Abstract:
:The deployment of next-generation renewable biofuels can be enhanced by improving their compatibility with the current infrastructure for transportation, storage and utilization. Propane, the bulk component of liquid petroleum gas, is an appealing target as it already has a global market. In addition, it is a gas under standard conditions, but can easily be liquefied. This allows the fuel to immediately separate from the biocatalytic process after synthesis, yet does not preclude energy-dense storage as a liquid. Here we report, for the first time, a synthetic metabolic pathway for producing renewable propane. The pathway is based on a thioesterase specific for butyryl-acyl carrier protein (ACP), which allows native fatty acid biosynthesis of the Escherichia coli host to be redirected towards a synthetic alkane pathway. Propane biosynthesis is markedly stimulated by the introduction of an electron-donating module, optimizing the balance of O2 supply and removal of native aldehyde reductases.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Kallio P,Pásztor A,Thiel K,Akhtar MK,Jones PRdoi
10.1038/ncomms5731subject
Has Abstractpub_date
2014-09-02 00:00:00pages
4731issn
2041-1723pii
ncomms5731journal_volume
5pub_type
杂志文章abstract::The development of integrated photonics and lab-on-a-chip platforms for environmental and biomedical diagnostics demands ultraviolet electroluminescent materials with high mechanical, chemical and environmental stability and almost complete compatibility with existing silicon technology. Here we report the realization...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1683
更新日期:2012-02-21 00:00:00
abstract::Storage of anthropogenic CO2 in geological formations relies on a caprock as the primary seal preventing buoyant super-critical CO2 escaping. Although natural CO2 reservoirs demonstrate that CO2 may be stored safely for millions of years, uncertainty remains in predicting how caprocks will react with CO2-bearing brine...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12268
更新日期:2016-07-28 00:00:00
abstract::Many crystals, such as those of metals, can transform from one symmetry into another having lower free energy via a diffusionless transformation. Here we create binary colloidal crystals consisting of polymer microspheres, pulled together by DNA bridges, that induce specific, reversible attractions between two species...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2206
更新日期:2012-01-01 00:00:00
abstract::dDsk2 is a conserved extraproteasomal ubiquitin receptor that targets ubiquitylated proteins for degradation. Here we report that dDsk2 plays a nonproteolytic function in transcription regulation. dDsk2 interacts with the dHP1c complex, localizes at promoters of developmental genes and is required for transcription. T...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8049
更新日期:2015-04-28 00:00:00
abstract::Insulin resistance is closely associated with obesity and is one of the earliest symptoms of type-2 diabetes. Endothelial cells are involved in the pathogenesis of insulin resistance through their role in insulin delivery and adipose tissue angiogenesis. Here we show that Ecscr (endothelial cell surface expressed chem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3389
更新日期:2013-01-01 00:00:00
abstract::The rice blast fungus Magnaporthe oryzae is a model for studying fungal-plant interactions. Although it produces two types of spores (microconidia and macroconidia), previous infection studies have exclusively dealt with macroconidia. Germination of microconidia has not been reported, and their role in plant infection...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5518
更新日期:2014-08-01 00:00:00
abstract::Methane cold seep systems typically exhibit extensive buildups of authigenic carbonate minerals, resulting from local increases in alkalinity driven by methane oxidation. Here, we demonstrate that modern seep authigenic carbonates exhibit anomalously low clumped isotope values (Δ47), as much as ∼0.2‰ lower than expect...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12274
更新日期:2016-07-22 00:00:00
abstract::Shear-wave anisotropy in Earth's mantle helps constrain the lattice-preferred orientation of anisotropic minerals due to viscous flow. Previous studies at the Japan Trench subduction zone using land-based seismic networks identified strong anisotropy in the mantle wedge, reflecting viscous flow induced by the subducti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19541-y
更新日期:2020-11-10 00:00:00
abstract::High-field magnets of up to tens of teslas in strength advance applications in physics, chemistry and the life sciences. However, progress in generating such high fields has not been matched by corresponding advances in magnetic field measurement. Based mostly on nuclear magnetic resonance, dynamic high-field magnetom...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13702
更新日期:2016-12-02 00:00:00
abstract::Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule u...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12667
更新日期:2016-10-11 00:00:00
abstract::Macrophages serve multiple functions including immune regulation, morphogenesis, tissue homeostasis and healing reactions. The current paradigm holds that mammary gland macrophages first arise postnatally during the prepubertal period from the bone marrow-derived monocytes. Here we delineate the origins of tissue-resi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08065-1
更新日期:2019-01-17 00:00:00
abstract::Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are unknown. Here we examine the role of upstream inputs to PCs-excitatory granule cells (GCs) and inhibitory molecular layer interneurons-in processing of whisking sign...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00312-1
更新日期:2017-08-10 00:00:00
abstract::Intricate biomineralization processes in molluscs engineer hierarchical structures with meso-, nano- and atomic architectures that give the final composite material exceptional mechanical strength and optical iridescence on the macroscale. This multiscale biological assembly inspires new synthetic routes to complex ma...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10097
更新日期:2015-12-03 00:00:00
abstract::This corrects the article DOI: 10.1038/ncomms15587. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/ncomms16220
更新日期:2018-07-13 00:00:00
