensional saddle shapes. Surprisingly, despite thei...

journal_title：Nature communications

authors： Mouthuy PO,Coulombier M,Pardoen T,Raskin JP,Jonas AM

更新日期：2012-01-01 00:00:00

abstract：:Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to promote the localization of other factors, including 53BP1, to DSB sites. Here, by using CRISPR-Cas9 engi...

journal_title：Nature communications

authors： Salguero I,Belotserkovskaya R,Coates J,Sczaniecka-Clift M,Demir M,Jhujh S,Wilson MD,Jackson SP

更新日期：2019-11-15 00:00:00

abstract：:The exploration of chemical space for new reactivity, reactions and molecules is limited by the need for separate work-up-separation steps searching for molecules rather than reactivity. Herein we present a system that can autonomously evaluate chemical reactivity within a network of 64 possible reaction combinations ...

journal_title：Nature communications

authors： Dragone V,Sans V,Henson AB,Granda JM,Cronin L

更新日期：2017-06-09 00:00:00

abstract：:Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T...

journal_title：Nature communications

authors： Thapa P,Das J,McWilliams D,Shapiro M,Sundsbak R,Nelson-Holte M,Tangen S,Anderson J,Desiderio S,Hiebert S,Sant'angelo DB,Shapiro VS

更新日期：2013-01-01 00:00:00

abstract：:Polarization-driven resistive switching in ferroelectric tunnel junctions (FTJs)--structures composed of two electrodes separated by an ultrathin ferroelectric barrier--offers new physics and materials functionalities, as well as exciting opportunities for the next generation of non-volatile memories and logic devices...

journal_title：Nature communications

authors： Lu H,Lipatov A,Ryu S,Kim DJ,Lee H,Zhuravlev MY,Eom CB,Tsymbal EY,Sinitskii A,Gruverman A

更新日期：2014-11-24 00:00:00

abstract：:The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin of human liver parenchymal tissue generation during embryonic development, homeostasis or repair. Here we report the existence of a hepatobiliary hybrid progenitor (HHyP) population i...

journal_title：Nature communications

authors： Segal JM,Kent D,Wesche DJ,Ng SS,Serra M,Oulès B,Kar G,Emerton G,Blackford SJI,Darmanis S,Miquel R,Luong TV,Yamamoto R,Bonham A,Jassem W,Heaton N,Vigilante A,King A,Sancho R,Teichmann S,Quake SR,Nakauchi H,Rash

更新日期：2019-07-26 00:00:00

abstract：:Considering the rapid increase of CO2 emission, especially from power plants, there is a constant need for materials which can effectively eliminate post-combustion CO2 (the main component: CO2/N2 = 15/85). Here, we show the design and synthesis of a Cu(II) metal-organic framework (FJI-H14) with a high density of acti...

journal_title：Nature communications

authors： Liang L,Liu C,Jiang F,Chen Q,Zhang L,Xue H,Jiang HL,Qian J,Yuan D,Hong M

更新日期：2017-11-01 00:00:00

abstract：:A high-sugar diet has been associated with reduced lifespan in organisms ranging from worms to mammals. However, the mechanisms underlying the harmful effects of glucose are poorly understood. Here we establish a causative relationship between endogenous glucose storage in the form of glycogen, resistance to oxidative...

journal_title：Nature communications

authors： Gusarov I,Pani B,Gautier L,Smolentseva O,Eremina S,Shamovsky I,Katkova-Zhukotskaya O,Mironov A,Nudler E

更新日期：2017-06-19 00:00:00

abstract：:A central paradigm in conservation biology is that population bottlenecks reduce genetic diversity and population viability. In an era of biodiversity loss and climate change, understanding the determinants and consequences of bottlenecks is therefore an important challenge. However, as most studies focus on single sp...

journal_title：Nature communications

authors： Stoffel MA,Humble E,Paijmans AJ,Acevedo-Whitehouse K,Chilvers BL,Dickerson B,Galimberti F,Gemmell NJ,Goldsworthy SD,Nichols HJ,Krüger O,Negro S,Osborne A,Pastor T,Robertson BC,Sanvito S,Schultz JK,Shafer ABA,Wolf JBW

更新日期：2018-11-16 00:00:00

abstract：:Transition metal dichalcogenides have attracted research interest over the last few decades due to their interesting structural chemistry, unusual electronic properties, rich intercalation chemistry and wide spectrum of potential applications. Despite the fact that the majority of related research focuses on semicondu...

journal_title：Nature communications

authors： Qi Y,Naumov PG,Ali MN,Rajamathi CR,Schnelle W,Barkalov O,Hanfland M,Wu SC,Shekhar C,Sun Y,Süß V,Schmidt M,Schwarz U,Pippel E,Werner P,Hillebrand R,Förster T,Kampert E,Parkin S,Cava RJ,Felser C,Yan B,Medvedev S

更新日期：2016-03-14 00:00:00

abstract：:Inelastic collisions involving molecular species are key to energy transfer in gaseous environments. They are commonly governed by an energy gap law, which dictates that transitions are dominated by those between initial and final states with roughly the same ro-vibrational energy. Transitions involving rotational ine...

journal_title：Nature communications

authors： Yang D,Huang J,Hu X,Guo H,Xie D

更新日期：2019-10-11 00:00:00

abstract：:Deep learning algorithms have been successfully used in medical image classification. In the next stage, the technology of acquiring explainable knowledge from medical images is highly desired. Here we show that deep learning algorithm enables automated acquisition of explainable features from diagnostic annotation-fr...

journal_title：Nature communications

authors： Yamamoto Y,Tsuzuki T,Akatsuka J,Ueki M,Morikawa H,Numata Y,Takahara T,Tsuyuki T,Tsutsumi K,Nakazawa R,Shimizu A,Maeda I,Tsuchiya S,Kanno H,Kondo Y,Fukumoto M,Tamiya G,Ueda N,Kimura G

更新日期：2019-12-18 00:00:00

abstract：:Mesa structures made of Bi2Sr2CaCu2O8+δ high-temperature superconductor represent stacks of atomic scale intrinsic Josephson junctions. They can be used for generation of high-frequency electromagnetic waves. Here we analyze Josephson emission from small-but-high mesas (with a small area, but containing many stacked j...

journal_title：Nature communications

authors： Borodianskyi EA,Krasnov VM

更新日期：2017-11-23 00:00:00