abstract::Plants influence extreme heat events by regulating land-atmosphere water and energy exchanges. The contribution of plants to changes in future heat extremes will depend on the responses of vegetation growth and physiology to the direct and indirect effects of elevated CO2. Here we use a suite of earth system models to...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03472-w
更新日期:2018-03-15 00:00:00
abstract::Elemental phosphorus is attracting growing interest across fundamental and applied fields of research. However, atomistic simulations of phosphorus have remained an outstanding challenge. Here, we show that a universally applicable force field for phosphorus can be created by machine learning (ML) from a suitably chos...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19168-z
更新日期:2020-10-29 00:00:00
abstract::Astrocytic endfeet cover the entire cerebral vasculature and serve as exchange sites for ions, metabolites and energy substrates from the blood to the brain. They maintain endothelial tight junctions that form the blood-brain barrier (BBB) and release vasoactive molecules that regulate vascular tone. Malignant gliomas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5196
更新日期:2014-06-19 00:00:00
abstract::Specialized cells in the medial entorhinal cortex (mEC), such as speed cells, head direction (HD) cells, and grid cells, are thought to support spatial navigation. To determine whether these computations are dependent on local circuits, we record neuronal activity in mEC layers II and III and optogenetically perturb l...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06104-5
更新日期:2018-09-12 00:00:00
abstract::Genetic noise together with genome duplication and volume changes during cell cycle are significant contributors to cell-to-cell heterogeneity. How can cells buffer the effects of these unavoidable epigenetic and genetic variations on phenotypes that are sensitive to such variations? Here we show that a simple network...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12959
更新日期:2016-10-03 00:00:00
abstract::Transient precursor states are often experimentally observed for molecules adsorbing on surfaces. However, such precursor states are typically rather short-lived, quickly yielding to more stable adsorption configurations. Here we employ first-principles calculations to systematically explore the interaction mechanism ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3569
更新日期:2013-01-01 00:00:00
abstract::Natural killer (NK) cells limit viral replication by direct recognition of infected cells, antibody-dependent cellular cytotoxicity (ADCC), and releasing cytokines. Although growing evidence supports NK cell antiviral immunity in HIV-1 infection, further knowledge of their response is necessary. Here we show that NK c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03618-w
更新日期:2018-03-23 00:00:00
abstract::In genome editing with CRISPR-Cas9, transgene integration often remains challenging. Here, we present an approach for increasing the efficiency of transgene integration by homology-dependent repair (HDR). CtIP, a key protein in early steps of homologous recombination, is fused to Cas9 and stimulates transgene integrat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03475-7
更新日期:2018-03-19 00:00:00
abstract::Many of the largest known viruses belong to the PRD1-adeno structural lineage characterised by conserved pseudo-hexameric capsomers composed of three copies of a single major capsid protein (MCP). Here, by high-resolution cryo-EM analysis, we show that a class of archaeal viruses possess hetero-hexameric MCPs which mi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09451-z
更新日期:2019-03-29 00:00:00
abstract::The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine essential for the virulence of many disease causing Gram-negative bacteria. At the core of the injectisome structure is the needle complex, a continuous channel formed by the highly oligomerized inner and outer membrane hollow rin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06298-8
更新日期:2018-09-21 00:00:00
abstract::We characterized the population-level neural coding of ensemble representations in visual working memory from human electroencephalography. Ensemble representations provide a unique opportunity to investigate structured representations of working memory because the visual system encodes high-order summary statistics a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13592-6
更新日期:2019-12-11 00:00:00
abstract::Symmetry-breaking phase transitions are an example of non-equilibrium processes that require real-time treatment, a major challenge in strongly coupled systems without long-lived quasiparticles. Holographic duality provides such an approach by mapping strongly coupled field theories in D dimensions into weakly coupled...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8406
更新日期:2015-06-23 00:00:00
abstract::Amazon forests have experienced frequent and severe droughts in the past two decades. However, little is known about the large-scale legacy of droughts on carbon stocks and dynamics of forests. Using systematic sampling of forest structure measured by LiDAR waveforms from 2003 to 2008, here we show a significant loss ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05668-6
更新日期:2018-08-09 00:00:00
abstract::Significant advances have been made towards fault-tolerant operation of silicon spin qubits, with single qubit fidelities exceeding 99.9%, several demonstrations of two-qubit gates based on exchange coupling, and the achievement of coherent single spin-photon coupling. Coupling arbitrary pairs of spatially separated q...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08970-z
更新日期:2019-03-05 00:00:00
abstract::The coupling of ordered electronic phases with lattice, spin, and orbital degrees of freedom are of central interest in strongly correlated systems. Their interplay has been intensively studied from femtosecond to picosecond time scales, while their dynamics beyond nanoseconds are usually assumed to follow lattice coo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04199-4
更新日期:2018-05-04 00:00:00
abstract::The force generated by the actomyosin cytoskeleton controls focal adhesion dynamics during cell migration. This process is thought to involve the mechanical unfolding of talin to expose cryptic vinculin-binding sites. However, the ability of the actomyosin cytoskeleton to directly control the formation of a talin-vinc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4095
更新日期:2014-01-01 00:00:00